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Matti Narkia

Researchers Discover Mechanistic Link Between High-Fat Diet and Type 2 Diabetes - 1 views

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    "In an article published in the December 29, 2005, issue of the journal
    Cell, the researchers report that knocking out a single gene encoding
    the enzyme GnT-4a glycosyltransferase (GnT-4a ) disrupts insulin
    production. Importantly, the scientists showed that a high-fat diet
    suppresses the activity of GnT-4a and leads to type 2 diabetes due to
    failure of the pancreatic beta cells.

    "We have discovered a mechanistic explanation for beta cell failure
    in response to a high-fat diet and obesity, a molecular trigger which
    begins the chain of events leading from hyperglycemia to insulin
    resistance and type 2 diabetes," said Jamey Marth, a Howard Hughes
    Medical Institute investigator at the University of California, San
    Diego (UCSD). Marth and first author Kazuaki Ohtsubo at UCSD
    collaborated on the studies with researchers from the Kirin Brewery Co.
    Ltd., and the University of Fukui, both in Japan."
Matti Narkia

Cell - Dietary and Genetic Control of Glucose Transporter 2 Glycosylation Promotes Insu... - 0 views

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    Dietary and genetic control of glucose transporter 2 glycosylation promotes insulin secretion in suppressing diabetes.
    Ohtsubo K, Takamatsu S, Minowa MT, Yoshida A, Takeuchi M, Marth JD.
    Cell. 2005 Dec 29;123(7):1307-21.
    PMID: 16377570
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