Salivary Testosterone and a Trinucleotide (CAG) Length Polymorphism in the Androgen Rec... - 0 views
www.ncbi.nlm.nih.gov/...PMC2825741
CAG androgen receptors AR androgen receptor Testosterone hormone hormones male men
shared by Nathan Goodyear on 22 Jun 15
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Testosterone correlated inversely with participant age (r = −0.39, p = 0.012) and positively with number of CAG repeats
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transactivation potential of the AR appears to decline in graded relation to an increasing number of CAG repeats, which are distributed over a normative range of 11–37 and, in Caucasian populations, commonly average 21–22 repeats
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When activated by androgens, ARs translocate to the cell nucleus, where they exert transcriptional control of androgen-dependent genes by binding to androgen response elements within gene regulatory sequences
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androgens (like other steroid hormones) promote or repress the expression of genes specifying an array of cellular proteins
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salivary testosterone correlated negatively with participant age and positively with CAG length variation in the AR gene
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CAG repeat number varied inversely with reactivity of the ventral amygdala to facial expressions of negative affect
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Because circulating testosterone is regulated via negative feedback through the hypothalamic-pituitary-gonadal axis, diminished androgen sensitivity at higher CAG repeat lengths may reduce feedback suppression of luteinizing hormone (LH). LH would then be maintained at higher levels, in turn promoting higher testosterone production
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Oxytocin exerts an inhibitory influence on AVP expression in the central amygdala, and the synthesis of oxytocin is mediated by estrogen and estrogen receptors