Group items tagged

1. Basic Science of Gene Therapy for Hemophilia * Basic science, tropism, transduction efficiency & tolerability of Adeno associated virus (AAV) * AAV antibody seroprevalence, titer- assessment, reduction & tolerance * Role of immunosuppression in managing immune response and potential retreatment * Effect of Gene Therapy on liver biology 2. Basic Science of TFPI & Anti-TFPI Monoclonal Antibodies * Basic biology of TFPI interactions with Protein C, ATIII & Protein S * Cross talk among regulators (e.g., Protein S being a co-factor for both Protein C and TFPI) * Role of different TFPI pools in regulation of coagulation * Impact of concomitant treatments (especially antifibrinolytics) added to anti-TFPI on the physiology of hemostasis * Note: Pfizer will not supply study drug 3. Burden of disease: Clinical Hemophilia A and B * Natural history of hemophilia and adherence to current standard of care * Arthropathy: presence, development, clinical burden & joint damage in hemophilia * Patient experiences with hemophilia, treatment preferences and quality of care * Quality of Life/Work analysis and cost of care in Hemophilia

Through this Funding Opportunity Announcement (FOA), the National Cancer Institute (NCI) as a part of its Beau Biden Cancer Moonshot Initiative invites submission of applications requesting support for projects that will accelerate cancer research. Specifically, this FOA targets the following area designated as a scientific priority by the Blue Ribbon Panel (BRP) as Recommendation I: Generation of Human Tumor Atlases. The overarching goal of this FOA is to accelerate research efforts conducted and led by the Human Tumor Atlas Network (HTAN, humantumoratlas.org) via the implementation of three-dimensional (3D) imaging technologies that will allow for a comprehensive view of the dynamic multidimensional ecosystems that define tumors in humans. Each project will lead to the multiplexed 3D characterization of at least one cancer transition investigated by the HTAN (pre-malignant to malignant, primary to metastatic, therapy responsive to resistant). The data and analytical tools generated through this FOA will be made available for use by the research and clinical communities through the activities of the HTAN Data Coordinating Center.

Navigating the New Arctic (NNA) embodies an important forward-looking response by the Foundation to these profound challenges. NNA seeks innovations in fundamental convergence research across the social, natural, environmental, computing and information sciences, and engineering that address the interactions or connections among natural and built environments and social systems, and how these connections inform our understanding of Arctic change and its local and global effects. This solicitation requests proposals that fall within one of three tracks: NNA Planning Grants, dedicated to developing convergence research questions and teams to tackle projects of larger scope in the future; NNA Research Grants, aimed to support creative projects on fundamental research that address convergent scientific and engineering challenges related to the rapidly changing Arctic; and NNA Collaboratory Grants, designed to support collaborative teams undertaking research and training initiatives on critical themes of a broad scope related to the New Arctic.

In emerging areas of technology at the interface between fields such as the engineering of biology and cellular biomanufacturing, including the field of synthetic biology, there is an even greater need for collaborative precompetitive research that will ensure the success of these nascent technology areas. In particular, research that contributes to the establishment of standards for production; provides tools for the assessment of quality, robustness and stability of the process and product; and develops metrics that will facilitate risk assessment associated with a regulatory framework, will be essential for the eventual commercialization of products from the engineering of biology.

This funding opportunity announcement (FOA) in support of the Human Placenta Project (HPP) aims to support the initial stages of development of entirely new or next-generation placental imaging and assessment technologies and methods that will increase our capability to assess human placental structure and function safely in vivo throughout gestation and to explore the impact of environmental influences on placental structure and function across pregnancy.

The purpose of this Funding Opportunity Announcement (FOA) is to support short-term exploratory, developmental, and transdisciplinary research to understand the immunologic events that occur during blood feeding by hematophagous arthropods. The scientific objectives of this initiative are (1) to understand the immunological events in the vertebrate host, which occur during and after blood feeding by hematophagous arthropods, at the bite site (skin) and systemically; (2) to identify and characterize the immune modulatory properties of arthropod salivary components; and (3) to understand the immunological events in the hematophagous arthropods following a blood meal.

To support generation of single cell datasets for one or more brain regions relevant to opioid use disorder and persistent HIV infection. If fully successful, this project will generate 1. A cellular parts list for selected NIDA-relevant brain regions, 2. Reveal how cell types within these brain regions differ from one another with respect to gene expression, 3. Reveal how cell types within these brain regions are altered by chronic opioid exposure providing potential novel therapeutic targets for opioid addiction, 4. Reveal how HIV infection in the CNS influences single cells, providing potential targets for improving HIV neurobiological sequelae, and 5. Uncover potential synergistic effects of chronic opioid exposure and HIV infection in the CNS.

The purpose of this NOFO is to provide funding and technical assistance for PEPFAR countries to establish HIV recent infection surveillance to detect recent infections, monitor trends in the HIV epidemic, identify hot spots associated with recent HIV transmission, and inform programmatic interventions to reach epidemic control. Point-of-care tests for recent infection distinguish between recent (HIV seroconversion in the last 6 months, on average) and non-recent HIV infection and provide results within minutes. These data may be linked to HIV case-based surveillance for ongoing epidemic monitoring and used by programs to provide enhanced counselling for immediate ART initiation, prioritize index testing, and intervene to prevent HIV transmission. This NOFO will require a multi-disciplinary team with expertise in surveillance, laboratory, prevention, HIV testing services, health informatics, data management, data analytics, and supply chain to support the planning, implementation, and impact evaluation of this PEPFAR priority activity.

The PREPARE program aims to develop programmable gene modulators for humans that can provide specific, effective, safe, and transient medical countermeasures and prophylaxes to combat chemical, biological, radiological, and/or nuclear (CBRN) threats.

The NIH Research Education Program (R25) supports research educational activities that complement other formal training programs in the mission areas of the NIH Institutes and Centers. The over-arching goals of the NIH R25 program are to: (1) complement and/or enhance the training of a workforce to meet the nation's biomedical, behavioral and clinical research needs; (2) encourage individuals from diverse backgrounds, including those from groups underrepresented in the biomedical and behavioral sciences, to pursue further studies or careers in research; (3) help recruit individuals with specific specialty or disciplinary backgrounds to research careers in biomedical, behavioral and clinical sciences; and (4) foster a better understanding of biomedical, behavioral and clinical research and its implications.

his FOA will assist Liberia in intensifying its surveillance of EVD through training Epidemiologists at the local and National level, providing National Epidemiologist EVD subject matter experts to assist County field teams in their work; as well as provide logistical support, supplies and equipment for Epidemiology Field teams to be able to conduct EVD surveillance. Laboratory systems will be strengthened through the assistance of a Senior Laboratory Data specialist, upgrades to the Laboratory Data Integration systems, and provision of much needed laboratory supplies, reagents, and equipment. EVD Chain of Transmission activities will include assessment of facilities throughout the country; and epidemiological active surveillance country wide, at the county level. Health Care Workers and community health leaders will be trained on water, sanitation and hygiene (WASH) activities, and infection prevention and control (IPC) activities.

The effects of the current SARS-CoV-2 outbreak have shown that epidemics and pandemics cannot be managed on a solely national level; instead, the global framework needs to be taken into account. To be better prepared for the diverse aspects of global waves of infection, it is essential to support wide-ranging research across different disciplines. In addition to investigating the current pandemic, it is important to identify fundamental research questions that produce generalizable scientific findings. The Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) is therefore issuing a call for a multidisciplinary funding initiative. Funding is available for projects addressing the prevention, early detection, containment and investigation of the causes, impacts and management of epidemics and pandemics, taking the example of SARS-CoV-2 and other microorganisms and viruses that are pathogenic to humans.

The AWS Diagnostic Development Initiative supports AWS customers who are working to bring better, more accurate diagnostic solutions to market faster. Given the need, the emphasis initially will be on COVID-19, but we will also consider other infectious disease diagnostic projects. The program will be open to accredited research institutions, research consortia, and private entities, that are using AWS to support research-oriented workloads for the development of point-of-care diagnostic (testing that can be done at home or at a clinic with same-day results) and other diagnostic techniques. We will not support administrative workloads to run routine IT operations through this program.

To support generation of single cell RNA-sequencing data sets for at least one brain region relevant to persistent HIV infection and opioid, cocaine and/or methamphetamine use disorder