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Most postsurgical patients experience moderate to severe acute pain which, in some patients, transitions to chronic postsurgical pain (CPSP). Optimal pain control of acute surgical pain will likely blunt or prevent the transition of acute postsurgical pain (APSP) to CPSP. While there are known risk factors for such chronification of pain type, and certain surgeries (such as limb amputation) and approaches (open versus laparoscopic) are associated with higher rates, it is impossible to predict which patients will transition to CPSP. Additionally, despite knowledge and an armamentarium of analgesics, APSP may be suboptimally controlled.

Congenital insensitivity to pain (CIP) is a rarely syndrome and is characterized by unresponsiveness to painful stimulants, anhydrous, mental retardation, and recurring feverish episodes. In this case report we presented our anesthesia management in a patient with congenital insensitivity to pain for lower extremity surgery due to osteomyelitis. For more details : http://scidoc.org/IJAR-2332-2780-04-1001.php

International Journal of Chronic Diseases & Therapy (IJCDT) is a comprehensive, peer reviewed journal devoted to Chronic Diseases and Therapy. publishes original research, latest developments, review papers, scientific data, editorials from leading scientists and scholars around the world.IJCDT publishes following fields:Chronic Diseases and Therapy,Allergy,Obesity and Overweight,Asthma,Cancer,Dynamic treatment regimes,Chronic medicine,Blindness,Chronic treatment,Blood Pressure,Sickle Cell Anemia and other hemoglobin disorders,Autoimmune diseases,Chronic graft-versus-host disease (GVHD),Cardiovascular diseases,Myalgic encephalomyelitis,Chronic hepatitis,Cerebral palsy,Periodontal disease,Chronic pain syndromes,Lyme Disease,Epidemiology,Osteoarticular diseases,Renal diseases,Chronic respiratory diseases,Diabetes mellitus,Deafness and hearing impairment,Endometriosis,Fibromyalgia,Epilepsy,Mental illness. For more details : http://scidoc.org/chronic-diseases-and-therapy.php

Thygeson's superficial punctate keratitis (TSPK) is a chronic, recurrent disorder affecting the anterior surface of the cornea. Common symptoms include photophobia, epiphora, pain and blurred vision. The management of TSPK is challenging, and long-term combined therapy is often required, namely steroids. We present a case of TSPK that was managed with a novel regenerative agent (RGTA) resulting in the symptomatic control of the condition.