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Stretch Marks

Prevention Cream For Stretch Marks - 1 views

I was really afraid to get pregnant because I knew then that my skin will be prone to stretch marks. That is why I have researched on How to get rid of stretch marks to prevent it from appearing o...

skin care how to get rid of stretch marks

started by Stretch Marks on 28 Feb 12 no follow-up yet
Stretch Marks

Prevention Cream For Stretch Marks - 1 views

I was really afraid to get pregnant because I knew then that my skin will be prone to stretch marks. That is why I have researched on How to get rid of stretch marks to prevent it from appearing o...

how to get rid of stretch marks skin care

started by Stretch Marks on 29 Feb 12 no follow-up yet
felipp windsor

Thank You The Dental Co. - 1 views

I really got worried when I found out that I got some tooth problems. For one thing, I have low tolerance to pain and I do not want to lose any of my teeth. That is why I looked for the best dentis...

teeth whitening windsor

started by felipp windsor on 03 Dec 13 no follow-up yet
Sonny Cher

Party All You Want After Work - 1 views

My current job ends at 10 in the evening. However, it is my friend's homecoming party and he invited me to come by after work. I knew I would definitely feel exhausted after work and I am afraid I ...

stimulants

started by Sonny Cher on 17 May 11 no follow-up yet
Sonny Cher

Party All You Want After Work - 1 views

My current job ends at 10 in the evening. However, it is my friend's homecoming party and he invited me to come by after work. I knew I would definitely feel exhausted after work and I am afraid I ...

stimulants

started by Sonny Cher on 20 Apr 11 no follow-up yet
Nathan Goodyear

microRNA Expression in Ethnic Specific Early Stage Breast Cancer: an Integration and Co... - 0 views

www.nature.com/...s41598-017-16978-y

genetics cancer epigenetics breast cancer

shared by Nathan Goodyear on 06 Feb 18 - No Cached
mamdouh_hfz liked it
  • dysregulated miRNA could be involved in tumor cell proliferation and growth as well as cell cycle progression
  • under-expression of miR-497, 376c and 1271 in Lebanese breast cancer tissues
  • The upregulated miR-183 in our samples was predicted to be responsible for the decrease in expression of the BTG1 mRNA whose protein is involved in cell cycle arrest and apoptosis in breast cancer cells18.
  • ...9 more annotations...
  • nother molecule related to cell proliferation that was over-expressed in our data and suggested as a target of downregulated miR-376c is AURKA
  • the over-expression of miR-183 and miR-21 in Lebanese breast cancer tissues is consistent with downregulation of two important tumor suppressor predicted targets: AKAP12 whose protein regulates cellular adhesion dynamics by controlling cytoskeletal architecture, cell migration, and mitogenic signaling20; and LATS2 whose protein causes cell cycle arrest
  • dysregulation in cancer particularly in breast cancer highlights their importance in tumor development
  • mRNA-miRNA integration analysis of early breast cancer revealed a potential role of miRNA in increasing cellular proliferation and progression, and decreasing invasion and migration
  • most of the miRNA dysregulated in Lebanese breast cancer patients are similar to those dysregulated in American patients, differences in miRNA expression exist and could be attributed either to the patients’ age at diagnosis or to ethnic variation in miRNA epigenetic regulation and sequence variation of pre-miRNA
  • the number one cancer killer of women worldwide
  • microRNA (miRNA) are small non-coding 18–25 nucleotide RNA molecules currently being studied as potential diagnostic, prognostic and therapeutic biomarkers for cancer and other diseases
  • Extensive research on these post-transcriptional modulators has proven that they are deregulated in breast cancerous tissues and even in biological fluids from breast cancer patients
  • five candidate miRNAs (miR-10b, miR-148b, miR-221, miR-21, and miR-155)
  • Nathan Goodyear on 06 Feb 18
     
    Epigenetics plays a role, via disregulated miRNA, in increased cell growth, progression, and invasion in Lebanese women with breast cancer.  It is not just genetics that play a role, but epigenetics.
Barbara Smith

The Health Service That You Truly Deserve - 1 views

I have been suffering from my migraine for several years already. The medicines which I used only gave me temporary relief but did not really solve my problem. I was already hopeless thinking that ...

started by Barbara Smith on 10 Oct 12 no follow-up yet
Edgar Anderson

Losing Weight The Healthy Way - 1 views

I admit it was not that easy for me to lose weight. In fact, I have used a lot of products that did not work and I have spent a long period of time in the gym, yet nothing happened. I was about to ...

started by Edgar Anderson on 28 Nov 12 no follow-up yet
Barbara Smith

Effective Chiropractic Solution - 1 views

I had the worst back pain ever. I already tried all types of painkillers and back pain remedies but none of them worked for me. I was about to give up when a friend told me about The Chiropractic D...

started by Barbara Smith on 08 Jan 13 no follow-up yet
Justin Stone

Effective Stretch Mark Remedy - 4 views

I gave birth six months ago. What bothers me are these stretch marks that are found in my belly. I could not wear my swim wear attire whenever my family would decide to stay at the beach to swim. I...

skin care stretch mark cream

started by Justin Stone on 28 Feb 12 no follow-up yet
Justin Stone

Effective Stretch Mark Remedy - 1 views

I gave birth six months ago. What bothers me are these stretch marks that are found in my belly. I could not wear my swim wear attire whenever my family would decide to stay at the beach to swim. I...

stretch mark cream

started by Justin Stone on 29 Feb 12 no follow-up yet
Justin Stone

Effective Stretch Mark Remedy - 3 views

I gave birth six months ago. What bothers me are these stretch marks that are found in my belly. I could not wear my swim wear attire whenever my family would decide to stay at the beach to swim. I...

stretch mark cream treatment skin care

started by Justin Stone on 07 Mar 12 no follow-up yet
Day Spa Adelaide

I went to Shantai and I was Rebourned - 1 views

Nothing can be as good as relieving oneself from the daily pressures of life than treating yourself to a rejuvenating and satisfying facial treatment. Such is what I did when I felt that my stress...

Day Spa Adelaide

started by Day Spa Adelaide on 25 Nov 11 no follow-up yet
Nathan Goodyear

Lowered testosterone in male obesity: Mechanisms, morbidity and management Tang Fui MN,... - 0 views

www.ajandrology.com/article.asp

Testosterone male obesity overweight men hormone hormones low T Low T

shared by Nathan Goodyear on 15 Jan 14 - No Cached
  • The number of overweight people is expected to increase from 937 million in 2005 to 1.35 billion in 2030
  • Similarly the number of obese people is projected to increase from 396 million in 2005 to 573 million in 2030
  • By 2030, China alone is predicted to have more overweight men and women than the traditional market economies combined
  • ...37 more annotations...
  • diacylglycerol O-acyltransferase 2 (DGAT2), mechanistically implicated in this differential storage, [10] is regulated by dihydrotestosterone, [11] suggesting a potential role for androgens to influence the genetic predisposition to either the MHO or MONW phenotype.
  • bariatric surgery achieves 10%-30% long-term weight loss in controlled studies
  • The fact that obese men have lower testosterone compared to lean men has been recognized for more than 30 years
  • Reductions in testosterone levels correlate with the severity of obesity and men
  • epidemiological data suggest that the single most powerful predictor of low testosterone is obesity, and that obesity is a major contributor of the age-associated decline in testosterone levels.
  • healthy ageing by itself is uncommonly associated with marked reductions in testosterone levels
  • obesity blunts this LH rise, obesity leads to hypothalamic-pituitary suppression irrespective of age which cannot be compensated for by physiological mechanisms
  • Reductions in total testosterone levels are largely a consequence of reductions in sex hormone binding globulin (SHBG) due to obesity-associated hyperinsulinemia
  • although controversial, measurement of free testosterone levels may provide a more accurate assessment of androgen status than the (usually preferred) measurement of total testosterone in situations where SHBG levels are outside the reference range
  • SHBG increases with age
  • marked obesity however is associated with an unequivocal reduction of free testosterone levels, where LH and follicle stimulating hormone (FSH) levels are usually low or inappropriately normal, suggesting that the dominant suppression occurs at the hypothalamic-pituitary level
  • adipose tissue, especially when in the inflamed, insulin-resistant state, expresses aromatase which converts testosterone to estradiol (E 2 ). Adipose E 2 in turn may feedback negatively to decrease pituitary gonadotropin secretion
  • diabetic obesity is associated with decreases in circulatory E 2
  • In addition to E 2 , increased visceral fat also releases increased amounts of pro-inflammatory cytokines, insulin and leptin; all of which may inhibit the activity of the HPT axis at multiple levels
  • In the prospective Massachusetts Male Aging Study (MMAS), moving from a non-obese to an obese state resulted in a decline of testosterone levels
  • weight loss, whether by diet or surgery, increases testosterone levels proportional to the amount of weight lost
  • fat is androgen-responsive
  • low testosterone may augment the effects of a hypercaloric diet
  • In human male ex vivo adipose tissue, testosterone decreased adipocyte differentiation by 50%.
  • Testosterone enhances catecholamine-induced lipolysis in vitro and reduces lipoprotein lipase activity and triglyceride uptake in human abdominal adipose tissue in vivo
  • in men with prostate cancer receiving 12 months of androgen deprivation therapy, fat mass increased by 3.4 kg and abdominal VAT by 22%, with the majority of these changes established within 6 months
  • severe sex steroid deficiency can increase fat mass rapidly
  • bidirectional relationship between testosterone and obesity
  • increasing body fat suppresses the HPT axis by multiple mechanisms [30] via increased secretion of pro-inflammatory cytokines, insulin resistance and diabetes; [19],[44] while on the other hand low testosterone promotes further accumulation of total and visceral fat mass, thereby exacerbating the gonadotropin inhibition
  • androgens may play a more significant role in VAT than SAT
  • men undergoing androgen depletion for prostate cancer show more marked increases in visceral compared to subcutaneous fat following treatment
    • Nathan Goodyear
      Nathan Goodyear on 16 Jan 14
       
      Interesting: low T increases VAT, yet T therapy does not reduce VAT, yet T therapy reduces SAT.
  • irisin, derived from muscle, induces brown fat-like properties in rodent white fat
  • androgens can act via the PPARg-pathway [37] which is implicated in the differentiation of precursor fat cells to the energy-consuming phenotype
  • low testosterone may compound the effect of increasing fat mass by making it more difficult for obese men to lose weight via exercise
  • pro-inflammatory cytokines released by adipose tissue may contribute to loss of muscle mass and function, leading to inactivity and further weight gain in a vicious cycle
  • Sarcopenic obesity, a phenotype recapitulated in men receiving ADT for prostate cancer, [55] may not only be associated with functional limitations, but also aggravate the metabolic risks of obesity;
  • observational evidence associating higher endogenous testosterone with reduced loss of muscle mass and crude measures of muscle function in men losing weight
  • genuine reactivation of the HPT axis in obese men requires more substantial weight-loss
  • A number of intervention studies have confirmed that both diet- and surgically-induced weight losses are associated with increased testosterone, with the rise in testosterone generally proportional to the amount of weight lost
  • men, regardless of obesity level, can benefit from the effect of weight loss.
  • inconsistent effect of testosterone on VAT
  • Nathan Goodyear on 15 Jan 14
     
    to be read
Sonny Cher

Getting High Legally! - 1 views

After getting out of rehab, I still cannot shake off my need to get high. However, I vowed not to resort to illegal drugs again. After consulting a friend about it, he introduced legal drugs and ma...

Kronic

started by Sonny Cher on 27 May 11 no follow-up yet
Sonny Cher

Energy Pills for Extra Energy - 2 views

I am always tired after working for the whole day. And my boyfriend is already mad at me because he felt neglected. I do not have time for him to go out on a date because I do not have the energy t...

legal highs

started by Sonny Cher on 02 May 11 no follow-up yet
Sonny Cher

Energy Pills for Extra Energy - 2 views

I am always tired after working for the whole day. And my boyfriend is already mad at me because he felt neglected. I do not have time for him to go out on a date because I do not have the energy t...

Legal highs

started by Sonny Cher on 06 May 11 no follow-up yet
becomea paramedic

My Paramedic Dream Came True - 1 views

Two years ago, I pursued my dream of becoming a paramedic in the London Ambulance Service. I know it would be tough since there were many applicants vying for the few slots. But, I was undeterred i...

How To Become A Paramedic

started by becomea paramedic on 28 Oct 11 no follow-up yet
Nathan Goodyear

Testosterone deficiency and cardiovascular mortality Morgentaler A, - Asian J Androl - 0 views

www.ajandrology.com/preprintarticle.asp

testosterone low t low Testosterone CVD cardiovascular mortality therapy

shared by Nathan Goodyear on 01 Dec 14 - No Cached
  • overall mortality and CV mortality were inversely associated with serum T concentrations.
  • men with low serum T, defined as < 8.7 nmol l−1 (250 ng dl−1 ), demonstrated significantly greater all-cause mortality than men with higher serum T (hazard ratio [HR]: 2.24; 95% CI: 1.41-3.57), as well as greater CV mortality
  • lower T levels were significantly associated with the presence of any CV disease
  • ...19 more annotations...
  • more than 30 years of studies suggesting that low levels of T represent an increased risk for CV and overall mortality,
  • lower serum T concentrations also are associated with CV disease, including incident coronary artery disease [17],[18],[19] and atherosclerosis,
  • the actual rate of adverse events was only half as great in the T group (123 events in 1223 men at risk = 10.1%) as in the untreated group (1587 events in 7486 men = 21.2%)
  • The study by Vigen et al. [7] has already undergone two published corrections,
  • 29 medical societies have called for retraction of the article, asserting "gross data mismanagement and contamination," that rendered the study "no longer credible
  • Mortality in T-treated men was reduced by approximately half in treated men compared with untreated men, at 10.3% versus 20.7%, respectively
  • The mortality rate for men who received TTh was 3.4 deaths per 100 person-years, and 5.7 deaths per 100 person-years in untreated men
  • HR of 0.61 (95%CI: 0.42-0.88; P = 0.008), indicating a significant reduction in mortality with TTh
  • men in the highest prognostic MI risk quartile, treatment with TTh was associated with reduced risk
  • tripling in T prescriptions in the US over the last decade
  • a majority of observational studies have found that low endogenous serum T levels are associated with increased mortality.
  • Men who received TTh were able to exercise significantly longer without ischemia compared with men who received placebo
  • In men with congestive heart failure, those who received T demonstrated greater walking distance and other functional endpoints compared with those who received placebo
  • TTh has been shown uniformly and repeatedly to improve several known CV risk factors, including reduced fat mass, body fat percent, and waist circumference, and increased lean mass
  • improved glycemic control
  • reductions in insulin resistance.
  • the evidence strongly points to improved CV status with normal serum T or treatment with TTh in men with TD
  • analysis of health insurance claims data that reported a 36% increased rate of nonfatal MI in the 90d following receipt of a T prescription compared with the 12 prior months.
  • Comparison with men who received a prescription for a phosphodiesterase type 5 inhibitor (PDE5i) revealed no increased rate of MI following the prescription
  • Nathan Goodyear on 01 Dec 14
     
    Great review by Morgentaler of Testosterone and CVD.  He highlights the significant flaws in the JAMA and the NEJM articles of Testosterone therapy risks.  Morgentaler highlights the significant evidence that points to low T and increased risk of CVD. On contention I have, is Morgantaler seems to flip aside the massive uptick of Testosterone use in the US as compared to other countries.  The evidence definitely points to Testosterone therapy as being safe in those with low T, but there is definitely a problem of significant Testosterone doping that is taking place as well.
indiacardiacsurg

Marla Banza from Congo Received Heart Surgery By Dr. Naresh Trehan India ~ Medical Tour... - 0 views

medical-tourism-magazine.blogspot.com/...by-dr-naresh-trehan-india.html

Congo Dr. Naresh Trehan dr naresh trehan contact number dr trehan cardiologist delhi dr trehan medanta hospital gurgaon

shared by indiacardiacsurg on 03 Dec 21 - No Cached
  • indiacardiacsurg on 03 Dec 21
     
    In a single sentence, my experience of India and about the surgeon has been incredible. I really can't comment the Dr. Naresh Trehan enough. I had no problem coming again. It cost him only £4,800 and that included the cost of my flight from Congo to India and back. I feel very fit and fine now than what I was feeling earlier."
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