Long-term stabilization of stage 4 colon cancer using sodium dichloroacetate therapy - 1 views
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inhibition of mitochondrial pyruvate dehydrogenase kinase
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inhibition of aerobic glycolysis (the Warburg effect) and activation of mitochondrial potassium ion channels
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angiogenesis blockade
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changes in expression of HIF1-α
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alteration of pH regulators V-ATPase and MCT1, and other cell survival regulators such as PUMA, GLUT1, Bcl2 and p53
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DCA as a cancer stabilizing agent
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A protocol of natural medications was developed to address the dose-limiting neurologic toxicity, in collaboration with a naturopathic physician (Andrews). The oral DCA regimen that was developed included three natural medications acetyl L-carnitine[29-31], R-alpha lipoic acid[32-34] and benfotiamine[35-37], for the primary purpose of neuropathy prevention
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measurable benefits from DCA therapy in 60%-70% of cases
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Good review of dichloracetate or DCA in antitumor activity. DCA has been shown to have numerous anticancer properties.