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Millions of people suffer from asthma, a frightening disease that makes you feel like you're drowning. Using both mouse and human cells - and a humanized mouse to show how human type 2 innate lymphoid cells (ILC2) work in the body, researchers at Janssen Research and Development, Dana-Farber Cancer Institute and Harvard Medical School are figuring out ILC2's role in asthma. Their findings have important implications in the quest for effective asthma therapies!

We aim to provide all you want to know about animal research, whether you are a concerned member of the public or have a special interest. If you are a teacher, student, scientist, policy maker or a journalist, select one of the tabs above to find the content of particular interest to you.

Comprehensive list of sites regarding animal research.

A single genetic mutation causes resistance to DDT and pyrethroids (an insecticide class used in mosquito nets), new research concludes. With the continuing rise of resistance, the research is key as scientists say that this knowledge could help improve malaria control strategies. The researchers used a wide range of methods to narrow down how the resistance works, finding a single mutation in the GSTe2 gene, which makes insects break down DDT so it's no longer toxic. They have also shown that this gene makes insects resistant to pyrethroids raising the concern that GSTe2 gene could protect mosquitoes against the major insecticides used in public health.

This 22 min video provides insight into the benefits of bioscience research and the important role laboratory animals play in the scientific process. It introduces viewers to four people age 55 and older who have benefited from medical advances made possible by years of animal-based research. Viewers also meet four scientists who are helping make these advances a reality

Data Nuggets are free classroom activities, co-designed by scientists and teachers, designed to bring contemporary research and authentic data into the classroom. Data Nuggets include a connection to the scientist behind the data and the true story of their research. Each activity gives students practice working with 'messy data' and interpreting quantitative information. Students are guided through the entire process of science, including identifying hypotheses and predictions, visualizing and interpreting data, making evidence based claims, and asking their own questions for future research. Because of their simplicity and flexibility, Data Nuggets can be used throughout the school year and across grades K-16, as students grow in their quantitative abilities and gain confidence." Sounds like real science to me!

The article "Data back ban of artificial trans fats" (10.8 readability score) summarizes new research showing that banning artificial trans fats in foods could reduce the risk of heart attacks and strokes. Students can focus on details reported in the article, follow connections to earlier articles about trans fats research, engage in a classroom discussion of related scientific and government policy questions and make connections between the science of food and their health. Students can also conduct their own experiments to analyze foods for fats and then research the types of fats within different foods to make recommendations about dietary consumption.

The activity begins with students observing different organisms or phenomena and developing questions based on their observations. They then sort their questions into those that can and cannot be answered using the methods of science. Students practice writing scientific questions, designing experiments to address scientific questions, developing questions that involve cause and effect, and understanding the importance of cause and effect questions in scientific research. At the end of the activity, students determine the research questions being asked from reading journal article titles and parts of a published paper or other reported results. Several possible extension activities are provided for continuing the investigation and research of phenomena.

Normally, male squirrel monkeys can't distinguish between red and green hues-they're what is called color-blind in humans. The South American Saimiri genus lacks a gene that allows color-sensitive cells in the eye, called cones, to differentiate red and green from gray. To these animals, other colors, such as blue, brown and orange, appear faded. But Sam was one of two males in the experimental group of a groundbreaking 2009 ophthalmological study conducted at the Washington National Primate Research Center in Seattle. Husband-and-wife vision researchers Jay and Maureen Neitz injected a viral vector behind the retinas, the part of the eye that responds to color, of Sam and his simian lab partner, Dalton. The virus contained the genetic code in human eyes for red pigment, giving the monkeys an extra class of cone photoreceptor.

curricular unit on Genetic Research

So how do animals play a role in this research? Well, in a couple of ways. First, the chlorotoxin in Tumor Paint was derived from scorpion venom. Second, researchers worked with dogs before moving into human trials to determine the likelihood of success. After promising results in canines, human trials are now underway at Cedars Sinai Medical Center! Right now, the study is aimed at proving that Tumor Paint is able to reach the brain tumor successfully. If all goes well, it's possible that this could lead to more successful surgical outcomes.

A British researcher has received permission to use a powerful new genome editing technique on human embryos, even though researchers throughout the world are observing a voluntary moratorium on making changes to DNA that could be passed down to subsequent generations.

"inquiryHub is a research practice partnership engaged in research and development of materials, tools, and processes to promote equitable student learning of STEM. inquiryHub Biology is an open access, deeply digital high school biology curriculum designed to support the Next Generation Science Standards.  "

While surveying the seafloor last fall, a research vessel spotted bubbles rising from the depths. Now, another ship has gone back to investigate, and found a variety of life on the seafloor surrounding a methane seep, according to an update from researchers with the National Oceanic and Atmospheric Administration (NOAA).

Last month, researchers announced they were studying a 30,000-year-old giant virus called Mollivirus sibericum that they found in melted Siberian permafrost. The virus was functional and able to infect amoeba. This isn't the first time researchers have found big viruses that have challenged what we thought we knew about the tiny invaders. Mimivirus, discovered in 2003, has 1,200 genes and is twice the width of traditional viruses.

research summaries

Such descriptions of GMOs raises fears about whether gene transfer between species is outside of how evolution operates and therefore unnatural. Research, however, has repeatedly shown the opposite to be true. In May 2015, researchers showed that practically every known species of cassava (sweet potato) contained genes from Agrobacterium, a bacterial species whose genes we have also harnessed to create other GM crops. The genes were inserted over 8,000 years ago and may have helped the tuber evolve into its current, edible form. This phenomenon of genetic transfer during evolution between species, also known as 'horizontal gene transfer' is not restricted to plants.

Curriculum materials for the following topics: HeLa Cells & HPV Genes: Immortality & Cancer, which reviews basic cell biology, tissue culture, and human subjects research in the context of privacy, rights, and compensation. Link: http://www.stemcellcurriculum.org/hela-cells-hpv-genes-immortality-cancer.html · Eggs & Blood: Gifts & Commodities, which addresses the value placed on some bodily tissues/cells and not on others. Link: http://www.stemcellcurriculum.org/eggs-and-blood.html · Disease, Disability, & Immortality: Hope & Hype, which explores the natural physical and cognitive variability in the human population and questions the goal of a "cure" in biomedical research. Link: http://www.stemcellcurriculum.org/disease-disability-immortality-hope-hype.html · Stem Cells & Policy: Values & Religion, which analyzes how policy is shaped in pluralistic societies that require tolerance of different points of view. Link: http://www.stemcellcurriculum.org/stem-cells-policy-values-and-religion.html

In a unique twist on human genomics studies that seek to identify genetic variants linked to human disease, researchers have combined whole-exome sequencing of 50,726 adults with the individuals' long-term electronic health record (EHR) data. The effort, by researchers at the Geisinger Health System in Pennsylvania and Regeneron Genetics Center, a subsidiary of New York-based Regeneron Pharmaceuticals, has yielded novel disease-linked variants, including loss-of-function alleles. The team behind the project, called DiscovEHR, has also found that about one in 30 of the individuals harbors a deleterious genetic variant for which a screen or treatment already exists. The group's analysis is described in two papers published today (December 22) in Science.

Six years ago, Yale University's Stephen Stearns and colleagues took advantage of a long-running study in Framingham, Massachusetts, to assess whether the effects of natural selection could be discerned among the people in the multigenerational study population. Over the last seven decades, public-health researchers have been monitoring the residents of Framingham, noting their vital statistics as well as blood sugar and cholesterol levels to understand the factors that lead to heart disease. As the initial group of research subjects got older, the study started to include their children, and then their grandchildren. The records provide a unique view of the health of a segment of the American population since 1948.