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MiamiOH OARS

Genomic Innovator Award (R35 Clinical Trial Optional) - 0 views

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    This program supports highly creative individuals in NHGRI priority research areas, such as the development of resources, approaches, or technologies that will accelerate genomic research on the structure of genomes, the biology of genomes, or the biology of disease; that will advance the science of genomic medicine; that will incorporate genomics to improve the effectiveness of healthcare; or that will advance genomic technology development, computational genomics, or research on the ethical, legal, and societal implications of genomics and genetics research.  This program supports the development of approaches that can be used broadly.  A hallmark of genomic research is comprehensiveness across the genome, such as all genes, variants, or regulatory elements, rather than specific sets.  The focus should be on developing approaches that can be applied generally, although an approach may be tested with specific genes, genomic elements, variants, cell types, diseases, traits, or model organisms.  Studies that focus on one or a few specific genes should be paradigm-setting and yield findings relevant at the genomic level.  The application should explain how broadly useful the approaches will be.
MiamiOH OARS

Plant Genome Research Program - 0 views

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    This program is a continuation of the Plant Genome Research Program (PGRP) that began in FY 1998 as part of the National Plant Genome Initiative (NPGI). Since the inception of the NPGI and the PGRP, there has been a tremendous increase in the availability of functional genomics tools and sequence resources for use in the study of key crop plants and their models. Proposals are welcomed that build on these resources to develop conceptually new and different ideas and strategies to address grand challenge questions in plants of economic importance on a genome-wide scale. There is also a critical need for the development of novel and creative tools to facilitate new experimental approaches or new ways of analyzing genomic data. Especially encouraged are proposals that provide strong and novel training opportunities integral to the research plan and particularly across disciplines that include, but are not limited to, plant physiology, plant breeding, quantitative genetics, biochemistry, bioinformatics and engineering. Activities in four focus areas will be supported in FY 2015: (1) Genomics-empowered plant research (RESEARCH-PGR)to tackle fundamental questions in plant sciences on a genome-wide scale; (2) Development of tools and resources for plant genome research (TOOLS-PGR) including novel technologies and analysis tools to enable discovery; (3) Mid-Career Investigator Awards in Plant Genome Research (MCA-PGR) to increase participation of investigators trained primarily in fields other than plant genomics; and, (4) Early CareerInvestigator Awards in Plant Genome Research (ECA-PGR) to increase the participation of early-career scientists in plant genome research. Proposals addressing these opportunities are welcomed at all scales, from single-investigator projects through multi-investigator, multiinstitution projects, commensurate with the scope and scale of the work proposed. The PGRP encourages proposals from investigators and institutions that have not participate
MiamiOH OARS

Centers of Excellence in Genomic Science (CEGS) (RM1) - 0 views

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    The Centers of Excellence in Genomic Science (CEGS) program establishes academic Centers for advanced genome research.  Each CEGS grant supports a multi-investigator, interdisciplinary team to develop innovative genomic approaches to address a particular biomedical problem.  A CEGS project will address a critical issue in genomic science or genomic medicine, proposing a solution that would be a very substantial advance.  Thus, the research conducted at these Centers will entail substantial risk, balanced by outstanding scientific and management plans and very high potential payoff.  A CEGS will focus on the development of novel technological or computational methods for the production or analysis of comprehensive data sets, or on a particular genome-scale biomedical problem, or on other ways to develop and use genomic approaches for understanding biological systems and/or significantly furthering the application of genomic knowledge, data and methods towards clinical applications.  Exploiting its outstanding scientific plan and team, each CEGS will nurture genomic science at its institution by facilitating the interaction of investigators from different disciplines, and by providing training to new and experienced investigators, it will expand the pool of highly-qualified professional genomics scientists and engineers.
MiamiOH OARS

Plant Genome Research Program - 0 views

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    This program is a continuation of the Plant Genome Research Program (PGRP) that began in FY 1998 as part of the National Plant Genome Initiative (NPGI). Since the inception of the NPGI and the PGRP, there has been a tremendous increase in the availability of functional genomics tools and sequence resources for use in the study of key crop plants and their models. Proposals are welcomed that build on these resources to develop conceptually new and different ideas and strategies to address grand challenge questions in plants of economic importance on a genome-wide scale. There is also a critical need for the development of novel and creative tools to facilitate new experimental approaches or new ways of analyzing genomic data. Especially encouraged are proposals that provide strong and novel training opportunities integral to the research plan and particularly across disciplines that include, but are not limited to, plant physiology, quantitative genetics, biochemistry, bioinformatics and engineering.Activities in four focus areas will be supported in FY 2014: (1) Genomics-empowered plant research to tackle fundamental questions in plant sciences on a genome-wide scale; (2) Development of tools and resources for plant genome research including novel technologies and analysis tools to enable discovery; (3) Mid-Career Investigator Awards in Plant Genome Research (MCA-PGR) to increase participation of investigators trained primarily in fields other than plant genomics; and, (4) Advancing Basic Research in Economically Important Crop Plants (ABR-PG) to develop sequence resources that are critically needed to enable basic research resources in crop plants.
MiamiOH OARS

Centers of Excellence in Genomic Science (RM1 Clinical Trials Optional) - 0 views

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    The Centers of Excellence in Genomic Science (CEGS) program establishes academic Centers for advanced genome research. Each CEGS award supports a multi-investigator, interdisciplinary team to develop transformative genomic approaches to address a biomedical problem. A CEGS project will address a critical issue in genomic science or genomic medicine, proposing a highly innovative solution that would be a major advance. The research will entail substantial risk, balanced by outstanding scientific and management plans and very high potential payoff. A CEGS will focus on the development of novel technological or computational methods for the production or analysis of comprehensive data sets, on a genome-scale biomedical problem, or on other ways to develop and use genomic approaches for understanding biological systems or furthering the application of genomic knowledge, data, and methods towards clinical applications. Each CEGS will nurture genomic science at its institution by facilitating the interaction of investigators from several disciplines. By training new and experienced investigators it will expand the pool of genomics scientists and engineers.
MiamiOH OARS

Plant Genome Research Program | NSF - National Science Foundation - 0 views

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    The Plant Genome Research Program (PGRP) supports genome-scale research in plant genomics that addresses challenging questions of biological importance and of relevance to society. The Program encourages the development of innovative tools, technologies and resources that push the boundaries of research capabilities and permit the community to answer seemingly intractable and pressing questions on a genome-wide scale. Emphasis is placed on the creativity of the approach and the scale and depth of the question being addressed. Data produced by plant genomics should be usable, accessible, integrated across scales and of high impact across biology. Training and career advancement in plant genomics is featured as an essential element of scientific progress. The PGRP continues to focus on plants of economic importance and biological processes and interactions that will have broad impact on the scientific research community and society in general.
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    The Plant Genome Research Program (PGRP) supports genome-scale research in plant genomics that addresses challenging questions of biological importance and of relevance to society. The Program encourages the development of innovative tools, technologies and resources that push the boundaries of research capabilities and permit the community to answer seemingly intractable and pressing questions on a genome-wide scale. Emphasis is placed on the creativity of the approach and the scale and depth of the question being addressed. Data produced by plant genomics should be usable, accessible, integrated across scales and of high impact across biology. Training and career advancement in plant genomics is featured as an essential element of scientific progress. The PGRP continues to focus on plants of economic importance and biological processes and interactions that will have broad impact on the scientific research community and society in general.
MiamiOH OARS

RFA-RM-18-012: Rodent Testing Centers for Development of Reporter Systems and Evaluatio... - 0 views

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    The purpose of this Funding Opportunity Announcement (FOA) is to create rodent reporter models for testing in vivo genome editing technologies, and to use these animal models to test genome editing delivery technologies and new genome editors developed under RFA-RM-18-016 and RFA-RM-18-017. The deliverables from the initiative will be a set of animal models (mice and rat), containing one or more reporter genes expressed in all cell types, that will allow facile and quantitative evaluation of genome editing in any cell type of interest. The Testing Centers will use these models to validate new delivery systems and genome editing tools developed by other investigators in the Somatic Cell Genome Editing program.  The creation and testing of these rodent models will accelerate the translation of genome editing technologies into treatments for human diseases. 
MiamiOH OARS

Initiative to Maximize Research Education in Genomics: Diversity Action Plan (R25) - 0 views

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    The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The overarching goal of this NHGRI R25 program is to support educational activities that The overarching goal of this NHGRI R25 program is to support educational activities that enhance the diversity of the biomedical, behavioral and clinical research workforce in genomics. This funding opportunity announcement seeks to expose underrepresented students at the undergraduate, post-baccalaureate and graduate levels to the foundational sciences relevant to genomics to enable them to pursue careers that span all areas of interest to NHGRI - genome sciences, genomic medicine and genomics and society. For the purposes of this FOA, the term genomics encompasses issues and activities in these three areas of genomic research.
MiamiOH OARS

RFA-MH-21-100: Fine-Mapping Genome-Wide Associated Loci to Identify Proximate Causal Me... - 0 views

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    Genome-wide association studies (GWAS) identify statistical relationships between common single nucleotide variants (SNVs) across the genome and a trait of interest. Due to the correlated nature of nearby SNVs (i.e., linkage disequilibrium), GWAS implicate regions of the genome (loci) and do not necessarily pinpoint the causal variant(s), gene(s), isoform(s) or proximate molecular mechanism(s) underlying the trait association. Greater than 90% of genome-wide significant variants associated with traits fall within non-coding regions of the genome. A minority of these variants will be the actual causal variants and a majority will not affect the nearest genes. Moreover, functional annotation of the non-coding genome is still incomplete; the target genes of many genomic regulatory elements such as enhancers remain unknown. This presents a major challenge to mapping variants onto genes and genes onto traits. Thus, an immediate barrier to translating genetic associations into causal disease mechanisms is the uncertain relationship between statistically identified genetic variants and the resultant molecular changes influencing, directly or indirectly, a trait.
MiamiOH OARS

RFA-HG-19-002: High Quality Human Reference Genomes (HQRG) (U01 Clinical Trial Not Allo... - 0 views

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    The National Human Genome Research Institute (NHGRI) seeks applications for the production of High Quality Human Reference Genomes (HQRG) as a component of the NHGRI Human Genome Reference Program (HGRP). One aim of the HGRP is to develop a genome reference that is representative of human population genetic diversity. To help achieve this goal, this HQRG initiative is expected to establish metrics for high quality-genome assemblies; collaborate with other HGRC awardees on sample selection and prioritization; produce on the order of 350 high quality haplotype-resolved human genomes, using diverse samples consented for full data release; and provide capacity to help resolve error reports received by the HGRC.
MiamiOH OARS

Genomic Centers for Infectious Diseases (U19 Clinical Trial Not Allowed) - 0 views

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    The purpose of this initiative is to support Genomic Centers for Infectious Diseases (GCID) to promote broad use and expand the application of genomics technologies and computational analysis to understand infectious diseases, with an emphasis on pathogens, their interaction with the host and microbiome, and to aid in the development of novel genomics-based tools to diagnose, prevent and treat infectious diseases. The GCID will support innovative technology development in all aspects of genomics, including the use of synthetic and genome editing technologies as well as functional genomics to address basic, translational, and clinically relevant questions in host-pathogen interactions. The knowledge generated, including research data, analytical software tools, computational models, experimental protocols, and reagents, is expected to be widely disseminated to the scientific community through publicly accessible databases and reagent repositories.
MiamiOH OARS

Genomic Community Resources (U24 Clinical Trial Not Allowed) - 0 views

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    To facilitate genomic research and the dissemination of its products, NHGRI supports genomic resources that are crucial for basic research, disease studies, model organism studies, and other biomedical research. Awards under this FOA will support the development and distribution of genomic resources that use cost-effective approaches and will be valuable for the broad research community. Such resources include (but are not limited to) databases and informatics resources (such as human and model organism databases, ontologies, and analysis toolsets), comprehensive identification and collections of genomic features (such as functional genomic elements), and standard data types produced using central sets of samples (such as structural variants in 1000 Genomes or GTEx samples).
MiamiOH OARS

Plant Genome Research Program (PGRP) (nsf21507) | NSF - National Science Foundation - 0 views

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    The Plant Genome Research Program (PGRP) supports genome-scale research that addresses challenging questions of biological, societal and economic importance. PGRP encourages the development of innovative tools, technologies and resources that empower a broad plant research community to answer scientific questions on a genome-wide scale. Emphasis is placed on the scale and depth of the question being addressed and the creativity of the approach. Data produced by plant genomics should be usable, accessible, integrated across scales and of high impact across biology. Training, broadening participation, and career development are essential to scientific progress and should be integrated in all PGRP-funded projects. Two funding tracks are currently available: RESEARCH-PGR TRACK: Genome-scale plant research to address fundamental questions in biology, including processes of economic and/or societal importance. TRTech-PGR TRACK: Tools, resources and technology breakthroughs that further enable functional plant genomics.
MiamiOH OARS

View Opportunity | GRANTS.GOV - 0 views

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    This Funding Opportunity Announcement (FOA) solicits applications to start a new initiative, the Genomics of Gene Regulation (GGR), which is intended to explore genomic approaches to understanding the role of genomic sequence in the regulation of gene networks. A long-term goal of functional genomics is to decipher the rules by which gene networks are regulated and to understand how such regulation affects cellular function, development and disease. The GGR initiative will address the genome-proximal component of the regulation of gene networks by supporting a set of demonstration projects to develop and validate models that describe how a comprehensive set of sequence-based functional elements work in concert to regulate the finite set of genes that determine a biological phenomenon, using RNA amounts, and perhaps transcript structure, as the readout. This FOA seeks to support substantial improvement in the methods for developing gene regulatory network models, rather than an incremental improvement on existing methods. This work will move the field closer to the long-term goal of reading DNA sequence and accurately predicting when and at what levels a gene is expressed, in the context of a particular cell state. These demonstration projects will be organized as a research consortium to accelerate progress through the coordination of analytical methods and functional genomic data.
MiamiOH OARS

Plant Genome Research Program (PGRP) (nsf15548) - 0 views

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    This program is a continuation of the Plant Genome Research Program (PGRP) that began in FY 1998 as part of the National Plant Genome Initiative (NPGI). Since the inception of the NPGI and the PGRP, there has been a tremendous increase in the availability of functional genomics tools and sequence resources for use in the study of key crop plants and their models. Proposals are welcomed that build on these resources to develop conceptually new and different ideas and strategies to address grand challenge questions in plants of economic importance on a genome-wide scale. There is also a critical need for the development of novel and creative tools to facilitate new experimental approaches or new ways of analyzing genomic data. Especially encouraged are proposals that provide strong and novel training opportunities integral to the research plan and particularly across disciplines that include, but are not limited to, plant physiology, plant breeding, quantitative genetics, biochemistry, bioinformatics and engineering.
MiamiOH OARS

PAR-18-844: Investigator Initiated Research in Computational Genomics and Data Science ... - 0 views

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    The purpose of this funding opportunity announcement (FOA) is to invite applications for a broad range of research efforts in computational genomics, data science, statistics, and bioinformatics relevant to one or both of basic or clinical genomic science, and broadly applicable to human health and disease. This FOA supports fundamental genomics research developing innovative analytical methodologies and approaches, early stage development of tools and software, and refinement or hardening of software and tools of high value to the biomedical genomics community. Work supported under this FOA should be enabling for genomics and be generalizable or broadly applicable across diseases and biological systems. All applications should address how the methods would scale to address larger and larger data sets. Also listed under R21
MiamiOH OARS

Investigator Initiated Research in Computational Genomics and Data Science (R21 Clinica... - 0 views

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    The purpose of this funding opportunity announcement (FOA) is to invite applications for a broad range of research efforts in computational genomics, data science, statistics, and bioinformatics relevant to one or both of basic or clinical genomic science, and broadly applicable to human health and disease. This FOA supports fundamental genomics research developing innovative analytical methodologies and approaches, early stage development of tools and software, and refinement or hardening of software and tools of high value to the biomedical genomics community. Work supported under this FOA should be enabling for genomics and be generalizable or broadly applicable across diseases and biological systems. All proposals should address how the methods would scale to address larger and larger data sets.
MiamiOH OARS

RFA-HG-17-011: The NHGRI Genomic Data Science Analysis, Visualization, and Informatics ... - 0 views

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    The scope of this FOA is to establish the NHGRI Genomic Data Science Analysis, Visualization, Informatics Lab-space ("AnVIL") in support of genomic research. The AnVIL aims to create an interoperable resource for the research community by co-locating data, storage and computing infrastructure with commonly used services and tools for analyzing and sharing data. The AnVIL will further advance research by leveraging a cloud-based infrastructure to facilitate genomic data access by the broad scientific community, integration and computing on and across large datasets generated by NHGRI programs, or programs funded by others in support of human genomics research. In particular, the AnVIL resource will provide genomic researchers with the following:
MiamiOH OARS

Grants.gov - Find Grant Opportunities - Opportunity Synopsis - 0 views

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    This FOA invites applications to develop sensitive technologies or methods for obtaining high quality and comprehensive nucleic acids-based genomic data from limited quantities of human specimens that are easy to collect, handle, and store. Applications that address all of the steps from the collection of specimens, through storage and nucleic acids extraction, to obtaining genomic data will be considered as having highest priority to this FOA. The ease of proposed sample collection methods should be at least comparable to that of the current dried blood spot collection method. The developed technologies or methods should be applicable to clinical point-of-care testing in terms of speed and ease, and ultimately have the potential to be scalable to high throughput settings, while maintaining cost effectiveness. The genomic data obtained must be at least equivalent to that which can be obtained from fresh whole blood in terms of quality and comprehensiveness. It is expected that the research conducted under this FOA will enhance the availability of comprehensive nucleic acids-based genomic data for various clinical and research applications in need of obtaining genomic data from easy-to-collect and handle human specimens.
MiamiOH OARS

PAR-16-209: Investigator-Initiated Clinical Sequencing Research (R01) - 0 views

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    The purpose of this funding opportunity announcement is to broaden the NHGRI investigator-initiated portfolio in genomic medicine by stimulating research that informs the implementation of genome sequencing in clinical care. This includes, but is not limited to, studies of whether and how clinical genome sequencing impacts disease diagnosis and treatment, studies that address current barriers to the implementation of clinical genome sequencing, and studies of approaches to improve the identification and interpretation of genomic variants for dissemination in clinical settings.
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