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Music, an abstract stimulus, can arouse feelings of euphoria and craving, similar to tangible rewards that involve the striatal dopaminergic system. Using the neurochemical specificity of [11C]raclopride positron emission tomography scanning, combined with psychophysiological measures of autonomic nervous system activity, we found endogenous dopamine release in the striatum at peak emotional arousal during music listening. To examine the time course of dopamine release, we used functional magnetic resonance imaging with the same stimuli and listeners, and found a functional dissociation: the caudate was more involved during the anticipation and the nucleus accumbens was more involved during the experience of peak emotional responses to music. These results indicate that intense pleasure in response to music can lead to dopamine release in the striatal system. Notably, the anticipation of an abstract reward can result in dopamine release in an anatomical pathway distinct from that associated with the peak pleasure itself. Our results help to explain why music is of such high value across all human societies.

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ScienceDaily (Jan. 12, 2011) - Scientists have found that the pleasurable experience of listening to music releases dopamine, a neurotransmitter in the brain important for more tangible pleasures associated with rewards such as food, drugs and sex. The new study from The Montreal Neurological Institute and Hospital -- The Neuro at McGill University also reveals that even the anticipation of pleasurable music induces dopamine release [as is the case with food, drug, and sex cues]. Published in the journal Nature Neuroscience, the results suggest why music, which has no obvious survival value, is so significant across human society.

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IF YOU want to lose weight, convince yourself that everything you eat is highly calorific. It could lower your levels of a hunger hormone, potentially suppressing your appetite. Alia Crum at Yale University and her colleagues gave 46 healthy volunteers the same 380-calorie milkshake but were told it was either a sensible, low-calorie choice or an indulgent, high-calorie one. The team also measured levels of ghrelin - a hormone released by the stomach when we are hungry - before and after participants drank the shake. Ghrelin levels have been shown to spike half an hour before mealtimes and return to normal after eating. Volunteers who thought they had indulged showed significantly greater drops in ghrelin levels than those who thought they had consumed less. The authors suggest that merely thinking that one has eaten something unhealthy can quell hunger pangs and perhaps help curb overeating (Health Psychology, DOI: 10.1037/a0023467). The study shows that food labels can affect consumption in unexpected ways, says David Cummings, an endocrinologist at the University of Washington in Seattle.

Fats in foods like potato chips and french fries make them nearly irresistible because they trigger natural marijuana-like chemicals in the body called endocannabinoids, researchers at the University of California, Irvine, have found. The researchers discovered that when rats tasted something fatty, cells in their upper gut started producing endocannabinoids, while sugars and proteins did not have this effect. How fats create, like, a buzz It starts on the tongue, where fats in food generate a signal that travels first to your brain, and then through a nerve bundle called the vagus to your intestines. There, the signal stimulates the production of endocannabinoids, which initiates a surge in cell signaling that prompts you to totally pig out - probably by initiating the release of digestive chemicals linked to hunger and satiety that compel us to eat more. And that leads to obesity, diabetes and cancer, the researchers said. But they suggest it might be possible to curb this process by obstructing endocannabinoid activity: for example, by using drugs that "clog" cannabinoid receptors. The trick: bypassing the brain to avoid creating anxiety and depression (which happens when endocannabinoid signaling is blocked in the brain). I'm guessing McDonald's won't be adding that drug to their fries. Ref.: Daniele Piomelli, et al., An endocannabinoid signal in the gut controls dietary fat intake, PNAS, 2011; in press

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"We're looking at traits that are associated with the way that people process the emotional world and the way that they respond to it," said University of Illinois psychology professor Florin Dolcos, who conducted the study with postdoctoral researcher Sanda Dolcos and University of Alberta postdoctoral researcher Ekaterina Denkova. "We wanted to look not only at how personality traits might influence what and how people remember, but also to examine how that impacts their (subsequent) emotional state.""

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