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Using a patient's own stem cells, researchers have corrected the genetic alteration that causes sickle cell disease, a painful, disabling inherited blood disorder that affects mostly African-Americans. The corrected stem cells were coaxed into immature red blood cells in a test tube that then turned on a normal version of the gene

NIH module on Sickle cell anemia.  A bit dated but provides a nice visual on sickling

Animated video walks students through a sickle cell anemia case study, guided by a genetic counselor, with breaks for questions and interactive responses.

University of Washington: lessons include - pasta genetics - Cells and scale -build an animal -Toothpick Fish -traits handout -sickle cell anemia -genetics of taste

Over the last decade, as DNA-sequencing technology has grown ever faster and cheaper, our understanding of the human genome has increased accordingly. Yet scientists have until recently remained largely ham-fisted when they've tried to directly modify genes in a living cell. Take sickle-cell anemia, for example. A debilitating and often deadly disease, it is caused by a mutation in just one of a patient's three billion DNA base pairs. Even though this genetic error is simple and well studied, researchers are helpless to correct it and halt its devastating effects.

1 minute animated video

A keenly observant young man named Tony Allison, working in East Africa in the 1950s, first noticed the connection and assembled the pieces of the puzzle. His story stands as the first and one of the best understood examples of natural selection, where the selective agent, adaptive mutation, and molecule involved are known-and this is in humans to boot. The protection against malaria by the sickle-cell mutation shows how evolution does not necessarily result in the best solution imaginable but proceeds by whatever means are available.

7 minute video; mash up of multiple cool animation videos - 0-1:20   supercoiling DNA to chromosomes 1:25- 1:40 cell division/mitosis 1:45-2:50  DNA replication  2:55-4:45   transcription  4:50-6:55  translation 7:00-7:47

We create interactive lessons for high school and college educators to engage their students in discussions of ethics and personal genetics. The lessons are relevant to multiple subjects, including biology, health, social studies, law, physical education and psychology. All of our lesson plans contain background reading for teachers and students, a selection of classroom activities, discussion points, in some cases a slide presentation or video clip, and an evaluation. Each lesson can stand alone, or all the lessons can be taught as a unit.