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DARPA Defense Sciences Office (DSO) wants to identify and pursue high-risk, high-payoff research initiatives across a broad spectrum of science and engineering disciplines and to transform these initiatives into important, radically new, game-changing technologies for U.S. national security. The current overarching office themes include accelerating scientific discovery, exploring fundamental limits, and expecting the unexpected. In support of this mission, the DSO Office-wide BAA invites proposers to submit innovative basic or applied research concepts in one or more of the following technical areas: Mathematics, Modeling and Design; Physical Systems; Human-Machine Systems; and Social Systems. Each of these areas is described below and includes a list of example research topics that highlight several (but not all) potential areas of interest. Proposals must investigate innovative approaches that enable revolutionary advances. DSO is explicitly not interested in approaches or technologies that primarily result in evolutionary improvements to the existing state of practice.

The purpose of the Mentored Quantitative Research Career Development Award (K25) is to attract to NIH-relevant research those investigators whose quantitative science and engineering research has thus far not been focused primarily on questions of health and disease. The K25 award will provide support and protected time for a period of supervised study and research for productive professionals with quantitative (e.g., mathematics, statistics, economics, computer science, imaging science, informatics, physics, chemistry) and engineering backgrounds to integrate their expertise with NIH-relevant research. Prospective candidates are encouraged to contact the relevant NIH staff for IC-specific programmatic and budgetary information: Table of IC-Specific Information, Requirements and Staff Contacts.

The Collegiate Inventors Competition recognizes student inventors whose research and inventions will change our future.   The Competition promotes exploration in invention, science, engineering, technology, and other creative endeavors and provides a window on the technologies from which society will benefit in the future. Entries are judged on the originality and inventiveness of the new idea, process, or technology. The entry must be complete, workable, and well articulated. Entries are also judged on their potential value to society (socially, environmentally, and economically), and on the scope of use.   Students must be enrolled (or have been enrolled) full-time in any U.S. college or university at least part of the 12-month period prior to the date the entry is submitted. In the case of a team (maximum of four students), at least one member of the team must meet the full-time eligibility criteria. The other team members must have been enrolled on a part-time basis (at a minimum) sometime during the 12-month period prior to the date the entry is submitted.

The Centers of Excellence in Genomic Science (CEGS) program establishes academic Centers for advanced genome research.  Each CEGS grant supports a multi-investigator, interdisciplinary team to develop innovative genomic approaches to address a particular biomedical problem.  A CEGS project will address a critical issue in genomic science or genomic medicine, proposing a solution that would be a very substantial advance.  Thus, the research conducted at these Centers will entail substantial risk, balanced by outstanding scientific and management plans and very high potential payoff.  A CEGS will focus on the development of novel technological or computational methods for the production or analysis of comprehensive data sets, or on a particular genome-scale biomedical problem, or on other ways to develop and use genomic approaches for understanding biological systems and/or significantly furthering the application of genomic knowledge, data and methods towards clinical applications.  Exploiting its outstanding scientific plan and team, each CEGS will nurture genomic science at its institution by facilitating the interaction of investigators from different disciplines, and by providing training to new and experienced investigators, it will expand the pool of highly-qualified professional genomics scientists and engineers.

EPA-ORD seeks applications from eligible entities to enter into a cooperative agreement with EPA that will provide training opportunities for undergraduate and graduate students on-site at ORD's Ground Water and Ecosystems Research Division (GWERD) research facilities located in Ada, Oklahoma.  It is envisioned that the training program will increase both the effectiveness and number of future environmental scientists. The training received under the mentorship of EPA scientists will complement the trainees' academic coursework. The recipient will be responsible for ensuring that the training projects are supportive of the trainees' academic training.  Some appropriate fields of study for trainees include, but are not limited to, environmental science, water policy, chemistry, engineering, computer science, ecology, and physical and biological sciences.

NIST is soliciting applications for financial assistance for Fiscal Year 2016 (FY16) within the following NIST Laboratory grant programs: (1) the Material Measurement Laboratory (MML) Grant Program; (2) the Physical Measurement Laboratory (PML) Grant Program; (3) the Engineering Laboratory (EL) Grant Program; (4) the Fire Research (FR) Grant Program; (5) the Information Technology Laboratory (ITL) Grant Program; (6) the Communications Technology Laboratory (CTL) Grant Program; (7) the NIST Center for Neutron Research (NCNR) Grant Program; (8) the Center for Nanoscale Science and Technology (CNST) Grant Program; (9) the Special Programs Office (SPO) Grant Program; (10) the Standards Coordination Office (SCO) Grant Program; (11) the International and Academic Affairs Office (IAAO) Grant Program; and (12) the Associate Director for Laboratory Programs (ADLP) Grant Program.

NIST is soliciting applications for financial assistance for Fiscal Year 2016 (FY16) within the following NIST Laboratory grant programs: (1) the Material Measurement Laboratory (MML) Grant Program; (2) the Physical Measurement Laboratory (PML) Grant Program; (3) the Engineering Laboratory (EL) Grant Program; (4) the Fire Research (FR) Grant Program; (5) the Information Technology Laboratory (ITL) Grant Program; (6) the Communications Technology Laboratory (CTL) Grant Program; (7) the NIST Center for Neutron Research (NCNR) Grant Program; (8) the Center for Nanoscale Science and Technology (CNST) Grant Program; (9) the Special Programs Office (SPO) Grant Program; (10) the Standards Coordination Office (SCO) Grant Program; (11) the International and Academic Affairs Office (IAAO) Grant Program; and (12) the Associate Director for Laboratory Programs (ADLP) Grant Program.

The International Research Network Connections (IRNC) program supports high-performance network connectivity required by international science and engineering research and education collaborations involving the NSF research community. NSF expects to make 1-2 awards to link U.S. research networks with peer networks in Europe and Africa and leverage existing international network connectivity. High-performance network connections funded by this program are intended to support science and engineering research and education applications, and preference will be given to solutions that provide the best economy of scale and demonstrate the ability to support the largest communities of interest with the broadest services. Funded projects will assist the U.S. research and education community by enabling state-of-the-art international network services and access to increased collaboration and data services. Through extended international network connections, additional research and production network services will be enabled, complementing those currently offered or planned by domestic research networks.

The International Research Network Connections (IRNC) program supports high-performance network connectivity required by international science and engineering research and education collaborations involving the NSF research community. NSF expects to make 1-2 awards to link U.S. research networks with peer networks in Europe and Africa and leverage existing international network connectivity. High-performance network connections funded by this program are intended to support science and engineering research and education applications, and preference will be given to solutions that provide the best economy of scale and demonstrate the ability to support the largest communities of interest with the broadest services. Funded projects will assist the U.S. research and education community by enabling state-of-the-art international network services and access to increased collaboration and data services. Through extended international network connections, additional research and production network services will be enabled, complementing those currently offered or planned by domestic research networks.

The purpose of the Mentored Quantitative Research Career Development Award (K25) is to attract to NIH-relevant research those investigators whose quantitative science and engineering research has thus far not been focused primarily on questions of health and disease. The K25 award will provide support and "protected time" for a period of supervised study and research for productive professionals with quantitative (e.g., mathematics, statistics, economics, computer science, imaging science, informatics, physics, chemistry) and engineering backgrounds to integrate their expertise with NIH-relevant research. This Funding Opportunity Announcement (FOA) is designed specifically for applicants proposing to lead basic science experimental studies involving humans, referred to in NOT-OD-18-212 as prospective basic science studies involving human participants. These studies fall within the NIH definition of a clinical trial and also meet the definition of basic research. Types of studies that should submit under this FOA include studies that prospectively assign human participants to conditions (i.e., experimentally manipulate independent variables) and that assess biomedical or behavioral outcomes in humans for the purpose of understanding the fundamental aspects of phenomena without specific application towards processes or products in mind. Studies conducted with specific applications toward processes or products in mind should submit under the companion PA-18-395.

The Industry-University Cooperative Research Centers (IUCRC) program develops long-term partnerships among industry, academe, and government. The Centers are catalyzed by an investment from the National Science Foundation (NSF) and are primarily supported by industry Center members, with NSF taking a supporting role in the development and evolution of the Center. Each Center is established to conduct research that is of interest to both the industry members and the Center faculty. An IUCRC contributes to the nation's research infrastructure base and enhances the intellectual capacity of the engineering and science workforce through the integration of research and education. As appropriate, an IUCRC uses international collaborations to advance these goals within the global context.

The PRMRP Investigator-Initiated Research Award (IIRA) is intended to support studies that will make an important contribution toward research and/or patient care for a disease or condition related to at least one of the FY19 PRMRP Topic Areas. The rationale for a research idea may be derived from a laboratory discovery, population-based studies, a clinician's first-hand knowledge of patients, or anecdotal data. Applications must include relevant data that support the rationale for the proposed study. These data may be unpublished or from the published literature

The National Science Foundation (NSF) seeks to develop and nurture a national innovation ecosystem that builds upon research to guide the output of scientific discoveries closer to the development of technologies, products and processes that benefit society.

Future ultra-low-energy computing, storage and signal-processing systems can be built on principles derived from organic systems that are at the intersection of chemistry, biology, and engineering. New information technologies can be envisioned that are based on biological principles and that use biomaterials in the fabrication of devices and components; it is anticipated that these information technologies could enable stored data to be retained for more than 100 years and storage capacity to be 1,000 times greater than current capabilities. These could also facilitate compact computers that will operate with substantially lower power than today's computers. Research in support of these goals can have a significant impact on advanced information processing and storage technologies. This focused solicitation seeks high-risk/high-return interdisciplinary research on novel concepts and enabling technologies that will address the scientific issues and technological challenges associated with the underpinnings of synthetic biology integrated with semiconductor technology. This research will foster interactions among various disciplines including biology, engineering, physics, chemistry, materials science, computer science, and information science that will enable heretofore-unanticipated breakthroughs as well as meet educational goals.

NIST is soliciting applications from eligible institutions of higher education in the U.S. and its territories that offer two- or four- year degrees in academic science, technology, engineering and mathematics (STEM) disciplines, which include but are not limited to biochemistry, biological sciences, chemistry, computer science, engineering, electronics, materials science, mathematics, nanoscale science, neutron science, physical sciences, physics, and statistics, to establish and manage a program to support collaborative research relationships among NIST staff, undergraduate and graduate students, individuals with bachelor's or master's degrees, post-doctoral fellows, and academic affiliates, and the PREP researchers' academic institutions. These collaborative relationships will include research opportunities at the relevant NIST campuses in Boulder, Colorado (CO) (PREP Boulder), or Gaithersburg, Maryland (MD), and/or Charleston, South Carolina (SC) (PREP Gaithersburg). Eligible applicants may apply to establish and manage a PREP Boulder program or a PREP Gaithersburg program or may apply to establish and manage programs for both.

Secretary of the Air Force Heather Wilson announced in September 2017 inception of the "S&T Strategy 2030" study. The study's objective is to update the Air Force methods for conducting research and development (R&D) to meet the projected national security challenges of 2030. Secretary Wilson appointed the Air Force Research Laboratory (AFRL) to lead this strategy development.The Air Force's goals for the study are: 1. Evaluate technical approaches and focus areas to advance the Air Force's mission through R&D; and 2. Improve Air Force processes and organizational structures to manage early stage research.

The Division of Molecular and Cellular Biosciences (MCB) has developed a new opportunity to enable researchers with a strong track record of prior accomplishment to pursue a new avenue of research or inquiry. This funding mechanism is designed to facilitate and promote a PI's ability to effective adopt empowering technologies that might not be readily accessible in the PI's current research environment or collaboration network. Transformative research likely spans disciplines and minimizing the practical barriers to doing so will strengthen research programs poised to make significant contributions. The award is intended to allow mid-career or later-stage researchers (Associate or Full Professor, or equivalent) to expand or make a transition in their research programs via a sabbatical leave or similar mechanism of professional development and then develop that research program in their own lab. This award will also enable the PI to acquire new scientific or technical expertise, facilitate the investigator's competitiveness, and potentially lead to transformational impacts in molecular and cellular bioscience.