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The PCC has supported world-class research since 2009, spending more than $8.0 M to support novel science. Research and grant-making are the foundation of the PCC and are the focus of everyday business activity. PCC-supported research contributes to a movement in addressing doping's root causes and ultimately decreasing the use of performance-enhancing drugs by all participants in all sports at all levels of play. With an emphasis on original work that focuses on improving existing analytical methods for detecting particular drugs, developing new analytical methods to test for substances not currently detectable, and discovering cost-effective approaches for testing widely abused substances across all levels of sport, the following areas of investigation reflect the PCC's current research priorities: - Developing methods of cost-effective testing to detect and deter the use of banned and illegal substances. - Developing testing protocols to detect designer substances used for doping purposes. - Improving existing analytical methods to detect particular drugs, ex. GH, IGF-1, EPO, hCG. - Developing analytical methods to detect performance enhancing drugs not currently detectable. - Longitudinal urinary excretion patterns, metabolism and dose-concentration. - Critical reviews to support interpretation of laboratory data. - Alternative specimens, (ex. oral fluid, dried blood/plasma spots) for testing.

The Chemical Theory, Models and Computational Methods program supports the discovery and development of theoretical and computational methods or models to address a range of chemical challenges, with emphasis on emerging areas of chemical research. Proposals that focus on established theoretical or computational approaches should involve innovative additions or modifications that substantially broaden their applicability. Areas of interest include, but are not limited to, electronic structure, quantum reaction dynamics, statistical mechanics, molecular dynamics, and simulation and modeling techniques for molecular systems and systems in condensed phases. Areas of application span the full range of chemical systems from small molecules to mesoscopic aggregates, including single molecules, biological systems and materials in condensed phases. Despite the diverse application areas, the goal of the program is to support the development of new theoretical and computational methodologies that have the potential of being broadly applicable to a range of challenging chemical problems. We are particularly interested in fundamental areas of chemical research that are difficult or impossible to address using current synthetic, experimental, and/or computational methodologies. We encourage the integration of innovative software development with methodological and algorithmic development, especially computational approaches that allow efficient utilization of the high end computers of the future.Proposals that utilize established theoretical and modeling approaches to solve problems in chemistry, biology or materials discovery and design may be more appropriate for other programs in either the Chemistry division or in other Divisions or Directorates.

This Funding Opportunity Announcement (FOA) encourages applications for Countermeasures Against Chemical Threats (CounterACT) Cooperative Agreement (U01) Research Projects for research on the identification of small molecule or biologic lead compounds that are excellent candidates for therapeutic development. The mission of the CounterACT program is to foster and support research and development of new and improved therapeutics for chemical threats. Chemical threats are toxic chemicals that could be used in a terrorist attack or accidentally released from industrial production, storage or shipping. They include traditional chemical warfare agents, toxic industrial chemicals, pharmaceutical-based agents, and pesticides. The scope of research supported by this FOA includes confirmation of molecular targets for therapeutic development, demonstration of in vitro activity of candidate therapeutics, preliminary in vivo proof-of-concept efficacy data, preliminary adsorption, distribution, metabolism, excretion, and toxicity (ADME/Tox) evaluations and pharmacokinetics/pharmacodynamics (PK/PD) data. These studies should result in the identification of at least one lead compound ready for optimization. Lead compounds are biologically active and synthetically feasible compounds where specificity, affinity, potency, target selectivity, efficacy, and safety have been established. Lead compounds should be ready for more advanced development under possible support from other programs such as the one described in the companion FOA "CounterACT Optimization of Therapeutic Lead Compound (U01)" (PAR-18-NNN). The scope of this FOA encompasses Technical Readiness Level (TRL) 1-3 - see TRLs. Each project must include annual milestones that create discrete go or no-go decision points in a progressive translational study plan.

This Funding Opportunity Announcement (FOA) encourages applications for Countermeasures Against Chemical Threats (CounterACT) Cooperative Agreement (U01) Research Projects for research on the optimization of small molecule or biologic compounds that are excellent candidates for therapeutic development. The mission of the CounterACT Program is to foster and support research and development of new and improved therapeutics for chemical threats. Chemical threats are toxic chemicals that could be used in a terrorist attack or accidentally released from industrial production, storage or shipping. They include traditional chemical warfare agents, toxic industrial chemicals, pharmaceutical-based agents, and pesticides. A previously identified lead compound is required to be eligible for this funding opportunity. In this regard, lead compounds are defined as biologically active compounds or hits where affinity, potency, target selectivity, and preliminary safety have been established. The scope of research supported by this FOA includes development of appropriate human-relevant animal models and generation of in vivo efficacy data consistent with the intended use of the product in humans. It also includes bioanalytical assay development and validation, laboratory-scale and scaleable manufacturing of the product, and non-GLP toxicity and pharmacology studies. The scope of this FOA encompasses Technical Readiness Levels (TRLs) 4-5 - see TRLs. Each project must include annual milestones that create discrete go or no-go decision points in a progressive translational study plan.

The purpose of this Funding Opportunity Announcement (FOA) is to invite exploratory/developmental research grant (R21) applications for the development of innovative methods and algorithms in biomedical computing, informatics, and data science addressing priority needs across the cancer research continuum, including cancer biology, cancer treatment and diagnosis, cancer prevention, cancer control and epidemiology, and/or cancer health disparities. As a component of the NCI's Informatics Technology for Cancer Research (ITCR) Initiative, this FOA encourages applications focused on the development of novel computational, mathematical, and statistical algorithms and methods that can considerably improve acquisition, management, analysis, and dissemination of relevant data and/or knowledge. The central mission of ITCR is to promote research-driven informatics technology across the development lifecycle to address priority needs in cancer research. In order to be successful, the proposed informatics method or algorithm must have a clear rationale on why it is novel and how it will benefit the cancer research field.

This funding opportunity announcement (FOA) focuses on sensitivity and tolerance mechanisms underlying the development of alcohol use disorders. The intent of this FOA is to: (1) develop hypotheses about cellular, molecular or network mechanisms that regulate sensitivity and tolerance to alcohol, and (2) develop quantitative models to predict the development of tolerance and the progression to alcohol dependence. These objectives will be accomplished with a Phased Innovation (R21/R33) mechanism, in which secondary data analysis or pilot studies can occur during the R21 phase, and research testing the hypotheses can be expanded in the R33 phase. The transition to the R33 phase will be determined by NIAAA program staff after evaluation of the achievement of specific milestones set for the R21 phase. Applicants interested in the genetic basis of tolerance may consider FOA (PA-18-660).

The mission of DOE's Fossil Energy R&D Program is to ensure the nation can continue to rely on traditional resources for clean, secure and affordable energy while enhancing environmental protection. The Carbon Capture program focuses on developing technologies to control emissions from either post-combustion units (e.g., pulverized coal) or pre-combustion (e.g., Integrated Gasification Combined Cycle, or IGCC). First Generation technologies (i.e. those that are currently being demonstrated or that are commercially available) exist, and Second Generation Technologies (i.e., those that include technology components currently in R&D and are expected to be ready for demonstration in the 2020-2025 timeframe) have shown potential for improvement towards an economic goal for cost of capture at less than $40/tonne, but are still cost prohibitive for broad deployment to the existing coal fleet. For Fiscal Year (FY) 2018, the Carbon Capture Program will solicit applications under this FOA to develop technologies in the area of pre-combustion carbon capture. Approaches that look at either hydrogen (H2) separation or carbon dioxide (CO2) separation will be accepted. The carbon capture technologies developed through this FOA will have direct application to coal gasification processes where coal derived synthesis gas or hydrogen are produced. Additionally, because gasification technology is often used to produce industrial chemicals, the technologies developed through this FOA will also be directly applicable to industrial gasifiers.

The USAFA is seeking unclassified research white papers and proposals that do not contain proprietary information. If proprietary information is submitted it is the offerors' responsibility to mark the relevant portions of their proposal as specified in USAFA-BAA-2015. CAStLE performs a range of structural integrity research tasks in support of multiple Government, academic and commercial sponsors. Among these pursuits, CAStLE engages in a wide range of corrosion engineering and material science research efforts, with more emphasis on applied research, and that part of development not related to a specific system or hardware procurement. Current CAStLE research strengths include: high temperature materials development; advanced barrier coatings; static strength, static stability design, corrosion modeling, prevention and control; validation testing, analysis and methods development; computational structural and fracture mechanics; failure analysis, flight data acquisition system development, installation, maintenance and data analysis; structural risk analysis, and support of the USAF Aircraft Structural Integrity Program (ASIP). The interaction between corrosion and cracking damage mechanisms and their effect on the structural integrity has been a long-standing interest of CAStLE. There is Department of Defense (DoD) level interest in material degradation in structures-to include corrosion, cracking and other service-related damage mechanisms. The DoD level material degradation interest is the subject of this CALL, while also serving a dual public purpose.

A large amount of the research and development of post-combustion carbon capture technology focuses on three main technologies: adsorption, absorption and membranes. Each of these technologies have energy and techno-economic advantages and disadvantages. However, an optimal process may involve the integration of multiple technologies into a single, hybrid, transformative process that is more economical and energy efficient. The challenge of developing this type of process is the integration of rigorous process sub-models into a single framework, where hybrid designs can be evaluated and optimized. The National Energy Technology Laboratory (NETL) has significant expertise in the development of rigorous process models and modeling for the advancement and acceleration of the commercialization of carbon capture process systems. A large part of the effort is the Carbon Capture Simulation Initiative (CCSI). The computational tools and multi-scale modeling techniques comprising the CCSI Toolset can be broadly applied for the development of a wide variety of technologies well beyond carbon capture including chemicals production, petroleum refining, natural gas processing and biofuel production.

The PCC has supported world-class research since 2008, spending more than $18.0 M to support novel science around the world. Research and grant-making are the foundation of the PCC and are the focus of everyday business activity. PCC-supported research contributes to a movement in addressing doping's root causes and ultimately decreasing the use of performance-enhancing drugs by all participants in all sports at all levels of play. Grant Cycle Deadlines: Pre-Applications are due March 1st, July 1st, and November 1st of each year. Applicants invited to submit full applications must do so by April 1st, August 1st, or December 1st, depending on the cycle (30 days after the pre-application due date). With an emphasis on original work that focuses on improving existing analytical methods for detecting particular drugs, developing new analytical methods to test for substances not currently detectable, and discovering cost-effective approaches for testing widely abused substances across all levels of sport, the following areas of investigation reflect the PCC's current research priorities: Developing methods of cost-effective testing to detect and deter the use of banned and illegal substances. Developing testing protocols to detect designer substances used for doping purposes. Improving existing analytical methods to detect particular drugs, ex. GH, IGF-1, EPO, hCG. Developing analytical methods to detect performance enhancing drugs not currently detectable. Longitudinal urinary excretion patterns, metabolism and dose-concentration. Critical reviews to support interpretation of laboratory data. Alternative specimens, (ex. oral fluid, dried blood/plasma spots) for testing. There is no maximum amount for PCC funding, though the average funding amount is $225,000. To date, over 80 projects have been funded in over 14 countries world-wide. Approximately 33% of applicants are awarded PCC funding.

Background A large amount of the research and development of post-combustion carbon capture technology focuses on three main technologies: adsorption, absorption and membranes. Each of these technologies have energy and techno-economic advantages and disadvantages. However, an optimal process may involve the integration of multiple technologies into a single, hybrid, transformative process that is more economical and energy efficient. The challenge of developing this type of process is the integration of rigorous process sub-models into a single framework, where hybrid designs can be evaluated and optimized. The National Energy Technology Laboratory (NETL) has significant expertise in the development of rigorous process models and modeling for the advancement and acceleration of the commercialization of carbon capture process systems. A large part of the effort is the Carbon Capture Simulation Initiative (CCSI) [Reference 1]. The computational tools and multi-scale modeling techniques comprising the CCSI Toolset can be broadly applied for the development of a wide variety of technologies well beyond carbon capture including chemicals production, petroleum refining, natural gas processing and biofuel production.

Genomic Science program supports basic research aimed at identifying the foundational principles that drive biological systems. These principles govern the translation of the genetic code into integrated networks of proteins, enzymes, regulatory elements, and metabolite pools that are the functional processes of organisms including microbes and multispecies communities relevant to DOE missions in energy and the environment. To address the DOE mission in sustainable Bioenergy development, the Genomic Science program brings omics-driven tools of modern systems biology to bear on the challenges associated with microbial production of advanced Biofuels and Bioproducts.Developing an increased understanding of how biological systems function and translating that knowledge to enhance the production capabilities of microbes and plants forms the basis of DOE's mission in sustainable Bioenergy. To harness the biosynthetic processing power of the microbial world for advanced Biofuels and Bioproducts production, an expanded set of platform organisms with appropriate metabolic capabilities and stress tolerance characteristics with a suite of modification tools will need to be developed. To foster this development, the DOE-BER Genomic Science program supports research aimed at understanding the principles that govern the functional properties of bioenergy relevant organisms at the genomic scale.

DOE-NE's mission is to encourage development and exploration of advanced nuclear science and technology. DOE-NE promotes nuclear energy as a resource capable of meeting the nation's energy, environmental, and national security needs by resolving scientific, technical, and regulatory challenges through research, development, and demonstration. IUP supports DOE-NE's Nuclear Energy University Program (NEUP), which enables outstanding, cutting-edge, and innovative research at U.S. IHEs through the following: * Integrating research and development (R&D) at U.S. IHEs, national laboratories, and industry to revitalize nuclear education and support NE'sPrograms * Attracting the brightest students to the nuclear professions and supporting the nation's intellectual capital in science and engineering disciplines * Improving U.S. IHE's infrastructure for conducting R&D and educating students * Facilitating knowledge transfer to the next generation ofworkers Educating undergraduate and graduate students in NS&E will: * Support the ongoing need for personnel who can develop and maintain the nation's nuclear power technology * Enhance the R&D capabilities of U.S. IHEs * Fulfill national demand for highly trained scientists and engineers to work in NS&E areas

Growing Convergence Research (GCR) at the National Science Foundation was identified as one of 10 Big Ideas. Convergence research is a means for solving vexing research problems, in particular, complex problems focusing on societal needs. It entails integrating knowledge, methods, and expertise from different disciplines and forming novel frameworks to catalyze scientific discovery and innovation. GCR identifies Convergence Research as having two primary characteristics: Research driven by a specific and compelling problem. Convergence Research is generally inspired by the need to address a specific challenge or opportunity, whether it arises from deep scientific questions or pressing societal needs. Deep integration across disciplines. As experts from different disciplines pursue common research challenges, their knowledge, theories, methods, data, research communities and languages become increasingly intermingled or integrated. New frameworks, paradigms or even disciplines can form sustained interactions across multiple communities. A distinct characteristic of convergence research, in contrast to other forms of multidisciplinary research, is that from the inception, the convergence paradigm intentionally brings together intellectually diverse researchers and stakeholders to frame the research questions, develop effective ways of communicating across disciplines and sectors, adopt common frameworks for their solution, and, when appropriate, develop a new scientific vocabulary. Research teams practicing convergence aim at developing sustainable relationships that may not only create solutions to the problem that engendered the collaboration, but also develop novel ways of framing related research questions and open new research vistas.

NIJ seeks proposals for basic or applied research and development projects that will: (1) increase the body of knowledge to guide and inform forensic science policy and practice or (2) lead to the production of useful materials, devices, systems, or methods that have the potential for forensic application. The intent of this program is to direct the findings of basic scientific research, research and development in broader scientific fields applicable to forensic science, and ongoing forensic science research toward the development of highly discriminating, accurate, reliable, cost-effective, and rapid methods for the identification, analysis, and interpretation of physical evidence for criminal justice purposes.

In pursuing a long-term development of high performance LSC, the client seeks a partner that is capable of realizing highly efficient luminescence down-shifting, light-propagation technologies, and prototyping the LSC. Proposals from highly motivated organization are also welcomed that have not worked on a light downshifting at this particular wavelength but are experienced in other wavelengths. The client will provide its development capability, such as research funds, facility, and human resources, to the selected partner, in order to overcome the challenges toward developing LSC with a large collection area.

The purpose of this Funding Opportunity Announcement (FOA) is to solicit grant applications that propose to establish Consortia for HIV/AIDS Vaccine Development (CHAVD) to support a coordinated, multidisciplinary team(s) of researchers focused on iterative approaches to accelerate HIV vaccine development by addressing key immunogen design roadblocks to the discovery and development of a safe and effective antibody-mediated preventive HIV vaccine.

The purpose of this funding opportunity announcement (FOA) is to support research to continue the development of drug development tools that have an accepted Letter of Intent within CDER's Drug Development Tool Qualification Program.

The purpose of this initiative is to encourage research that investigates the role of epigenetic or non-coding RNA regulatory pathways in the development, maintenance, or treatment of chronic pain. Ultimately research in the area will provide foundational knowledge that can be exploited to develop novel and non-addictive pain medications or to develop biomarkers that predict chronic pain progression or treatment response.

The mission of the Alternatives Research & Development Foundation is to fund and promote the development, validation, and adoption of non-animal methods in biomedical research, product testing, and education. To advance this mission, the foundation is soliciting proposals for its Annual Open Grant Program, which supports research projects aimed at developing methods to replace or reduce the use of animals in science. Expert reviewers will evaluate proposals based on scientific merit and feasibility, as well as the potential to reduce or replace the use of animals in science in the near future. Proposals are considered in the areas of research, testing, and/or education.