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This Funding Opportunity Announcement (FOA) invites applications for a Data Coordinating Center (DCC) that will support the Diabetic Foot Consortium (DFC) for clinical research on diabetic foot ulcers. The first studies will validate biomarkers that predict healing or response to therapy and assess infection or recurrence risk.  Future research may involve clinical trials and studies on the pathophysiology of diabetic foot ulcers.  The applicant must have experience serving as the DCC for studies on complex, clinical conditions because of the multi-faceted nature of diabetic foot ulcers and their treatments.  The DCC will provide overall project coordination, administration, quality control, data management, and biostatistical support.

This Funding Opportunity Announcement (FOA) invites applications for a Data Coordinating Center (DCC) that will support the Diabetic Foot Consortium (DFC) for clinical research on diabetic foot ulcers. The first studies will validate biomarkers that predict healing or response to therapy and assess infection or recurrence risk. Future research may involve clinical trials and studies on the pathophysiology of diabetic foot ulcers. Given the clinical complexity of diabetic wound healing, the applicant must have experience serving as the DCC on clinical studies of diabetic foot ulcers. The DCC will provide overall project coordination, administration, quality control, data management, and biostatistical support.

The purpose of this funding opportunity announcement (FOA) is to stimulate clinical research that applies a social genomics approach to chronic wound risk, presence, progression, and healing. The field of social genomics focuses on how the social environment influences gene expression, and how this gene expression may in turn impact health outcomes. Chronic wounds (e.g., diabetic ulcers, venous or arterial ulcers) are multidimensional and, as such, there is benefit to a holistic approach that goes beyond a focus on the wound (i.e., repairing the skin and underlying tissue) to include an approach that focuses on the person with the wound. A better understanding of social environmental factors (positive and negative) and associated molecular mechanisms is needed to advance therapeutic strategies aimed at reducing chronic wound risk in addition to improving healing outcomes and quality of life.

 Research Fellowship Awards are intended to encourage the development of individuals with research potential to help them prepare for a career of independent basic and/or clinical investigation in the area of Crohn's disease  and ulcerative colitis.

Half of all Crohn's disease patients will develop disease complications, one of which is development of fibrotic strictures (fibrostenosis) leading to GI tract obstruction and severe clinical consequences. Fibrostenosis is also a serious problem for ulcerative colitis, with approximately 8 percent incidence over a lifetime. Currently there is no clinical solution for preventing or treating fibrostenosis in patients with inflammatory bowel disease (IBD) except for surgical intervention. Therefore, there is a great unmet need to understand fibrotic complications in IBD and how to prevent and treat them.

The mission of the Crohn's & Colitis Foundation is to cure Crohn's disease and ulcerative colitis, and to improve the quality of life of children and adults affected by these diseases. In order to pursue this mission, the Crohn's & Colitis Foundation seeks to support and accelerate the discovery and development of research-based products with potential for positive impact for patients suffering from inflammatory bowel diseases (IBD). The Foundation hereby solicits proposals from companies and academic investigators seeking support for the discovery and development of such products. Proposals will be reviewed in order to determine whether programs are eligible for Foundation support through the Entrepreneurial Investing (EI) Initiative to fund the discovery and development of products with potential for benefit in the IBD field. Funded programs may be led by investigators at companies or academic institutions. The EI program is not a traditional research grant mechanism. Its objective is to identify and support organizations that will benefit from partnership with the Foundation in pursuit of product discovery and development. This document identifies program policies and terms, funding and resources available for fundees, eligibility, selection criteria and application procedures.

Inflammatory bowel disease (IBD), encompassing Crohn’s disease and ulcerative colitis, is characterized by chronic inflammation of gastrointestinal tract. In 2015, approximately three million US adults reported having a diagnosis of IBD and the estimated number has increased greatly from 1.8 million since 1999. While the exact cause is unknown, the severity and progression of the disease largely impacts the patients’ quality of life and imposes huge financial burden to the US healthcare system. The purpose of this announcement is to 1) establish a new IBD registry to estimate incidence of IBD in the adult and pediatric populations and extrapolate to the US population; 2) describe the natural history and outcomes of IBD; 3) determine racial/ethnic variation in the detection and management of IBD; and 4) identify evidence-based strategies to improve disease outcomes. The results are anticipated to enhance understanding of the impact of IBD on the overall health of affected persons and the impact of various clinical practices and healthcare delivery approaches on the disease outcomes.

Support to patients with primary sclerosing cholangitis, an autoimmune disease that causes the bile ducts inside and outside the liver to become scarred, narrowed, and eventually blocked, as well as their families and caregivers, and to raise funds for research on the causes, treatments, and a cure for PSC. To that end, the foundation offers grants of up to $60,000 over two years tor research projects that address an important and novel, basic, or clinical research question related to PSC and closely allied diseases (such as inflammatory bowel diseases, ulcerative colitis, or Crohn's disease).

To that end, the foundation offers grants of up to $60,000 over two years tor research projects that address an important and novel, basic, or clinical research question related to PSC and closely allied diseases (such as inflammatory bowel diseases, ulcerative colitis, or Crohn's disease).