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Dennis OConnor

How COVID-19 Is Shaping the Patient Experience (PDF) - 0 views

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    Recommended by Meg Sweeney © 2020 Press Ganey Associates LLCIn a Press Ganey analysis of 350,000 comments from ED and medical practice patients between January 1 and March 20, 2020, the number of comments mentioning COVID-19 has grown at an average rate of 134% each week from early February through mid-March.To identify emerging themes and provide insights and recommendations to provider organizations, we isolated and analyzed the nearly 12,000 COVID-19-related comments, generating approximately 27,000 insights and leading to the following observations
Dennis OConnor

GA4GH (Global Alliance for Genomics & Health) Community Response to COVID-19 - 0 views

  • A Message from the GA4GH Executive Committee Ewan Birney, Heidi Rehm, Peter Goodhand, and Kathryn North The urgency of scientific data sharing is never more apparent than during a global disease outbreak. Rapid sharing of high quality data is critical for the effective and timely response to any pandemic. GA4GH has joined Wellcome and others to call for rapid, open sharing of research findings and data relevant to COVID-19. The GA4GH community is responding through the development of a variety of research and data sharing platforms and initiatives…. But in order to ensure truly equitable access to and participation in both the scientific process and its benefits, we must rigorously maintain technical and ethical standards that support the open sharing of data and knowledge—now and always.
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    Recommended by DeAunne Denmark, MD. Phd.
Dennis OConnor

about - COVID HUMAN GENETIC EFFORT - 0 views

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    Recommended by DeAunne Denmark, MD. Phd. : Summary of Our Work For many years, up to 25 years for some, members of the COVID Human Genetic Effort have studied the human genetic basis of life-threatening diseases striking previously healthy human beings in the course of primary infection by a variety of viruses, bacteria, fungi, or parasites. In particular, we and others have identified monogenic inborn errors of immunity (IEI) that selectively underlie life-threatening or lethal viral diseases in previously healthy children or adults, including various severe diseases caused by Epstein-Barr virus, herpes simplex virus encephalitis, varicella zoster virus encephalitis, fulminant hepatitis due to hepatitis A virus, lethal primary infection by cytomegalovirus, severe pneumonitis due to influenza virus or rhinovirus, beta-papillomavirus-driven skin cancer, human herpes virus 8-driven Kaposi sarcoma, and others (see references below).
Dennis OConnor

A global effort to define the human genetics of protective immunity to SARS-CoV-2 infec... - 0 views

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    Recommended by Meg Sweeney: "Abstract SARS-CoV-2 infection displays immense inter-individual clinical variability, ranging from silent infection to lethal disease. The role of human genetics in determining clinical response to the virus remains unclear. Studies of outliers - individuals remaining uninfected despite viral exposure and healthy young patients with life-threatening disease - presents a unique opportunity to reveal human genetic determinants of infection and disease."
Dennis OConnor

IT'S TIME TO BUILD | a16z Podcast by Marc Andreessen - 0 views

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    Recommended by Dr. Michael Kurisu D.O.
Dennis OConnor

The Great Realisation - YouTube - 0 views

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    Suggested by Ozzie Gontang, "A bed time story of how it started, and why hindsight's 2020."
Dennis OConnor

The Risks - Know Them - Avoid Them by Erin Bromage - 0 views

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    Recommended by Tyler Orion, "It seems many people are breathing some relief, and I'm not sure why. An epidemic curve has a relatively predictable upslope and once the peak is reached, the back slope can also be predicted. We have robust data from the outbreaks in China and Italy, that shows the backside of the mortality curve declines slowly, with deaths persisting for months. Assuming we have just crested in deaths at 70k, it is possible that we lose another 70,000 people over the next 6 weeks as we come off that peak. That's what's going to happen with a lockdown. "
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    Erin Bromage: I am a Comparative Immunologist and Professor of Biology (specializing in Immunology) at the University of Massachusetts Dartmouth. I balance Teaching, Research, and Public Service (that is, when we are allowed in our labs)."
Dennis OConnor

Which Covid-19 Data Can You Trust? - 0 views

  • incomplete or incorrect data can also muddy the waters, obscuring important nuances within communities, ignoring important factors such as socioeconomic realities, and creating false senses of panic or safety, not to mention other harms such as needlessly exposing private information.
  • Right now, bad data could produce serious missteps with consequences for millions.
  • Whether you’re a CEO, a consultant, a policymaker, or just someone who is trying to make sense of what’s going on, it’s essential to be able to sort the good data from the misleading — or even misguided.
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  • These non-transparent, un-validated interventions — which are now being rolled out (or rolled back) in countries such as China, India, Israel and Vietnam — are in direct contravention to the open cross-border collaboration that scientists have adopted to address the Covid-19 pandemic.
  • Data products that are too broad, too specific, or lack context.
  • Public health practitioners and data privacy experts rely on proportionality
  • only use the data that you absolutely need for the intended purpose and no more.
  • Even data at an appropriate spatial resolution must be interpreted with caution — context is key.
  • Simply presenting them, or interpreting them without a proper contextual understanding, could inadvertently lead to imposing or relaxing restrictions on lives and livelihoods, based on incomplete information.
  • The technologies behind the data are unvetted or have limited utility.
  • Both producers and consumers of outputs from these apps must understand where these can fall short.
  • In the absence of a tightly coupled testing and treatment plan, however, these apps risk either providing false reassurance to communities where infectious but asymptomatic individuals can continue to spread disease, or requiring an unreasonably large number of people to quarantine.
  • Some contact-tracing apps follow black-box algorithms, which preclude the global community of scientists from refining them or adopting them elsewhere.
  • common red flags
  • Models are produced and presented without appropriate expertise.
  • Epidemiological models that can help predict the burden and pattern of spread of Covid-19 rely on a number of parameters that are, as yet, wildly uncertain.
  • n the absence of reliable virological testing data, we cannot fit models accurately, or know confidently what the future of this epidemic will look like
  • and yet numbers are being presented to governments and the public with the appearance of certainty
  • Read Carefully and Trust Cautiously
  • Transparency: Look for how the data, technology, or recommendations are presented.
  • Thoughtfulness: Look for signs of hubris.
  • Example: Telenor
  • Expertise: Look for the professionals. Examine the credentials of those providing and processing the data.
  • Open Platforms: Look for the collaborators.
  • technology companies like Camber Systems, Cubeiq and Facebook have allowed scientists to examine their data,
  • The Covid-19 Mobility Data Network, of which we are part, comprises a voluntary collaboration of epidemiologists from around the world analyzes aggregated data from technology companies to provide daily insights to city and state officials from California to Dhaka, Bangladesh
  • This pandemic has been studied more intensely in a shorter amount of time than any other human event.
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    "This pandemic has been studied more intensely in a shorter amount of time than any other human event. Our globalized world has rapidly generated and shared a vast amount of information about it. It is inevitable that there will be bad as well as good data in that mix. These massive, decentralized, and crowd-sourced data can reliably be converted to life-saving knowledge if tempered by expertise, transparency, rigor, and collaboration. When making your own decisions, read closely, trust carefully, and when in doubt, look to the experts."
Dennis OConnor

Gapminder Tools - 0 views

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    Hans Rosling - Gap Minder - 2019 Iife Expectancy World Regions
Dennis OConnor

Brain Health In The Time of the Coronavirus - BrainHQ from Posit Science - 1 views

    • Dennis OConnor
       
      I've done 163 days of BrainHQ Training. I have experienced significant improvement in all categories of training: Attention, Brain Speed, Memory, People Skills, Intelligence, Navigation. Basic training schedule is every other day for 30 minutes.
  • If staying at home can contribute to a decline in our physical health—which we can address with an exercise program—what does staying at home and socially isolating do to our cognitive health?
  • our favorite topic at Posit Science: brain plasticity, the science of how the brain rewires itself through learning and experience.
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  • brain plasticity is a two-way street. In the same way that the brain can build itself through positive brain plasticity, the brain can “unbuild” itself through negative brain plasticity.
  • while we are staying at home and avoiding social contact, we’re depriving our brains of the cognitive stimulation and new learning that naturally come through our everyday lives and interactions with friends, co-workers, and even random strangers.
  • get your quarantine cognitive exercise program started:
  • New learning
  • Cognitive engagement
  • BrainHQ
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    I found Posit Science and BrainHQ thanks to a suggestion from Dr. Kurisu. He recommended Norman Doige's books, The Brain That Changes Itself; Personal Triumphs from the Frontiers of Brain Science and The Brain's Way of Healing: Remarkable Discoveries and Recoveries from the Frontiers of Neuroplasticity. One of the case studies is about Dr. Michael Merzenich, a research who was vilified by the medical establishment for investigating neuroplasticity. Great story. Merzenich is a founder of PositScience and BrainHQ.
Dennis OConnor

Everything we know about coronavirus immunity, and plenty we still don't - 0 views

  • an accurate positive test may be hard to interpret: the virus is so new that researchers cannot say for sure what sort of results will signal immunity or how long that armor will last.
  • policymakers may be making sweeping economic and social decisions — plans to reopen businesses or schools, for example — based on limited data, assumptions, and what’s known about other viruses.
  • most experts do think an initial infection from the coronavirus, called SARS-CoV-2, will grant people immunity to the virus for some amount of time.
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  • With data limited, “sometimes you have to act on a historical basis,” Anthony Fauci,
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    Recommended by Tyler Orion: "People who think they've been exposed to the novel coronavirus are clamoring for antibody tests - blood screens that can detect who has previously been infected and, the hope is, signal who is protected from another case of Covid-19."
Dennis OConnor

A Texas team comes up with a COVID vaccine that could be a global game changer | Nevada... - 0 views

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    "A vaccine authorized in December for use in India may help solve one of the most vexing problems in global public health: How to supply lower-income countries with a COVID-19 vaccine that is safe, effective and affordable. The vaccine is called CORBEVAX. It uses old but proven vaccine technology and can be manufactured far more easily than most, if not all, of the COVID-19 vaccines in use today."
Dennis OConnor

Commentaray: Another step (count) towards leveraging mobile health data for clinical pr... - 0 views

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    Advances in wearable device and home blood pressure monitoring technology offer promising opportunities to characterise population health and to improve understanding of cardiovascular disease risk. These devices also allow for remote longitudinal patient monitoring, increased engagement and health literacy, and delivery of personalised behavioural interventions all while reducing overall health-care costs.1 Various health systems and start-ups seek to combine these data with clinical information from the electronic medical record, and several insurance companies are already trying to incentivise the uptake of wearable devices.2
Dennis OConnor

MIPACT Research Tools - 0 views

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    "The MIPACT study is a prospective cohort study designed to integrate multiple sources of digital data to better understand clinical phenotypes. Participants were recruited from Michigan Medicine and the surrounding communities and provided with an Apple Watch series 3 or 4 and an Omron Evolv Wireless Blood Pressure Monitor. Participants consented to provide access to parts of their electronic medical record and to provide a blood sample for laboratory and genetic analyses. Participants were asked to perform regular tasks including guided breathing, BP monitoring, and quarterly survey completion. The study was funded in part by Apple, Inc and performed in partnership with Michigan Medicine."
Dennis OConnor

MIPACT Research Tools - 0 views

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    "This app contains physiologic and activity data for nearly 7,000 MIPACT study participants from the University of Michigan. To protect patient anonymity, data will only be displayed when 10 or more study participants have the selected combination of attributes. Data is available from the first 90-days of study participation and may be updated at a later date. Visit our MIPACT study website for more information."
Dennis OConnor

▶︎ Blue Fire in Memory of Hari Das | Guru Shabad Singh - 0 views

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    NEW SONG BY GURU SHABAD SINGH FOR CHARITY, TO BUILD A SAT NAM RASAYAN SCHOOL IN CHIAPAS MEXICO. In honor of his beloved, departed Hari Das, Guru Shabad Singh invites you to contribute to creating a global, multi-cultural, multi-modality healing center space for students and practitioners in San Cristóbal de las Casas, Chiapas, Mexico.  ( People from around the world will come to experience and train in multiple healing modalities, including Sat Nam Rasayan, in which Hari Das was a dedicated and devoted senior teacher.( ( The Center is in its nascent stage, with initial plans coming together for the space and the programming. Your donation is a precious chance to honor Hari Das' legacy as a healer of the planet. ( To learn more about Sat Nam Rasayan please visit: www.satnamrasayan.it
Dennis OConnor

Cryptocurrency and Nonprofits - Nonprofit Law Blog - 0 views

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    "Can Nonprofits Accept Cryptocurrencies as Donations? Generally, it is lawful for a nonprofit to accept a donation in the form of a cryptocurrency. However, this does not necessarily mean that it would be prudent for all nonprofits to do so. First, nonprofits must understand how cryptocurrency gifts work and what risks may be involved with taking and holding onto cryptocurrency."
Dennis OConnor

Crash Course | Snyder Lab Studies - Genetics - Stanford University School of Medicine - 0 views

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    Recommended"Stanford University researchers are recruiting ME/CFS, Chronic Lyme, and Long COVID patients for a study to better understand symptom flares such as post-exertional malaise (PEM), or "crashes"."
Dennis OConnor

Moderna Booster for Certain Populations Sails Through FDA Panel | MedPage Today - 0 views

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    "An FDA advisory panel recommended emergency use authorization (EUA) of a booster dose of Moderna's COVID-19 vaccine for adults ages 65 and older, as well as for younger adults with high-risk medical conditions or at high risk of occupational or institutional exposure."
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