The objective of this program is to develop such tools with the broadest possible impact to the community of suppliers and end-users of CMCs. Specifically, modeling tools are sought that: (a) allow for optimization of microstructure and/or meso-structural properties relevant to quality and durability, (b) are capable of being integrated with models for assessing mechanical behavior, (c) are appropriately verified and validated with coupon or subcomponent/feature tests, and (d) have a clear transition path to impacting CMCs for US Air Force applications.
The goal of a Bioengineering Research Partnership (BRP) is to drive the development and speed the adoption of promising tools and technologies that can address important biomedical problems for which insufficient or no solutions exist. The use of engineering principles is encouraged to establish these tools and technologies as robust, well-characterized solutions that fulfill an unmet need. A synergistic partnership between engineering and the life, physical, and computational sciences is also encouraged, where the unique skills of each discipline combine to enhance our understanding of life science processes or the practice of medicine.
The purpose of this FOA is to encourage BRP applications that: 1) establish a robust engineering solution to a problem in biomedical research or the practice of medicine; 2) develop a strategic alliance of multidisciplinary partners based on a well-defined leadership plan; and 3) realize a specific endpoint within 5-10 years based on a detailed plan with a timeline and quantitative milestones.
The Plant Genome Research Program (PGRP) supports genome-scale researchthat addresses challenging questions of biological, societal and economic importance. PGRPencourages the development of innovative tools, technologies and resources that empower a broad plant research community to answer scientific questions on a genome-wide scale. Emphasis is placed on thescale and depth of the question being addressed and the creativity of the approach.Data produced by plant genomics should be usable, accessible, integrated across scales and of high impact across biology. Training, broadening participation, and career development are essential to scientific progress and shouldbe integrated in all PGRP-funded projects. Two funding tracks are currently available: 1. RESEARCH-PGR TRACK: Genome-scale plant research to address fundamental biological questions in biology, including economically important processes of societal importance. 2. TRTech-PGR TRACK: tools, resources and technology breakthroughs that further enable functional plant genomics.
The U.S. Department of Energy's Geothermal Technology Office(GTO) Zonal Isolation for Manmade Geothermal Reservoirs funding opportunity announcement (FOA) supports early-stage development of enhanced geothermal systems (EGS) tools and technologies, and will seek to improve the performance and economics of EGS systems by funding research in zonal isolation. Zonal isolation technologies can radically improve the performance and economics of EGS, or manmade geothermal reservoirs. These technologies provide the ability to target specific zones for stimulation activities, which can enable the command and control of fracture location and the economy of resources. In turn, this reduces development costs and operational risks associated with EGS development and promotes more power from fewer wellbores. Under this funding opportunity, GTO is interested in two topic areas: Topic 1 - Invention and Innovative Design of Zonal Isolation Technologies and Techniques for EGS Stimulation; and, Topic 2 - Adaption of Existing Zonal Isolation Technologies for EGS Stimulation. The projects selected from this FOA will aim to develop reliable zonal isolation tools and technologies that: * Present low risk to wellbore integrity or the conductivity of fractures; * Can operate at high-temperatures in corrosive, hard rock environments for extended periods of time; and * Withstand large pressure differentials.
The NIH Blueprint for Neuroscience Research is a collaborative framework through which 14 NIH Institutes, Centers and Offices jointly support neuroscience-related research, with the aim of accelerating discoveries and reducing the burden of nervous system disorders. This Funding Opportunity Announcement (FOA) will solicit research projects focused on the development of new technology and tools, or novel mechanistic studies, or a combination of mechanistic and technology development studies specific to central nervous system (CNS, which includes retina) small blood and lymphatic vessels in health and disease, across the life span. The program aims at facilitating the development of tools and technology to image, profile and map CNS small blood and lymphatic vessels. Additional goals are to elucidate the mechanisms underlying CNS small blood and lymphatic vessels structural and functional heterogeneity, differential susceptibility to injury, role in disease and repair processes, and their responses to therapies. Preclinical studies using in vitro and/or animal models specific to CNS small blood and lymphatic vessels alone or in combination with pilot human studies are appropriate for this FOA.
The NIH Blueprint for Neuroscience Research is a collaborative framework through which 14 NIH Institutes, Centers and Offices jointly support neuroscience-related research, with the aim of accelerating discoveries and reducing the burden of nervous system disorders. This Funding Opportunity Announcement (FOA) will solicit research projects to facilitate the development and translation of tools and technology for non-invasive imaging and profiling of human central nervous system (CNS, including retina) small blood and lymphatic vessels; to investigate their role in CNS physiology, disease, repair processes, and responses to therapy using novel approaches. Applications can be focused on the development of new technology and tools, novel target or biomarker identification and validation studies, or a combination of mechanistic and technology development studies specific to human CNS small blood and lymphatic vessels in health and disease, across the life span.
The purpose of this Funding Opportunity Announcement (FOA) is to invite Cooperative Agreement (U24) applications for the continued development and sustainment of high-value informatics research resources to serve current and emerging needs across the cancer research continuum including cancer biology, cancer treatment and diagnosis, cancer prevention, cancer control and epidemiology, and/or cancer health disparities. As a component of the NCIs Informatics Technology for Cancer Research (ITCR) Program, this FOA focuses on supporting activities necessary for improved user experience and availability of existing, widely-adopted informatics tools and resources.This is in contrast to early-stage and advanced development efforts to generate these tools and resources that are supported by companion ITCR FOAs. The central mission of ITCR is to promote research-driven informatics technology across the development lifecycle to address priority needs in cancer research. In order to be successful, the proposed sustainment plan must provide clear justifications for why the research resource should be maintained and how it has benefited and will continue to benefit the cancer research field.In addition, mechanisms for assessing and maximizing the value of the resource to researchers and supporting collaboration and/or deep engagement between the resource and the targeted research community should be described.
This program seeks to prepare, nurture, and grow the national scientific research workforce for creating, utilizing, and supporting advanced cyberinfrastructure (CI) to enable and potentially transform fundamental science and engineering research and contribute to the Nation's overall economic competitiveness and security. The goals of this solicitation are to (i) ensure broad adoption of CI tools, methods, and resources by the research community in order to catalyze major research advances and to enhance researchers' abilities to lead the development of new CI; and (ii) integrate core literacy and discipline-appropriate advanced skills in advanced CI as well as computational and data-driven science and engineering into the Nation's educational curriculum/instructional material fabric spanning undergraduate and graduate courses for advancing fundamental research. Pilot and Implementation projects may target one or both of the solicitation goals, while Large-scale Project Conceptualization projects must address both goals. For the purpose of this solicitation, advanced CI is broadly defined as the set of resources, tools, methods, and services for advanced computation, large-scale data handling and analytics, and networking and security for large-scale systems that collectively enable potentially transformative fundamental research.
The Human Cell Atlas (HCA) is a global effort to create a reference map of all cell types in the human body. The Chan Zuckerberg Initiative and the Helmsley Charitable Trust are pleased to announce continued support for the Human Cell Atlas by collaborating on two new funding mechanisms that the community can access through a single application portal. The Chan Zuckerberg Initiative seeks to continue the work of the HCA community with a focus on interdisciplinary work and collaboration through the formation of 3 year Seed Networks. The Helmsley Charitable Trust welcomes applications that will construct a detailed atlas of the human gut.
Project Specifications
This Request for Applications (RFA) seeks to support the continued growth of nascent projects and to incubate new networks. The Seed Networks should generate new tools, open source analysis methods, and significant contributions of diverse data types to the Human Cell Atlas Data Coordination Platform. Applications should have a primary focus on the healthy tissues that will contribute to a reference atlas.
Seed Networks
Seed Networks should consist of at least three principal investigators, including at least one computational biologist or software engineer, together with additional computational biologists, engineers, experimental biologists, and/or physicians. CZI Seed Networks aim to support foundational tools and resources for the HCA and will not require a gut component in the application.
CZI Seed Network Grants have four overarching scientific goals:
- Build and support networks of collaborating scientists and engineers;
- Contribution of high-quality data to v1.0 of the HCA;
- Development of new technologies and benchmark data sets, particularly those anchored in spatial as well as molecular information;
- Support of computational biology within the Human Cell Atlas community.
DMREF is the primary program by which NSF participates in the Materials Genome Initiative (MGI) for Global Competitiveness. MGI recognizes the importance of materials science and engineering to the well-being and advancement of society and aims to "deploy advanced materials at least twice as fast as possible today, at a fraction of the cost." MGI integrates materials discovery, development, property optimization, and systems design with a shared computational framework. This framework facilitates collaboration and coordination of research activities, analytical tools, experimental results, and critical evaluation in pursuit of the MGI goals. Consistent with theMGI Strategic Plan, DMREFhighlights four sets of goals: · Leading a culture shift in materials science and engineering research to encourage and facilitate an integrated team approach; · Integrating experimentation, computation, and theory and equipping the materials scienceand engineering communities with advanced tools and techniques; · Making digital data accessible, findable,and useful to the community; and · Creating a world-class materials science and engineering workforce that is trained for careers in academia or industry. Accordingly, DMREF will support activities that significantly accelerate materials discovery and/or development by building the fundamental knowledge base needed to design and make materials and/or devices with specific and desired functions or properties.
The objective of this Funding Opportunity Announcement is to solicit and competitively seek applications for the development of tools and methods needed to improve the measurement and reduce the uncertainty in the measurement of in-situ maximum principal stress in the deep surface and understand and predict the geomechanical impact of pressure migration due to injection on the storage complex including the underburden and basement formations. The Areas of Interest of this Announcement are tools and Methods for Determining Maximum Principal Stress in the Deep Surface and Methods for Understanding Impact of Vertical Pressure Migration due to Injection on State of Subsurface Stress.
CR1: Sensor Fusion
· CR2: Machine Learning Systems for Wireless Cyber Environments
· DD1: Research on emerging software development including
· DD2: Reserved
· DD3: Research and Development of laser propagation, energy density, manufacturing, control, beam forming, and related topics to lasers as weapons in a marine environment
· DD4: Research on analysis of mission engineering for emerging weapon systems, systems engineering techniques and algorithms, platform level analysis capabilities, integrated platform analysis capabilities, missions thread visualizations capabilities, and related research topics
· DD5: Modeling and simulation research and development including: innovative Model-Based Systems Engineering (MBSE) methods and tools, methods for aggregating data across higher and lower-level simulations, and tools for approaches for linking simulation results with mission effectiveness
· DD6: Research on Radar unitization in a marine environment to include component development, power density, advanced signal processing, track processing, and related topics for surface radar applications
· DD7: Railgun developmental research including: materials for rail ablation reduction, energy storage, weight reduction, energy recovery, component development, high energy systems components, advanced cooling techniques and related research for railgun systems.
This funding opportunity announcement (FOA) supports efforts to disseminate resources and to integrate them into neuroscience research practice. Projects should be highly relevant to specific goals of the BRAIN Initiative, goals that are described in the planning document "BRAIN 2025: A Scientific Vision." They should engage in one or more of the following activities: distribution of tools and reagents; user training on the usage of new technologies or techniques; providing access to existing technology platforms and specialized facilities; minor improvements to increase the scale/efficiency of resource production and delivery; minor adaptations to meet the needs of a user community. Applications strictly focused on technology or software development, rather than dissemination of an existing resource, are not responsive to this FOA. Refinements to microscopes or tools necessary to customize them to the experimental needs of the end users are allowed. Projects should address compelling needs of neuroscience researchers working toward the goals of the BRAIN 2025 report that are otherwise unavailable or impractical in their current form.
The focus of this BAA is primarily on projects that continue to advance the systems engineering approach needed for the design, fabrication, and manufacture of structural components to address challenges in system weight, performance, affordability, and/or survivability. The foundation of this approach should include the integration of materials information, captured in computational tools, with engineering product performance analysis and manufacturing-process simulation termed commonly as Integrated Computational Materials Engineering (ICME). From this foundation it is expected the integration of manufacturing process information and product performance information utilizing the full range of engineering and analytical tools, processes, and principles to improve efficiency and effectiveness of their integrated approach. The intent is to bring together materials designers, materials suppliers, product designers, and manufacturers to collaborate on the design, production, and commercialization of novel affordable, manufacturable systems. Projects may include basic and applied research, technology and component development, and prototyping; but may also focus on manufacturing supply-chain technical support and integration, workforce development, and manufacturing education.
The Office of Naval Research is seeking proposals that address both (1) the acquisition of noise data for multi-stream, hot, supersonic jets issuing from relevant, complex nozzle geometries and (2) the development and validation (using noise data acquired in (1)) of engineering design models/tools for noise prediction that could be used in future tactical aircraft system studies. The datasets and prediction models should address noise levels for relevant jet conditions at locations on the carrier deck and in the far-field where community noise is an issue.
The goal of theBiomedical Engineering(BME)program is to provide research opportunities to develop novel ideas into discovery-level and transformative projects that integrate engineering and life sciences in solving biomedical problems that serve humanity in the long-term. BME projects must be at the interface of engineering and life sciences, and advance both engineering and life sciences. The projects should focus on high impact transformative methods and technologies. Projects should include methods, models and enabling tools of understanding and controlling living systems; fundamental improvements in deriving information from cells, tissues, organs, and organ systems; new approaches to the design of structures and materials for eventual medical use in the long-term; and novel methods for reducing health care costs through new technologies. The long-term impact of the projects can be related to fundamental understanding of cell and tissue function, effective disease diagnosis and/or treatment, improved health care delivery, or product development.
The goal of theBiomedical Engineering(BME)program is to provide research opportunities to develop novel ideas into discovery-level and transformative projects that integrate engineering and life sciences in solving biomedical problems that serve humanity in the long-term. BME projects must be at the interface of engineering and life sciences, and advance both engineering and life sciences. The projects should focus on high impact transformative methods and technologies. Projects should include methods, models and enabling tools of understanding and controlling living systems; fundamental improvements in deriving information from cells, tissues, organs, and organ systems; new approaches to the design of structures and materials for eventual medical use in the long-term; and novel methods for reducing health care costs through new technologies. The long-term impact of the projects can be related to fundamental understanding of cell and tissue function, effective disease diagnosis and/or treatment, improved health care delivery, or product development.
This program element solicits proposals for the acquisition and analysis of new scientific data from the K2 mission (http://keplerscience.arc.nasa.gov). K2 repurposes the space-borne hardware and ground-based operations of the Kepler mission (http://keplerscience.arc.nasa.gov) for a pointed survey of predetermined locations along the ecliptic plane. The single, visible-wavelength instrument on board K2 provides high-precision photometry capability, with short cadence and long cadence modes (1 minute and 30 minute exposures, respectively), and provides a powerful tool for broadband variability analyses of planetary, stellar, extragalactic, and solar system sources.
This program element solicits proposals for the acquisition and analysis of new scientific data from the K2 mission (http://keplerscience.arc.nasa.gov). K2 repurposes the space-borne hardware and ground-based operations of the Kepler mission (http://keplerscience.arc.nasa.gov) for a pointed survey of predetermined locations along the ecliptic plane. The single, visible-wavelength instrument on board K2 provides high-precision photometry capability, with short cadence and long cadence modes (1 minute and 30 minute exposures, respectively), and provides a powerful tool for broadband variability analyses of planetary, stellar, extragalactic, and solar system sources.
The purpose of this BD2K Funding Opportunity Announcement (FOA) is to support the development, improvement and implementation of tools and approaches that increase the efficiency and effectiveness of digital curation processes used to characterize and describe the digital data used in or resulting from biomedical research.
The purpose of this BD2K Funding Opportunity Announcement (FOA) is to support the development, improvement and implementation of tools and approaches that increase the efficiency and effectiveness of digital curation processes used to characterize and describe the digital data used in or resulting from biomedical research.
The Chemical Measurement and Imaging Program supports research focusing on chemically-relevant measurement science and chemical imaging, targeting both improved understanding of new and existing methods and development of innovative approaches and instruments. Research areas include but are not limited to sampling and separation science; electroanalytical chemistry; spectrometry; and frequency- and time-domain spectroscopy. Development of new chemical imaging and measurement tools probing chemical properties and processes are supported. Innovations enabling the monitoring and imaging of chemical and electronic processes across a wide range of time and length scales are also relevant. New approaches to data analysis and interpretation (including chemometrics) are encouraged. Proposals addressing established techniques must seek improved understanding and/or innovative approaches to substantially broaden applicability. Sensor-related proposals should address new approaches to chemical sensing, with prospects for broad utility and significant enhancement of current capabilities.
The Chemical Measurement and Imaging Program supports research focusing on chemically-relevant measurement science and chemical imaging, targeting both improved understanding of new and existing methods and development of innovative approaches and instruments. Research areas include but are not limited to sampling and separation science; electroanalytical chemistry; spectrometry; and frequency- and time-domain spectroscopy. Development of new chemical imaging and measurement tools probing chemical properties and processes are supported. Innovations enabling the monitoring and imaging of chemical and electronic processes across a wide range of time and length scales are also relevant. New approaches to data analysis and interpretation (including chemometrics) are encouraged. Proposals addressing established techniques must seek improved understanding and/or innovative approaches to substantially broaden applicability. Sensor-related proposals should address new approaches to chemical sensing, with prospects for broad utility and significant enhancement of current capabilities.
Recent advances in communications, computation, and sensing technologies offer unprecedented opportunities for the design of cyber-physical systems with increased responsiveness, interconnectivity and automation. To meet new challenges and societal needs, the Energy, Power, Control and Networks (EPCN) Program invests in systems and control methods for analysis and design of cyber-physical systems to ensure stability, performance, robustness, and security. Topics of interest include modeling, optimization, learning, and control of networked multi-agent systems, higher-level decision making, and dynamic resource allocation as well as risk management in the presence of uncertainty, sub-system failures and stochastic disturbances. EPCN also invests in adaptive dynamic programing, brain-like networked architectures performing real-time learning, and neuromorphic engineering. EPCN supports innovative proposals dealing with systems research in such areas as energy, transportation, and nanotechnology. EPCN places emphasis on electric power systems, including generation, transmission, storage, and integration of renewables; power electronics and drives; battery management systems; hybrid and electric vehicles; and understanding of the interplay of power systems with associated regulatory and economic structures and with consumer behavior. Also of interest are interdependencies of power and energy systems with other critical infrastructures. Topics of interest also include systems analysis and design for energy scavenging and alternate energy technologies such as solar, wind, and hydrokinetic. The program also supports innovative tools and test beds, as well as curriculum development integrating research and education. In addition to single investigator projects, EPCN encourages cross-disciplinary proposals that benefit from active collaboration of researchers with complementary skills.
Recent advances in communications, computation, and sensing technologies offer unprecedented opportunities for the design of cyber-physical systems with increased responsiveness, interconnectivity and automation. To meet new challenges and societal needs, the Energy, Power, Control and Networks (EPCN) Program invests in systems and control methods for analysis and design of cyber-physical systems to ensure stability, performance, robustness, and security. Topics of interest include modeling, optimization, learning, and control of networked multi-agent systems, higher-level decision making, and dynamic resource allocation as well as risk management in the presence of uncertainty, sub-system failures and stochastic disturbances. EPCN also invests in adaptive dynamic programing, brain-like networked architectures performing real-time learning, and neuromorphic engineering. EPCN supports innovative proposals dealing with systems research in such areas as energy, transportation, and nanotechnology. EPCN places emphasis on electric power systems, including generation, transmission, storage, and integration of renewables; power electronics and drives; battery management systems; hybrid and electric vehicles; and understanding of the interplay of power systems with associated regulatory and economic structures and with consumer behavior. Also of interest are interdependencies of power and energy systems with other critical infrastructures. Topics of interest also include systems analysis and design for energy scavenging and alternate energy technologies such as solar, wind, and hydrokinetic. The program also supports innovative tools and test beds, as well as curriculum development integrating research and education. In addition to single investigator projects, EPCN encourages cross-disciplinary proposals that benefit from active collaboration of researchers with complementary skills.
