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Nathan Goodyear

PET/CT Standardized Uptake Values (SUVs) in Clinical Practice and Assessing Response to... - 0 views

www.ncbi.nlm.nih.gov/...PMC3026294

cancer PET scan PET_CT CT PET_CT scan

shared by Nathan Goodyear on 20 Feb 18 - No Cached
  • use of PET in clinical research, clinical trials, and drug discovery
  • use of PET/CT in assessing response to therapy
  • In some cases, such as Hodgkins lymphoma, quantitative PET/CT imaging may not actually be needed, as success can be defined by the complete absence of tracer uptake in the PET image following a course of standardized therapy
  • ...9 more annotations...
  • The utilization of PET/CT to assess response to therapy is increasing in the US related, in part, to the creation and subsequent favorable results of the National Oncologic PET Registry (NOPR)
  • Changes in size as a result of therapy may take many months to develop and any opportunity to make early decisions about therapy success or failure is often unduly delayed or lost altogether
  • measures of changes in metabolic activity via FDG PET/CT can provide an alternate approach to assess response to therapy -- often very early in the course of treatment
  • Current recommendations are that tumor SUVs should be reported
  • The true tracer uptake in a patient is composed of two components: the first being the amount of tracer uptake (e.g. FDG) associated with the disease status (the signal of interest), which can be modified by the biophysiological status of the patient. One of the more important patient parameters is the blood glucose level, which has been shown to inversely-linearly affect SUVs
  • A prospective study by Crippa et al.30 in eight patients showed that as blood glucose levels were increased from 92.4 ±10.2 to 158 ± 13.8 mg/100 ml by glucose loading, the average SUV of 20 liver metastases decreased from 9.4 ± 5.7 to 4.3 ± 8.3
  • chemotherapy can result in impaired renal function, significantly reducing the clearance of plasma FDG through the kidney and thus increasing tumor SUV relative to an initial PET scan
  • The second component of the true tracer uptake is biological variability
  • The biological variability has been estimated in several test-retest studies7,32–35 at approximately 10% for scans repeated within a few days
  • Nathan Goodyear on 20 Feb 18
     
    Good review of the SUVs of a PET/CT scan.
Nathan Goodyear

Understanding the Role of Nutrition and Wound HealingNutrition in Clinical Practice - J... - 0 views

journals.sagepub.com/...0884533609358997

nutrition surgery IV nutrition malnutrition

shared by Nathan Goodyear on 13 Jul 17 - No Cached
  • Nathan Goodyear on 13 Jul 17
     
    Malnutrition linked to poor wound healing, decreased wound tensile strength, and increased infection rates.
Nathan Goodyear

Medical education in pharmacogenomics-results from a survey on pharmacogenetic knowledg... - 0 views

www.ncbi.nlm.nih.gov/...PMC5599468

genetics pharmacogenetics

shared by Nathan Goodyear on 17 Jan 18 - No Cached
  • Of participants, 84.3% found pharmacogenomics relevant to their current practice
  • More than two-thirds (65.7%) did not order nor recommend a pharmacogenomic test in the past year
  • pharmacogenomic testing was understood mainly for assessment of the variability of genes affecting drug disposition, metabolism and drug transport leading to individual responses to drugs
  • ...4 more annotations...
  • Pre-emptive, prospective, genotyping to make individualised drug therapy feasible is seen to contribute to personalised medicine
  • assumed to improve drug efficacy and safety
  • Potential benefits of pharmacogenomics (PGx) have been defined such as predicting intended response to medication by more accurate dosing, avoiding adverse drug reactions and therefore enhancing drug safety and reducing health care cost
  • survey among Dutch pharmacists revealed 14.7% recent users of PGx diagnostics [27], whereas in our cohort, the percentage was with 34.3% higher.
  • Nathan Goodyear on 17 Jan 18
     
    Doctors and pharmacists are slow to integrate pharmacogenetics. Good working definition of pharmacogenetics as well.
ericdale1211

Dog neutering & spaying: pre & post-operative care tips - Richmond Valley Veterinary Pr... - 0 views

richmondvalleyvet.com/...g-pre-post-operative-care-tips

dogs veterinarians animal

shared by ericdale1211 on 09 Jul 19 - No Cached
  • ericdale1211 on 09 Jul 19
     
    Learn more about the pre and post operative care tips for dog neutering or spaying.
Nathan Goodyear

Apolipoprotein B and Cardiovascular Disease Risk: Position Statement from the AACC Lipo... - 0 views

clinchem.aaccjnls.org/...407

apo B Apolipoprotein B cardiovascular disease LDL cholesterol

shared by Nathan Goodyear on 13 Dec 17 - No Cached
  • Nathan Goodyear on 13 Dec 17
     
    ApoB is a better measure of risk than LDL.
Nathan Goodyear

Low-Dose Naltrexone in Combination with High-Dose Vitamin C in Cancer Patients: Our Exp... - 0 views

LDN metastasis IV vitamin C vitamin C cancer High dose IV vitamin C dose high dose vitamin C low naltrexone)

shared by Nathan Goodyear on 09 Mar 21 - No Cached
  • Nathan Goodyear on 09 Mar 21
     
    Review of one clinics experience with HDIVC and LDN.
Nathan Goodyear

Venous Thromboembolism Prophylaxis and Treatment in Patients With Cancer: ASCO Clinical... - 0 views

ascopubs.org/...JCO.19.01461

DVT pulmonary embolus deep venous thrombosis PE pulmonary emboli anti-coagulant cancer

shared by Nathan Goodyear on 04 Jul 21 - No Cached
  • Nathan Goodyear on 04 Jul 21
     
    Updated recommendations
Nathan Goodyear

Herbal Treatment for Prostate Cancer? - 0 views

restorativemedicine.org/...cer-in-a-naturopathic-practice

artemisinin prostate cancer

shared by Nathan Goodyear on 24 Aug 20 - No Cached
  • Nathan Goodyear on 24 Aug 20
     
    Pulsed artemisinin, 400 mg po TID, found to top tumor growth. Pulsed dosing is required due to stop in absorption after 5-7 days.
Nathan Goodyear

Cancer-Related Hypercalcemia | JCO Oncology Practice - 0 views

ascopubs.org/...jop.2016.011155

cancer hypercalcemia

shared by Nathan Goodyear on 24 Jun 20 - No Cached
  • Nathan Goodyear on 24 Jun 20
     
    Great review of the causes and management of hypercalcemia in cancer.
brookegibbs

What is the difference between organic and non-organic food? - 1 views

The primary difference between organic and non-organic food lies in their farming and production methods. Organic food is grown without the use of synthetic pesticides, herbicides, or fertilizers, ...

Food

started by brookegibbs on 01 Dec 24 no follow-up yet
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