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Dennis OConnor

Stakeholders Identify Actions for Providers, Patients & Research Community to Advance P... - 0 views

academyhealth.org/...-advance-patient-centered-care

shared by Dennis OConnor on 06 Oct 19 - No Cached
  • Supported by the Robert Wood Johnson Foundation (RWJF), AcademyHealth convened meeting participants whose comments grouped into six major areas of discussion and related actionable strategies. Ideas outlined in the full meeting report include the need to:  Strengthen training opportunities for providers, patients, and caregivers Improve the diversity of the health care workforce Engage community members as partners in patient care Keep patients at the center of innovations in service delivery Improve the transparency of care and costs Invest in implementation research
Dennis OConnor

At the Cusp of Solving Cognitive Aging? - Mike Merzenich - Medium - 0 views

medium.com/...g-cognitive-aging-9907a8b7775f

merzenich aging cognition brainHQ

shared by Dennis OConnor on 18 Oct 19 - No Cached
  • Bookmark story
  • the ACTIVE Study.
  • hree different theories
  • ...24 more annotations...
  • memory
  • reasoning
  • speed of processing
  • ACTIVE tracked people for 10 years
  • 74 to 84
  • who would have expected faster cognitive processing speed 10 years later
  • The big question was do those gains transfer to real-world activities.And, the answer is: they do.
  • At the end of 10 years
  • about three years more protection against decline
  • speed training
  • ● 38% less risk of onset of depressive symptoms● 30% less risk of deepening of depressive symptoms● 68% stronger feeling of confidence and control● 48% less risk of at-fault car crashes
  • I (Mike Merzenich) have spent decades studying brain plasticity — the brain’s ability to change (at any age), chemically, structurally and functionally.
  • What changes in the brain as it gets older?
  • basic science question
  • every single thing we measured in the aging brain changed (and none for the better).
  • The top row
  • we built a brain-training program designed to make a rat’s brain faster and more accurate.
  • to improve auditory precision and speed.
  • It turns out that this kind of brain training — continuously and progressively challenging the speed and accuracy of brain processing — improves every aspect of brain health we could measure.
  • we could build, test, refine and validate a training program to improve all the major systems of the brain.
  • plasticity-based training
  • cognition (eg, speed, attention, memory, executive function)
  • quality of life (eg, mood, confidence, self-rated health)
  • dementia?
Dennis OConnor

The proximal origin of SARS-CoV-2 | Nature Medicine - 1 views

www.nature.com/...s41591-020-0820-9

covid research origins-covid-19

shared by Dennis OConnor on 17 Mar 20 - No Cached
  • Here we review what can be deduced about the origin of SARS-CoV-2 from comparative analysis of genomic data
  • Our analyses clearly show that SARS-CoV-2 is not a laboratory construct or a purposefully manipulated virus.
  • The receptor-binding domain (RBD) in the spike protein is the most variable part of the coronavirus genome1,2. Six RBD amino acids have been shown to be critical for binding to ACE2 receptors and for determining the host range of SARS-CoV-like viruses7.
  • ...18 more annotations...
  • Theories of SARS-CoV-2 originsIt is improbable that SARS-CoV-2 emerged through laboratory manipulation of a related SARS-CoV-like coronavirus.
  • the genetic data irrefutably show that SARS-CoV-2 is not derived from any previously used virus backbone
  • we propose two scenarios that can plausibly explain the origin of SARS-CoV-2: (i) natural selection in an animal host before zoonotic transfer; and (ii) natural selection in humans following zoonotic transfer.
  • COVID-19 were linked to the Huanan market in Wuhan
  • it is likely that bats serve as reservoir hosts for its progenitor
  • Malayan pangolins (Manis javanica) illegally imported into Guangdong province contain coronaviruses similar to SARS-CoV-221
  • Although no animal coronavirus has been identified that is sufficiently similar to have served as the direct progenitor of SARS-CoV-2, the diversity of coronaviruses in bats and other species is massively undersampled
  • For a precursor virus to acquire both the polybasic cleavage site and mutations in the spike protein suitable for binding to human ACE2, an animal host would probably have to have a high population density (to allow natural selection to proceed efficiently) and an ACE2-encoding gene that is similar to the human ortholog
  • It is possible that a progenitor of SARS-CoV-2 jumped into humans, acquiring the genomic features described above through adaptation during undetected human-to-human transmission.
  • All SARS-CoV-2 genomes sequenced so
  • are thus derived from a common ancestor that had them too
  • Estimates of the timing of the most recent common ancestor of SARS-CoV-2 made with current sequence data point to emergence of the virus in late November 2019 to early December 201923,
  • compatible with the earliest retrospectively confirmed cases
  • Basic research involving passage of bat SARS-CoV-like coronaviruses in cell culture and/or animal models has been ongoing for many years in biosafety level 2 laboratories across the world27, and there are documented instances of laboratory escapes of SARS-CoV28. We must therefore examine the possibility of an inadvertent laboratory release of SARS-CoV-2.
  • The finding of SARS-CoV-like coronaviruses from pangolins with nearly identical RBDs, however, provides a much stronger and more parsimonious explanation of how SARS-CoV-2 acquired these via recombination or mutation1
  • it is reasonable to wonder why the origins of the pandemic matter
  • Detailed understanding of how an animal virus jumped species boundaries to infect humans so productively will help in the prevention of future zoonotic events.
  • More scientific data could swing the balance of evidence to favor one hypothesis over another.
Dennis OConnor

LearnSphere - 0 views

pslcdatashop.web.cmu.edu/LearnSphere

innovation AI data cmu lies

shared by Dennis OConnor on 19 Jul 19 - No Cached
  • Dennis OConnor on 19 Jul 19
     
    This is the CMU Tigris login page.
Dennis OConnor

Why Crypto needs a Doctor and Medicine needs Blockchain Technology - It's not... - 0 views

medium.com/...ot-what-you-think-9a193c2b9d02

blockchain Cahana

shared by Dennis OConnor on 20 Jul 21 - No Cached
  • This journey took me through Pain Medicine and cognitive neuroscience, phenomenological investigation, and behavioral economics, finally leading me to systems thinking and my interest in blockchain distributed ledger technologies.
  • Healthcare is a multi-stakeholder, mal-aigned, friction-full, opaque, heavily-regulated, lacking-of-trust, data-rich environment that does lend itself to a spectrum of blockchain-based platforms.
  • that the opposite of health is not disease but rather ISOLATION. That as we get sicker, our world contracts, gets smaller and smaller until one morning we wake up take a Xanax, an Oxycontin, drink a Chardonnay (or beer if you prefer) and overdose.
  • ...1 more annotation...
  • how blockchain technology can change behaviors, encourage sustainable practices and reign in the disproportionate power incumbents have on predatory practices.
  • Dennis OConnor on 20 Jul 21
     
    By Alex Cahana 1. Why isn't there a doctor in the house? First reason: MD's hate HIT (health information technology) 2. Most MD's have no idea what Blockchain does, let alone what it IS
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