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The purpose of the Mentored Quantitative Research Career Development Award (K25) is to attract to NIH-relevant research those investigators whose Quantitative science and engineering research has thus far not been focused primarily on questions of health and disease. The K25 award will provide support and "protected time" for a period of supervised study and research for productive professionals with Quantitative (e.g., mathematics, statistics, economics, computer science, imaging science, informatics, physics, chemistry) and engineering backgrounds to integrate their expertise with NIH-relevant research. This Funding Opportunity Announcement (FOA) is designed specifically for applicants proposing research that does not involve leading an independent clinical trial, a clinical trial feasibility study, or an ancillary clinical trial. Applicants to this FOA are permitted to propose research experience in a clinical trial led by a mentor or co-mentor. Applicants proposing a clinical trial or an ancillary clinical trial as lead investigator, should apply to the companion FOA (xxxx).

The purpose of the Mentored Quantitative Research Career Development Award (K25) is to attract to NIH-relevant research those investigators whose Quantitative science and engineering research has thus far not been focused primarily on questions of health and disease. The K25 award will provide support and "protected time" for a period of supervised study and research for productive professionals with Quantitative (e.g., mathematics, statistics, economics, computer science, imaging science, informatics, physics, chemistry) and engineering backgrounds to integrate their expertise with NIH-relevant research. This Funding Opportunity Announcement (FOA) is designed specifically for applicants proposing to lead basic science experimental studies involving humans, referred to in NOT-OD-18-212 as prospective basic science studies involving human participants. These studies fall within the NIH definition of a clinical trial and also meet the definition of basic research. Types of studies that should submit under this FOA include studies that prospectively assign human participants to conditions (i.e., experimentally manipulate independent variables) and that assess biomedical or behavioral outcomes in humans for the purpose of understanding the fundamental aspects of phenomena without specific application towards processes or products in mind. Studies conducted with specific applications toward processes or products in mind should submit under the companion PA-18-395.

The purpose of the Mentored Quantitative Research Career Development Award (K25) is to attract to NIH-relevant research those investigators whose Quantitative science and engineering research has thus far not been focused primarily on questions of health and disease. The K25 award will provide support and protected time for a period of supervised study and research for productive professionals with Quantitative (e.g., mathematics, statistics, economics, computer science, imaging science, informatics, physics, chemistry) and engineering backgrounds to integrate their expertise with NIH-relevant research. Prospective candidates are encouraged to contact the relevant NIH staff for IC-specific programmatic and budgetary information: Table of IC-Specific Information, Requirements and Staff Contacts.

This funding opportunity announcement (FOA) invites applications for mentored career enhancement (K18) awards in research areas that are highly relevant to the NIH BRAIN Initiative. This career enhancement program will support development of research capability for the BRAIN Initiative, with specific emphasis on cross-training independent investigators in a substantively different area of neuroscience, neuroethics, or in a quantitative and physical discipline (e.g., physics, chemistry, engineering, computer science, mathematics); and vice versa, cross-training independent investigators trained in a quantitative or physical discipline proposing to gain in-depth training in a high-priority area of neuroscience. The research project conducted under this K18 should enhance the candidate's ability to significantly contribute to or lead projects that investigate questions central to the goals of the BRAIN Initiative. Eligible candidates are independent investigators at any faculty rank or level.

This funding opportunity announcement (FOA) invites applications for mentored career enhancement (K18) awards in research areas that are highly relevant to the NIH BRAIN Initiative. This career enhancement program will support development of research capability for the BRAIN Initiative, with specific emphasis on cross-training independent investigators in a substantively different area of neuroscience, neuroethics, or in a quantitative and physical discipline (e.g., physics, chemistry, engineering, computer science, mathematics); and vice versa, cross-training independent investigators trained in a quantitative or physical discipline proposing to gain in-depth training in a high-priority area of neuroscience. The research project conducted under this K18 should enhance the candidate's ability to significantly contribute to or lead projects that investigate questions central to the goals of the BRAIN Initiative. Eligible candidates are independent investigators at any faculty rank or level.

The Division of Molecular and Cellular Biosciences (MCB) supports quantitative, predictive, and theory-driven fundamental research and related activities designed to promote understanding of complex living systems at the molecular, subcellular, and cellular levels. MCB is soliciting proposals for hypothesis-driven and discovery research and related activities in four core clusters: Molecular Biophysics Cellular Dynamics and Function Genetic Mechanisms Systems and Synthetic Biology MCB gives high priority to research projects that use theory, methods, and technologies from physical sciences, mathematics, computational sciences, and engineering to address major biological questions.  Research supported by MCB uses a range of experimental approaches--including in vivo, in vitro and in silico strategies--and a broad spectrum of model and non-model organisms, especially microbes and plants. Typical research supported by MCB integrates theory and experimentation.  Projects that address the emerging areas of multi-scale integration, molecular and cellular evolution, quantitative prediction of phenome from genomic information, and development of methods and resources are particularly welcome.

The Biotechnology, Biochemical, and Biomass Engineering (BBBE) program supports fundamental engineering research that advances the understanding of cellular and biomolecular processes (in vivo, in vitro, and/or ex vivo) and eventually leads to the development of enabling technology and/or applications in support of the biopharmaceutical, biotechnology, and bioenergy industries, or with applications in health or the environment.  Quantitative assessments of bioprocesses are considered vital to successful research projects in the BBBE program.  Fundamental to many research projects in this area is the understanding of how biomolecules and cells interact in their environment, and how those molecular level interactions lead to changes in structure, function, phenotype, and/or behavior.  The program encourages proposals that address emerging research areas and technologies that effectively integrate knowledge and practices from different disciplines, and effectively incorporate ongoing research into educational activities. Research projects of particular interest in BBBE include, but are not limited to: Metabolic engineering and synthetic biology Quantitative systems biotechnology Tissue engineering and stem cell culture technologies Protein engineering/protein design Development of novel "omics" tools for biotechnology applications

The purpose of this administrative supplement is to facilitate translational research partnerships between junior researchers with quantitative backgrounds (in engineering or computational or physical sciences) and junior clinician-scientists from active CTSA institutions (PAR-15-304, PAR-18-464). The supplement will support the quantitative researcher, the NIBIB Translational Research Scholar, contingent upon his/her collaborating with a clinician-scientist KL2 scholar, the "partnering clinician-scientist". The partnering clinician-scientist will be supported independently of this supplement through the parent KL2 award throughout the duration of the proposed supplement. Both team members will be selected by the KL2 PI. The KL2 PI will assist the NIBIB Translational Research Scholar and the partnering clinician-scientist in developing a translational research project aligned with NIBIBs research mission under the guidance of their identified basic and clinical/translational science mentors. Based on this project, the KL2 PI will submit a supplement request under this FOA.

The Biotechnology and Biochemical Engineering (BBE) program supports fundamental engineering research that advances the understanding of cellular and biomolecular processes in engineering biology and eventually leads to the development of enabling technology for advanced manufacturing and/or applications in support of the biopharmaceutical, biotechnology, and bioenergy industries, or with applications in health or the environment.  A quantitative treatment of biological and engineering problems of biological processes is considered vital to successful research projects in the BBE program.

The Biotechnology and Biochemical Engineering (BBE) program supports fundamental engineering research that advances the understanding of cellular and biomolecular processes in engineering biology and eventually leads to the development of enabling technology for advanced manufacturing and/or applications in support of the biopharmaceutical, biotechnology, and bioenergy industries, or with applications in health or the environment.  A quantitative treatment of biological and engineering problems of biological processes is considered vital to successful research projects in the BBE program. 

The Biotechnology and Biochemical Engineering (BBE) program supports fundamental engineering research that advances the understanding of cellular and biomolecular processes in engineering biology and eventually leads to the development of enabling technology for advanced manufacturing and/or applications in support of the biopharmaceutical, biotechnology, and bioenergy industries, or with applications in health or the environment.  A quantitative treatment of biological and engineering problems of biological processes is considered vital to successful research projects in the BBE program.

The Biotechnology and Biochemical Engineering (BBE) program supports fundamental engineering research that advances the understanding of cellular and biomolecular processes in engineering biology and eventually leads to the development of enabling technology for advanced manufacturing and/or applications in support of the biopharmaceutical, biotechnology, and bioenergy industries, or with applications in health or the environment.  A quantitative treatment of biological and engineering problems of biological processes is considered vital to successful research projects in the BBE program.

The purpose of this Dear Colleague Letter is to advise you about funding opportunities at the National Science Foundation for the research community to propose research projects or workshops that will gather data on the implementation and impacts of recent science policy initiatives including, but not limited to those noted earlier.  Especially encouraged are proposals that will: Develop new, or improve existing, analytical frameworks for evaluating the impacts of federal science policy initiatives; Explore different agencies' approaches to the implementation of particular policies to examine how variations in approach affect the achievement of intended policy outcomes; Collect case-study or quantitative data that facilitate identification of best practices in science and innovation policy implementation.

The Biotechnology and Biochemical Engineering (BBE) program supports fundamental engineering research that advances the understanding of cellular andbiomolecular processes in engineering biology and eventually leads to the development of enabling technology for advanced manufacturing and/or applications in support of the biopharmaceutical, biotechnology, and bioenergy industries, or with applications in health or the environment. A quantitative treatment of biological and engineering problems of biological processes is considered vital to successful research projects in the BBE program. Fundamental to many research projects in this area is the understanding of how biomolecules, cells and cell populations interact in their environment, and how those molecular level interactions lead to changes in structure, function, phenotype, and/or behavior. The program encourages highly innovative and potentially transformative engineering research leading to novel bioprocessing and manufacturing approaches, and proposals that address emerging research areas and technologies that effectively integrate knowledge and practices from different disciplines while incorporating ongoing research into educational activities. 

An objective of the Critical Infrastructure Resilience Institute (CIRI) is to bring together capabilities of colleges, universities, federal laboratories, industry, and nonprofit organizations to assess and improve resilience in the ten critical infrastructures for which the Department of Homeland Security is the designated sector-specific agency: * Chemical * Commercial Facilities * Communications * Critical Manufacturing * Dams * Emergency Services * Government Facilities * Information Technology * Nuclear Reactors, Materials, and Waste * Transportation Systems CIRI activities are organized around four themes: 1. Understanding resilient critical infrastructure systems. 2. Application of critical infrastructure in the real world. 3. The business case for infrastructure resiliency. 4. The future of resiliency. With those objectives in mind, CIRI is seeking proposals for projects that will improve the nation's ability to * Understand vulnerabilities and risks * Quantitatively assess risks and resilience measures * Mitigate risks and improve resilience * Establish the business case for resiliency * Deploy resiliency measures

The purpose of the BRAIN Initiative Fellows (F32) program is to enhance the research training of promising postdoctorates, early in their postdoctoral training period, who have the potential to become productive investigators in research areas that will advance the goals of the BRAIN Initiative. Applications are encouraged in any research area that is aligned with the BRAIN Initiative, including neuroethics. Applicants are expected to propose research training in an area that complements their predoctoral research. Formal training in quantitative perspectives and analytical tools is expected to be an integral part of the proposed research training plan. In order to maximize the training potential of the F32 award, this program encourages applications from individuals who have not yet completed their terminal doctoral degree and who expect to do so within 12 months of the application due date. On the application due date, candidates may not have completed more than 6 months of postdoctoral training.  

The overarching goal of INFEWS is to catalyze well-integrated interdisciplinary and convergent research to transform scientific understanding of the FEW nexus (integrating all three components rather than addressing them separately), in order to improve system function and management, address system stress, increase resilience, and ensure sustainability. The NSF INFEWS initiative is designed specifically to attain the following goals: 1. Significantly advance our understanding of the food-energy-water system through quantitative, predictive and computational modeling, including support for relevant cyberinfrastructure; 2. Develop real-time, cyber-enabled interfaces that improve understanding of the behavior of FEW systems and increase decision support capability; 3. Enable research that will lead to innovative solutions to critical FEW systems problems; and 4. Grow the scientific workforce capable of studying and managing the FEW system, through education and other professional development opportunities.

The Cellular and Biochemical Engineering (CBE) program supports fundamental engineering research that advances the understanding of cellular and biomolecular processes in engineering biology and eventually leads to the development of enabling technology for advanced biomanufacturing in support of the therapeutic cells, biochemical, biopharmaceutical and biotechnology industries.  A quantitative treatment of biological and engineering problems of biological processes is considered vital to successful research projects in the CBE program.  Fundamental to many research projects in this area is the understanding of how biomolecules, cells and cell populations interact in the biomanufacturing environment, and how those molecular-level interactions lead to changes in structure, function, and behavior.  The program encourages highly innovative and potentially transformative engineering research leading to novel bioprocessing and biomanufacturing approaches, and proposals that address emerging research areas and technologies that effectively integrate knowledge and practices from different disciplines while incorporating ongoing research into educational activities.

The goal of the Biological and Environmental Interactions of Nanoscale Materials program is to support research to advance fundamental and quantitative understanding of the interactions of biological and environmental media with nanomaterials and nanosystems. Materials of interest include one- to three-dimensional nanostructures, heterogeneous nano-bio hybrid assemblies, and other nanoparticles. Such nanomaterials and systems frequently exhibit novel physical, chemical, and biological behavior in living systems and environmental matrices as compared to the bulk scale. This program supports research that explores the interaction of nanomaterials in biological and environmental media.    

This Funding Opportunity Announcement (FOA) encourages bioengineering applications that will accelerate the development and adoption of promising tools and technologies that can address important biomedical research problems. The objectives are to establish these tools and technologies as robust, well-characterized solutions that fulfill an unmet need and are capable of enhancing our understanding of life science processes or the practice of medicine. Awards will focus on supporting multidisciplinary teams that apply an integrative, quantitative bioengineering approach to developing these technologies and engage biomedical researchers or clinicians throughout the project. The goal of the program is to support projects that can realize meaningful solutions within 5-10 years.

Scientific advances such as genomics, quantitative structural biology, imaging techniques, and modeling of complex systems have created opportunities for exciting research careers at the interface between the physical/computational sciences and the biological sciences. Tackling key problems in biology will require scientists trained in areas such as chemistry, physics, applied mathematics, computer science, and engineering. Recognizing the vital role such cross-trained scientists will play in furthering biomedical science, the Burroughs Wellcome Fund has developed the Career Awards at the Scientific Interface. These grants are intended to foster the early career development of researchers who have transitioned or are transitioning from undergraduate and/or graduate work in the physical/mathematical/computational sciences or engineering into postdoctoral work in the biological sciences, and who are dedicated to pursuing a career in academic research. Candidates are expected to draw from their training in a scientific field other than biology to propose innovative approaches to answer important questions in the biological sciences.

DARPA seeks new methods for analysis and decoding of neural signals in order to understand how neural stimulation could be applied to facilitate recovery of memory encoding following brain injury. Ultimately, it is desired to develop a prototype implantable neural device that enables recovery of memory in a human clinical population. Additionally, the program encompasses the development of quantitative models of complex, hierarchical memories and exploration of neurobiological and behavioral distinctions between memory function using the implantable device versus natural learning and training.

The nuclear theory program encompasses the structure and reactions of nuclei, and of hadrons in few-nucleon and nuclear environments, and the quark/gluon substructure expressed by QCD.  Supported research includes contributions to broad theoretical advances as well as model building and applications to experimental programs at facilities such as NSCL, RHIC and Jefferson Laboratory, and to astrophysical phenomena. This includes formulating new approaches for theoretical, computational, and experimental research that explore the fundamental laws of physics and the behavior of physical systems; formulating quantitative hypotheses; exploring and analyzing the implications of such hypotheses analytically and computationally; and, in some cases, interpreting the results of experiments. Some awards are co-funded with other programs in the Physics Division and in other divisions.