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The purpose of this case is to teach introductory college biology students the basic process of mitosis, focusing on the fundamental cellular processes that occur during each of the stages-prophase, prometaphase, metaphase, anaphase, telophase and cytokinesis. It would also be appropriate for AP Biology students. The case is framed around solving a murder. The murder plot involves a naturally-occurring poison derived from Yew trees, known as paclitaxel. Paclitaxel is a mitotic inhibitor that works by inhibiting the depolymerization of microtubules so that the cell is arrested in metaphase. At the end of the case, students will be able to describe the basic process of mitosis, including the fundamental processes that occur in each stage. The discovery of paclitaxel led to the development of the chemotherapeutic drug, Taxol ®, and the case concludes by having students think about the correlations between poisons and chemotherapies. The case involves the use of videos, one of which was made by the author for this case, and can be used in a flipped classroom.

How does the real process of science really work?  Gain a new perspective of the dynamic process of science and how it relates to you with this iTunes U course co-produced by the California Academy of Sciences and University of California Museum of Paleontology.  Content from this course was inspired by the Understanding Science website produced by UCMP. Designed for middle- and high- school science educators to broaden their own knowledge and understanding and to use with students, the course weaves together activities, videos, and classroom-ready materials into a primer on the process of science that includes exploration and discovery, testing ideas, community feedback and peer review, and benefits and outcomes. 

The WHO recently announced that eating too much processed meat can lead to cancer, but what makes processed meat so bad for you?

While scientists study how nature works, engineers create new things, such as products, websites, environments, and experiences. Because engineers and scientists have different objectives, they follow different processes in their work. Scientists perform experiments using the scientific method; whereas, engineers follow the creativity-based engineering design process.

Different disciplines follow different versions of the inquiry process. Graphic comparing: problem solving, scientific method, writing process, computation, theater, and engineering design.

In the past, sailors on whaling ships would carve whale teeth into works of art in a process called scrimshaw. These pieces would be brought home to loved ones as mementos of the voyage. Design incubator Studio Swine is attempting to recycle found materials and turn this aged art form into a more sustainable practice. In this short film, travel to remote parts of the ocean, where "the closest people are in a space station," and watch as the process of collecting ocean trash and transforming it into beautiful treasure unfolds.

Paul Andersen explains the two major portions of the molecular biology lab in AP Biology. He starts by discussing the process of transformation. He explains how you can use the pGLO plasmid to produce glowing E. coli bacteria. He then describes how you can use restriction enzymes and the process of gel electrophoresis to cut and separate DNA.

This clicker case study follows a dialogue between two college students, Lucy and Dan, as they discover how alternative splicing of mRNA molecules can allow a single gene to code for multiple proteins. Dan is participating in a clinical trial for a drug that may treat his migraines by inhibiting calcitonin gene-related peptide, and Lucy is working in a summer research lab that studies the protein calcitonin. They soon realize that the two proteins are both encoded by the same gene, and through their questioning and dialogue they come to understand the phenomenon of alternative splicing. They also learn about other steps of mRNA processing and about monoclonal antibodies. This case was designed to be taught in a flipped classroom, but could easily be adapted for a more traditional classroom setting if content covered in the pre-class videos is covered during the case study instead. It was designed for an introductory-level molecular biology course, but could be adapted for higher levels by including more information about the physiology and regulatory mechanisms involved.

Metacognition refers to awareness of one's own knowledge-what one does and doesn't know-and one's ability to understand, control, and manipulate one's cognitive processes (Meichenbaum, 1985). It includes knowing when and where to use particular strategies for learning and problem solving as well as how and why to use specific strategies. Metacognition is the ability to use prior knowledge to plan a strategy for approaching a learning task, take necessary steps to problem solve, reflect on and evaluate results, and modify one's approach as needed.

This case is an exploration of the process of natural selection using white clover (Trifolium repens) as an example. In general, two forms of white clover can be found around the world in various habitats. One type is able to produce cyanide in its leaves, while the other is not. This variation within the clover species, along with the fact that cyanide production is paired with the production of a white stripe on the leaf, is used to teach the process of evolution through natural selection. 

In order to be useful in treating human infections, antibiotics must selectively target bacteria for eradication and not the cells of its human host. Indeed, modern antibiotics act either on processes that are unique to bacteria--such as the synthesis of cell walls or folic acid--or on bacterium-specific targets within processes that are common to both bacterium and human cells, including protein or DNA replication. Following are some examples.

A zebrafish model of a rare genetic disease has revealed an unexpected regulatory pathway for cholesterol absorption and processing. The findings, reported in the Journal of Molecular Medicine, were "quite surprising and have the potential to teach us about the basic physiology of cholesterol management," said Ela Knapik, M.D., associate professor of Medicine and Cell and Developmental Biology.

3:00 video Transcription is a vital process in biological lifeforms. It is through this process that the biological roadmap encoded in a strand of DNA is used to produce a complementary RNA copy. The RNA can then go on to help produce the proteins and enzymes that power living organisms.

In biology classes, students are typically taught that spontaneous generation does not take place. And yet, at the origin of life, life had to arise without parents from abiotic processes. What were those processes that gave rise to the first life?  This case study uses an interrupted format to guide students through the Miller-Urey experiment of 1953, which showed that organic molecules could be produced from abiotic precursors and conditions thought to be prevalent on the early Earth. The case also addresses the more speculative implications about where these reactions may have taken place to create the organic building blocks of life on this planet. The first three parts of the case, which explore the Miller-Urey experiment, are ideal for introductory biology courses and take about 45-50 minutes to complete. The remaining sections, which explore whether such chemical reactions took place in outer space, were used in a non-major astrobiology course and require a further hour to complete.

Michael Mosley looks into the dangerous ingredients added to processed meat that becomes a suspect in causing cancer.

Every day, billions of new cells are produced, so mitosis occurs billions of times. Whether it's for new skin cells, muscle cells, or onion root cells, the process of mitosis is the same. In this lab, the student observes chromosomes and identifies specific steps in the process of mitosis.

This interrupted case study is designed to introduce beginning biology students to the process of science by exploring a question that is accessible to students with limited scientific background. The giraffe (Giraffa camelopardialis) is the tallest terrestrial mammal and has a disproportionally long neck. Historically, this trait has been hypothesized to be an adaptation for competition between the giraffe and other herbivore species. Guided by a PowerPoint presentation and (optional) worksheet, students will propose hypotheses to explain the giraffe's uniquely long neck and will examine the results of field experiments to test the prevalent historical hypothesis that the long neck allows the giraffe to exploit high food sources. They will find that the data do not support this initial hypothesis and will use other field observations to propose and examine an alternative hypothesis. Throughout the activity students will engage in the process of science; they will propose hypotheses, design experiments, make predictions, and draw conclusions from published field observations.

Michael Mosley looks into the dangerous ingredients added to processed meat that becomes a suspect in causing cancer.

"Biologists and informaticists at Indiana University have produced one of the most extensive pictures ever of mutation processes in the DNA sequence of an organism, elucidating important new evolutionary information about the molecular nature of mutations and how fast those heritable changes occur."

Don't tell your kids that they are smart. More than three decades of research shows that a ocus on "process"-not on intelligence or ability-is key to success in school and in life