Proposed mechanism
Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and h... - 0 views
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The data show that pharmacologic ascorbate concentrations produced Asc•− selectively in extracellular fluid compared with blood and that H2O2 formation occurred when Asc•− concentrations were >100 nM in extracellular fluid.
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These data validate the hypothesis that ascorbate is a prodrug for selective delivery of reactive species to the extravascular space
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Ascorbic Acid Chemosensitizes Colorectal Cancer Cells and Synergistically Inhibits Tumo... - 0 views
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therapeutic potential has been supported by a large and consistent body of evidences from in vitro
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Ascorbic acid might act as a way to deliver hydrogen peroxide (H2O2) to the tissues
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pharmacological concentrations of AA were capable of inducing anti-proliferative, cytotoxic and genotoxic effects
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