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More than 60 years ago, Johns Hopkins researchers took cells from a cancer patient - cells that fueled medical breakthroughs, but were used without her consent. Now, her family has reached an agreement with the National Institutes of Health. Terrell Brown reports.

Autism is rooted in genetics, including the mutation of certain genes that result in a failure of neurons in the brain to properly connect. Based on earlier genetic research funded by Autism Speaks, such as the Autism Genome Project (AGP), scientists have discovered some of these genes. But much more gene discovery needs to take place. The Autism Genome 10K Project will mark a substantial leap forward on this journey. The Autism Genome 10K Project builds on the successes of Autism Speaks' Autism Genetic Resource Exchange program (AGRE), a high-quality collection of more than 12,000 DNA samples from families affected by autism. The AGRE program has facilitated many high-impact scientific discoveries in recent years, including the risk genes discovered by the AGP and other researchers. With BGI sequencing the full complement of 10,000 samples collected by AGRE and collaborators in China, Autism Genome 10K leverages BGI's cutting-edge expertise and globally unrivaled capacity for high-quality genome sequencing.

This case study introduces students to the structure and function of cellular organelles and seeks to show their importance by discussing diseases and disorders that can result when an organelle does not function as it should. The storyline follows a family whose joy at bringing home a new baby is soon altered by their child's sudden illness, which is eventually diagnosed as Leigh Disease. This disease occurs when defective mitochondria fail to produce energy needed by the cell, particularly affecting cells with high-energy needs like those in the brain, muscle, and gastrointestinal tract. The narrative also discusses some of the ways in which Leigh disease is inherited, treatment options, and the typical prognosis. The case was designed for an introductory non-majors biology course, but could also be used in other science or health related courses. Instructors also have the option of running the case in a "flipped classroom" in which students watch three recommended videos outside of class as a way of preparing for working on the case in class.

All in the familyl PBS manipulative with evidence and examples.

n Wednesday, it happened again. Yohannes Haile-Selassie of the Cleveland Museum of Natural History and his colleagues reported finding a jaw in Ethiopia that belonged to an ancient human relative that lived some time between 3.3 and 3.5 million years. They argue that the jaw belongs to an entirely new species, which they dubbed Australopithecus deyiremeda.

Online activity: imagine you are an investigator looking for genes that influence niicotene addiction.  View video interviews, written surveys, and official records for the Marshall family and trace their pedigree.

Anthracobunidae is an Eocene family of large mammals from south Asia that is commonly considered to be part of the radiation that gave rise to elephants (proboscideans) and sea cows (sirenians). We describe a new collection of anthracobunid fossils from Middle Eocene rocks of Indo-Pakistan that more than doubles the number of known anthracobunid fossils and challenges their putative relationships, instead implying that they are stem perissodactyls.

The Birds-of-Paradise Project reveals the astounding beauty of 39 of the most exquisitely specialized animals on earth. After 8 years and 18 expeditions to New Guinea, Australia, and nearby islands, Cornell Lab scientist Ed Scholes and National Geographic photojournalist Tim Laman succeeded in capturing images of all 39 species in the bird-of-paradise family for the first time ever. This trailer gives a sense of their monumental undertaking and the spectacular footage that resulted.

With moving personal stories from India, Japan, Kenya, and China, "World in the Balance" gives an up-to-date global snapshot of today's human family, now numbering 6.3 billion and likely to increase to nearly 9 billion by 2050. Paradoxically, the world is now careening in two completely different directions

Behind the unprecedented Ebola outbreak in West Africa lies a species with an incredible power to overtake its host. Zaire ebolavirus and the family of filoviruses to which it belongs owe their virulence to mechanisms that first disarm the immune response and then dismantle the vascular system.

The STAR-G Project has put together fact sheets about disorders commonly screened for by newborn screening. The fact sheets were written specifically for families that have received an initial diagnosis of one of the disorders and want to know more general information. They address issues and answer questions that are of particular concern to parents. Each fact sheet was written by a genetic counselor and reviewed by metabolic and genetic specialists.

After her two children were diagnosed with a rare genetic condition, Sharon Terry dedicated her life to creating systems-level solutions that will alleviate burdens for consumers and build opportunities for them to be empowered in their own health care. She is the CEO of Genetic Alliance, an international non-profit organization, now in its 25th year, that is the world's largest network of health related organizations working from a consumer perspective. Genetic Alliance builds capacity within the genetics and health community by forging novel partnerships, promoting informed decision-making, and sharing individual, family, and community perspectives.

If thinking about the billions of bacteria taking up residence in and on your body gives you the willies, you probably won't find it comforting that humans are also full of viruses. These maligned microbes are actually intertwined in the very fibers of our being-about 8 percent of our genetic material is made up of absorbed forms of retroviruses, the viral family to which HIV, the pathogen that causes AIDS, belongs.

Fascinating narrative science that explores the next frontier in medicine and genetics through the very personal prism of the children and families gene therapy has touched. Eight-year-old Corey Haas was nearly blind from a hereditary disorder when his sight was restored through a delicate procedure that made medical history.  Like something from a science fiction novel, doctors carefully introduced viruses bearing healing genes into Corey's eyes-a few days later, Corey could see, his sight restored by gene therapy.

Stories of families with newborn screening disorders

Jackson would eventually be diagnosed with the rare genetic eye disease Autosomal Dominant Neovascular Inflammatory Vitreoretinopathy (ADNIV), which eventually causes blindness in those who carry the gene.

When it comes to charting the tree of life, the most important difference between humans and sharks isn't limbs versus fins or even lungs versus gills. It all comes down to our skeletons. Sharks' skeletons are made of cartilage, placing them along with rays and skates in a group of jawed vertebrates called cartilaginous fish. Humans-along with most other living vertebrates-belong to the same group as bony fish, whose skeletons are made of bone. Scientists knew that these groups diverged more than 420 million years ago, but what the last common ancestor looked like remained a mystery. Now, new discoveries inside the head of a small fossil fish from Siberia may provide some clues.

This video excerpt from NOVA examines the dilemma some people face when they are deciding whether to undergo genetic testing. Journalist Catherine Elton describes her decision to refuse a test for BRCA1, a mutation that signals an increased risk of breast and ovarian cancers, despite the history of disease in her family. The video also explains that genetic testing results can help some individuals improve their wellness, prevent the onset of diseases they are at risk for, or lessen the harmfulness of diseases they do contract.

Genomics resources for teachers, from state of Michigan. This website includes three main sections: Family History- which looks into genomics at the organism level Multifactorial Traits- which looks into genomics at the cellular and gene level Genetic Variation- which looks into genomics at the molecular level

Now a study of 15 Finnish families, published in the Journal of Medical Genetics, provides the first proof that musical ability is indeed linked to genes.