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β-Glucans (or beta-glucans) are polysaccharides of D-glucose monomers linked by glycosidic bonds. They occur most commonly as cellulose in plants and trees, the bran of cereal grains, the cell wall of baker's yeast, certain types of fungi, and many kinds of mushrooms and bacteria. Some forms of beta glucans are useful in human nutrition as texturing agents and as soluble fiber supplements, but problematic in brewing as excessive levels make the wort too viscous. Yeast derived beta glucans are notable for their immunomodulatory function

beta-glucan A polysaccharide isolated from the cell walls of bacteria, plants, and fungi with immunostimulant and antineoplastic activities. In a solubilized form, beta-glucan binds to a lectin site within complement receptor 3 (CR3) on leukocytes, priming the receptor to trigger cytotoxic degranulation of leukocytes when leukocyte CR3 binds to complement 3 (iC3b)-coated tumors. Thus, the attachment of beta-glucan to CR3 of circulating leukocytes simulates leukocytes to kill iC3b-coated tumor cells in the same way as they kill iC3b-coated yeast. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)

Beta Glucan is primarily cultured extract of Baker's Yeast cell wall. It is used as an immunostimulant.  Beta glucans are sugar molecules (polysaccharides). They are found bound together as a sugar/protein complex.  Certain plants and microorganisms are naturally high in this polysaccharide compound.  The richest concentrated source is baker's yeast cell walls. (Because there is basically no yeast left in the products and they have low protein levels, it is considered hypoallergenic.) It is present in lesser amounts in mushroom extracts and Lentinen, Barley, Oat, etc. Sodium alginate is also an excellent source, but the high sodium content is a major drawback in the processing for supplemental use. An expensive research extract called Zymosan™ has been used for doing research for over 45 years. Much of the research has been in combining it with conventional approaches, such as chemotherapy, but it has been found to work well on its own.

Derived from the cap and stem of the mushroom, Reishi mushroom is used as an immune stimulant by patients with HIV or cancer. The active constituents are thought to include both beta-glucan polysaccharides and triterpenes (1). Extracts of Reishi can stimulate macrophages and alter the levels of TNF and interleukins (2) (3) (4) (5). Reishi also inhibited platelet aggregation (11) (12) and improved lower urinary tract symptoms (LUTS) in men (9) (10). Studies done in rats have shown that Reishi extract may alleviate chemotherapy-induced nausea (13). In clinical studies, Reishi increased plasma antioxidant capacity (6) (7)and enhanced immune responses in advance-stage cancer patients (8).

Immune Protect with PARACTIN® contains a combination of patented ingredients that have been clinically shown to boost immune function, increasing the body's natural ability to combat challenges.* Immune Protect with PARACTIN® provides 100 milligrams of a proprietary, patented form of betaglucan that has been proven to activate the host immune system's primary defenders by activating complementary systems, enhancing macrophages and natural killer cell function.7-12* The immune cell-priming capabilities of this patented, highly purified yeast derivative exceed those of all other sources of immune supplements tested to date

Derived from the cap and stem of the mushroom. The active constituent is thought to be a beta-glucan polysaccharide. The whole mushroom is used primarily as a dietary element, but extracts and supplements are sold as immune stimulants for patients with HIV or cancer. While no adverse effects have been reported, some studies reveal a hypoglycemic effect following administration of maitake extract (9) (12). Maitake was shown to enhance bone marrow colony formation, reduce doxorubicin toxicity in vitro (11), and to inhibit tumor metastasis

Shiitake mushroom, native to East Asia, is cultivated worldwide for its purported health benefits. The fresh and dried forms of the mushroom are commonly used in East Asian cooking. It is also valued as an anticancer agent. Lentinan (1,3 Beta-D-glucan), a polysaccharide isolated from Shiitake, has been well studied and is thought responsible for its beneficial effects. It was shown to have anticancer effects in colon cancer cells (1), which may be due to its ability to suppress cytochrome P450 1A enzymes that are known to metabolize pro-carcinogens to active forms

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