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Many newly diagnosed prostate cancers present as low Gleason score tumors that require no treatment intervention. Distinguishing the many indolent tumors from the minority of lethal ones remains a major clinical challenge. We now show that low Gleason score prostate tumors can be distinguished as indolent and aggressive subgroups on the basis of their expression of genes associated with aging and senescence. Using gene set enrichment analysis, we identified a 19-gene signature enriched in indolent prostate tumors. We then further classified this signature with a decision tree learning model to identify three genes-FGFR1, PMP22, and CDKN1A-that together accurately predicted outcome of low Gleason score tumors. Validation of this three-gene panel on independent cohorts confirmed its independent prognostic value as well as its ability to improve prognosis with currently used clinical nomograms. Furthermore, protein expression of this three-gene panel in biopsy samples distinguished Gleason 6 patients who failed surveillance over a 10-year period. We propose that this signature may be incorporated into prognostic assays for monitoring patients on active surveillance to facilitate appropriate courses of treatment.

"Previous research on rhesus macaques discovered that social rank influenced components of the stress response, brain, and immune system. With gene chip technology for measuring the expression of over 6,000 different genes, Tung, Gilad and colleagues at Yerkes, Emory University, and Johns Hopkins looked for the first time in primates at the effects of social rank on genetic function. Comparing 49 different female monkeys of different rank revealed significant changes in the expression of 987 genes, including 112 genes associated with immune system function. The result fits with data in monkeys where low rank and chronic stress lead to compromised immune function, and, more loosely, with human studies linking low socioeconomic status and high social stress to elevated disease risk."

A thought to keep in mind as you read this - what happens to the already overburdened graduate whose job gets outsourced, and then can't find another because he's deemed "overqualified" for the low skilled, low wage jobs available? Answer: Look up "capitalization of interest" and then note that one can't erase student loan debt by declaring bankruptcy. What will result will be the mathematical equivalent of charging compound interest on a loan that the graduate has been deprived of the means of repaying.

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Low lobster prices are making it tough for Maine fishemen, such as this father and son team in Port Clyde Maine.

Future Mars outposts or colonies may seem more distant than ever with NASA's exploration plans in flux, but the rocket technology that could someday propel a human mission to the red planet in as little as 40 days may already exist. A company founded by former NASA astronaut Franklin Chang-Diaz has been developing a new rocket engine that draws upon electric power and magnetic fields to channel superheated plasma out the back. That stream of plasma generates steady, efficient thrust that uses low amounts of propellant and builds up speed over time. "People have known for a long time, even back in the '50s, that electric propulsion would be needed for serious exploration of Mars," said Tim Glover, director of development at the Ad Astra Rocket Company.

Loans for bad credit are quick and short term financial alternative which is arranges sufficient funds to those people who have low credit record and face financial crisis in middle of the month. It is an ideal monetary aid in which you can take an amount varying from AUD $100 to AUD $1000 for short time of period such as 14 to 31 days.

"Here we show that four days of immersion in nature, and the corresponding disconnection from multi-media and technology, increases performance on a creativity, problem-solving task by a full 50% in a group of naive hikers. Our results demonstrate that there is a cognitive advantage to be realized if we spend time immersed in a natural setting. We anticipate that this advantage comes from an increase in exposure to natural stimuli that are both emotionally positive and low-arousing and a corresponding decrease in exposure to attention demanding technology, which regularly requires that we attend to sudden events, switch amongst tasks, maintain task goals, and inhibit irrelevant actions or cognitions. A limitation of the current research is the inability to determine if the effects are due to an increased exposure to nature, a decreased exposure to technology, or to other factors associated with spending three days immersed in nature."

"Synthetic Biology promises low-cost, exponentially scalable products and global health solutions in the form of self-replicating organisms, or "living devices." As these promises are realized, proof-of-concept systems will gradually migrate from tightly regulated laboratory or industrial environments into private spaces as, for instance, probiotic health products, food, and even do-it-yourself bioengineered systems. What additional steps, if any, should be taken before releasing engineered self-replicating organisms into a broader user space? In this review, we explain how studies of genetically modified organisms lay groundwork for the future landscape of biosafety."

"Le président de CaptainDash, Gilles Babinet, Digital champion pour la France auprès de l'Europe, révèle l'émergence d'un nouveau phénomène : le biohacking. Une nouvelle manière en fait de faire des biotechs en mode low-cost. Une initiative proche de l'esprit open source qui a touché l'informatique et les fab-labs."

"In2Care is a private limited company registered and based in the Netherlands. Founded and privately owned by three leading entomologists, a serial entrepreneur and a chief commercial officer, In2Care has more than 30 years of combined research experience in vector control. Our core expertise lies in the translation of scientific knowledge into novel insect control products. We offer low-cost, proven, primarily biological solutions to combat disease-carrying mosquitoes"

If there is organic life deep under the ice on Europa, why would we need to disturb it at all? Potential source of unknown viruses etc. Risks of releasing something are low I guess, but the assumption that whatever may be there needs Earth-like conditions to survive and multiply is dangerous.

"Over the last 10 years, MIT biologist Leonard Guarente and other researchers have demonstrated that very-low-calorie diets provoke a comprehensive physiological response, which promotes survival due to a set of proteins called sirtuins. A new report by Guarente published online in Cell has now demonstrated that sirtuins may also have a key part in the psychological response to dietary restriction. "

Auch der X-chromosomal lokalisierte genetische Polymorphismus des Monoaminooxydase-A-Gens, eines Schlüsselenzyms im Katabolismus von Serotonin und anderen Monoaminen, zeigt eine Beziehung zu Aktivierungsmustern in Hirn arealen, die bedeutsam für die Affektregulation sind. So fand sich bei Trägern des Low(L)-Allels im Vergleich zu Trägern des High(H)-Allels eine höhere Aktivität der Amygdala und eine geringere Aktivität in cingulären und orbitofrontalen Arealen, die auch mit strukturellen Unterschieden, nämlich geringeren limbischen und paralimbischen Volumina bei den Individuen mit der L-Variante, einhergingen (Meyer-Lindenberg, Buckholtz et al. 2006). Diese Befunde könnten einen Beitrag zum Verständnis leisten, warum MAOA-L-Träger eine schlechtere Fähigkeit zur emotionalen Regulation zeigen

"BioCurious is a completely volunteer run non-profit organization. We serve the community by providing low-cost lab space and classes to members. "

A new study in The Lancet rates the harmfulness of 20 psychoactive drugs according to 16 criteria and finds that alcohol comes out on top. Although that conclusion is generating headlines, it is not at all surprising, since alcohol is, by several important measures (including acute toxicity, impairment of driving ability, and the long-term health effects of heavy use), the most dangerous widely used intoxicant, and its abuse is also associated with violence, family breakdown, and social estrangement. A group of British drug experts gathered by the Independent Scientific Committee on Drugs (ISCD) rated alcohol higher than most or all of the other drugs for health damage, mortality, impairment of mental functioning, accidental injury, economic cost, loss of relationships, and negative impact on community. Over all, alcohol rated 72 points on a 100-point scale, compared to 55 for heroin, 54 for crack cocaine, and 33 for methamphetamine. Cannabis got a middling score of 20, while MDMA (Ecstasy), LSD, and psilocybin mushrooms were at the low end, with ratings of 9, 7, and 6, respectively.

It's possible to get the mental equivalent of whiplash from the latest medical findings, as risk factors are identified one year and exonerated the next. According to a panel at the American Association for the Advancement of Science, this isn't a failure of medical research; it's a failure of statistics, and one that is becoming more common in fields ranging from genomics to astronomy. The problem is that our statistical tools for evaluating the probability of error haven't kept pace with our own successes, in the form of our ability to obtain massive data sets and perform multiple tests on them. Even given a low tolerance for error, the sheer number of tests performed ensures that some of them will produce erroneous results at random.

"Vitamin D is quickly becoming the "go-to" remedy for treating a wide range of illnesses, from osteoporosis to atherosclerosis. However, new evidence from a Wake Forest University School of Medicine study suggests that supplementing vitamin D in those with low levels may have different effects based on patient race and, in black individuals, the supplement could actually do harm."

Recent formulations of sexual selection theory emphasise how mate choice can be affected by environmental factors, such as predation risk and resource quality. Women vary greatly in the extent to which they prefer male masculinity and this variation is hypothesised to reflect differences in how women resolve the trade-off between the costs (e.g., low investment) and benefits (e.g., healthy offspring) associated with choosing a masculine partner. A strong prediction of this trade-off theory is that women's masculinity preferences will be stronger in cultures where poor health is particularly harmful to survival. We investigated the relationship between women's preferences for male facial masculinity and a health index derived from World Health Organization statistics for mortality rates, life expectancies, and the impact of communicable disease. Across 30 countries, masculinity preference increased as health decreased. This relationship was independent of cross-cultural differences in wealth or women's mating strategies. These findings show non-arbitrary cross-cultural differences in facial attractiveness judgments and demonstrate the utility of trade-off theory for investigating cross-cultural variation in women's mate preferences.

The supply of secure, clean, sustainable energy is arguably the most important scientific and technical challenge facing humanity in the 21st century. Rising living standards of a growing world population will cause global energy consumption to double by mid-century and triple by the end of the century. Even in light of unprecedented conservation, the additional energy needed is simply not attainable from long discussed sources these include nuclear, biomass, wind, geothermal and hydroelectric. The global appetite for energy is simply too much. Petroleum-based fuel sources (i.e., coal, oil and gas) could be increased. However, deleterious consequences resulting from external drivers of economy, the environment, and global security dictate that this energy need be met by renewable and sustainable sources. The dramatic increase in global energy need is driven by 3 billion low-energy users in the non-legacy world and by 3 billion people yet to inhabit the planet over the next half century. The capture and storage of solar energy at the individual level personalized solar energy drives inextricably towards the heart of this energy challenge by addressing the triumvirate of secure, carbon neutral and plentiful energy. This talk will place the scale of the global energy issue in perspective and then discuss how personalized energy (especially for the non-legacy world) can provide a path to a solution to the global energy challenge. Daniel G. Nocera is the Henry Dreyfus Professor of Energy at the Massachusetts Institute of Technology, Director of the Solar Revolutions Project and Director of the Eni Solar Frontiers Center at MIT. His group pioneered studies of the basic mechanisms of energy conversion in biology and chemistry. He has recently accomplished a solar fuels process that captures many of the elements of photosynthesis outside of the leaf. This discovery sets the stage for a storage mechanism for the large scale, distributed, deployment of solar energy. He has b