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This Funding Opportunity Announcement (FOA) requests applications to explore human pancreatic tissues for the discovery of early biomarkers of T1D pathogenesis, the description of specific signaling or processing pathways that may contribute to the asymptomatic phase of T1D, the development of clinical diagnostic tools for the detection and staging of early T1D in at-risk or recently-diagnosed individuals, and/or the identification of therapeutic targets for the development of preventative or early treatment strategies. Successful applicants will join the Consortium on Beta Cell Death and Survival (CBDS), whose mission is to better define and detect the mechanisms of beta cell stress and destruction central to the development of T1D in humans, with the long-term goal of detecting beta cell destruction and protecting the residual beta cell mass in T1D patients as early as possible in the disease process, and of preventing the progression to autoimmunity. The CBDS is part of a collaborative research framework, the Human Islet Research Network (HIRN, https://hirnetwork.org), whose overall mission is to support innovative and collaborative translational research to understand how human beta cells are lost in T1D, and to find innovative strategies to protect and replace functional beta cell mass in humans. This FOA will only support studies with a primary focus on increasing our understanding of human disease biology (as opposed to rodent or other animal models).

Complete information, including the Request for Information (RFI), can be found on the EERE Exchange website - https://eere-exchange.energy.gov. Through this Request for Information (RFI), the United States Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE), Water Power Technologies Office (WPTO) seeks input on new research to maximize the value of hydropower's contribution to grid resiliency and reliability today and into the future. This strategy includes pumped storage and traditional hydropower, and covers both new technology design as well as modeling and analysis to assess the range of value streams hydropower provides in the current and future power grid. This research will build targeted insight into economic, policy and technological barriers, inform future hydropower technology development, and improve the tools by which investment and operational decisions are made. WPTO seeks concise feedback from all relevant stakeholders. Responses to this RFI must be submitted electronically to WPTORFI@ee.doe.gov no later than 5:00pm (ET) on April 6, 2018. Responses must be provided as attachments to an email. Complete information, including the RFI, can be found on the EERE Exchange website - https://eere-exchange.energy.gov.

This Funding Opportunity Announcement (FOA) seeks applications for the design and development of technologies to monitor health or deliver care in a real-time, accessible, effective, and minimally obtrusive way for older adults with a chronic heart, lung, blood, or sleep (HLBS) condition. These technologies may be novel sensor or monitoring systems, home-use point-of-care devices, home or mobile therapy or rehabilitation tools, or information systems and should have the goal of fostering healthy and independent living for aging adults with HLBS conditions. The development of such technologies should incorporate specific human factors for aging adults including disabilities, mild impairments, as well as chronic HLBS conditions. Technology usability for these populations must be incorporated early in the development of the design. Usability considerations include but are not limited to patient-facing displays, hearing and visual impairments, tactile limitations, literacy, and design preferences between men and women. These improvements in technology design could yield more accurate and earlier detection of changes that may interfere with healthy and independent living for older adults.

The U.S. Department of Energy seeks to understand the key technical and other barriers that may prevent long-term access to low-cost water supplies that could be best addressed through challenges and prize competitions. For the purposes of this Request for Information (RFI), challenges and prize competitions are tools and approaches the Federal government and others can use to engage a broad range of stakeholders, including the general public, in developing solutions to difficult problems. Challenges and prize competitions rely on competitive structures to drive innovation among participants and usually offer rewards (financial and/or other) to winners and/or finalists. DOE may use the information provided through this RFI to develop challenges and prize competitions to address key water issues. This RFI is not designed to solicit input on DOE's broader R&D efforts on affordable water. The purpose of this Request for Information (RFI) is to gather feedback from stakeholders prior to DOE potentially issuing a Funding Opportunity Announcement (FOA). This RFI is not a FOA; therefore, DOE is not accepting applications at this time. All responses to this RFI must be provided as an attachment (in Microsoft Word format) to an e-mail message addressed to waterprizerfi@ee.doe.gov. Responses must be received no later than 5:00 pm EDT on May 14, 2018. The full content of the announcement can be found on the EERE Exchange website at https://eere-exchange.energy.gov/

The Office of Advanced Scientific Computing Research (ASCR) of the SC, U.S. Department of Energy (DOE), hereby invites applications for basic research that address fundamental challenges within DOE's mission areas of energy, environment and security, and from a perspective that requires new integrated efforts across multiple mathematical, statistical and computational disciplines. This solicitation is for new Mathematical Multifaceted Integrated Capability Centers (MMICCs) to enable greatly enhanced scientific discovery, design, optimization or decision-support capabilities for the increasingly complex systems, processes, and problems that arise in science and energy research. Proposed research tightly focused on the solution of a particular science or engineering problem are outside the scope of this solicitation.These MMICCs will enable applied mathematics researchers to work together in large, collaborative teams to develop the mathematics needed to address significant scientific computing research challenges. The MMICCs allow researchers to take a broader view of the problem as a whole, and devise solution strategies that attack the problem in its entirety by building fundamental, multidisciplinary mathematical capabilities and tools cognizant of both existing and emerging computing paradigms. The MMICCs teams will have the flexibility and technical expertise to consider all aspects of the problem-solving process simultaneously - ranging from the mathematical formulation to the development, analysis, integration of appropriate models and methods, and demonstration of results and capabilities.

PAS Kolkata seeks proposals for the project titled "Cyber Safe East India-Workshops on Cyber Security for E-Businesses." Based on funding availability, the Recipient organization will organize a series of workshops for business practitioners in Ranchi, Jamshedpur, and Guwahati. The workshops will be devised and implemented by the grantee with the help of U.S. cyber security and data protection experts. The goal of the workshops is to connect American and Indian cyber security experts to help small and medium businesses adopt safer business practices, ultimately ensuring the shared prosperity between the U.S. and India. The grantee will solicit participation from local and American cyber security experts, academics, chamber of commerce representatives, cyber law enforcing agency officials, and other relevant stakeholders to conduct a needs assessment of local business owners regarding web-based business tools. Collaborations should start early and virtually and will continue in-person during the workshops. The experts, in tandem with the grantee, will design the curriculum for a series of three workshops that help business owners mitigate e-business risks. The curriculum should be practical and relevant to a wide spectrum of businesses.The workshops should be conducted in Ranchi, Jamshedpur, and Guwahati. Other workshop locations are a possibility depending on the findings of the needs assessments conducted by the grantee as a pre- workshop survey. Workshop duration and the number of participants at each city will be determined by the grantee and experts in close consultation with PAS Kolkata.

The NIH Research Evaluation and Commercialization Hub (REACH) program is envisioned as a partnership program between NIH and the qualifying research institutions to accelerate the creation of small businesses and the transition of discoveries originating from academic research into products that improve health. REACH Hubs will foster the advancement of therapeutics, preventatives, diagnostics, devices, and tools in a manner consistent with business case development, that address the needs of patients and public health.

The objective of this FOA is to solicit and competitively seek cost shared research proposals for the development of tools, methods, and/or technologies needed to address critical gaps in the general understanding of unconventional reservoirs and their response to stimulation and production in order to optimize UOG development and enable more efficient and cost-effective UOG resource recovery; and characterize emerging UOG plays and develop and/or apply technologies that can accelerate the development of emerging UOG plays.

The purpose of this funding opportunity announcement (FOA) is to support non-commercial lab-to-user dissemination of novel, reliable imaging and bioengineering technologies of high interest to NIBIB, including biomedical devices, software, methods and imaging agents. Technologies proposed for dissemination should have been prototyped and validated and have demonstrated potential for high value to the research community but for which dissemination via commercialization is not a viable pathway. Projects should focus on transforming functioning prototypes into reliable tools and delivering them to end users. Related activities may include, but are not limited to, quality control, scale-up production, user training, and minor technical improvements.

The Department of Energys (DOEs) National Energy Technology Laboratory (NETL) on behalf of the Office of Electricity Delivery and Energy Reliability (OE) Cybersecurity for Energy Delivery Systems (CEDS) Research and Development (R&D) program is seeking applications under this Funding Opportunity Announcement (Announcement) to conduct research, development and demonstrations (RD&D) for innovative approaches to advance cyber resilient energy delivery systems. This RD&D will lead to next generation tools and technologies that are not available today that will become widely adopted throughout the energy sector to reduce the risk that a cyber incident could disrupt energy delivery.

This Funding Opportunity Announcement (FOA) encourages Small Business Innovation Research (SBIR) grant applications from small business concerns (SBCs) that propose to further the development of Advanced Technology Training (ATT) products for: the health and safety training of hazardous materials (HAZMAT) workers; waste treatment personnel; skilled support personnel associated with an emergency/disaster; emergency responders in biosafety response, infectious disease training and cleanup; emergency responders in disasters and resiliency training; and for ATT tools to assist in research into the acute and long-term health effects of environmental disasters. ATT as defined by the Worker Training Program (WTP) includes, but is not limited to, online training, virtual reality, and serious gaming, which complement all aspects of training from development to evaluation including advanced technologies that enhance, supplement, improve, and provide health and safety training for hazardous materials workers. These products must complement the goals and objectives of the WTP http://www.niehs.nih.gov/careers/hazmat/about_wetp/. The major objective of the NIEHS WTP is to prevent work related harm by assisting in the training of workers in how best to protect themselves and their communities from exposure to hazardous materials. The financial support for this initiative comes directly from NIEHS Worker Education and Training Branch SBIR funds.

Recent advances in communications, computation, and sensing technologies offer unprecedented opportunities for the design of cyber-physical systems with increased responsiveness, interconnectivity and automation. To meet new challenges and societal needs, the Energy, Power, Control andNetworks (EPCN) Program invests in systems and control methods for analysis and design of cyber-physical systems to ensure stability, performance, robustness, and security. Topics of interest include modeling, optimization, learning, and control of networked multi-agent systems, higher-level decision making, and dynamic resource allocation as well as risk management in the presence of uncertainty, sub-system failures and stochastic disturbances. EPCN also invests in adaptive dynamic programing, brain-like networked architectures performing real-time learning, and neuromorphic engineering. EPCN supports innovative proposals dealing with systems research in such areas as energy, transportation, and nanotechnology. EPCN places emphasis on electric power systems, including generation, transmission, storage, and integration of renewables; power electronics and drives; battery management systems; hybrid and electric vehicles; and understanding of the interplay of power systems with associated regulatory and economic structures and with consumer behavior. Also of interest are interdependencies of power and energy systems with other critical infrastructures. Topics of interest also include systems analysis and design for energy scavenging and alternate energy technologies such as solar, wind, and hydrokinetic. The program also supports innovative tools and test beds, as well as curriculum development integrating research and education. In addition to single investigator projects, EPCN encourages cross-disciplinary proposals that benefit from active collaboration of researchers with complementary skills. Proposals for the EPCN program may involve collaborative research to capture the breadth of

The Geotechnical Engineering and Materials Program (GEM) supports fundamental research in soil and rock mechanics and dynamics in support of physical civil infrastructure systems. Also supported is research on improvement of the engineering properties of geologic materials for infrastructure use by mechanical, biological, thermal, chemical, and electrical processes. The Program supports the traditional areas of foundation engineering, earth structures, underground construction, tunneling, geoenvironmental engineering, and site characterization, as well as the emerging area of bio-geo engineering, for civil engineering applications, with emphasis on sustainable geosystems. Research related to the geotechnical engineering aspects of geothermal energy and geothermal heat pump systems is also supported. The GEM program encourages knowledge dissemination and technology transfer activities that can lead to broader societal benefit and implementation for provision of physical civil infrastructure. The Program also encourages research that explores and builds upon advanced computing techniques and tools to enable major advances in Geotechnical Engineering.

The Science of Science & Innovation Policy (SciSIP) program supports research designed to advance the scientific basis of science and innovation policy. The program funds research to develop models, analytical tools, data and metrics that can be applied in the science policy decision making process and concern the use and allocation of scarce scientific resources. For example, research proposals may develop behavioral and analytical conceptualizations, frameworks or models that have applications across the broad array of science and innovation policy challenges. Proposals also may develop methodologies to analyze science, technology and innovation data, and to usefully convey that information to a variety of audiences. Proposals that create and improve science, engineering and innovation data, including the design of new metrics and indicators, particularly proposals that demonstrate the viability of collecting and analyzing data on knowledge generation and innovation in organizations, are encouraged.

This Funding Opportunity Announcement (FOA) invites applications that seek to apply one or more innovative methodologies in communication research across the cancer control continuum, from prevention, early detection, diagnosis, treatment, and survivorship, to end of life. Applications to this FOA should utilize one or more of the following analytic approaches, methods, and data sources, including but not limited to social media data mining, Natural Language Processing (NLP) techniques, online social network analysis, crowdsourcing research tools (e.g., mTurk), online search data, Ecological Momentary Assessment, neuroscience and biobehavioral approaches to communication, and geographic information systems. Studies should assess outcomes related to cancer prevention and control (e.g., knowledge, attitudes, beliefs, perceived risk, decision making in screening and treatment, information inequalities, social support, shared decision making, persuasion, caregiving, behavioral intentions, preventive behaviors, and policy support, among others). Also listed under R21

The NRA is for the development of experiment hardware with enhanced capabilities; modification of existing hardware to enable increased efficiencies (crew time, power, etc.); development of tools that allow analyses of samples and specimens on orbit; enhanced ISS infrastructure capabilities (ex. Communications or data processing); and specific technology demonstration projects. Upon its release date this NRA will be available electronically through NSPIRES at http://nspires.nasaprs.com/external/ by selecting NASA Research Announcement: NNJ13ZBG001N.Participation is open to all categories of organizations, domestic, including industry, educational institutions, nonprofit organizations, NASA centers, and other Government agencies except for foreign entities.Proposal due dates are listed in the NRA. The electronic submission of each proposal's Cover Page/Proposal Summary/Budget Summary is required by the due date for proposal submission.Notwithstanding the posting of this opportunity at FedBizOpps.gov, nspires.nasaprs.com/external, or at both sites, NASA reserves the right to determine the appropriate award instrument for each proposal selected pursuant to this announcement.Designate the appropriate technical points of contact as appropriate, such as:Direct questions specifically regarding this solicitation to: Miyoshi J. Thompson, Contracting Officer, 2101 NASA Parkway, Houston, TX 77058; 281.244.1683; miyoshi.thompson-1@nasa.gov

The Division of Computer and Network Systems (CNS) within the National Science Foundation's (NSF) Directorate for Computer and Information Science and Engineering (CISE) supports research and education activities that develop a better understanding of the fundamental properties of computer and network systems and to create better abstractions and tools for designing, building, analyzing, and measuring future systems. The Networking Technology and Systems (NeTS) program in the CNS division supports transformative research on fundamental scientific and technological advances leading to the development of future-generation, high-performance networks and future Internet architectures.

This Funding Opportunity Announcement (FOA) invites applications to conduct research to advance the understanding and application of synthetic biology for human health. It will support 1) the development of innovative tools and technologies in synthetic biology and 2) their application in biomedical research and human health. An integrative research plan based on collaborations of synthetic biologists with computational scientists, cell biologists, engineers, and/or physician scientists is strongly recommended. Early stage investigators in Synthetic Biology are especially encouraged to apply.

The U.S. Department of Energy's Office of Science, Biological and Environmental Research (BER) hereby announces interest in receiving applications for genomics-based research that will lead to the improved use of plant biomass and feedstocks for the production of biofuels and renewable chemical feedstocks. Applications are sought for research on candidate herbaceous and woody plants with improved resistance/tolerance to disease and disease complexes, and non-food oil seed crops for improved winter cold tolerance/survivability and agronomic traits. Research to overcome these biological barriers to the low-cost, high-quality, scalable and sustainable production of dedicated bioenergy biomass feedstocks using the tools of genetics and genomics are encouraged.

The Engineering of Biomedical Systems (EBMS)program is part of the Engineering Biology and Health cluster, which also includes 1) Biophotonics; 2) Biosensing; 3) Cellular and Biochemical Engineering; and 4) Disability and Rehabilitation Engineering. The goal of theEBMS program is to provide research opportunities for creating discovery-level and transformative projects that integrate engineering and life sciences to solve biomedical problems and serve humanity in the long term.EBMS projects must be at the interface of engineering and biomedical sciences. They are expected to use an engineering framework (for example, design or modeling) that supports increased understanding of physiological or pathophysiological processes. The project must include objectives that advance both engineering and biomedical sciences. EMBS projects should focus on high-impact, transformative methods and technologies -- especially those that potentially will have a broad impact on biomedical challenges. Projects may include: methods, models, and enabling tools applied to understand or control living systems; fundamental improvements in deriving information from cells, tissues, organs, and organ systems; or new approaches to the design of systems that include both living and non-living components for eventual medical use in the long term. TheEBMS programsupports fundamental and transformative research in the following areas of biomedical engineering: