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Nathan Goodyear

Intravenous Vitamin C Administration Improves Quality of Life in Breast Cancer Patients... - 0 views

iv.iiarjournals.org/...983.abstract

vitamin C IV intravenous therapy treatment cancer

shared by Nathan Goodyear on 14 Nov 11 - No Cached
  • Nathan Goodyear on 14 Nov 11
     
    IV vitamin C shown to improve quality of life measures in breast cancer patients during chemo/radiation.  What this shows, is that IV vitamin C is not only safe for healthy individuals, but healthy for cancer patients.
Nathan Goodyear

MECHANISMS OF ASCORBATE-INDUCED CYTOTOXICITY IN PANCREATIC CANCER - 0 views

www.ncbi.nlm.nih.gov/...PMC2807999

pancreatic cancer cancer IV vitamin C intravenous vitamin C vitamin C IV vitamin C intravenous alternative

shared by Nathan Goodyear on 26 Aug 14 - No Cached
  • Nathan Goodyear on 26 Aug 14
     
    Good discussion of the mechanism of action of IV vitamin C in cancer therapy.
Nathan Goodyear

Ascorbic acid: Chemistry, biology and the treatment of cancer - 0 views

www.ncbi.nlm.nih.gov/...PMC3608474

IV vitamin C Intravenous vitamin C vitamin C vitamin C cancer treatment ascorbic acid

shared by Nathan Goodyear on 26 Aug 14 - No Cached
  • Nathan Goodyear on 26 Aug 14
     
    IV vitamin C as an adjuvant in the treatment of cancer.
Nathan Goodyear

JTM | Full text | Intravenous ascorbic acid to prevent and treat cancer-associated sepsis? - 0 views

www.translational-medicine.com/...25

cancer vitamin C ascorbic acid SIRS sepsis

shared by Nathan Goodyear on 29 Feb 12 - No Cached
  • Nathan Goodyear on 29 Feb 12
     
    Cancer patients are depeleted of vitamin C.  IV vitamin C is suggested as a therapy to treat sepsis or SIRS in those individuals with cancer.
Nathan Goodyear

New Developments and Novel Therapeutic Perspectives for Vitamin C - 0 views

jn.nutrition.org/...2171.abstract

vitamin C IV intravenous therapy treatment cancer cardiovascular

shared by Nathan Goodyear on 14 Nov 11 - No Cached
  • Nathan Goodyear on 14 Nov 11
     
    vitamin C is powerful anti-oxidant that has implications in cardiovascular disease and cancer; but High serum levels of vitamin C are hard to maintain orally, but can be maintained via IV therapy
Nathan Goodyear

In vivo reactivation of DNases in impla... [J Histochem Cytochem. 2001] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...11118483

IV vitamin C IV vitamin K3 vitamin C K K3 DNase vitamin C vitamin K3 prostate cancer

shared by Nathan Goodyear on 16 Oct 13 - No Cached
  • Nathan Goodyear on 16 Oct 13
     
    IV vitamin C/K3 combination therapy reactivates DNase activity in mouse model of prostate cancer.
Nathan Goodyear

Orthomolecular Oncology Review: Ascorbic Acid and Cancer 25 Years Later - 0 views

ict.sagepub.com/...32.abstract

vitamin C cancer treatment therapy

shared by Nathan Goodyear on 19 Jul 11 - No Cached
  • Nathan Goodyear on 19 Jul 11
     
    IV vitamin C shown to be highly effective in cancer therapy.  This article is a great review of the literature for IV vitamin C
Nathan Goodyear

Paradoxical effects of antioxidants on cancer. [Rejuvenation Res. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24828241

cancer antioxidants vitamin C

shared by Nathan Goodyear on 27 May 14 - No Cached
  • Nathan Goodyear on 27 May 14
     
    Just the abstract available here.  Cancer is proving to be very complex--no surprise here.  Antioxidant therapy can actually promote cancer progression as can tumor suppressor genes.  The issue is context of the environment and the tumor in that environment.   Vitamin C is antioxidant in serum, but pro oxidant in the cancer cell.  The result is a production of H2O2 and lysis of the cell.
Nathan Goodyear

High-dose intravenous vitamin C in the treatment of a patient with renal cell carcinoma... - 0 views

www.riordanclinic.org/...89023775_jom.pdf

IV vitamin C vitamin C IVC IV vitamin C intravenous cancer

shared by Nathan Goodyear on 29 May 13 - No Cached
  • Nathan Goodyear on 29 May 13
     
    This is a case study of a patient with cancer of the kidney treated with vitamin C. Therapy was obviously successive in obtaining remission.
Nathan Goodyear

Intravenously administered vitamin C as cancer therapy: three cases - 0 views

www.canadianmedicaljournal.ca/...937.short

IV intravenous vitamin C mineral therapy treatment cancer

shared by Nathan Goodyear on 22 Nov 11 - No Cached
  • Nathan Goodyear on 22 Nov 11
     
    high dose IV vitamin C shown to be of benefit in cancer treatment therapies.
Nathan Goodyear

Intravenous Ascorbate as a Tumor Cytotoxic Chemotherapeutic Agent - 0 views

www.seanet.com/...d_hypotheses_1995-v44-p207.htm

vitamin C cancer IV vitamin C ascorbic acid

shared by Nathan Goodyear on 05 Mar 18 - No Cached
  • There is a 10 — 100-fold greater content of catalase in normal cells than in tumor cells
  • induce hydrogen peroxide generation
  • Ascorbic acid and its salts (AA) are preferentially toxic to tumor cells in vitro (6 — 13) and in vivo
  • ...36 more annotations...
  • related to intracellular hydrogen peroxide generation
  • only be obtained by intravenous administration of AA
  • Preferentially kills neoplastic cells
  • Is virtually non-toxic at any dosage
  • Does not suppress the immune system, unlike most chemotherapy agents
  • Increases animal and human resistance to infectious agents by enhancing lymphocyte blastogenesis, enhancing cellular immunity, strengthening the extracellular matrix, and enhancing bactericidal activity of neutrophils and modulation of complement protein
  • Strengthens the structural integrity of the extracellular matrix which is responsible for stromal resistance to malignant invasiveness
  • 1969, researchers at the NCI reported AA was highly toxic to Ehrlich ascites cells in vitro
  • In 1977, Bram et al reported preferential AA toxicity for several malignant melanoma cell lines, including four human-derived lines
  • Noto et al reported that AA plus vitamin K3 had growth inhibiting action against three human tumor cell lines at non-toxic levels
  • Metabolites of AA have also shown antitumor activity in vitro
  • The AA begins to reduce cell proliferation in the tumor cell line at the lowest concentration, 1.76 mg/dl, and is completely cytotoxic to the cells at 7.04 mg/dl
  • the normal cells grew at an enhanced rate at the low dosages (1.76 and 3.52 mg/dl)
  • preferential toxicity of AA for tumor cells. >95% toxicity to human endometrial adenocarcinoma and pancreatic tumor cells (ATCC AN3-CA and MIA PaCa-2) occurred at 20 and 30 mg/dl, respectively.
  • No toxicity or inhibition was demonstrated in the normal, human skin fibroblasts (ATCC CCD 25SK) even at the highest concentration of 50 mg/dl.
  • the use of very high-dose intravenous AA for the treatment of cancer was proposed as early as 1971
  • Cameron and Pauling have published extensive suggestive evidence for prolonged life in terminal cancer patients orally supplemented (with and without initial intravenous AA therapy) with 10 g/day of AA
  • AA, plasma levels during infusion were not monitored,
  • the long-term, oral dosage used in those experiments (10 g/day), while substantial and capable of producing immunostimulatory and extracellular matrix modulation effects, was not high enough to achieve plasma concentrations that are generally cytotoxic to tumor cells in culture
  • This low cytotoxic level of AA is exceedingly rare
  • 5 — 40 mg/dl of AA is required in vitro to kill 100% of tumor cells within 3 days. The 100% kill levels of 30 mg/dl for the endometrial carcinoma cells and 40 mg/dl for the pancreatic carcinoma cells in Figure 2 are typical
  • normal range (95% range) of 0.39-1.13 mg/dl
  • 1 h after beginning his first 8-h infusion of 115 g AA (Merit Pharmaceuticals, Los Angeles, CA), the plasma AA was 3.7 mg/dl and at 5 h was 19 mg/dl. During his fourth 8-h infusion, 8 days later, the 1 h plasma level was 158 mg/dl and 5 h was 185 mg/dl
  • plasma levels of over 100 mg/dl have been maintained in 3 patients for more than 5 h using continuous intravenous infusion
  • In rare instances of patients with widely disseminated and rapidly proliferating tumors, intravenous AA administration (10 — 45 g/day) precipitated widespread tumor hemorrhage and necrosis, resulting in death
  • Although the outcomes were disastrous in these cases, they are similar to the description of tumor-necrosis-factor-induced hemorrhage and necrosis in mice (52) and seem to demonstrate the ability of AA to kill tumor cells in vivo.
  • toxic effects of AA on one normal cell line were observed at 58.36 mg/dl and the lack of side effects in patients maintaining >100 mg/dl plasma levels
  • Although it is very rare, tumor necrosis, hemorrhage, and subsequent death should be the highest priority concern for the safety of intravenous AA for cancer patients.
  • Klenner, who reported no ill effects of dosages as high as 150 g intravenously over a 24-h period
  • Cathcart (55) who describes no ill effects with doses of up to 200 g/d in patients with various pathological conditions
  • following circumstances: renal insufficiency, chronic hemodialysis patients, unusual forms of iron overload, and oxalate stone formers
  • Screening for red cell glucose-6-phosphate dehydrogenase deficiency, which can give rise to hemolysis of red blood cells under oxidative stress (57), should also be performed
  • any cancer therapy should be started at a low dosage to ensure that tumor hemorrhage does not occur.
  • patient is orally supplementing between infusions
  • a scorbutic rebound effect can be avoided with oral supplementation. Because of the possibility of a rebound effect, measurement of plasma levels during the periods between infusions should be performed to ensure that no such effect takes place
  • Every effort should be made to monitor plasma AA levels when a patient discontinues intravenous AA therapy.
  • Nathan Goodyear on 05 Mar 18
     
    Older study, 1995, but shows the long-standing evidence that IVC preferentially is cytotoxic to cancer cells.`
Nathan Goodyear

The Association of Vitamins C and K3 Kills Cancer Cells Mainly by Autoschizis, a Novel ... - 0 views

IV vitamin C cancer autoschizis vitamin C vitamin K3

shared by Nathan Goodyear on 23 Jul 19 - No Cached
  • Nathan Goodyear on 23 Jul 19
     
    Awesome review of the combination approach to vitamin C and K3 to induce oxidative cytotoxicity and autoschizis of cancer cells.
Nathan Goodyear

Intravenously administered vitamin C as cancer therapy: three cases -- Padayatty et al.... - 0 views

www.cmaj.ca/...937

intravenously vitamin C cancer

shared by Nathan Goodyear on 09 Feb 11 - Cached
  • high-dose vitamin C, given by intravenous and oral routes, may improve symptoms and prolong life in patients with terminal cancer
  • Nathan Goodyear on 09 Feb 11
     
    High-dose IV vitamin C benefits cancer patients:review of 3 case studies
Nathan Goodyear

Aging | Doxycycline, Azithromycin and Vitamin C (DAV): A potent combination therapy for... - 0 views

www.aging-us.com/...text

cancer stem cells cancer azithromycin IV vitamin C vitamin C doxycycline CSC

shared by Nathan Goodyear on 21 May 19 - No Cached
  • Nathan Goodyear on 21 May 19
     
    Triple attack on cancer stem cells. Doxy and Azithromycin with vitamin C found to significantly inhibit CSC mitochondrial activity.
Nathan Goodyear

High doses of multiple antioxidant vitamins: essential ingredients in improving the eff... - 0 views

www.ncbi.nlm.nih.gov/...10067654

antioxidant antioxidants vitamin C vitamin E vitamin A carotenoids cancer vitamins

shared by Nathan Goodyear on 28 Sep 18 - No Cached
  • Nathan Goodyear on 28 Sep 18
     
    only abstract available here from older study, finds antioxidants i.e. C, A, E, and carotenoids augment cancer therapies.
Nathan Goodyear

The ROS-induced cytotoxicity of ascorbate is attenuated by hypoxia and HIF-1alpha in th... - 0 views

onlinelibrary.wiley.com/...full

vitamin C IV IV vitamin C hypoxia HIF-1alpha HBO hyperbaric oxygen hyperbaric cancer

shared by Nathan Goodyear on 13 Nov 14 - No Cached
  • Nathan Goodyear on 13 Nov 14
     
    vitamin C effects decreased by hypoxia which increases HIF-1alpha.  The authors propose oxygen therapy, hyperbaric, to improve and augment the cytotoxic effects of vitamin C.
Nathan Goodyear

Ascorbic Acid Chemosensitizes Colorectal Cancer Cells and Synergistically Inhibits Tumo... - 0 views

www.ncbi.nlm.nih.gov/...PMC6064950

cancer vitamin C ascorbic acid colorectal cancer

shared by Nathan Goodyear on 26 Mar 22 - No Cached
  • therapeutic potential has been supported by a large and consistent body of evidences from in vitro
  • Ascorbic acid might act as a way to deliver hydrogen peroxide (H2O2) to the tissues
  • pharmacological concentrations of AA were capable of inducing anti-proliferative, cytotoxic and genotoxic effects
  • ...12 more annotations...
  • chemosensitizing
  • pharmacological concentrations of AA can sensitize cancer cells to chemotherapy, enhancing its antineoplastic effect
  • synergistic effect with conventional chemotherapeutic drugs is a fact already reported, in various types of cancer, by numerous authors, namely in pancreatic (Espey et al., 2011), prostate (Gilloteaux et al., 2014), lung (Lee et al., 2017), breast (Kurbacher et al., 1996; Wu et al., 2017) and ovarian (Ma et al., 2014) cancers.
  • chemosensitizing effect of vitamin C has already been proven by several authors in various types of cancer
  • intravenous pharmacological concentrations, may not only potentiate the effects of conventional chemotherapy, but also improve the quality of life of cancer patients
  • AA reinforced the anti-proliferative activity of 5-FU
  • Combined treatment induced a reduction of 11.5% and 43% in cell viability compared with AA or Iri therapies, respectively, emphasizing the synergistic effect
  • cytotoxic effect occurred with treatment with Iri alone, but also this effect was further potentiated by the presence of AA.
  • association of AA with Oxa showed very promising results, considering that a synergistic effect was demonstrated, in almost all conditions
  • AA and Oxa seem to act synergistically by the activation of the intrinsic pathway of apoptosis, translated on the statistically significant increase of the ratio between BAX and BCL-2 proteins, which in turn is associated with a decrease of Δψm
    • Nathan Goodyear
      Nathan Goodyear on 26 Mar 22
       
      Apoptosis -> decrease in mitochondrial membrane potential
  • Previous results obtained by our group showed that AA mediates reactive oxygen species (ROS) formation capable of irreparably damaging DNA
  • oxidative role of AA may be a key factor on the synergistic anti-cancer mechanism
Nathan Goodyear

Intravenously administered vitamin C as cancer therapy: three cases - 0 views

www.cmaj.ca/...937.full.pdf+html

IV vitamin C IV intravenous vitamin C cancer

shared by Nathan Goodyear on 25 Sep 13 - No Cached
  • Nathan Goodyear on 25 Sep 13
     
    3 case studies on high dose IV vitamin C in cancer treatment.
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