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Nathan Goodyear

Nonantibiotic Effects of Fluoroquinolones in Mammalian Cells - 0 views

www.jbc.org/...22287.long

flouroquinolones cipro levaquin epigenetics HIF-1alpha tendinopathy

shared by Nathan Goodyear on 16 Nov 17 - No Cached
  • Nathan Goodyear on 16 Nov 17
     
    New study suggests global epigenetics is the cause behind fluoroquinolone mechanism of the Tendinopathies.  Specifically, they suggest that Iron chelation by the fluoroquinolones supresses the expression of P4HA1 and LH1 to lead to weakend collagen.  They also described decreased epigenetic changes in collagen hydroxylation and suppression of HIF-1alpha as mechanisms contributing to the tendinopathies as well.
Nathan Goodyear

Fluoroquinolones and Tendinopathy: A Guide for Athletes and Sports Clinicians and a Sys... - 0 views

www.ncbi.nlm.nih.gov/...PMC4080593

fluoroquinolones tendinopathy

shared by Nathan Goodyear on 02 Aug 17 - No Cached
  • Nathan Goodyear on 02 Aug 17
     
    Fluoroquinolone induced tendon injury research review from '14
Nathan Goodyear

Diminished Ciprofloxacin-Induced Chondrotoxicity by Supplementation with Magnesium and ... - 0 views

www.ncbi.nlm.nih.gov/...PMC1803142

fluoroquinolones magnesium vitamin E

shared by Nathan Goodyear on 02 Aug 17 - No Cached
  • Nathan Goodyear on 02 Aug 17
     
    Magnesium and vitamin E to treat fluoroquinolone induced chrondrotoxicity in animal study.
Nathan Goodyear

Severe shoulder tendinopathy associated with levofloxacin - ScienceDirect - 0 views

www.sciencedirect.com/...S1413867012000645

levaquin tendinopathy tendinitis fluoroquinolones

shared by Nathan Goodyear on 02 Aug 17 - No Cached
  • Nathan Goodyear on 02 Aug 17
     
    Case study of should tendinopathy in a patient after use of levaquin
Nathan Goodyear

The Risk of Fluoroquinolone-induced Tendinopathy and Tendon Rupture - 0 views

www.ncbi.nlm.nih.gov/...PMC2921747

flouroquinolones ciprofloxacin levoquin tendinitis tendinopathy Tendon rupture

shared by Nathan Goodyear on 02 Aug 17 - No Cached
  • Achilles tendinitis or rupture is among the most serious side effects associated with FQ use
  • The large body of data provided by clinical reports, histopathological examination, and experimental studies provides cogent evidence supporting a direct link between FQ use and tendonitis/tendon rupture
  • Risk factors associated with FQ-induced tendon disorders include age greater than 60 years, corticosteroid therapy, renal failure, diabetes mellitus, and a history of musculoskeletal disorders
  • ...17 more annotations...
  • The average age of FQ-induced tendinopathy is 64 years, with a male-to-female ratio of 2:1, and a 27-percent incidence of bilateral involvement
  • Although more than 95 percent of cases of tendinitis/rupture secondary to FQ involve the Achilles tendon, other reported sites of tendon involvement include the quadriceps, peroneus brevis, and rotator cuff
  • FQs demonstrate a 3.8-fold greater risk for development of Achilles tendinitis/rupture
  • a large population-based case control analysis, patients treated with FQs exhibited a substantially increased risk of developing tendon disorders overall (1.7-fold), tendon rupture (1.3-fold), and ATR (4.1-fold)
  • patients taking FQs with concurrent exposure to corticosteroids were found to experience a compounding effect on the risk of tendon rupture, specifically a 46-fold greater predisposition
  • Some authors have recommended that patients with a history of Achilles tendinitis and advanced age should not be prescribed FQ antibiotics
  • Approximately 50 percent of patients will recover within 30 days, with 25 percent of patients having symptoms persistent for longer than two months
  • The mean latency period between the start of FQ treatment and occurrence of tendinopathy has been reported to be a few hours to months, with a median onset of 6 days
  • The exact pathophysiology of FQ-induced tendinopathy remains elusive
  • it is possible that FQs have a direct cytotoxic effect on enzymes found in mammalian musculoskeletal tissue
  • It has been theorized that FQs disproportionately affect human tendons that have a limited capacity for repair, such as in older patients or structural compromise (i.e., pre-existing tendinopathy or trauma)
  • histopathological findings are similar to those observed in overuse conditions in athletes
  • Treatment with a FQ should be discontinued and physical therapy initiated
  • treatment should include rest and decreasing the physical load on the tendon.
  • Approximately 85 percent of patients present in less than one month
  • Because rupture can occur even late in the course of treatment or after discontinuation of FQ use, patients receiving a FQ should be counseled to seek medical attention immediately if symptoms, such as redness, pain, swelling, and stiffness, develop
  • FQs should be used cautiously in patients with risk factors associated with tendinitis, such as advanced age, history of tendon rupture, corticosteroid use, and/or acute or chronic renal dysfunction
  • Nathan Goodyear on 02 Aug 17
     
    Great review of the link between flouroquinolones and Tendinitis and Tendon rupture.  Yes, there is a direct link.
Nathan Goodyear

[Fluoroquinolone-induced Achilles tendon rupture]. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...18236349

flouroquinolones tendinopathy tendinitis levaquin

shared by Nathan Goodyear on 02 Aug 17 - No Cached
  • Nathan Goodyear on 02 Aug 17
     
    abstract of a case study of a Flouroquinolone induced Achilles tendon rupture.
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