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The current pipeline of candidate antimicrobial products is insufficient to counter the threat of antimicrobial resistance . A novel collaborative model is needed to spur innovation and investment towards new antimicrobial products to repopulate the early development pipeline. In 2014, the United States Government released the National Strategy for Combating Antimicrobial Resistant Bacteria. A component of the National Strategy is to establish a Biopharmaceutical Accelerator for Combating Antibiotic-Resistant Bacteria [Accelerator] to fund Research and Development (R&D) activities to help progress candidate products from the proof-of-concept stage through pre-clinical development. Candidates that graduate from the Accelerator will be better positioned for R&D investment and clinical development. There are various Accelerator models in the marketplace. The Biomedical Advanced Research and Development Authority (BARDA) and the National Institute of Allergy and Infectious Diseases (NIAID) Accelerator will be a non-equity accelerator that provides non-dilutive funding to product developers for R&D activities and enables the product developers to retain full ownership and control of their company. The Accelerator for CARB will be focusing only on antibacterial products. BARDA will provide direct funding and NIAID will provide in-kind services (e.g. preclinical services, technical expertise) to the Accelerator [the cooperative agreement recipient] that will manage a portfolio of investments of early stage antimicrobial product candidates.

The current pipeline of candidate antimicrobial products is insufficient to counter the threat of antimicrobial resistance . A novel collaborative model is needed to spur innovation and investment towards new antimicrobial products to repopulate the early development pipeline. In 2014, the United States Government released the National Strategy for Combating Antimicrobial Resistant Bacteria. A component of the National Strategy is to establish a Biopharmaceutical Accelerator for Combating Antibiotic-Resistant Bacteria [Accelerator] to fund Research and Development (R&D) activities to help progress candidate products from the proof-of-concept stage through pre-clinical development. Candidates that graduate from the Accelerator will be better positioned for R&D investment and clinical development. There are various Accelerator models in the marketplace. The Biomedical Advanced Research and Development Authority (BARDA) and the National Institute of Allergy and Infectious Diseases (NIAID) Accelerator will be a non-equity accelerator that provides non-dilutive funding to product developers for R&D activities and enables the product developers to retain full ownership and control of their company. The Accelerator for CARB will be focusing only on antibacterial products. BARDA will provide direct funding and NIAID will provide in-kind services (e.g. preclinical services, technical expertise) to the Accelerator [the cooperative agreement recipient] that will manage a portfolio of investments of early stage antimicrobial product candidates.

This ROSES-2014 NRA (NNH14ZDA001N) solicits basic and applied research in support of NASA's Science Mission Directorate (SMD). This NRA covers all aspects of basic and applied supporting research and technology in space and Earth sciences, including, but not limited to: theory, modeling, and analysis of SMD science data; aircraft, scientific balloon, sounding rocket, International Space Station, CubeSat, and suborbital reusable launch vehicle investigations; development of experiment techniques suitable for future SMD space missions; development of concepts for future SMD space missions; development of advanced technologies relevant to SMD missions; development of techniques for and the laboratory analysis of both extraterrestrial samples returned by spacecraft, as well as terrestrial samples that support or otherwise help verify observations from SMD Earth system science missions; determination of atomic and composition parameters needed to analyze space data, as well as returned samples from the Earth or space; Earth surface observations and field campaigns that support SMD science missions; development of integrated Earth system models; development of systems for applying Earth science research data to societal needs; and development of applied information systems applicable to SMD objectives and data.

This ROSES-2014 NRA (NNH14ZDA001N) solicits basic and applied research in support of NASA's Science Mission Directorate (SMD). This NRA covers all aspects of basic and applied supporting research and technology in space and Earth sciences, including, but not limited to: theory, modeling, and analysis of SMD science data; aircraft, scientific balloon, sounding rocket, International Space Station, CubeSat, and suborbital reusable launch vehicle investigations; development of experiment techniques suitable for future SMD space missions; development of concepts for future SMD space missions; development of advanced technologies relevant to SMD missions; development of techniques for and the laboratory analysis of both extraterrestrial samples returned by spacecraft, as well as terrestrial samples that support or otherwise help verify observations from SMD Earth system science missions; determination of atomic and composition parameters needed to analyze space data, as well as returned samples from the Earth or space; Earth surface observations and field campaigns that support SMD science missions; development of integrated Earth system models; development of systems for applying Earth science research data to societal needs; and development of applied information systems applicable to SMD objectives and data.

The purpose of this Funding Opportunity Announcement (FOA) is to invite Cooperative Agreement (U01) applications for the development of enabling informatics technologies to improve the acquisition, management, analysis, and dissemination of data and knowledge across the cancer research continuum including cancer biology, cancer treatment and diagnosis, cancer prevention, cancer control and epidemiology, and/or cancer health disparities. As a component of the NCI's Informatics Technology for Cancer Research (ITCR) Program, this FOA focuses on early-stage development from prototyping to hardening and adaptation. Early-stage development is defined for the purpose of this FOA as the initial development or the significant modification of existing tools for new applications. The central mission of ITCR is to promote research-driven informatics technology across the development lifecycle to address priority needs in cancer research. In order to be successful, proposed development plans must have a clear rationale on why the proposed technology is needed and how it will benefit the cancer research field.

The purpose of this Funding Opportunity Announcement (FOA) is to invite Cooperative Agreement (U24) applications for advanced development and enhancement of emerging informatics technologies to improve the acquisition, management, analysis, and dissemination of data and knowledge across the cancer research continuum, including cancer biology, cancer treatment and diagnosis, cancer prevention, cancer control and epidemiology, and/or cancer health disparities. As a component of the NCI's Informatics Technology for Cancer Research (ITCR) Initiative, this FOA focuses on emerging informatics technology, defined as one that has passed the initial prototyping and pilot development stage, has demonstrated potential to have a significant and broader impact, has compelling reasons for further improvement and enhancement, and has not been widely adopted in the cancer research field. The central mission of ITCR is to promote research-driven informatics technology across the development lifecycle to address priority needs in cancer research.In order to be successful, proposed development plans must have a clear rationale on why the proposed technology is needed and how it will benefit the cancer research field. In addition, mechanisms to solicit feedback from users and collaborators throughout the development process should be included. Potential applicants who are interested in early-stage development or informatics resource sustainment should consult companion FOAs listed above.

Morton Cure Paralysis Fund (MCPF) is committed to developing effective therapies (cures) for paralysis associated with spinal cord injury and other disorders of the central nervous system (CNS).  MCPF funds activities that hold promise of identifying therapies (cures) for paralysis in humans. MCPF has particular focus of placing projects in the research pipeline that is, enabling scientists to develop the proof concept data necessary to apply for larger NIH grants. MCPF has particular focus of placing projects in the research pipeline that is, enabling scientists to develop the proof concept data necessary to apply for larger NIH grants. The development of effective therapies for chronic injury is a high priority for the organization. Basic research will be supported if it has clear potential to accelerate progress at the applied end of the continuum and/or if it reflects innovative research or a 'change of direction.

Morton Cure Paralysis Fund (MCPF) is committed to developing effective therapies (cures) for paralysis associated with spinal cord injury and other disorders of the central nervous system (CNS).  MCPF funds activities that hold promise of identifying therapies (cures) for paralysis in humans. MCPF has particular focus of placing projects in the research pipeline that is, enabling scientists to develop the proof concept data necessary to apply for larger NIH grants. MCPF has particular focus of placing projects in the research pipeline that is, enabling scientists to develop the proof concept data necessary to apply for larger NIH grants. The development of effective therapies for chronic injury is a high priority for the organization. Basic research will be supported if it has clear potential to accelerate progress at the applied end of the continuum and/or if it reflects innovative research or a 'change of direction.

The Chemical Measurement and Imaging Program supports research focusing on chemically-relevant measurement science and imaging, targeting both improved understanding of new and existing methods and development of innovative approaches and instruments. Research areas include but are not limited to sampling and separation science; electrochemistry; spectrometry; frequency- and time-domain spectroscopy; sensors and bioassays; and microscopy. Chemical (as opposed to morphological) imaging and measurement tools probing chemical properties and processes across a wide range of spatial scales - from macroscopic structures down to single molecules - are supported, as are innovations enabling the monitoring and imaging of rapid chemical and electronic processes and new approaches to data analysis and interpretation, including chemometrics. Proposals addressing established techniques must seek improved understanding and/or innovative approaches to substantially broaden applicability. Sensor-related proposals should address new science and/or entirely new approaches with prospects for broad utility and significant enhancement of current capabilities. Assembly of array-type devices using known sensing mechanisms is better suited to programs elsewhere, as is tailoring of known sensing mechanisms to specific new applications. Similarly, engineering aspects of microfluidics and "lab-on-a-chip" device design, technology, and application, are better directed elsewhere. Development of imaging contrast agents is not supported, although proposals addressing entirely new mechanisms of chemical imaging can be.Included among proposals considered by the Program are those (formerly submitted to the CRIF:ID program) for which the primary focus is on development of new instrumentation enabling chemical measurements likely to be of wide interest and utility to the chemistry research community. Such proposals should include the words "Instrument Development" at the beginning

This Funding Opportunity Announcement (FOA) invites exploratory/developmental applications that propose transformative engineering solutions to technical challenges associated with meaningful development, substantial optimization of existing technologies and clinical translation of intraoral biodevices. Proposed technologies are expected to advance development of oral biodevices to clinical use, including but not limited to: precision medicine-based detection, diagnosis and treatment of oral and overall health conditions, and measurement of patient functional status and clinical outcome assessment. Areas of interest in this FOA include engineering approaches that allow integration of electronic, physical, and biological systems essential to the development of functional biodevices that are safe and effective for detection, diagnosis and treatment of oral and systemic disease. Products of this research will be proof-of-concept prototype biodevices, dedicated biosensors and associated core technologies that enable development of safe and effective intra-oral biodevices intended for specific clinical applications. To streamline the development of oral biodevices that advance precision medicine-based approaches in clinical practice, this FOA encourages interdisciplinary collaborations across engineering, multifunctional sensors, pharmacology, chemistry, medicine, and dentistry, as well as between academia and industry.

The Division of Graduate Education announces the Graduate Research Internship Program (GRIP) to provide professional development to NSF Graduate Research Fellows through internships developed in partnership with federal agencies (see the GRIP website for a current list of partner agencies). Through this initiative, NSF Graduate Fellows will participate in mission-related, collaborative research under the guidance of host research mentors at federal facilities and national laboratories. The internship experiences will support Fellows with developing expertise in critical STEM areas, enhancing professional skills, developing networks, and preparing for a wide array of career options. The sponsor agencies will benefit by engaging Fellows in mission-critical projects, helping to develop a highly skilled U.S. workforce in areas of national need.

The Science of Science & Innovation Policy (SciSIP) program supports research designed to advance the scientific basis of science and innovation policy. Research funded by the program thus develops, improves and expands models, analytical tools, data and metrics that can be applied in the science policy decision making process. For example, research proposals may develop behavioral and analytical conceptualizations, frameworks or models that have applications across a broad array of SciSIP challenges, including the relationship between broader participation and innovation or creativity. Proposals may also develop methodologies to analyze science and technology data, and to convey the information to a variety of audiences. Researchers are also encouraged to create or improve science and engineering data, metrics and indicators reflecting current discovery, particularly proposals that demonstrate the viability of collecting and analyzing data on knowledge generation and innovation in organizations. Among the many research topics supported are:examinations of the ways in which the contexts, structures and processes of science and engineering research are affected by policy decision, the evaluation of the tangible and intangible returns from investments in science and from investments in research and development, the study of structures and processes that facilitate the development of usable knowledge, theories of creative processes and their transformation into social and economic outcomes, the collection, analysis and visualization of new data describing the scientific and engineering enterprise. The SciSIP program invites the participation of researchers from all of the social, behavioral and economic sciences as well as those working in domain-specific applications such as chemistry, biology, physics, or nanotechnology. The program welcomes proposals for individual or multi-investigator research projects, doctoral dissertation improvement awards, conferences, wo

The International Research Experiences for Students (IRES) program supports international research and research-related activities for U.S. science and engineering students. The IRES program contributes to development of a diverse, globally-engaged workforce with world-class skills. IRES focuses on active research participation by undergraduate or graduate students in high quality international research, education and professional development experiences in NSF-funded research areas. The overarching, long-term goal of the IRES program is to enhance U.S. leadership in research and education and to strengthen economic competitiveness through training the next generation of research leaders. This solicitation features three mechanisms; proposers are required to select one of the following tracks to submit their proposal. Track I focuses on the development of world-class research skills in international cohort experiences. Track II is dedicated to targeted, intensive learning and training opportunities that leverage international knowledge at the frontiers of research. Track III supports U.S. institutional collaborations to develop, implement and evaluate innovative models for high-impact, large-scale international research and professional development experiences for U.S. graduate students. Student participants supported by IRES funds must be citizens, nationals, or permanent residents of the United States. Students do not apply directly to NSF to participate in IRES activities. Students apply to NSF-funded investigators who receive IRES awards. To identify appropriate IRES projects, students should consult the directory of active IRES awards. All PIs, co-PIs and Senior Personnel on IRES proposals must be from U.S. based institutions.

The mission of DOE's Fossil Energy R&D Program is to ensure the nation can continue to rely on traditional resources for clean, secure and affordable energy while enhancing environmental protection. The Carbon Capture program focuses on developing technologies to control emissions from either post-combustion units (e.g., pulverized coal) or pre-combustion (e.g., Integrated Gasification Combined Cycle, or IGCC). First Generation technologies (i.e. those that are currently being demonstrated or that are commercially available) exist, and Second Generation Technologies (i.e., those that include technology components currently in R&D and are expected to be ready for demonstration in the 2020-2025 timeframe) have shown potential for improvement towards an economic goal for cost of capture at less than $40/tonne, but are still cost prohibitive for broad deployment to the existing coal fleet. For Fiscal Year (FY) 2018, the Carbon Capture Program will solicit applications under this FOA to develop technologies in the area of pre-combustion carbon capture. Approaches that look at either hydrogen (H2) separation or carbon dioxide (CO2) separation will be accepted. The carbon capture technologies developed through this FOA will have direct application to coal gasification processes where coal derived synthesis gas or hydrogen are produced. Additionally, because gasification technology is often used to produce industrial chemicals, the technologies developed through this FOA will also be directly applicable to industrial gasifiers. Finally, as these technologies are successfully developed, they can represent an export opportunity to other countries that have a larger installed base of gasifiers than the U.S.

The DOE SC program in Basic Energy Sciences (BES) hereby announces its interest in receiving new and renewal applications from small groups (2-3 principal investigators) and integrated multidisciplinary teams (typically from multiple institutions) in Computational Chemical Sciences (CCS). Single-investigator applications are not responsive to the objectives of this FOA. CCS will support basic research to develop validated, open-source codes for modeling and simulation of complex chemical processes and phenomena that allow full use of emerging exascale and future planned DOE leadership-class computing capabilities. The focus for CCS is on developing capabilities that allow modeling and simulation of new or previously inaccessible complex chemical systems and/or provide dramatic improvement in fidelity, scalability, and throughput. Teams should bring together expertise in domain areas (e.g., electronic structure, chemical dynamics, statistical mechanics, etc.) and other areas important to advance computational tools such as data science, algorithm development, and software architectures. Priority will be given to efforts that address reaction chemistry across multiple scales in complex environments important in geosciences, catalysis, biochemistry, or electrochemistry. CCS will continue to support the DOE Exascale Computing Initiative (ECI). The ECI aims to accelerate the research and development needed to overcome key exascale challenges and maximize benefits of high-performance computing. This funding opportunity continues the BES commitment to ECI by developing open-source codes that can take full advantage of emerging exascale and future planned DOE leadership-class computing facilities.

The Centers of Excellence in Genomic Science (CEGS) program establishes academic Centers for advanced genome research.  Each CEGS grant supports a multi-investigator, interdisciplinary team to develop innovative genomic approaches to address a particular biomedical problem.  A CEGS project will address a critical issue in genomic science or genomic medicine, proposing a solution that would be a very substantial advance.  Thus, the research conducted at these Centers will entail substantial risk, balanced by outstanding scientific and management plans and very high potential payoff.  A CEGS will focus on the development of novel technological or computational methods for the production or analysis of comprehensive data sets, or on a particular genome-scale biomedical problem, or on other ways to develop and use genomic approaches for understanding biological systems and/or significantly furthering the application of genomic knowledge, data and methods towards clinical applications.  Exploiting its outstanding scientific plan and team, each CEGS will nurture genomic science at its institution by facilitating the interaction of investigators from different disciplines, and by providing training to new and experienced investigators, it will expand the pool of highly-qualified professional genomics scientists and engineers.

The Centers of Excellence in Genomic Science (CEGS) program establishes academic Centers for advanced genome research.  Each CEGS grant supports a multi-investigator, interdisciplinary team to develop innovative genomic approaches to address a particular biomedical problem.  A CEGS project will address a critical issue in genomic science or genomic medicine, proposing a solution that would be a very substantial advance.  Thus, the research conducted at these Centers will entail substantial risk, balanced by outstanding scientific and management plans and very high potential payoff.  A CEGS will focus on the development of novel technological or computational methods for the production or analysis of comprehensive data sets, or on a particular genome-scale biomedical problem, or on other ways to develop and use genomic approaches for understanding biological systems and/or significantly furthering the application of genomic knowledge, data and methods towards clinical applications.  Exploiting its outstanding scientific plan and team, each CEGS will nurture genomic science at its institution by facilitating the interaction of investigators from different disciplines, and by providing training to new and experienced investigators, it will expand the pool of highly-qualified professional genomics scientists and engineers.

This Funding Opportunity Announcement (FOA) encourages exploratory/developmental grant (R21) applications from institutions and organizations that propose to study the effects and functional consequences of cannabis and cannabinoid exposures on the developing brain, from pre-, peri-, post-natal development through young adulthood in animal models and humans. Topics of interest pertaining to this PA include, but are not limited to: molecular and cellular mechanisms of cannabis/cannabinoid effects on the developing brain; long term functional consequences of cannabis/cannabinoid exposure on learning and memory, cognitive and emotional development. 

With this solicitation, NIJ seeks proposals for basic or applied research and development projects. An NIJ forensic science research and development grant supports a discrete, specified, circumscribed project that will: (1) increase the body of knowledge to guide and inform forensic science policy and practice, or (2) lead to the production of useful material(s), device(s), system(s), or method(s) that have the potential for forensic application. The intent of this program is to direct the findings of basic scientific research; research and development in broader scientific fields applicable to forensic science; and ongoing forensic science research toward the development of highly-discriminating, accurate, reliable, cost-effective, and rapid methods for the identification, analysis, and interpretation of physical evidence for criminal justice purposes. Projects should address the challenges and needs of the forensic science community. The operational needs discussed at NIJ's FY 2016 Forensic Science TWG meeting may be found on NIJ.gov. Additional research needs of the forensic science community can be found at the Organization of Scientific Area Committees website. While the goals and deliverables of proposed projects do not necessarily need to result in immediate solutions to the posted challenges or needs, they should speak to them and produce knowledge that adds to work towards eventual resolutions.

The primary objective is to support scholarships for nuclear science, engineering, technology and related disciplines to develop a workforce capable of supporting the design, construction, operation, and regulation of nuclear facilities and the safe handling of nuclear materials. The primary objective is to support fellowships for nuclear science, engineering, technology and related disciplines to develop a workforce capable of supporting the design, construction, operation, and regulation of nuclear facilities and the safe handling of nuclear materials. The primary objective is to support faculty development for nuclear science, engineering, technology and related disciplines to develop a workforce capable of supporting the design, construction, operation, and regulation of nuclear facilities and the safe handling of nuclear materials. The grants specifically target probationary, tenure-track faculty during the first 6 years of their career and new faculty hires in the following academic areas: Nuclear, Mechanical, Civil, Environmental, Electrical, Fire Protection, Geotechnical, Structural and Materials Sciences Engineering as well as Health Physics. The program provides support to enable newer faculty to enhance their careers as professors and researchers in the university department where employed.

The NSF/Intel Partnership on Computer Assisted Programming for Heterogeneous Architectures (CAPA) aims to address the problem of effective software development for diverse hardware architectures through groundbreaking university research that will lead to a significant, measurable leap in software development productivity by partially or fully automating software development tasks that are currently performed by humans. The main research objectives for CAPA include programmer effectiveness, performance portability, and performance predictability. In order to address these objectives, CAPA seeks research proposals that explore (1) programming abstractions and/or methodologies that separate performance-related aspects of program design from how they are implemented; (2) program synthesis and machine learning approaches for automatic software construction that are demonstrably correct; (3) advanced hardware-based cost models and abstractions to support multi-target code generation and performance predictability for specified heterogeneous hardware architectures; and (4) integration of research results into principled software development practices.

The Chemical Theory, Models and Computational Methods program supports the discovery and development of theoretical and computational methods or models to address a range of chemical challenges, with emphasis on emerging areas of chemical research.  Proposals that focus on established theoretical or computational approaches should involve innovative additions or modifications that substantially broaden their applicability.  Areas of interest include, but are not limited to, electronic structure, quantum reaction dynamics, statistical mechanics, molecular dynamics, and simulation and modeling techniques for molecular systems and systems in condensed phases.  Areas of application span the full range of chemical systems from small molecules to mesoscopic aggregates, including single molecules, biological systems and materials in condensed phases.   Despite the diverse application areas, the goal of the program is to support the development of new theoretical and computational methodologies that have the potential of being broadly applicable to a range of challenging chemical problems. We are particularly interested in fundamental areas of chemical research that are difficult or impossible to address using current synthetic, experimental, and/or computational methodologies.  We encourage the integration of innovative software development with methodological and algorithmic development, especially computational approaches that allow efficient utilization of the high end computers of the future.

The Advanced Research Projects Agency ? Energy (ARPA-E), an organization within the Department of Energy, is chartered by Congress in the America COMPETES Act of 2007 (P.L. 110-69), as amended by the America COMPETES Reauthorization Act of 2010 (P.L. 111-358), to support the creation of transformational energy technologies and systems through funding and managing Research and Development (R&D) efforts. Originally chartered in 2007, the Agency was first funded through the American Recovery and Reinvestment Act of 2009. The mission of ARPA-E is to identify and fund research to translate science into breakthrough energy technologies that are too risky for the private sector and that, if successfully developed, will create the foundation for entirely new industries. Successful projects will address at least one of ARPA-E?s two Mission Areas: 1. Enhance the economic and energy security of the United States through the development of energy technologies that result in: a. reductions of imports of energy from foreign sources; b. reductions of energy-related emissions, including greenhouse gases; and c. improvement in the energy efficiency of all economic sectors. 2. Ensure that the United States maintains a technological lead in developing and deploying advanced energy technologies.