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MiamiOH OARS

Systems Biology of Bioenergy-Relevant Microbes to Enable Production of Next-Generation ... - 0 views

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    Genomic Science program supports basic research aimed at identifying the foundational principles that drive biological systems. These principles govern the translation of the genetic code into integrated networks of proteins, enzymes, regulatory elements, and metabolite pools that are the functional processes of organisms including microbes and multispecies communities relevant to DOE missions in energy and the environment. To address the DOE mission in sustainable Bioenergy development, the Genomic Science program brings omics-driven tools of modern systems biology to bear on the challenges associated with microbial production of advanced Biofuels and Bioproducts.Developing an increased understanding of how biological systems function and translating that knowledge to enhance the production capabilities of microbes and plants forms the basis of DOE's mission in sustainable Bioenergy. To harness the biosynthetic processing power of the microbial world for advanced Biofuels and Bioproducts production, an expanded set of platform organisms with appropriate metabolic capabilities and stress tolerance characteristics with a suite of modification tools will need to be developed. To foster this development, the DOE-BER Genomic Science program supports research aimed at understanding the principles that govern the functional properties of bioenergy relevant organisms at the genomic scale.
MiamiOH OARS

PAR-18-252: Image-guided Drug Delivery (R01 Clinical Trial Optional) - 0 views

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    This Funding Opportunity Announcement (FOA) will support innovative research projects that are focused on image-guided drug delivery (IGDD), including real-time image guidance, monitoring, quantitative in vivo characterizations and validation of delivery and response. It will support research in development of integrated imaging-based systems for delivery of drugs or biologics in cancer and other diseases, quantitative imaging assays of drug delivery, and early intervention.
MiamiOH OARS

PAR-18-221: Fast-Track Development of Medications to Treat Cannabis Use Disorders (UG3/... - 0 views

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    The purpose of this Funding Opportunity Announcement (FOA) is to accelerate the discovery and development of medications to treat Cannabis Use Disorders (CUDs) using the UG3/UH3 mechanism. The objective is to advance medications toward the ultimate goal of obtaining FDA approval. Advances in understanding the cannabinoid systems and the effects of marijuana on the brain, coupled with the availability of both novel and marketed medications that may be efficacious to treat these disorders, offer unprecedented opportunities to develop safe and effective pharmacotherapies for CUDs.
    The compounds to be evaluated can be small molecules or biologics. They can be tested in pre-clinical models and/or for the clinical manifestations of CUDs or their consequences such as withdrawal, craving, or cannabis use relapse. Applications may focus on the development of new chemical entities, new formulations of marketed medications available for other indications, or combinations of medications that hold promise for the treatment of CUDs.
    The UG3/UH3 Phase Innovation Awards Cooperative Agreement involves 2 phases. The UG3 is to support a project with specific milestones to be accomplished by the end of the 2-year period. The UH3 is to provide funding for 3 years to a project that successfully completed the milestones set in the UG3. UG3 projects that have met their milestones will be administratively considered by NIDA and prioritized for transition to the UH3 phase. Investigators responding to this FOA must address both UG3 and UH3 phases.
MiamiOH OARS

Field Validation of Laboratory Tests to Assess Cracking Resistance of Asphalt Mixtures - 0 views

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    Cracking is a primary mode of distress in asphalt pavements. There are several modes of asphalt pavement cracking-thermal, reflection, fatigue, and top-down-and all are affected by numerous factors and their interactions. Recent research has evaluated a variety of laboratory tests and models to assess the cracking potential of asphalt mixtures and several are recommended for routine use. As asphalt mix designs become more complex with the use of asphalt modifiers, RAP and RAS, and warm mix asphalt technologies, highway engineers have recognized the need to establish and implement reliable performance tests that can be used to evaluate asphalt mixes and ultimately extend the life of asphalt pavements.
    NCHRP Project 09-57, "Experimental Design for Field Validation of Laboratory Tests to Assess Cracking Resistance of Asphalt Mixtures," developed experimental designs for the ruggedness testing and field validation of candidate laboratory tests to assess the resistance of asphalt mixtures to the four cracking types noted above. Candidate test methods were selected through (a) a critical review of relevant research and state mixture design practices and (b) a workshop with invited experts held in February 2015. The findings and conclusions of the project are summarized in NCHRP Research Results Digest 399: Field Validation of Laboratory Tests to Assess Cracking Resistance of Asphalt Mixtures: An Experimental Design; the contractor's final project report is available at http://onlinepubs.trb.org/onlinepubs/nchrp/docs/NCHRP09-57_FR.pdf.
    This project is the first in a series proposed to accomplish the field validation designed in Project 09-57. Research is needed to conduct ruggedness testing of the candidate test methods in anticipation of future field validation experiments.
MiamiOH OARS

Epidemiology and Prevention in Alcohol Research (R01 - Clinical Trial Optional) - 0 views

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    This Funding Opportunity Announcement (FOA) encourages the submission of investigator-initiated research grant applications to support research investigating the epidemiology of alcohol use, alcohol-related harms, and alcohol use disorders and the prevention of underage drinking, alcohol-related harms, and alcohol use disorders.
MiamiOH OARS

Energy Frontier Research Centers - 0 views

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    The Department of Energy's (DOE) Office of Basic Energy Sciences (BES) announces a re-competition of the Energy Frontier Research Centers (EFRC) and encourages both new and renewal applications. Applications will be required to address priority research directions identified by the series of "Basic Research Needs" reports, the scientific grand challenges identified in the report Directing Matter and Energy: Five Challenges for Science and the Imagination, and the opportunities described in the report Challenges at the Frontiers of Matter and Energy: Transformative Opportunities for Discovery Science. All of these reports are described below. Funding will be competitively awarded to the successful Energy Frontier Research Center applications selected by Federal officials, based on a rigorous merit review process as detailed in Section V of this Funding Opportunity Announcement (FOA).
MiamiOH OARS

Major Research Instrumentation (MRI) Program: Instrument Acquisition or Development (ns... - 0 views

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    The Major Research Instrumentation (MRI) Program serves to increase access to multi-user scientific and engineering instrumentation for research and research training in our Nation's institutions of higher education and not-for-profit scientific/engineering research organizations. An MRI award supports the acquisition or development of a multi-user research instrument that is, in general, too costly and/or not appropriate for support through other NSF programs.
MiamiOH OARS

Office of Naval Research (ONR) Navy and Marine Corps Department of Defense University R... - 0 views

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    1. Lithium-ion Battery Safety. Safety concerns continue to hamper full adoption of lithium-ion batteries for defense systems, despite significant research investments by the government and the private sector. This Defense initiative will advance promising lithium-ion battery safety technologies at university research laboratories into early laboratory prototypes and potentially minimum viable products for adoption by the defense and commercial sectors via early startups, small businesses and non-traditional defense contractors. Specific technical areas of interest include, but are not limited to, the following: improved electrolytes; stable high-energy anodes and cathodes; cell components and structures that enhance safety and reliability (e.g. use of electrode coatings and electrolyte additives); safety optimization through battery and battery module design and packaging; and battery management and state of health techniques that prevent and/or mitigate catastrophic failure. 2. Electrical Grid Reliability, Resiliency and Security. Both the defense and commercial sectors recognize the ever-growing criticality to enhance electrical grid reliability, resiliency and security through innovation at the component and system levels.
MiamiOH OARS

Global Chemical Security Engagement Activities - 0 views

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    The Office of Cooperative Threat Reduction (CTR), part of the Department's Bureau of International Security and Nonproliferation (ISN), sponsors foreign assistance activities funded by the Nonproliferation, Anti-terrorism, Demining and Related Programs (NADR) account, and focuses on mitigating proliferation risk in frontline states and regions where terrorist threats are on the rise, such as in the Middle East, Africa and Asia. ISN/CTR administers the Chemical Security Program (CSP) in partnership with government, security, academic, and industrial communities to strengthen their ability to prevent chemical attacks. CSP secures chemical weapons-related assets (such as chemicals, equipment, technologies, expertise, and infrastructure) against terrorist networks and proliferant states intent on conducting chemical attacks. To accomplish this mission, CSP sponsors efforts to identify and address chemical security vulnerabilities and to detect and investigate early warning signs of chemical attacks. CSP focuses its resources in countries where non-state actors and returning foreign fighters have demonstrated an ability or interest in using chemical weapons, and seeks to instill sustainable chemical security capabilities in partner countries.
MiamiOH OARS

Identification and application of acidification thresholds in coastal ecosystems - 0 views

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    The purpose of this document is to advise the public that NOAA/NOS/National Centers for Coastal Ocean Science (NCCOS and the NOAA Ocean Acidification Program (OAP) are soliciting proposals for the Identification and Application of Acidification Thresholds in Coastal Ecosystems. Funding is contingent upon the availability of Fiscal Year 2018 Federal appropriations. It is anticipated that projects funded under this announcement will have a September 1, 2018 start date. Total funding for this research: Applicants should submit proposals not to exceed $350,000 per year for projects generally 2-3 years in duration, with a total multi-year budget not to exceed $1,050,000. If funds become available for this program, up to approximately $1,000,000 may be available in Fiscal Year 2018 for the first year of about 1-3 projects with expected start dates of September 1, 2018. Funding for this program is contingent upon availability of funds, which may not have been appropriated at the time of this announcement.. While projects are expected to be 2-3 years in scope, funding may be spread over 4 federal fiscal years depending on how project timelines align with federal budgets.
MiamiOH OARS

Office of Naval Research (ONR) Navy and Marine Corps Department of Defense University R... - 0 views

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    1. Lithium-ion Battery Safety. Safety concerns continue to hamper full adoption of lithium-ion batteries for defense systems, despite significant research investments by the government and the private sector. This Defense initiative will advance promising lithium-ion battery safety technologies at university research laboratories into early laboratory prototypes and potentially minimum viable products for adoption by the defense and commercial sectors via early startups, small businesses and non-traditional defense contractors. Specific technical areas of interest include, but are not limited to, the following: improved electrolytes; stable high-energy anodes and cathodes; cell components and structures that enhance safety and reliability (e.g. use of electrode coatings and electrolyte additives); safety optimization through battery and battery module design and packaging; and battery management and state of health techniques that prevent and/or mitigate catastrophic failure. 2. Electrical Grid Reliability, Resiliency and Security. Both the defense and commercial sectors recognize the ever-growing criticality to enhance electrical grid reliability, resiliency and security through innovation at the component and system levels. This Defense initiative will advance relevant electrical grid innovations at university research laboratories into early laboratory prototypes and potentially minimum viable products for adoption by the defense and commercial sectors via early startups, small businesses and non-traditional defense contractors. Specific technical areas of interest include, but are not limited to, the following: advanced electrical power generation, transmission and distribution hardware and software; physical cyber secured industrial controls hardware and software; effective control of microgrids supporting high-dynamic loads; electrical grid protocols and controls to maintain secured operations of critical infrastructure under adverse conditions; hardening of e
MiamiOH OARS

Applying Metabolomics to Drive Biomarker Discovery in Symptom Science (R01 Clinical Tri... - 0 views

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    The purpose of this funding opportunity announcement is to encourage applications on biomarker discovery that utilize metabolomics approaches to advance the understanding, assessment and management of symptoms.
MiamiOH OARS

Applying Metabolomics to Drive Biomarker Discovery in Symptom Science (R01 Clinical Tri - 0 views

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    The purpose of this funding opportunity announcement is to encourage applications on biomarker discovery that utilize metabolomics approaches to advance the understanding, assessment and management of symptoms.
MiamiOH OARS

Advancing Translational and Clinical Probiotic/Prebiotic and Human Microbiome Research ... - 0 views

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    The purpose of this funding opportunity announcement (FOA) is twofold: 1. to accelerate translational and clinical Phase I and II a/b safety and efficacy studies for substantiating measurable functional benefits of probiotic/prebiotic components and/or their combinations; and; 2. to understand the underlying mechanisms of their action(s), and variability in responses to these interventions.
    This FOA calls for interdisciplinary collaborations across scientific disciplines engaged in microbiome and pro/prebiotic research including, but not limited to: nutritional science, microbiology, virology, microecology and microbiome, genomics, immunology, computational biology, chemistry, bioengineering, as well as integration of omics and computational approaches in DNA technologies.
MiamiOH OARS

George M. O'Brien Urology Cooperative Research Centers Program (U54-Clinical Trial Opti... - 0 views

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    The purpose of this Funding Opportunity Announcement (FOA) is to seek applications for the George M. O'Brien Urology Cooperative Research Centers Program. This program will provide a coordinated platform for multidisciplinary interactions between basic and clinical scientists with the overall goal of understanding the etiology and development of benign urologic diseases and disorders, and providing a collaborative venue to design better treatments, diagnostics, and prevention strategies for these disease conditions within the NIDDK mission interests. This program will also serve as a national resource to the larger urological research community and provide educational enrichment opportunities to scientists electing to pursue research in benign urology. Accordingly, applications are sought from individuals willing to cooperate with the NIDDK under a cooperative centers program. The funded Centers will work with the NIDDK in facilitating research collaborations and interactions within and among centers and with the larger research community to accomplish the overall goal of improving treatment of urologic disorders through enhanced communication and research excellence.
MiamiOH OARS

Examination of Survivorship Care Planning Efficacy and Impact (R01 Clinical Trial Optio... - 0 views

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    The purpose of this Funding Opportunity Announcement (FOA) is to stimulate research evaluating the effect of care planning on self-management of late effects of cancer therapy; adherence to medications, cancer screening, and health behavior guidelines; utilization of follow-up care; survivors' health and psychosocial outcomes. How organizational-level factors influence the implementation of care planning and its associated costs is also of interest. Specifically, the FOA aims to stimulate research that will: 1) develop and test metrics for evaluating the impact of survivorship care planning; 2) evaluate the impact of survivorship care planning on cancer survivors' morbidity, self-management and adherence to care recommendations, utilization of follow-up care; 3) evaluate effects of planning on systems outcomes, such as associated costs and impact on providers and organizations implementing the care planning; and 4) identify models and processes of care that promote effective survivorship care planning. The ultimate goal of this FOA is to generate a body of science that will inform the development and delivery of interventions that improve follow-up care for cancer survivors.
MiamiOH OARS

Examination of Survivorship Care Planning Efficacy and Impact (R21 Clinical Trial Optio... - 0 views

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    The purpose of this Funding Opportunity Announcement (FOA) is to stimulate developmental research evaluating the effect of care planning on self-management of late effects of cancer therapy; adherence to medications, cancer screening, and health behavior guidelines; utilization of follow-up care; survivors' health and psychosocial outcomes. How organizational-level factors influence the implementation of care planning and its associated costs is also of interest. Specifically, the FOA aims to stimulate research that will: 1) develop and test metrics for evaluating the impact of survivorship care planning; 2) evaluate the impact of survivorship care planning on cancer survivors' morbidity, self-management and adherence to care recommendations, utilization of follow-up care; 3) evaluate effects of planning on systems outcomes, such as associated costs and impact on providers and organizations implementing the care planning; and 4) identify models and processes of care that promote effective survivorship care planning. The ultimate goal of this FOA is to generate a body of science that will inform the development and delivery of interventions that improve follow-up care for cancer survivors.
MiamiOH OARS

NIDDK Program Projects (P01 Clinical Trial Optional) - 0 views

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    This Funding Opportunity Announcement (FOA) invites submission of investigator-initiated program project applications. The proposed programs should address scientific areas relevant to the NIDDK mission including diabetes, selected endocrine and metabolic diseases, obesity, digestive diseases and nutrition, and kidney, urologic and hematologic diseases, as well as new approaches to prevent, treat and cure these diseases, including clinical research. A description of NIDDK scientific program areas can be found at http://www.niddk.nih.gov/about-niddk/research-areas/pages/research-areas.aspx .
MiamiOH OARS

Clarifying the Relationship between Delirium and Alzheimers Disease and Related Dementi... - 0 views

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    This Funding Opportunity Announcement (FOA) invites applications that focus on clarifying the relationship between delirium and Alzheimer's disease and related dementias (ADRD). Specifically sought is research focusing on understanding why persons with ADRD are at increased risk to develop delirium, often with a worse prognosis compared to those without antecedent ADRD, and why patients who experience delirium are at higher risk to develop subsequent short- and/or long-term mild cognitive impairment or ADRD, often with an accelerated rate of cognitive decline compared to those without preceding delirium. Relevant research projects may focus on, but are not limited to, those that A) provide insight into possible common, sequential, causative, contributory and/or synergistic pathways underlying both ADRD and delirium, B) elucidate mechanisms that lead to the development of delirium against the background of aging and/or neurodegeneration, with particular emphasis on use of appropriate animal models, C) identify risk factors for the onset and/or progression of delirium in those with ADRD and vice versa, D) diagnose and assess one condition in the setting of the other, E) identify putative phenotypes of patients with co-existing ADRD and delirium, or F) test pharmacologic and/or non-pharmacologic strategies to prevent, treat, or reduce the impact of delirium in patients with ADRD and vice versa. Research supported by this FOA is intended to provide mechanistic insight to improve risk assessment, diagnosis, phenotyping, prevention, and management approaches for both delirium and ADRD.
MiamiOH OARS

Enabling Discovery through GEnomic Tools - 0 views

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    : The Division of Integrative Organismal Systems (IOS) continues to support the Enabling Discovery through GEnomic Tools (EDGE) program, previously a component of the IOS Core Programs solicitation (NSF 16-505). EDGE is designed to provide support for research addressing current impediments to research progress in organismal biology. In particular, the ability to directly test gene function is essential to improve understanding of the genomes-to-phenomes relationship, an area relevant to Understanding the Rules of Life, one of 10 Big Ideas for future NSF investment (www.nsf.gov/about/congress/reports/nsf_big_ideas.pdf). EDGE projects should focus on development of functional genomic tools, approaches, and associated infrastructure to enable direct tests of hypotheses about gene function in diverse organisms for which such tools and infrastructure are presently unavailable. EDGE proposals must include training and rapid dissemination plans enabling larger communities of investigators to utilize the newly-developed tools, thereby catalyzing an increase in the capacity of research communities to test cause-and-effect hypotheses about genes and phenotypes in organisms for which such tools and infrastructure are presently lacking.
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