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The epidemic of Zika Virus (ZV) drastically affected the health of more than one million people in Brazil resulting in twenty-fold increase of microcephaly (head circumference of newborn baby being less than or equal to thirty-two cms) in infected pregnant women. ZV crosses the placental barrier between maternal and fetal compartments. ZV has been found in amniotic fluid and fetal brain tissue of the human pregnancies complicated with ZV infection and microcephaly supporting cause and effect relationship between ZV and microcephaly. New knowledge about how ZV enters into the cells is mandatory for preventive and therapeutic research. ZV is a Flavivirus, therefore the Flavivirus receptors are candidate receptors for ZV too. ZV has been associated with high level of TYRO3 and AXL component of TAM, a Tyrosine Kinase receptor family, expression in the infected skin cells and neuronal stem cells. It predicts that AXL receptors may facilitate ZV entry into the trophoblasts and endothelial cells lining the fetal vessels present in the placenta. This hypothesis stems from the reported studies on ZV and AXL receptor expression, both in human tissues and animal models. If our hypothesis proves to be valid, it would be a great step towards the drug and therapeutic development to prevent ZV crossing the placental barrier and resulting in complications. For more info : http://scidoc.org/IJVR-03-401.php

In spite of being a minor cellular subset, cancer stem cells (CSCs) fundamentally contribute to intra-tumor heterogeneity. With the biological features of self-renewal and differentiation, CSCs confer a driving force for malignant recurrence and anti-cancer drug resistance in oncologic patients, which highlight an unmet clinical need calling for innovative medicine to Come up. Due to the elusiveness of specific biomarkers and biological regulation for CSCs, a number of precisely targeted therapeutic approaches against CSCs are at their infancy far from reaching the clinic. However, we have herein been able to sort out three groups of CSC inhibitors which are clinically available, and proposed to take the advantages of these drugs to improve the therapeutic efficacy of existing anti-cancer treatments. For more info : http://scidoc.org/JBR-TCEO-01-201.php

International Journal of Chronic Diseases & Therapy (IJCDT) is a comprehensive, peer reviewed journal devoted to Chronic Diseases and Therapy. publishes original research, latest developments, review papers, scientific data, editorials from leading scientists and scholars around the world.IJCDT publishes following fields:Chronic Diseases and Therapy,Allergy,Obesity and Overweight,Asthma,Cancer,Dynamic treatment regimes,Chronic medicine,Blindness,Chronic treatment,Blood Pressure,Sickle Cell Anemia and other hemoglobin disorders,Autoimmune diseases,Chronic graft-versus-host disease (GVHD),Cardiovascular diseases,Myalgic encephalomyelitis,Chronic hepatitis,Cerebral palsy,Periodontal disease,Chronic pain syndromes,Lyme Disease,Epidemiology,Osteoarticular diseases,Renal diseases,Chronic respiratory diseases,Diabetes mellitus,Deafness and hearing impairment,Endometriosis,Fibromyalgia,Epilepsy,Mental illness. For more details : http://scidoc.org/chronic-diseases-and-therapy.php

Human physiology studies how our cells, muscles and organs work together, how they interact. Immunology is a branch of biomedical science that covers the study of all aspects of the immune system in all organisms. For more info :http://scidoc.org/IJMBGSpecialIssues.php

Worldwide consumer's awareness and inclination towards healthful food products capable of conferring health benefits besides providing basic nutrition have led to coin the term functional foods. Foods that contain some health-promoting component(s) beyond traditional nutrients are termed as functional foods. For more info : http://scidoc.org/IJFS-2326-3350-05-002e.php