The Divisions of Chemical, Bioengineering and Environmental Transport (CBET) and Civil, Mechanical, and Manufacturing Infrastructure (CMMI) in the Engineering Directorate of the National Science Foundation (NSF) are partnering with The Center for the Advancement of Science in Space (CASIS) to solicit research projects in the general fields of tissue engineering and mechanobiology that can utilize the International Space Station (ISS) National Lab to conduct research that will benefit life on Earth. U.S. entities including academic investigators, non-profit independent research laboratories and academic-commercial teams are eligible to apply.
This Funding Opportunity Announcement (FOA) requests applications to explore human pancreatic tissues for the discovery of early biomarkers of T1D pathogenesis, the description of specific signaling or processing pathways that may contribute to the asymptomatic phase of T1D, the development of clinical diagnostic tools for the detection and staging of early T1D in at-risk or recently-diagnosed individuals, and/or the identification of therapeutic targets for the development of preventative or early treatment strategies. Successful applicants will join the Consortium on Beta Cell Death and Survival (CBDS), whose mission is to better define and detect the mechanisms of beta cell stress and destruction central to the development of T1D in humans, with the long-term goal of detecting beta cell destruction and protecting the residual beta cell mass in T1D patients as early as possible in the disease process, and of preventing the progression to autoimmunity. The CBDS is part of a collaborative research framework, the Human Islet Research Network (HIRN, https://hirnetwork.org), whose overall mission is to support innovative and collaborative translational research to understand how human beta cells are lost in T1D, and to find innovative strategies to protect and replace functional beta cell mass in humans. This FOA will only support studies with a primary focus on increasing our understanding of human disease biology (as opposed to rodent or other animal models).
The CZI Neurodegeneration Challenge Network has three goals: (1) to make fundamental advances toward understanding neurodegeneration; (2) to bring new ideas and talent to the field of neurodegeneration; and (3) to encourage a new type of interdisciplinary collaborative research involving scientists, clinicians and engineers.
We invite applications to join the Neurodegeneration Challenge Network through two RFA mechanisms:
CZI Ben Barres Early Career Acceleration Awards: five-year investigator grants for early career academic investigators, with an emphasis on those who are new to the field of neurodegeneration. We seek to empower investigators to pursue bold ideas and to take risks within a supportive and collaborative environment. Awardees will benefit from mentorship support, as well as professional development, training and network opportunities, and practical career guidance to help them navigate this early stage of their careers. It is with great pleasure that we name this Award in memory of Dr. Ben Barres. Through his research career and his life and humanity, Ben embodied both the spirit and the scientific aims of this Award and the Challenge Network approach.
CZI Collaborative Science Awards: three-year grants for small group interdisciplinary collaborations. At least one member of the collaboration should be a physician with active clinical engagement in an area relevant to the proposal. These grants are aimed to support innovative, bold, high risk/high impact projects at the interface of basic and disease biology. The scope of these collaborations should focus on foundational science (as opposed to translation and clinical application), aligned with clinical context.
The Chan Zuckerberg Initiative invites applications to join the CZI Neurodegeneration Challenge Network an interdisciplinary collaborative initiative to increase understanding of the fundamental biology of neurodegenerative disorders. Applications are being accepted for two funding mechanisms:
Awards are worth $350K total costs per year for three years, for a total of $1.05M (including up to 15% indirect costs).
The CZI Neurodegeneration Challenge Network has three goals:
(1) to make fundamental advances toward understanding neurodegeneration;
(2) to bring new ideas and talent to the field of neurodegeneration; and
(3) to encourage a new type of interdisciplinary collaborative research involving scientists, clinicians and engineers
ULI provides the opportunity for university teams to exercise technical and organizational leadership in proposing unique technical challenges, defining interdisciplinary solutions, establishing peer review mechanisms, and applying innovative teaming strategies to strengthen the research impact. By addressing the most complex challenges associated with ARMD strategic thrusts, universities will accelerate progress toward achievement of high impact outcomes while leveraging their capability to bring together the best and brightest minds across many disciplines. In order to transition their research, Principal Investigators (PIs) are expected to actively explore transition opportunities and pursue follow-on funding from stakeholders and industrial partners during the course of the award.
The Human Cell Atlas (HCA) is a global effort to create a reference map of all cell types in the human body. The Chan Zuckerberg Initiative and the Helmsley Charitable Trust are pleased to announce continued support for the Human Cell Atlas by collaborating on two new funding mechanisms that the community can access through a single application portal. The Chan Zuckerberg Initiative seeks to continue the work of the HCA community with a focus on interdisciplinary work and collaboration through the formation of 3 year Seed Networks. The Helmsley Charitable Trust welcomes applications that will construct a detailed atlas of the human gut.
Project Specifications
This Request for Applications (RFA) seeks to support the continued growth of nascent projects and to incubate new networks. The Seed Networks should generate new tools, open source analysis methods, and significant contributions of diverse data types to the Human Cell Atlas Data Coordination Platform. Applications should have a primary focus on the healthy tissues that will contribute to a reference atlas.
Seed Networks
Seed Networks should consist of at least three principal investigators, including at least one computational biologist or software engineer, together with additional computational biologists, engineers, experimental biologists, and/or physicians. CZI Seed Networks aim to support foundational tools and resources for the HCA and will not require a gut component in the application.
CZI Seed Network Grants have four overarching scientific goals:
- Build and support networks of collaborating scientists and engineers;
- Contribution of high-quality data to v1.0 of the HCA;
- Development of new technologies and benchmark data sets, particularly those anchored in spatial as well as molecular information;
- Support of computational biology within the Human Cell Atlas community.
The International Research Experiences for Students (IRES) program supports international research and research-related activities for U.S. science and engineering students. The IRES program contributes to development of a diverse, globally-engaged workforce with world-class skills. IRES focuses on active research participation by undergraduate or graduate students in high quality international research, education and professional development experiences in NSF-funded research areas. The overarching, long-term goal of the IRES program is to enhance U.S. leadership in research and education and to strengthen economic competitiveness through training the next generation of research leaders. This solicitation features three mechanisms; proposers are required to select one of the following tracks to submit their proposal. Track I focuses on the development of world-class research skills in international cohort experiences. Track II is dedicated to targeted, intensive learning and training opportunities that leverage international knowledge at the frontiers of research. Track III supports U.S. institutional collaborations to develop, implement and evaluate innovative models for high-impact, large-scale international research and professional development experiences for U.S. graduate students. Student participants supported by IRES funds must be citizens, nationals, or permanent residents of the United States. Students do not apply directly to NSF to participate in IRES activities. Students apply to NSF-funded investigators who receive IRES awards. To identify appropriate IRES projects, students should consult the directory of active IRES awards. All PIs, co-PIs and Senior Personnel on IRES proposals must be from U.S. based institutions.
The PRMRP Focused Program Award mechanism is intended to optimize research and accelerate the solution for a critical question related to at least one of the Congressionally directed FY18 PRMRP Topic Areas through a synergistic, multidisciplinary research program. The anticipated total costs budgeted for the entire period of performance for an FY18 PRMRP Focused Program Award will not exceed $10M.
The Smart and Autonomous Systems (S&AS) program focuses on Intelligent Physical Systems (IPS) that are capable of robust, long-term autonomy requiring minimal or no human operator intervention in the face of uncertain, unanticipated, and dynamically changing situations. IPS are systems that combine perception, cognition, communication, and actuation to operate in the physical world. Examples include, but are not limited to, robotic platforms, self-driving vehicles, underwater exploration vehicles, and smart grids. Most current IPS operate in pre-programmed ways and in a limited variety of contexts. They are largely incapable of handling novel situations, or of even understanding when they are outside their areas of expertise. To achieve robust, long-term autonomy, however, future IPS need to be aware of their capabilities and limitations and to adapt their behaviors to compensate for limitations and/or changing conditions. To foster such intelligent systems, the S&AS program supports research in four main aspects of IPS: cognizant, taskable, adaptive, and ethical. Cognizant IPS exhibit high-level awareness of their own capabilities and limitations, anticipating potential failures and re-planning accordingly. Taskable IPS can interpret high-level, possibly vague, instructions, planning out and executing concrete actions that are dependent on the particular context in which the system is operating. Adaptive IPS can change their behaviors over time, learning from their own experiences and those of other entities, such as other IPS or humans, and from instruction or observation. Ethical IPS should adhere to a system of societal and legal rules, taking those rules into account when making decisions. Each of these research areas requires the IPS to be knowledge-rich, employing a variety of representation and reasoning mechanisms, such as semantic, probabilistic, commonsense, and meta-reasoning.
The National Science Foundation (NSF), through the Directoratefor Engineering, the Directorate of Computer and Information Science and Engineering Division of Computer and Network Systems, and the Directorate for Mathematical and Physical Sciences Division of Materials Research, along with the U.S. Food and Drug Administration (FDA), through its Center for Devices and Radiological Health (CDRH), have established the NSF/FDA Scholar-in-Residence Program at FDA. This program comprises an interagency partnership for the investigation of scientific and engineering issues concerning emerging trends in medical device technology. This partnership is designed to enable investigators in science, engineering, and computer science to develop research collaborations within the intramural research environment at the FDA. Thissolicitation features three flexible mechanisms for support of research at the FDA: 1) Principal Investigators at FDA; 2) Postdoctoral Researchers at FDA; and 3) Graduate Students at FDA.
The National Science Foundation (NSF), through the Directorate for Engineering, the Directorate of Computer and Information Science and Engineering Division of Computer and Network Systems, and the Directorate for Mathematical and Physical Sciences Division of Materials Research, along with the U.S. Food and Drug Administration (FDA), through its Center for Devices and Radiological Health (CDRH), have established the NSF/FDA Scholar-in-Residence Program at FDA. This program comprises an interagency partnership for the investigation of scientific and engineering issues concerning emerging trends in medical device technology. This partnership is designed to enable investigators in science, engineering, and computer science to develop research collaborations within the intramural research environment at the FDA. This solicitation features three flexible mechanisms for support of research at the FDA: 1) Principal Investigators at FDA; 2) Postdoctoral Researchers at FDA; and 3) Graduate Students at FDA.
The IMEE program supports fundamental, multidisciplinary research on the impact of hazards and disasters upon civil infrastructure and society. The program is focused upon research on the mitigation of, preparedness for, response to, and recovery from multi-hazard disasters. Community and societal resilience and sustainability are important topics within the research portfolio of IMEE. The program is deeply multidisciplinary, integrating multiple perspectives, methods and results from diverse areas in engineering, social and natural sciences, and computing. Among these are civil, mechanical, transportation and system engineering; sociology, cognitive science and psychology, economics, geography, political science and urban planning; geology, biology and meteorology; and applied computing. Methodological innovations that span multiple, diverse disciplines are strongly encouraged.
The Engineering for Natural Hazards (ENH) program supports fundamental research that advances knowledge for understanding and mitigating the impact of natural hazards on constructed civil infrastructure. Natural hazards considered by the ENH program include earthquakes, windstorms (such as tornadoes and hurricanes), tsunamis, storm surge, and landslides. The constructed civil infrastructure supported by the ENH program includes building systems, such as the soil-foundation-structure-envelope-nonstructural system, as well as the façade and roofing, and other structures, geostructures, and underground facilities, such as tunnels. While research may focus on a single natural hazard, research that considers civil infrastructure performance over its lifetime in the context of multiple hazards, that is, a multi-hazard approach, is encouraged. Research may integrate geotechnical, structural, and architectural engineering advances with discoveries in other science and engineering fields, such as earth and atmospheric sciences, materials science, mechanics of materials, dynamic systems and control, systems engineering, decision theory, risk analysis, high performance computational modeling and simulation, and social, behavioral, and economic sciences. Multi-disciplinary and international collaborations are encouraged. The ENH program encourages research integrated with knowledge dissemination and activities that can lead to broader societal benefit for reducing the impact of natural hazards on civil infrastructure.
The HFSP supports novel, innovative and interdisciplinary basic research focused on the complex mechanisms of living organisms; topics range from molecular and cellular approaches to systems and cognitive neuroscience and the interactions between organisms. A clear emphasis is placed on novel collaborations that bring biologists together with scientists from fields such as physics, mathematics, chemistry, computer science and engineering to focus on problems at the frontier of the life sciences.
Computer systems support a broad range of applications and technologies that seamlessly integrate with human users. While many key building blocks of computer systems are today commercial technologies, the challenge ahead is to envision new technologies, as well as to combine existing technologies, software, and sensing systems into the computer systems of the future that will span wearable computing, the Internet of Things (IoT), "Smart Cities," intelligent transportation systems, personalized healthcare, and beyond. Such computer systems will require new, innovative, and visionary approaches to hardware, wired and wireless communications, consideration of human-computer interactions, and new programming languages and compilers that are limited only by the imagination. They will need to be reliable in the presence of unreliable components, adaptive to changing environments, capable of supporting high-throughput applications and large-scale data storage and processing, and able to meet performance and energy objectives for applications ranging from very low-power embedded systems to large high-performance computing systems. Furthermore, computer systems of the future will need to provide mechanisms for ensuring security and privacy.
Research supported by the Division of Materials Research (DMR) focuses on advancing fundamental understanding of materials, materials discovery, design, synthesis, characterization, properties, and materials-related phenomena. DMR awards enable understanding of the electronic, atomic, and molecular structures, mechanisms, and processes that govern nanoscale to macroscale morphology and properties; manipulation and control of these properties; discovery of emerging phenomena of matter and materials; and creation of novel design, synthesis, and processing strategies that lead to new materials with unique characteristics. These discoveries and advancements transcend traditional scientific and engineering disciplines. The Division supports research and education activities in the United States through funding of individual investigators, teams, centers, facilities, and instrumentation. Projects supported by DMR are essential for the development of future technologies and industries that meet societal needs, as well preparation of the next generation of materials researchers.
The U.S. Army Engineer Research and Development Center (ERDC) has issued a Broad Agency Announcement (BAA) for various research and development topic areas. The ERDC consists of the Coastal and Hydraulics Lab (CHL), the Geotechnical and Structures Lab (GSL), the Reachback Operations Center (UROC), the Environmental Lab (EL) and the Information Technology Lab (ITL) in Vicksburg, Mississippi, the Cold Regions Research and Engineering Lab (CRREL) in Hanover, New Hampshire, the Construction Engineering Research Lab (CERL) in Champaign, Illinois, and the Geospatial Research Laboratory (GRL) in Alexandria, Virginia. The ERDC is responsible for conducting research in the broad fields of hydraulics, dredging, coastal engineering, instrumentation, oceanography, remote sensing, geotechnical engineering, earthquake engineering, soil effects, vehicle mobility, self-contained munitions, military engineering, geophysics, pavements, protective structures, aquatic plants, water quality, dredged material, treatment of hazardous waste, wetlands, physical/mechanical/ chemical properties of snow and other frozen precipitation, infrastructure and environmental issues for installations, computer science, telecommunications management, energy, facilities maintenance, materials and structures, engineering processes, environmental processes, land and heritage conservation, and ecological processes.
This Funding Opportunity Announcement (FOA) seeks grant applications to catalyze major advances in genomics through technology development (beyond developing nucleic acid sequencing technologies). The goal is to provide a mechanism for support of very novel and high impact work from across this gamut of genomics technology development. This initiative seeks to support technologies that will have a major impact in the next five to seven years.
Request for Information - Upgrading Carbon Derived from Methane Pyrolysis This is a Request for Information (RFI) only. This RFI is not accepting application for financial assistance. The purpose of this RFI is solely to solicit input for ARPA-E consideration to inform the possible formulation of future programs. The Advanced Research Projects Agency -Energy (ARPA-E) in the US Department of Energy is seeking information concerning technologies to produce hydrogen and elemental carbon from the thermal decomposition of methane (also known as methane pyrolysis, methane cracking, or methane splitting). Recognizing that the value of the carbon product would be a key factor in the economic feasibility of such processes, ARPA-E seeks input from experts in the fields of materials science (including advanced carbon fiber synthesis), process engineering, methane pyrolysis, plasma chemistry, and chemical engineering regarding potential mechanisms for the bulk conversion of carbon materials, specifically from less valuable forms (e.g. amorphous carbon) or mixtures, to more valuable single allotropes or controlled mixtures of high-value carbon structures. Consistent with the agency's mission, ARPA-E is seeking insights on clearly disruptive, novel technologies for such conversions, early in the R&D cycle, and not integration strategies for existing technologies. The information you provide may be used by ARPA-E in support of program planning.
The Engineering Design and Systems Engineering (EDSE) program supports fundamental research into the basic processes and phenomena of engineering design and systems engineering. The program seeks proposals leading to improved understanding about how processes, organizational structure, social interactions, strategic decision making, and other factors impact success in the planning and execution of engineering design and systems engineering projects. It also supports advances pertaining to engineering design and systems engineering in areas that include, but are not limited to, decision making under uncertainty, including preference and demand modeling; problem decomposition and decision delegation; applications of reverse game theory (mechanism design); computer-aided design; design representation; system performance modeling and prediction; design optimization; uncertainty quantification; domain- or concern-specific design methods; and advanced computational techniques for supporting effective human cognition, decision making, and collaboration. Competitive proposals for novel methods will include a plan to evaluate rigorously the effectiveness and performance of the proposed approach. The EDSE program encourages multidisciplinary collaborations of experts in design and systems engineering with experts in other domains. Of particular interest is research on the design of engineering material systems that leverages the unique aspects of a particular material system to realize advanced design methods that are driven by performance metrics and incorporate processing/manufacturing considerations. The EDSE program does not support the development of ad-hoc approaches that lack grounding in theory, nor does it support design activities that do not advance scientific knowledge about engineering design or systems engineering. Prospective investigators are encouraged to discuss research ideas and project scope with the Program Director in advance of proposal preparation and
