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Nathan Goodyear

Oxytocin Increases Retention of Social Cognition in Autism - 0 views

www.biologicalpsychiatryjournal.com/...abstract

autism autism spectrum disorder ASD oxytocin

shared by Nathan Goodyear on 14 Aug 13 - No Cached
  • Nathan Goodyear on 14 Aug 13
     
    This could be a repeat post, but oxytocin shown to improve social behavior, especially recognition.
Nathan Goodyear

Dramatic improvement in sexual function induced by... [J Sex Med. 2012] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22458365

oxytocin intranasal libido ED hormone hormones

shared by Nathan Goodyear on 29 Jul 13 - No Cached
  • Nathan Goodyear on 29 Jul 13
     
    limited study as it is a case study of 1.  However, there was improvement with libido, erection, and orgasm in this case study of 1 with intranasal oxytocin.
Nathan Goodyear

Lower sexual interest in postpartum women: relati... [Horm Behav. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23085496

oxytocin libido hormone hormones intranasal

shared by Nathan Goodyear on 29 Jul 13 - No Cached
  • Nathan Goodyear on 29 Jul 13
     
    The right amygdala appears to play a role in the postpartum decline in libido in women.  This study found no difference with intranasal oxytocin spray.
Nathan Goodyear

Neuropeptidergic regulation of affiliative behavior and social bonding in animals - 0 views

www.sciencedirect.com/...S0018506X06001802

autism ASD autism spectrum disorder oxytocin vasopressin

shared by Nathan Goodyear on 14 Aug 13 - No Cached
  • Nathan Goodyear on 14 Aug 13
     
    The dogma on oxytocin and vasopressin, both posterior pituitary hormones, is being challenged by the literature.  Both hormones are proposed to be involved in improving social behavior in those with autism and other psychiatric disorders.
Nathan Goodyear

Salivary Testosterone and a Trinucleotide (CAG) Length Polymorphism in the Androgen Rec... - 0 views

www.ncbi.nlm.nih.gov/...PMC2825741

CAG androgen receptors AR androgen receptor Testosterone hormone hormones male men

shared by Nathan Goodyear on 22 Jun 15 - No Cached
  • Testosterone correlated inversely with participant age (r = −0.39, p = 0.012) and positively with number of CAG repeats
  • transactivation potential of the AR appears to decline in graded relation to an increasing number of CAG repeats, which are distributed over a normative range of 11–37 and, in Caucasian populations, commonly average 21–22 repeats
  • When activated by androgens, ARs translocate to the cell nucleus, where they exert transcriptional control of androgen-dependent genes by binding to androgen response elements within gene regulatory sequences
  • ...10 more annotations...
  • some evidence suggests a high number of CAG repeats may be associated with cognitive aging
  • androgens (like other steroid hormones) promote or repress the expression of genes specifying an array of cellular proteins
  • diurnal variation in testosterone levels
  • salivary testosterone correlated negatively with participant age and positively with CAG length variation in the AR gene
  • CAG repeat number varied inversely with reactivity of the ventral amygdala to facial expressions of negative affect
  • higher salivary testosterone was likewise associated with a greater number of AR CAG repeats
  • relative androgen insensitivity in ARs with a larger number of CAG repeats
  • Because circulating testosterone is regulated via negative feedback through the hypothalamic-pituitary-gonadal axis, diminished androgen sensitivity at higher CAG repeat lengths may reduce feedback suppression of luteinizing hormone (LH). LH would then be maintained at higher levels, in turn promoting higher testosterone production
  • Testosterone up-regulates AVP expression in the amygdala
  • Oxytocin exerts an inhibitory influence on AVP expression in the central amygdala, and the synthesis of oxytocin is mediated by estrogen and estrogen receptors
  • Nathan Goodyear on 22 Jun 15
     
    Study used saliva to measure Testosterone levels in men.  Testosterone levels were inversely associated with age, but positively associated with CAG repeat sequences in the AR.
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