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teekinghamzat

How Often Can You Donate Blood - Read This Before Donating - 2 views

You will know how often you can donate blood in this article today. I understand that you don't know if there is any risk attached to donating blood to a recipient. Well, one frequently asked q...

donor blood donations

started by teekinghamzat on 26 May 20 no follow-up yet
alexabert

for my project - 0 views

HELLO For my donation project, you may be the person I need. In short, my name is Alexandrea BERTUZZI, of Italian origin, but under medical observation in France. I suffer from a serious illness wh...

started by alexabert on 27 Jun 20 no follow-up yet
Nathan Goodyear

Vitamin C and cancer revisited - 0 views

www.ncbi.nlm.nih.gov/...PMC2516245

IV vitamin C cancer vitamin C H2O2 hydrogen peroxide Fe

shared by Nathan Goodyear on 05 Mar 18 - No Cached
  • It is well known that vitamin C, or ascorbic acid, is an effective biologic antioxidant and does not act as a pro-oxidant under normal conditions (5) because it does not readily autoxidize, i.e., react with oxygen (O2) to produce reactive oxygen species, such as superoxide radicals (O2•−) or H2O2
  • However, ascorbate readily donates an electron to redox-active transition metal ions, such as cupric (Cu2+) or ferric (Fe3+) ions, reducing them to cuprous (Cu+) and ferrous (Fe2+) ions, respectively
  • Reduced transition metal ions, in contrast to ascorbic acid, readily react with O2, reducing it to superoxide radicals (Reaction 2), which in turn dismutate to form H2O2 and O2
  • ...6 more annotations...
  • The H2O2 produced this way (Reactions 1–3) seems to be key to ascorbate's antitumor effect because H2O2 causes cancer cells to undergo apoptosis, pyknosis, and necrosis
  • In contrast, normal cells are considerably less vulnerable to H2O2
  • The reason for the increased sensitivity of tumor cells to H2O2 is not clear but may be due to lower antioxidant defenses
  • In fact, a lower capacity to destroy H2O2—e.g., by catalase, peroxiredoxins, and GSH peroxidases—may cause tumor cells to grow and proliferate more rapidly than normal cells in response to low concentrations of H2O2
  • These observations, combined with the inhibitory effect on xenograft growth, provide the proof of concept that millimolar concentrations of extracellular ascorbate, achievable by i.p. injection or i.v. infusion in experimental animals and humans, respectively, exert pro-oxidant, antitumor effects in vivo.
  • They also show that the concentration of the ascorbyl radical correlates with the concentration of H2O2 in interstitial fluid, whereas no H2O2 can be detected in blood or plasma
  • Nathan Goodyear on 05 Mar 18
     
    review of the mechanism of how extracellular AA, only obtainable from parenteral dosing, can produce H2O2 extracellularly to then be cytotoxic to cancer cells.
digitalorainfo

Happiness Ville Foundation - 0 views

www.happinessville.org

NGO in Ahmedabad India Donate Food Cloths

shared by digitalorainfo on 22 May 20 - No Cached
  • digitalorainfo on 22 May 20
     
    We, a young, dynamic and public-spirited team of activists at Happiness Ville, are constantly brainstorming ideas and ways to bring about the change we always talk about and hardly put into action. Our aim is to eradicate the 'mal' out of malnutrition, 'ill' out of the illiteracy, 'in' out of the injustice and the 'issues' out of the environment.
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