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October 24, 2008 - Google Tech Talks June 16, 2008 ABSTRACT Explore the brain's amazing ability to change throughout a person's life. This phenomenon-called neuroplasticty-is the science behind brain fitness, and it has been called one of the most extraordinary scientific discoveries of the 20th century. PBS had recently aired this special, The Brain Fitness Program, which explains the brain's complexities in a way that both scientists and people with no scientific background can appreciate. This is opportunity to learn more about how our minds work-and to find out more about the latest in cutting-edge brain research, from the founder of Posit Science and creator of the Brain Fitness Program software, Dr. Michael Merzenich. Speaker: Dr. Michael Merzenich, Ph.D. Michael M. Merzenich, PhD: Chief Scientific Officer Dr. Merzenich leads the company's scientific team. For more than three decades, Dr. Merzenich has been a leading pioneer in brain plasticity research. He is the Francis A. Sooy Professor at the Keck Center for Integrative Neurosciences at UCSF. Dr. Merzenich is a member of the National Academy of Sciences. He is the recipient of numerous awards and prizes, including the Ipsen Prize, Zulch Prize of the Max Planck Institute, Thomas Alva Edison Patent Award and Purkinje Medal. Dr. Merzenich has published more than 200 articles, including many in leading peer-reviewed journals, such as Science and Nature. His work is also often covered in the popular press, including the New York Times, the Wall Street Journal, Time and Newsweek. He has appeared on Sixty Minutes II, CBS Evening News and Good Morning America. In the late 1980s, Dr. Merzenich was on the team that invented the cochlear implant, now distributed by market leader Advanced Bionics. In 1996, Dr. Merzenich was the founding CEO of Scientific Learning Corporation (Nasdaq: SCIL), which markets and distributes software that applies principles of brain plasticity to assist children with language

How can architects build a new world of sustainable beauty? By learning from nature. At TEDSalon in London, Michael Pawlyn describes three habits of nature that could transform architecture and society: radical resource efficiency, closed loops, and drawing energy from the sun.

http://www.ted.com How can architects build a new world of sustainable beauty? By learning from nature. At TEDSalon in London, Michael Pawlyn describes three habits of nature that could transform architecture and society: radical resource efficiency, closed loops, and drawing energy from the sun. TEDTalks is a daily video podcast of the best talks and performances from the TED Conference, where the world's leading thinkers and doers give the talk of their lives in 18 minutes. Featured speakers have included Al Gore on climate change, Philippe Starck on design, Jill Bolte Taylor on observing her own stroke, Nicholas Negroponte on One Laptop per Child, Jane Goodall on chimpanzees, Bill Gates on malaria and mosquitoes, Pattie Maes on the "Sixth Sense" wearable tech, and "Lost" producer JJ Abrams on the allure of mystery. TED stands for Technology, Entertainment, Design, and TEDTalks cover these topics as well as science, business, development and the arts. Closed captions and translated subtitles in a variety of languages are now available on TED.com, at http://www.ted.com/translate.

""We've developed the enabling technologies to create upper-extremity prosthetics that are more natural in appearance and use, a truly revolutionary advancement in prosthetics," said APL's Michael McLoughlin, the program manager. "Now, in Phase 3, we are ready to test it with humans to demonstrate that the system can be operated with a patient's thoughts and that it can provide that patient with sensory feedback, restoring the sensation of touch.""

The Future of Science: Building a Better Collective Memory By Michael A. Nielsen

A new new brain imaging system that can identify a subject's simple thoughts may lead to clearer diagnoses for Alzheimer's disease or schizophrenia - as well as possibly paving the way for reading people's minds. Michael Greicius at Stanford University in California and colleagues used functional magnetic resonance imaging (fMRI) to identify patterns of brain activity associated with different mental states. He asked 14 volunteers to do one of four tasks: sing songs silently to themselves; recall the events of the day; count backwards in threes; or simply relax. Participants were given a 10-minute period during which they had to do this. For the rest of that time they were free to think about whatever they liked. The participants' brains were scanned for the entire 10 minutes, and the patterns of connectivity associated with each task were teased out by computer algorithms that compared scans from several volunteers doing the same task. This differs from previous experiments, in which the subjects were required to perform mental activities at specific times and the scans were then compared with brain activity when they were at rest. Greicius reasons his method encourages "natural" brain activity more like that which occurs in normal thought.

Imagine, Michael Chorost proposes, that four police officers on a drug raid are connected mentally in a way that allows them to sense what their colleagues are seeing and feeling. Tony Vittorio, the captain, is in the center room of the three-room drug den. He can sense that his partner Wilson, in the room on his left, is not feeling danger or arousal and thus has encountered no one. But suddenly Vittorio feels a distant thump on his chest. Sarsen, in the room on the right, has been hit with something, possibly a bullet fired from a gun with a silencer. Vittorio glimpses a flickering image of a metallic barrel pointed at Sarsen, who is projecting overwhelming shock and alarm. By deducing how far Sarsen might have gone into the room and where the gunman is likely to be standing, Vittorio fires shots into the wall that will, at the very least, distract the gunman and allow Sarsen to shoot back. Sarsen is saved; the gunman is dead. That scene, from his new book, "World Wide Mind," is an example of what Mr. Chorost sees as "the coming integration of humanity, machines, and the Internet." The prediction is conceptually feasible, he tells us, something that technology does not yet permit but that breaks no known physical laws.

Vera Gorbunova and Andrei Seluanov of the University of Rochester have found that human cells undergoing oxidative stress caused by environmental chemicals or routine cellular processes produce a protein (SIRT6) that stimulates cells to repair DNA double-strand breaks, thought to be associated with premature aging and cancer. The team first measured levels of SIRT6 in stressed cells, then treated a second group of stressed cells with a drug that deactivates the protein. DNA repair in the second group stopped, confirming SIRT6′s role.  The team also found that SIRT6 acts in concert with another protein, called PARP1, to make the repairs. Furthermore, the team found that increased levels of SIRT6 lead to faster DNA repair. They suspect that the protein acts as a "master regulator," coordinating stress and DNA repair activities. Ref.: Zhiyong Mao, Christopher Hine, Xiao Tian, Michael Van Meter, Matthew Au, Amita Vaidya, Andrei Seluanov, and Vera Gorbunova. SIRT6 Promotes DNA Repair Under Stress by Activating PARP1. Science 17 June 2011: 1443-1446. [DOI:10.1126/science.1202723]