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The purpose of this Funding Opportunity Announcement (FOA) is to stimulate collaborative research to understand the biological mechanisms of aging in dental, oral, and craniofacial (DOC) tissues, as they relate to parallel processes in other tissues and organs. The areas of emphasis under this FOA include inflammation, tissue healing and regeneration, and epigenetic regulation. The overarching long-term goal of this effort is to improve oral health in older adults by addressing knowledge gaps in our understanding of the basic biology of age-associated changes in health and disease states of DOC tissues. Also listed under R01

The goal of this reissued Funding Opportunity Announcement (FOA) is to expand understanding of age-related changes that occur in immune function during the aging process that influence responses to pathogens and/or vaccines, as well as oral and craniofacial health. Human studies are required, and inclusion of relevant animal studies is permitted for mechanistic understanding. This FOA solicits applications that will determine the mechanisms required for induction and maintenance of protective immunity in the elderly in response to infections and/or vaccinations, including the effects of chronic inflammation on those responses, and applications that will assess changes in immune processes in dental, oral and craniofacial tissues in the elderly.

The purpose of this funding opportunity announcement (FOA) is to encourage research grant applications to: (1) assess and describe the current state of oral anticancer medication utilization, delivery, and adherence; (2) identify structural, systemic, and psychosocial barriers to adherence; and (3) develop models and strategies to improve safe and effective delivery of these agents so that clinical outcomes are optimized. Applications should focus research questions on at least one of the following: specific cancer type; class of drugs; and/or groups subject to disparities (e.g., elderly populations, members of low socioeconomic groups, racial/ethnic minorities). Research may be focused at the patient (pediatric, adolescent, or adult), patient-caregiver, provider, health care team, or health care delivery system level, and may include intervention studies, observational studies, or mixed-methods studies. Observational studies should emphasize modifiable risk factors for future intervention research.

This funding opportunity is for competitive grants to be awarded to support systematic testing and documentation of innovative and promising practices that enhance the quality, effectiveness, and proven outcomes of nutrition programs and services within the aging services network. Innovative and promising practice projects awarded through previous INNU announcements have focused on at least one of the following areas; Creating partnerships between Universities and/or other research organizations in collaboration with aging network organizations to develop or test innovative evidence based programs or practices for senior nutrition; Modernizing the congregate and/or home delivered meal program infrastructure, delivery mechanisms, and/or marketing and outreach that can be used by the national aging network to ensure that States are able to maximize the return on their investment in nutrition programs and expanding the reach of the OAA target populations; Enhancing partnerships with health care partners (e.g. oral health, behavioral health, alternative health, and etc.) to further demonstrate the network's value in solving local and national problems, and/or increasing business acumen opportunities and; Advancing the use of technology within the aging and nutrition network Successful awardees will be expected to focus on outcomes including, but not limited to, methods to improve collaboration with local health care entities, decrease health care costs for a specific population, and/or decrease the incidence of the need for institutionalization among older adults.