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Dennis OConnor

Evidence Based Medicine Explained - YouTube - 1 views

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    "In this Sketchy EBM video, we explore the definition of Evidence-Based Medicine and a few of the risks."
Dennis OConnor

Michael Merzenich: Growing evidence of brain plasticity | TED Talk - 0 views

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    "Neuroscientist Michael Merzenich looks at one of the secrets of the brain's incredible power: its ability to actively re-wire itself. He's researching ways to harness the brain's plasticity to enhance our skills and recover lost function. This talk was presented at an official TED conference, and was featured by our editors on the home page."
Dennis OConnor

Norman Doidge: The Brain That Changes Itself - Full documentary - YouTube - 0 views

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    "The Brain That Changes Itself - Full documentary" Norman Doidge, FRCPC, is a psychiatrist, psychoanalyst, and author of The Brain that Changes Itself and The Brain's Way of Healing.
Dennis OConnor

Milasen: The drug that went from idea to injection in 10 months - 0 views

  • itting in freezer at Boston Children’s Hospital is a drug you won’t find anywhere else. It’s called milasen, and the 18 g that the hospital custom-ordered nearly 2 years ago should last for decades. That’s because milasen was designed to treat a single patient—a now 8-year-old girl named Mila Makovec. Milasen was built on decades of work on a class of drugs called antisense oligonucleotides. But after Boston Children’s Hospital scientist Timothy Yu diagnosed Mila with a never-before-seen genetic mutation, he took only 10 months to go from idea to injection. It’s a record-shattering sprint in the typical drug-development marathon, and an unprecedented degree of personalization for a chemical drug.
  • While the story of milasen could be seen as a template for other highly personalized drugs—what the field has come to call n-of-1 therapies—it also raises questions: Who should get these treatments? How will they be funded? And how will the US Food and Drug Administration regulate these projects?
  • Mila’s mom, Julia Vitarello, had started a group called Mila’s Miracle Foundation to raise money to develop a gene therapy for her daughter.
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  • Yu was intrigued. He reached out and offered to do whole-genome sequencing on Mila, her parents, and her younger brother.
  • Julia Vitarello, Mila's mother In March, Yu’s team found that a piece of DNA called a retrotransposon—the genetic remnants of viruses scattered throughout all of our genomes—had spontaneously inserted itself in the middle of a noncoding region of Mila’s CLN7 gene.
  • Black told Yu to renegotiate with the FDA. The 3-month safety study in rats, followed by another couple months to report the data, would take too long. After a letter from Vitarello outlining Mila’s decline, the FDA made a concession: Mila could get the drug after just 1 month of testing, so long as the rat studies continued to 3 months to understand any long-term toxicity.
  • Today, Mila continues to get injections of her drug approximately every 2 months. She used to have up to 30 seizures a day, each lasting more than a minute. Now, she only has a few a day, and they don’t last long,
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    "Sitting in freezer at Boston Children's Hospital is a drug you won't find anywhere else. It's called milasen, and the 18 g that the hospital custom-ordered nearly 2 years ago should last for decades. That's because milasen was designed to treat a single patient-a now 8-year-old girl named Mila Makovec. Milasen was built on decades of work on a class of drugs called antisense oligonucleotides. But after Boston Children's Hospital scientist Timothy Yu diagnosed Mila with a never-before-seen genetic mutation, he took only 10 months to go from idea to injection. It's a record-shattering sprint in the typical drug-development marathon, and an unprecedented degree of personalization for a chemical drug."
Dennis OConnor

Aging Successfully | Conversation | re'flect - 0 views

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    "Gray Matters, the new podcast series, will continue our mission to discuss how we can all age successfully.   re'flect, the documentary series has aired nationally on over 50 PBS stations in over 40 cities and is spreading the positive aging conversation around the US. "
Dennis OConnor

Team | reflect-copy - 1 views

  • HEIDI RATAJ
  • THERESA HOILES
  • PRODUCER, DIRECTOR & SPEAKE
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  • PRODUCER & WRITER
  • What’s more important, quality of life or quantity?”
  • Theresa learned early that age is not an excuse to slow down.
  • Through storytelling, she wants to break the stereotypes associated with aging.
  • This series convinced Heidi that life should be measured in quality not quantity
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    "Gray Matters, the new podcast series, will continue our mission to discuss how we can all age successfully. Heidi Rataj, MA Producer, Gerontologist & Entrepreneur re'flect, the documentary series has aired nationally on over 50 PBS stations in over 40 cities and is spreading the positive aging conversation around the US. "
Dennis OConnor

Association of Optimism With Cardiovascular Events and All-Cause Mortality: A Systemati... - 1 views

  • Abstract Importance  Optimism and pessimism can be easily measured and are potentially modifiable mindsets that may be associated with cardiovascular risk and all-cause mortality.Objective  To conduct a meta-analysis and systematic review of the association between optimism and risk for future cardiovascular events and all-cause mortality.
  • Conclusions and Relevance  The findings suggest that optimism is associated with a lower risk of cardiovascular events and all-cause mortality. Future studies should seek to better define the biobehavioral mechanisms underlying this association and evaluate the potential benefit of interventions designed to promote optimism or reduce pessimism.
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    Recommended by Kabir: "Abstract Importance  Optimism and pessimism can be easily measured and are potentially modifiable mindsets that may be associated with cardiovascular risk and all-cause mortality. Objective  To conduct a meta-analysis and systematic review of the association between optimism and risk for future cardiovascular events and all-cause mortality. Data Sources and Study Selection  PubMed, Scopus, and PsycINFO electronic databases were systematically searched from inception through July 2, 2019, to identify all cohort studies investigating the association between optimism and pessimism and cardiovascular events and/or all-cause mortality by using the following Medical Subject Heading terms: optimism, optimistic explanatory style, pessimism, outcomes, endpoint, mortality, death, cardiovascular events, stroke, coronary artery disease, coronary heart disease, ischemic heart disease, and cardiovascular disease."
Dennis OConnor

Social, Behavioral, and Environmental Enablers for Healthy Longevity - 1 views

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    A Workshop for the Global Roadmap for Healthy Longevity Initiative Nov. 6 (1 PM ET) - Nov. 8 (12:30 PM ET) Live Webcast Join us via live webcast for a 2-day public workshop that will examine the social, behavioral, and environmental enablers for healthy longevity. Workshop participants will discuss the challenges and opportunities, as well as potential solutions and disruptive approaches to enhance social structures that would enable healthier and socially fulfilled lives and ultimately create thriving societies around the world. Sir Michael Marmot, Director of the Institute of Health Equity at University College London, will deliver the keynote address. 
Dennis OConnor

Get Started - Quantified Self - 0 views

  • If your project requires a lot of work every day, you’re more likely to drop it before you learn anything useful.
  • Try a one number baseline: A baseline measurement can be as simple as a single number representing a single measurement.
  • collect and organize some of the most useful advice about self-tracking
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  • How do you get started with a self-tracking project?
  • The activities are: Questioning, Observing, Reasoning, and Consolidating Insight.
  • questions about a tool you’re currently using, try posting in the QS Forum.
  • Retrospective Annotation
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    "So: How do you get started with a self-tracking project? You can picture your project as involving four distinct activities. Although these activities blend into each other, they do each have their own particular flavor, and by outlining them separately we think we can give you a coherent and functional recipe. The activities are: Questioning, Observing, Reasoning, and Consolidating Insight."
Dennis OConnor

Upload Raw DNA Data & Your Health Info to Advance Medicine | LunaDNA - 1 views

  • LunaDNA is the first health and DNA discovery platform owned by its community of data contributors.
  • you remain in complete control of your data.
  • people are the most important players in research and deserve to be honored as partners in the process.
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    "The Future of Health Depends on Your Data The first people-powered platform where you share health data, advance science and take part in the value created."
Dennis OConnor

Just Putting Patients At The Center Of Health Care Is Not Enough To Improve Care | Heal... - 1 views

  • Just Putting Patients At The Center Of Health Care Is Not Enough To Improve Care
  • Yet, despite the tremendous work of the past 20 years, we have not achieved a health care system that is truly patient centered and equitable.
  • With the RWJF’s support, we managed a portfolio of research projects that examined what health care consumers value when they are buying and using health insurance, shopping for health care, and seeking care in a variety of new and traditional settings
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  • Why aren’t we there yet?
  • Barrier 1: Missing Information and How to Collect It
  • Barrier 2: Inadequate Trust and Respect
  • Barrier 3: Culture of Medicine
  • Barrier 4: Alignment of Incentives
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    "Just Putting Patients At The Center Of Health Care Is Not Enough To Improve Care"
Dennis OConnor

Precision Health: Know More About Your Body, Worry Less | Q Bio - 1 views

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    In 2008 Jeff Kaditz was rushed to the hospital after being hit by a car. He spent months in a hospital bed and had to learn to walk again. He was misdiagnosed twice before finding out he needed major surgery. Throughout the process he was frustrated by the lack of quantitative information that was available about his body, which led to a wide range of inconsistent diagnoses. Jeff imagined a day when everything about a person's body could be quickly measured, shared and analyzed. He started researching a solution and in 2015 he met Dr. Michael Snyder and Dr. Garry Choy. They immediately bonded over a shared vision that became Q.
Dennis OConnor

Juhi Ash Center - 0 views

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    FOUNDER & CHIEF PRACTITIONER Juhi Singh, MA, LAc is a Thought Leader in Integrative Medicine and one of the top Acupuncturists in New York City. Mike: speaking of integrative med… I had happy hour with friend Juhi Singh MA LAc who is launching a new multi-specialty integrative med Center. Juhi Ash Center. She is very data-driven in the integrative world.
Dennis OConnor

A third of people track their health or fitness. Who are they and why are they doing it? - 0 views

  • one in three people (33 percent) currently monitor or track their health or fitness via an online or mobile
  • international GfK survey
  • China is well in the lead
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  • Brazil and the USA come next
  • followed by Germany (28 percent) and France (26 percent).
  • To download full findings for each of the 16 countries, please visit www.gfk.com/global-studies/global-study-overview/
Dennis OConnor

N1: wellness by experiment - Down App to experiment - 0 views

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    N1: wellness by experiment 17+ Back your wellness with data INGH Available on iOS only You can use this app to join a clinical trial on cognition. Comparing 2 treatments using caffeine (50-400 mg) and caffeine (50-400 mg) in combination with L-theanine (250 mg) : L-theanine is a naturally occurring amino acid most commonly found in green tea. I've downloaded the app will join the study. Interesting screen by screen informed consent process. Will report what I discover at an upcoming Apollo Meeting.
Dennis OConnor

Videos - Exponential Medicine | November 2019 - 1 views

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    This is a San Diego based conference. Here is an archive of videos from the past few years. A quick scan will reveal synergy with Project Apollo.
Dennis OConnor

Milli | Artificial Intelligence Powered Health Coach - 0 views

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    "Meet Milli A self-teaching personalized medical intelligence platform built from real-time analysis of millions of patient/doctor interactions. The Medical Intelligence Platform™ makes it easy to capture, aggregate, and analyze comprehensive patient data with human-augmented Artificial Intelligence. We provide doctors with suggestions for the likely underlying dysfunctions that lead to disease, recommendations for follow up tests, and predictions for which intervention will be most effective for each patient. Our Virtual Health Assistant then provides intervention support to the patient and tracks their adherence and medical outcomes. This closed-loop process enables the platform to systematically learn from every provider/patient medical encounter to learn how to better prevent and reverse disease."
Dennis OConnor

Mt. Sinai Lab100 - 0 views

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    Part clinic, part research lab, Lab100 uses precision diagnostics to empower patients and help scientists advance our understanding of human health.
Dennis OConnor

Tempus Data-driven precision medicine - 0 views

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    Tempus is making precision medicine a reality. Through the power of artificial intelligence, we believe all patients will eventually be on their own personalized diagnostic and therapeutic path. With the world's largest library of clinical and molecular data, and an operating system to make that data accessible and useful, we enable physicians to make real-time, data-driven decisions to deliver personalized patient care and in parallel facilitate discovery, development and delivery of optimized therapeutic options for patients through distinctive solution sets.
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