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Over 200 scientific and medical journals are taking part. For our theme issue, we asked a wide variety of commentators worldwide—including clinicians, medical researchers, health reporters, policy makers, health activists, and development experts—to name the single intervention that they think would improve the health of those living in poverty.

From one month to five years of age, the main causes of death are pneumonia, diarrhoea, malaria, measles and HIV. Malnutrition contributes to more than half of deaths. Pneumonia is the prime cause of death in children under five years of age. Nearly three-quarters of all cases occur in just 15 countries. Addressing the major risk factors – including malnutrition and air pollution – is essential to preventing pneumonia, as is vaccination. Antibiotics and oxygen are vital tools for effectively managing the illness. Diarrhoeal diseases are a leading cause of sickness and death among children in developing countries. Treatment with Oral Rehydration Salts (ORS) combined with zinc supplements is safe, cost-effective, and saves lives. One African child dies every 30 seconds from malaria. Insecticide-treated nets prevent transmission and increase child survival. Over 90% of children with HIV are infected through mother-to-child transmission, which can be prevented with antiretrovirals, as well as safer delivery and feeding practices. About 20 million children under five worldwide are severely malnourished, which leaves them more vulnerable to illness and early death. About two-thirds of child deaths are preventable through practical, low-cost interventions. WHO is improving child health by helping countries to deliver integrated, effective care in a continuum - starting with a healthy pregnancy for the mother, through birth and care up to five years of age. Investing in strong health systems is key to delivering this preventive care.

What will be the next global pandemic? Avian influenza?  Smallpox? Well, in honor of March madness, I'm holding a tournament. We're going to find the next global pandemic, right here. We'll match up the scariest infectious diseases, and pick a winner - the next global pandemic.

U.S. falls behind other developed countries in infant mortality The United States ranks 29th. The rate has not improved because of an increase in premature births, health officials say.

A rise in twins and triplets, driven by the use of infertility treatments, contributed somewhat to the rise in premature and low-birth-weight births, Petrini said. But even accounting for those trends, premature births are increasing, possibly tied to rising rates of obesity, diabetes and hypertension.

"We as a nation place less emphasis on primary care and prevention than a lot of these other industrialized democracies do that have lower rates than we do," said Dr. Ann O'Malley of the Center for Studying Health System Change, a Washington-based research group.

How powerful is a light-weight tool in the right hands? During a six month pilot in Malawi, our partner doubled the number of people being treated for Tuberculosis.

Driven by local ownership and appropriate technology. In the developing world, lack of infrastructure prevents health workers from delivering efficient healthcare to rural areas. As health workers travel from clinics to reach isolated patients, they are often as disconnected from central clinics as the patients they are trying to serve. The mission of FrontlineSMS:Medic is to advance healthcare networks in the developing world by building and distributing innovative, appropriate mobile technologies. The centerpiece of our system is FrontlineSMS, a free, open-source software platform that enables large-scale, two-way text messaging using only a laptop, a GSM modem, and cell phones. We are also developing several applications for the FrontlineSMS platform that will enable better patient management, electronic medical records via the cell phone, cheap mobile diagnostics, and mapping of health services.

Sastry endorses David Kolb’s “learning loop” model: concrete experience, observation and reflection, forming abstract concepts, then further implementing and analyzing. She ponders if this cycle can transcend classroom learning to engender change in the world. Her own research and consulting in health care delivery are based on such a stepped method. She stresses that an integrated, holistic perspective is also required. For instance, a malnourished patient will be unable to absorb drugs administered for AIDS; medicine is insufficient without food. As to the larger picture, she says “obviously we’ve got to tackle global warming and carbon emissions, but we also need to tackle poverty.”

MIT Sloan School, GHD Project and MIT teams have made great progress in defining ways to work together to improve health care delivery, including training the cadre of leaders in the field. The Global Entrepreneurship Lab: Global Health Delivery (G-Lab GHD), the new version of MIT Sloan’s flagship international course, epitomizes the value of this collaboration as it brings together the expertise of MIT faculty with GHD’s experience in implementation.

From the start of our projects to the finish, it’s people who determine what FrontlineSMS:Medic does, when we do it, and why. The tech tools we use exist to serve patients, community health workers, and healthcare professionals – not the other way around. This mindset is critical for a number of reasons. I’ll explain. We strongly believe that projects should start when clinics ‘pull’ them to a site, as opposed to having projects ‘pushed’ onto healthcare providers. Ken Banks included the (very important) push/pull differentiation in his “Development best practices for beginners” series. Clinics are not just convenient places to pilot technology innovations. Healthcare providers should demand programs they need, and we should be ready to respond. Local staff should determine how the tech will be used, and we should be flexible and helpful in working through use cases and functionality.

The PIH Vision: Whatever it takes At its root, our mission is both medical and moral. It is based on solidarity, rather than charity alone. When a person in Peru, or Siberia, or rural Haiti falls ill, PIH uses all of the means at our disposal to make them well—from pressuring drug manufacturers, to lobbying policy makers, to providing medical care and social services. Whatever it takes. Just as we would do if a member of our own family—or we ourselves—were ill.