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This Funding Opportunity Announcement (FOA) encourages transdisciplinary research that will leverage cognitive neuroscience to improve traditional measurement of cognitive impairment following cancer treatment, often referred to as chemobrain. A better understanding of the acute- and late-term cognitive changes following exposure to adjuvant chemotherapy and molecularly-targeted treatments, including hormonal therapy, for non-central nervous system tumors can inform clinical assessment protocols with downstream implications for survivorship care plans.

This Funding Opportunity Announcement (FOA) encourages transdisciplinary research that will leverage cognitive neuroscience to improve traditional measurement of cognitive impairment following cancer treatment, often referred to as chemobrain. A better understanding of the acute- and late-term cognitive changes following exposure to adjuvant chemotherapy and molecularly-targeted treatments, including hormonal therapy, for non-central nervous system tumors can inform clinical assessment protocols with downstream implications for survivorship care plans.

This Funding Opportunity Announcement (FOA) encourages transdisciplinary research that will leverage cognitive neuroscience to improve traditional measurement of cognitive impairment following cancer treatment, often referred to as "chemobrain." A better understanding of the acute- and late-term cognitive changes following exposure to adjuvant chemotherapy and molecularly-targeted treatments, including hormonal therapy, for non-central nervous system tumors can inform clinical assessment protocols with downstream implications for survivorship care plans.

The Leukemia & Lymphoma Society is accepting Letters of Intent from researchers for projects to identify and develop safer, more effective treatments for patients with blood cancers. Through the Quest for Cures initiative, LLS, in partnership with biopharmaceutical company Celgene, will award two-year grants of between $200,000 and $400,000 a year for research projects that have a measurable impact over the next five to ten years on the diagnosis or treatment of patients with hematologic malignancies. Additional funding may be available for projects that have demonstrated exceptional progress in the initial two years. Specifically, the initiative will award grants in the following priority areas: Tumor cell clonal heterogeneity: This grant will support researchers seeking novel approaches for measuring and monitoring clonal heterogeneity and assessing its contribution to the response or resistance to therapy. New molecular stratification mechanisms: Recipients of this grant will work to identify key subsets of patients with B-cell malignancies to help predict which patients will have poor outcomes from current standard therapies so they may be directed to alternative therapies. Bone marrow and lymph node microenvironments: Researchers will seek to enhance the understanding of the role that the bone marrow and lymph node microenvironments play in either responding to or resisting therapy.

The Leukemia & Lymphoma Society has issued new Requests for Proposals through its Translational Research Program to support researchers in six critical areas of unmet medical need. The RFPs mark LLS's aggressive and proactive approach to addressing the challenge of improving outcomes for cancer patients with particularly urgent needs. The LLS Translational Research Program is designed to help accelerate the movement of promising discoveries from lab to clinic. The goal of translational research is to reduce the time between laboratory findings and actual treatment. The society aims to stimulate more academic research in the following areas: new immunotherapeutics for patients with acute myelogenous leukemia; novel therapeutics for patients with non-cutaneous T-cell malignancies; introduction of novel agents in the treatment of patients with diffuse large B-cell lymphoma and mantle cell lymphoma; therapies for patients with myelodysplastic syndromes who have failed hypomethylating agents; therapies for new targets such as bromodomains, methylation, and other epigenetic approaches for patients with high-risk myeloma; and research that addresses long-term and late effects of blood cancer therapies.

PCORI seeks to fund pragmatic clinical trials, large simple trials, or large-scale observational studies that compare two or more alternatives for addressing prevention, diagnosis, treatment, or management of a disease or symptom; improving healthcare system-level approaches to managing care; communicating or disseminating research results to patients, caregivers, or clinicians; or eliminating health or healthcare disparities. Proposed studies must address critical clinical choices faced by patients, their caregivers, clinicians, or delivery systems. They must involve broadly representative patient populations and be large enough to provide precise estimates of hypothesized effectiveness differences and to support evaluation of potential differences in treatment effectiveness in patient subgroups.

This year, PCAN has partnered with the Celgene Corporation to accelerate the development of novel therapies by establishing strong relationships between academia and industry through research grants. Funded projects will benefit from industry input and insight, leading to an accelerated translation to a therapeutic product. Projects should aim to identify novel targets and approaches to the treatment of pancreatic cancer or understand and circumvent treatment resistance. Of particular interest are projects that fall into at least one of these three areas of research: a) immune context and tumor micro-environment interactions; (b) regulators of pathogenesis, progression, and metabolism, with particular interest in epigenetic mechanisms; and (c) transcriptional networks essential for viability and maintenance of malignant phenotype.

Tobacco use remains the leading preventable cause of disease and death in the United States. More than half of smokers attempt to quit each year, but fewer than one in ten succeed. Evidence-based cessation treatments, including individual, group, and telephone counseling and seven FDA-approved cessation medications, exist, but are underutilized. The Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health is announcing the opportunity to apply for funds for a competitive, non-research cooperative agreement to provide technical assistance to state tobacco control programs and other partners to translate the science of tobacco control cessation into public health action in order to further increase the rate of cessation among tobacco users in the United States. The funded organizations will accomplish this by providing technical assistance to state tobacco control programs and other partners to 1) Implement health systems change initiatives that seek to integrate tobacco dependence treatment into routine clinical care, including care of persons with behavioral health conditions; and 2) Improve state quitlines' infrastructure, operations, and services to further enhance their effectiveness and efficiency, increase state quitlines' reach, especially among populations experiencing tobacco-related disparities, broaden the range of cessation services offered by state quitlines, and enhance quitline sustainability.

The mission of the American Society for Hematology, the world's largest professional organization dedicated to the causes and treatment of blood disorders, is to further the understanding, diagnosis, treatment, and prevention of disorders affecting the blood, bone marrow, and immunologic, hemostatic and vascular systems through the promotion of research, clinical care, education, training, and advocacy in hematology. To that end, ASH is accepting proposals from hematologists whose research would not otherwise be accomplished due to cuts in NIH funding. Established in January 2013, the long-term goal of the program is to help sustain recipients' research and contribute to their retention in hematology investigation. The Bridge Grants program will provide at least thirty one-year awards annually, in the amount of $150,000 each, to ASH members who applied for an NIH R01 grant or equivalent but were denied funding due to budget cuts. Grants will support projects in basic, translational, patient-oriented, or outcomes-based research.

The DeGregorio Family Foundation for Gastric and Esophageal Cancer seeks to promote and facilitate collaborative research on the pathogenesis, early diagnosis, and treatment of upper gastrointestinal malignancies. To that end, the foundation has issued a Request for Proposals for its ninth annual funding opportunity for gastroesophageal malignancies. Through the RFP, grants of up to $250,000 will be awarded in support of innovative, high-quality translational and bench research that improves the understanding of the biology of these diseases, identification of potential novel therapeutic targets, and/or the development and evaluation of novel biomarkers for early diagnosis and treatment. Pre-clinical research, basic mechanistic studies, genomic/epigenomic studies, and epidemiologic studies are eligible for support.

This Funding Opportunity Announcement (FOA) invites applications that seek to apply one or more innovative methodologies in communication research across the cancer control continuum, from prevention, early detection, diagnosis, treatment, and survivorship, to end of life. Applications to this FOA should utilize one or more of the following analytic approaches, methods, and data sources, including but not limited to social media data mining, Natural Language Processing (NLP) techniques, online social network analysis, crowdsourcing research tools (e.g., mTurk), online search data, Ecological Momentary Assessment, neuroscience and biobehavioral approaches to communication, and geographic information systems. Studies should assess outcomes related to cancer prevention and control (e.g., knowledge, attitudes, beliefs, perceived risk, decision making in screening and treatment, information inequalities, social support, shared decision making, persuasion, caregiving, behavioral intentions, preventive behaviors, and policy support, among others). This FOA utilizes the Exploratory/Developmental Grant (R21) mechanism, which supports investigation of novel scientific ideas or new model systems, tools, or technologies that have the potential for significant impact on biomedical or biobehavioral research.

The aim of the CDA is to support the next generation of researchers and to significantly improve outcomes and quality of life for breast cancer patients. The award will provide up to $100,000 per year for two years to be combined with matching funds or in kind contribution from the applicant's institution. Neither ASTRO nor BCRF will pay indirect costs as part of this award. One award will be funded. Research must be focused on understanding or treatment of breast cancer and include use or impact of radiation treatment.

The aim of the CDA is to support the next generation of researchers and to significantly improve outcomes and quality of life for prostate cancer patients. The award will provide up to $75,000 per year for three years to be combined with matching funds or in kind contribution from the applicant's institution. Neither ASTRO nor PCF will pay indirect costs as part of this award. One award will be funded. Research must be focused on understanding or treatment of prostate cancer and include use or impact of radiation treatment.

This FOA encourages research relevant to the development of therapeutic interventions for potentially fatal or disabling conditions that have been identified through newborn screening, as well as "high priority" genetic conditions where screening may be possible in the near future. Demonstrating the benefits of treatment is often a primary criterion for including a condition on a newborn screening panel; therefore, this FOA, a "high priority" condition is one where screening is not currently recommended but would significantly benefit from early identification and treatment. Also listed under R03

This Funding Opportunity Announcement (FOA) invites applications that seek to apply one or more innovative methodologies in communication research across the cancer control continuum, from prevention, early detection, diagnosis, treatment, and survivorship, to end of life. Applications to this FOA should utilize one or more of the following analytic approaches, methods, and data sources, including but not limited to social media data mining, Natural Language Processing (NLP) techniques, online social network analysis, crowdsourcing research tools (e.g., mTurk), online search data, Ecological Momentary Assessment, neuroscience and biobehavioral approaches to communication, and geographic information systems. Studies should assess outcomes related to cancer prevention and control (e.g., knowledge, attitudes, beliefs, perceived risk, decision making in screening and treatment, information inequalities, social support, shared decision making, persuasion, caregiving, behavioral intentions, preventive behaviors, and policy support, among others). Also listed under R21

Research progress in the treatment for diseases of the exocrine pancreas [chronic pancreatitis (CP), pancreatogenic diabetes mellitus, and pancreatic cancer] has been hampered by the disorders' heterogeneity, the limitations of previous small cross-sectional studies, the inability to safely obtain pancreatic tissue for discovery, and the lack of structured epidemiology tools, genetic testing, and biomarker development and validation. Mechanism-based research of these diseases has suffered from the lack of systematically collected clinical measures in longitudinal cohort studies linked with biospecimens. Given the increasing incidence and prevalence of CP and its association to the development of pancreatic cancer, its complications, high mortality rate, and associated health care cost, the National Institute for Diabetes and Digestive and Kidney Diseases and the National Cancer Institute established in 2015 the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer (CPDPC) Consortium as multidisciplinary teams composed of members from the Clinical Centers and Coordination and Data Management Center to undertake a comprehensive clinical, epidemiological, and biological characterization of patients with CP (including adults and children with recurrent acute pancreatitis) to develop treatments and gain insight into the pathophysiology of CP and its sequela: chronic pain, pancreatic exocrine and endocrine insufficiency, T3cDM, and the diabetes/pancreatic cancer association. Another objective was to undertake studies on the development of pancreatic cancer in newly diagnosed diabetic patients

This Funding Opportunity Announcement (FOA) encourages research project applications under the cooperative agreement (UG3/UH3) mechanism to address the development, optimization and validation of quantitative imaging (QI) software tools and methods for prediction and/or measurement of response to cancer therapies or for planning and validating radiation therapy treatment strategies in clinical trials. The scientific scope of this FOA includes: · Development and optimization of QI tools and/or methods for treatment planning, predicting or measuring response to therapy as open source tools that will translate into clinical trial decision support; · Validation of the optimized tools in clinical settings to demonstrate their value for decision support in ongoing single-site or multi-site clinical trials. A phased approach that emphasizes each of these activities must be proposed. Investigators must apply for both the UG3 and UH3 phases together in the single application. The UG3 effort is to be used for the development and optimization of QI tools and methods chosen for study by the investigating team, while the UH3 phase is for the validation of the tools/methods developed in the UG3 phase. The UG3 phase can be no more than 2 years in duration, and the total project cannot exceed 5 years. At completion, UG3 projects will be reviewed by program staff. Those that have met their milestones may be administratively considered by NCI program staff for transition to the UH3 validation phase.

A Kids' Brain Tumor Cure, a national non-profit organization, was founded in 2007 by a group of dedicated parents, physicians and friends to improve the treatment, quality of life, and long-term outlook for children with brain tumors through research, support, education, and advocacy. The number one priority of A Kids' Brain Tumor Cure Foundation is to act as a catalyst for researchers world-wide to turn their attention to the area of pediatric low grade glioma brain tumor research and to award research grants for the most promising programs and studies. Proposals related to basic and translational* projects that can advance understanding of the underlying biology of the development and treatment of PLGA tumors will be considered. Investigators in the early years of their careers are encouraged to apply.

BBCR works to advance its mission in four principal ways: supporting academic research institutions as they research tools and techniques that can increase the accuracy of and improve outcomes in biopsies and tumor removal procedures; identifying ways to improve patient outcomes and access; investing in emerging research and researchers; and serving as an active contributor to the culture of access and innovation in cancer care. To that end, BBCR is accepting applications from organizations doing breakthrough research focused on the prevention, treatment, and cures for breast and prostate cancer. Grants ranging between $5,000 and $25,000 will be awarded to teams doing research with the potential to significantly improve cancer prevention, treatment, access to, and, ultimately, a cure for breast and prostate cancer.

The AACR-The Mark Foundation for Cancer Research "Science of the Patient" (SOP) Grants Program represents a joint effort to stimulate novel research aimed at understanding the influence of the biology of the host (i.e., patient) on the genesis, development, treatment, and survivorship of cancer. Successful projects should emphasize the interplay of host physiological systems with the tumor and/or tumor microenvironment. Harnessing the powerful approach of examining cancer not as an isolated phenomenon but as a systemic disease that affects and is affected by both the normal and pathological functions of the patient's body, these grants are expected to yield important advancements in our understanding of cancer development, progression, and treatment. Individuals with innovative ideas that have the potential to affect future clinical practice are particularly encouraged to apply.  Each grant will provide $750,000 over three years for expenses related to the research project, which may include salary and benefits of the grant recipient and any collaborators, postdoctoral or clinical research fellows, graduate students (including tuition costs), and research assistants; research/laboratory supplies; equipment; travel applicable to the research project; publication charges for manuscripts that pertain directly to the funded project; other research expenses; and indirect costs.