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This Funding Opportunity Announcement (FOA) seeks applications for the design and development of technologies to monitor health or deliver care in a real-time, accessible, effective, and minimally obtrusive way for older adults with a chronic heart, lung, blood, or sleep (HLBS) condition. These technologies may be novel sensor or monitoring systems, home-use point-of-care devices, home or mobile therapy or rehabilitation tools, or information systems and should have the goal of fostering healthy and independent living for aging adults with HLBS conditions. The development of such technologies should incorporate specific human factors for aging adults including disabilities, mild impairments, as well as chronic HLBS conditions. Technology usability for these populations must be incorporated early in the development of the design. Usability considerations include but are not limited to patient-facing displays, hearing and visual impairments, tactile limitations, literacy, and design preferences between men and women. These improvements in technology design could yield more accurate and earlier detection of changes that may interfere with healthy and independent living for older adults.

The Administration on Aging (AoA) within the Administration for Community Living (ACL), U.S. Department of Health and Human Services (HHS) forecasts the possible availability of Fiscal Year (FY) 2018 funds to make three-year grants to approximately 10 entities to develop capacity, bring to scale, and sustain evidence-based programs that empower older adults and adults with disabilities to better manage their chronic conditions. ACL intends to compete these 10 grants via two options (both with 36-month grant periods): (A) Sustainable Systems Grants: approximately six grants of $500,000 to $900,000 focused on developing integrated, sustainable systems for delivering evidence-based chronic disease self-management education and self-management support programs. (B) Capacity-Building Grants: approximately four grants of $50,000 to $150,000 to build capacity to introduce and deliver evidence-based chronic disease self-management education and self-management support programs within underserved areas and/or populations.

The Administration on Aging (AoA) within the Administration for Community Living (ACL), U.S. Department of Health and Human Services (HHS) forecasts the possible availability of Fiscal Year (FY) 2018 funds to make three-year grants to approximately 10 entities to develop capacity, bring to scale, and sustain evidence-based falls prevention programs that will help to reduce the number of falls, fear of falling, and/or fall-related injuries in older adults. ACL aims to compete these 10 grants via two options (both with 36-month grant periods): (A) Sustainable Systems Grants: approximately six grants of $400,000 to $600,00 focused on developing integrated, sustainable systems for delivering falls prevention programs; (B) Capacity-Building Grants: approximately four grants of $50,000 to $150,000 to build capacity to introduce and deliver falls prevention programs within underserved areas and/or populations.

Cooperative agreements under this funding opportunity announcement (FOA), Alzheimer's Disease Program Initiative (ADPI), are dedicated to the development and expansion of dementia-capable home and community-based service (HCBS) systems in States and Communities. There are two application options contained in this FOA, one for States (Option A) and the other for Communities (Option B). No entity would be eligible to apply for both State and Community options. The systems resulting from program activities under both program options will provide quality, person-centered services that help individuals remain independent and safe in their communities.

Cooperative agreements under this funding opportunity announcement (FOA), Alzheimer's Disease Program Initiative (ADPI), are dedicated to the development and expansion of dementia-capable home and community-based service (HCBS) systems in States and Communities. There are two application options contained in this FOA, one for States (Option A) and the other for Communities (Option B). No entity would be eligible to apply for both State and Community options. The systems resulting from program activities under both program options will provide quality, person-centered services that help individuals remain independent and safe in their communities.

The purpose of this Funding Opportunity Announcement (FOA) is to promote research on interventions, based in healthcare settings, designed to reduce overscreening for breast, cervical, or colorectal cancers among average-risk older adults. While ongoing efforts to promote screening have been successful, there is growing concern that these tests may be overused, thereby subjecting adults to unnecessary risks. Overscreening older adults may be driven by factors at the individual, healthcare team, healthcare system and community organization levels. Therefore, research is needed both to understand the factors that drive overuse and to develop and test interventions that will reduce overuse in healthcare delivery systems. Research supported by this FOA should propose to intervene at two or more levels, and should measure outcomes at two or more levels, while accounting for interactions that occur between levels. Research supported by this FOA should enhance knowledge and consequences of overscreening to improve the health, independence, and quality of life of older adults.

The purpose of this funding opportunity announcement (FOA) is to encourage research grant applications to: (1) assess and describe the current state of oral anticancer medication utilization, delivery, and adherence; (2) identify structural, systemic, and psychosocial barriers to adherence; and (3) develop models and strategies to improve safe and effective delivery of these agents so that clinical outcomes are optimized. Applications should focus research questions on at least one of the following: specific cancer type; class of drugs; and/or groups subject to disparities (e.g., elderly populations, members of low socioeconomic groups, racial/ethnic minorities). Research may be focused at the patient (pediatric, adolescent, or adult), patient-caregiver, provider, health care team, or health care delivery system level, and may include intervention studies, observational studies, or mixed-methods studies. Observational studies should emphasize modifiable risk factors for future intervention research.

An existing or newly formed coalition with signed Memoranda of Understanding (MOUs) to develop a State coalition action plan that advances a full range of strategies to supporting decision making across the age spectrum. The MOUs should describe how the entities participated in the development of the application and how they plan to work together to ensure the goals and objectives included in the application are achieved. At a minimum, the partnership must include: A representative from the state Working Interdisciplinary Networks of Guardianship Stakeholders (WINGS) group, or other similar community network, or identify and recruit a State coalition that includes a WINGS representative, Person with an intellectual or developmental disability A representative from the State office of public guardianship representative (if State has one) and/or Bar Association Elder Law Section and Disability Law Section, A representative from the judicial system, A representative from the Legislative branch A Comprehensive plan that includes: A range of approaches to decisional support, including but not limited to Supported Decision Making (SDM) in the State; The State's guardianship operation/policy/system and/or policies relating to supporting a full range of decision making strategies across the age spectrum; Strategies currently being used to supporting a full range of decision making strategies across the age spectrum in the State; Analysis of any judicial precedent in decisional support; Key existing coalitions; Other state specific characteristics relating to supporting decision making across the age spectrum in the State; Promising practices; Perceived barriers; and Alternatives and limitations on reform of the use of supported decision making on guardianship A formative and consensus process to establish a draft State coalition action plan (or add to an existing one).

Cooperative agreements under this funding opportunity announcement (FOA), Alzheimer's Disease Program Initiative (ADPI), are dedicated to the development and expansion of dementia-capable home and community-based service (HCBS) systems in States and Communities. There are two application options contained in this FOA, one for States (Option A) and the other for Communities (Option B). No entity would be eligible to apply for both State and Community options. The systems resulting from program activities under both program options will provide quality, person-centered services that help individuals remain independent and safe in their communities.

Alzheimer's Disease Program Initiative (ADPI) cooperative agreements are dedicated to the development and expansion of dementia-capable home and community-based service (HCBS) systems in States and Communities. There will be two application options through this opportunity, one for States (Option A) and the other for Communities (Option B). No entity would be eligible to apply for both State and Community options. The systems resulting from program activities under both program options will provide quality, person-centered services that help individuals remain independent and safe in their communities.

The purpose of this Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is to encourage applications that will develop and validate novel tools to facilitate the detailed analysis of complex circuits and provide insights into cellular interactions that underlie brain function. The new tools and technologies should inform and/or exploit cell-type and/or circuit-level specificity. Plans for validating the utility of the tool/technology will be an essential feature of a successful application. The development of new genetic and non-genetic tools for delivering genes, proteins and chemicals to cells of interest or approaches that are expected to target specific cell types and/or circuits in the nervous system with greater precision and sensitivity than currently established methods are encouraged. Tools that can be used in a number of species/model organisms rather than those restricted to a single species are highly desired. Applications that provide approaches that break through existing technical barriers to substantially improve current capabilities are highly encouraged.

The purpose of this Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is to encourage applications that will develop and validate novel tools to facilitate the detailed analysis of complex circuits and provide insights into cellular interactions that underlie brain function. The new tools and technologies should inform and/or exploit cell-type and/or circuit-level specificity. Plans for validating the utility of the tool/technology will be an essential feature of a successful application. The development of new genetic and non-genetic tools for delivering genes, proteins and chemicals to cells of interest or approaches that are expected to target specific cell types and/or circuits in the nervous system with greater precision and sensitivity than currently established methods are encouraged. Tools that can be used in a number of species/model organisms rather than those restricted to a single species are highly desired. Applications that provide approaches that break through existing technical barriers to substantially improve current capabilities are highly encouraged.   

The goal of this FOA is to advance research on the underlying basis for the transfer (or transposition) of aging phenotypes observed between young and old rodents and discovered through heterochronic parabiosis. Examples of transposed phenotypes include reversal of cardiac hypertrophy, partial restoration of cognitive function, improved vascularization, and repair of skeletal muscle after cryo-injury (anti-geronic transposition), or as accelerated loss of cognitive function and neurogenesis (pro-geronic transposition). Other transposed phenotypes, as revealed solely through heterochronic parabiosis, may also be reported in the literature. There are also reports of candidate factors found in circulation that might be causally related to the transposition of these aging phenotypes; these are termed "circulating geronic factors" for purposes of this FOA. To date, these are proteins and peptides that pass between the young and old mice joined by parabiosis, due to anastomosis of their circulatory systems. Based on these novel findings and this novel experimental paradigm, the specific objective of this FOA is to test whether these candidate geronic factors are necessary for the transposition of aging phenotypes. The focus is on phenotypes transposed in heterochronic parabiosis and the candidate factors which are present and functional at physiological concentrations in circulation.

The goal of this FOA is to advance research on the underlying basis for the transfer (or transposition) of aging phenotypes observed between young and old rodents and discovered through heterochronic parabiosis. Examples of transposed phenotypes include reversal of cardiac hypertrophy, partial restoration of cognitive function, improved vascularization, and repair of skeletal muscle after cryo-injury (anti-geronic transposition), or as accelerated loss of cognitive function and neurogenesis (pro-geronic transposition). Other transposed phenotypes, as revealed solely through heterochronic parabiosis, may also be reported in the literature. There are also reports of candidate factors found in circulation that might be causally related to the transposition of these aging phenotypes; these are termed "circulating geronic factors" for purposes of this FOA. To date, these are proteins and peptides that pass between the young and old mice joined by parabiosis, due to anastomosis of their circulatory systems. Based on these novel findings and this novel experimental paradigm, the specific objective of this FOA is to test whether these candidate geronic factors are necessary for the transposition of aging phenotypes. The focus is on phenotypes transposed in heterochronic parabiosis and the candidate factors which are present and functional at physiological concentrations in circulation.

The Board of Regents is seeking high quality, focused cooperative education and internship program proposals from Ohio institutions of higher education and their partners. This program has been funded  through one-time casino licensing fees; it is expected that the funds will be awarded to build systems to sustain co-ops and internships beyond the direct investment from the State and to ensure these workbased learning opportunities are relevant to the needs of students and businesses. Funds will be awarded to build the capability and capacity of programs to engage more students, more businesses,  and more faculty members in co-op and internship programs. The programs should address the talent needs of JobsOhio key industries.

The purpose of this Funding Opportunity Announcement (FOA) is to encourage applications that propose either basic, clinical, or a combination of basic and clinical studies to investigate how functional changes in the sensory and/or motor systems impact the development and progression of Alzheimer's disease. Studies may include older adults and/or animal models and may employ a variety of approaches, including cellular, molecular, imaging, physiological and genetic, to address this need. For clinical studies, leveraging of existing longitudinal cohorts already collecting sensory and motor assessments is highly encouraged.

This Funding Opportunity Announcement (FOA) invites applications that propose Artificial Intelligence (AI), Machine Learning (ML), and/or Deep Learning (DL) approaches, collectively referred to here as "cognitive systems," that lead to the identification of gene mutations/variants that cause or contribute to the risk of or protection against the development of Alzheimer's disease (AD) and Alzheimer's disease related dementias (ADRD) via analysis of a variety of genetic, genomic, and biomarker data that are currently available to the research community.

The purpose of this announcement is to promote research that develops, characterizes, refines and enhances model systems for aging research.

Since 1985, the John A. Hartford Foundation authorized nearly $425 million in grants to improve the geriatric skills of current and future health professionals and redesign health care delivery. Foundation grants currently support over 100 programs that span the spectrum of academic and clinical training. These programs increase the nation's capacity and ability to serve older adults by engaging doctors, nurses, and social workers at all the stages of their formation and professional growth. In order to maximize the Foundation's impact on the health and the well-being of the nation's elders, grants are made in two priority areas. Academic Geriatrics and Training The Foundation supports efforts in selected academic medical centers and other health settings to strengthen the geriatric training of America 's physicians, nurses and social workers. Integrating and Improving Services The Foundation supports a limited number of sustainable efforts to improve and integrate the system of services needed by elders and their effectiveness. The emphasis is on nationally replicable models.

The participating NIH Institutes and Centers invite applications to address both the origins and the effects of low level chronic inflammation in the onset and progression of age-related diseases and conditions. Chronic inflammation, as defined by elevated levels of both local and systemic cytokines and other pro-inflammatory factors, is a hallmark of aging in virtually all higher animals including humans and is recognized as a major risk factor for developing age-associated diseases. The spectra of phenotypes capable of generating low-level chronic inflammation and their defining mediators are not clear. Further, a clear understanding of how chronic inflammation compromises the integrity of cells or tissues leading to disease progression is lacking. The role of dietary supplements and/or nutritional status in chronic inflammation in age-related disease is also poorly studied. Thus, there is a critical need to establish the knowledge base that will allow a better understanding of the complex interplay between inflammation and age-related diseases. Applications submitted to this FOA should aim to clarify the molecular and cellular basis for the increase in circulating inflammatory factors with aging, and/or shed light on the cause-effect relationship between inflammation and disease, using pre-clinical (animal or cellular based) models.

NIHCM Foundation is making up to $150,000 available to support investigator-initiated research with high potential to inform improvements to the U.S. health care system by reducing health spending growth, enhancing quality, and/or expanding access to health insurance and health care services. Projects must advance existing knowledge in the areas of health care financing, delivery, management and/or policy.

The purpose of this funding opportunity announcement (FOA) is to support and promote broad applications of optogenetic tools for research on normal and/or pathological aging of neural systems including sensory, motor, cognitive, emotional, autonomic, sleep, and neurovascular, or Alzheimer's disease (AD), as well as to encourage additional development of aging and AD specific optogenetic tools.