ApoE4 allele is known to increase Alzheimer's disease by 10 fold. One mechanism is through a lowering of SirT1 and an increase in the SirT1:SirT2 ratio. This SirT1 is the target of resveratrol in red wine.
The NAD+-dependent protein deacetylase family, Sir2 (or sirtuins), is important for many cellular processes including gene silencing,
regulation of p53, fatty acid metabolism, cell cycle regulation, and life span extension
resveratrol was shown to increase life span in three model organisms through a Sir2-dependent pathway.
Treatment of cells with resveratrol, a small-molecule agonist of Sirtuin activity, potentiates chromatin-associated SIRT1 protein on the cIAP-2 promoter region, an effect that correlates with a loss of NF-B-regulated gene expression