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Nathan Goodyear

Cell Research - Sirtuin deacetylases in neurodegenerative diseases of aging - 0 views

www.nature.com/...cr201370a.html

sirtuins neurodegenerative disease

shared by Nathan Goodyear on 11 Sep 13 - No Cached
  • Nathan Goodyear on 11 Sep 13
     
    Sirtuins and neurodegenerative diseases
Nathan Goodyear

Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Die... - 0 views

www.cell.com/...S1550-4131(11)00346-9

NAD nicotinamide mononucleotide sirtuins diabetes metabolism

shared by Nathan Goodyear on 07 Jun 16 - No Cached
  • Nathan Goodyear on 07 Jun 16
     
    NAD found to be useful in the treatment of diabetes in animal model.  The positive effect is through increased Sirtuin activity
Nathan Goodyear

Neuroprotective Sirtuin ratio reversed by ApoE4 - 0 views

www.pnas.org/...1314145110.abstract

ApoE4 alzheimer's disease Alzheimer's disease sirtuins SIRT1 resveratrol

shared by Nathan Goodyear on 23 Oct 13 - No Cached
  • Nathan Goodyear on 23 Oct 13
     
    ApoE4 allele is known to increase Alzheimer's disease by 10 fold.  One mechanism is through a lowering of SirT1 and an increase in the SirT1:SirT2 ratio.  This SirT1 is the target of resveratrol in red wine.
Nathan Goodyear

The NAD+ precursor nicotinamide riboside enhances oxidative metabolism and protects aga... - 0 views

www.ncbi.nlm.nih.gov/...PMC3616313

NAD nicotinamide riboside metabolism obesity SIRT sirtuins

shared by Nathan Goodyear on 07 Jun 16 - No Cached
  • Nathan Goodyear on 07 Jun 16
     
    nicotinamide riboside shown to offset the negative metabolic effects of American diet induced obesity.  NAD also increased SIRT1 and SIRT3 activity
Nathan Goodyear

Mechanism of Human SIRT1 Activation by Resveratrol - 0 views

www.jbc.org/...17187.short

Resveratrol SIRT1

shared by Nathan Goodyear on 18 Mar 11 - No Cached
  • The NAD+-dependent protein deacetylase family, Sir2 (or sirtuins), is important for many cellular processes including gene silencing, regulation of p53, fatty acid metabolism, cell cycle regulation, and life span extension
  • resveratrol was shown to increase life span in three model organisms through a Sir2-dependent pathway.
  • Nathan Goodyear on 18 Mar 11
     
    Resveratrol potentially increases life span through SIRT1 activation
Nathan Goodyear

Modulation of NF-[kappa]B-dependent transcription and cell survival by the SIRT1 deacet... - 0 views

www.nature.com/...7600244a.html

resveratrol inflammation

shared by Nathan Goodyear on 18 Mar 11 - No Cached
  • Treatment of cells with resveratrol, a small-molecule agonist of Sirtuin activity, potentiates chromatin-associated SIRT1 protein on the cIAP-2 promoter region, an effect that correlates with a loss of NF-B-regulated gene expression
  • Nathan Goodyear on 18 Mar 11
     
    resveratrol decreases NF-kappa Beta expression and thus reduces inflammation
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