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Canada has always had to fight hard to attract talent and investment

MaRS Vital to Toronto's life sciences vision is MaRS (derived from Medical and Related Sciences) a non-profit organisation and business centre located in the heart of the city. Its core function is as a biotech incubator and business park, known as MaRS Discovery District. The venture was first established in 2000 to help foster and accelerate the growth of successful Canadian businesses and, after some uncertain times, it is now gathering momentum. A separate technology transfer office, MaRS Innovation, has also been established that, it is hoped, can be a world beater in its own right (see Turning good ideas into world beaters below). The location of the MaRS building in central Toronto is important, as it is just a stone's throw away from an existing cluster of universities and academic hospitals. MaRS has many links with other research-based organisations, including collaborations with three local universities, 10 academic teaching hospitals and the Ontario Institute for Cancer Research. MaRS occupies the Old Toronto general hospital, where insulin was first discovered by Best and Banting in 1921 and then developed for use in human trials. The 21st Century organisation can build on this heritage in patient-focused discovery and development. Formerly the head of venture capital firm Primaxis, Ilse Treurnicht is chief executive of MaRS Discovery District. She acknowledges the crisis in venture capital funding, and says Canada's sector has always had less access funds through this route than other countries. This is one of the drivers behind the search for a new approach. Treurnicht says the old models of building biotech and life sciences businesses have to be discarded, as they have failed to build companies with critical mass. She says MaRS' new 'Convergence Innovation' strategy of bringing science, capital and business together will pay off.

"We call our strategy 'Convergence Innovation' and what we are trying to do is move away from the old linear model of academics struggling in their spare time to build companies or entrepreneurs doing this in a very incremental way."It takes time and it has many risk points along the way. So using this Convergence centre model to create a much more dynamic organisation which can help accelerate good ideas towards the commercialisation." But she says Canada's geography and demographics are always going to be a challenge. "This is a very large country with a small population. If you think in terms of clusters and hub regions, Canada's business hubs are separated geographically, and there is not much in between in terms of people."That means we can't try to be a little United States, because we just won't show up on the radar. We have to take a different approach. We have to think about collaboration as our potential competitive advantage - that means using networks and associations to solve problems and build businesses."So as new opportunities emerge, we can take them to market faster and hopefully with a higher success rate." The centre currently accommodates numerous start up companies, as well as those providing legal and financial services to them. AstraZeneca and GlaxoSmithKline also have offices on site. In all, MaRS provides mentoring for over 200 different companies across Ontario, and runs courses on entrepreneurship and preparing products for market.

Toronto, where a small firm is using 21st-century software to create maps with similar goals - the containment of disease - by showing infection patterns that can be understood at a glance.

Toronto, where a small firm is using 21st-century software to create maps with similar goals - the containment of disease - by showing infection patterns that can be understood at a glance.

There's nothing wrong with Infonaut using the H1N1 flu outbreak to gain exposure, as long as the company is careful in the tone it takes, said John Lute, president of Toronto communications firm Lute and Co.

Probably most impressive was The MaRS Centre - an old hospital converted into a non-profit innovation centre connecting science, technology and social entrepreneurs with business skills, networks and capital. The building is undeniably cool. Located in Toronto’s “Discovery District” -- two square kilometres have been designated as the city’s center of innovation. The MaRS Centre is a gateway of sorts to Canada’s largest concentration of scientific research. It’s anchored by major teaching hospitals, the University of Toronto and more than two dozen affiliated research institutes.

MaRS Centre from the outside

MaRS was created in 2000. The founding group raised significant capital (almost $100 million from all three levels of government and both institutional and individual private sector donors and an additional $130 million of debt and credit lease instruments were also secured) to support the development. What’s so clear is that leadership to drive public/private sector collaboration is required to effect real change. Many credit Ontario Premier Dalton McGuinty for helping to not only create the MaRS Centre but also invigorate the region as a whole.

nd development of new ideas. It provides not only office and lab space but also free mentoring assistance to new businesses in science, technology and social innovation. While there are probably no chickens hatching at MaRS, it wouldn't be at all surprising to find a company working on, say, a vaccine for bird flu. Approximately 20 incubator companies are currently housed at MaRS, including Clera Inc. - which is developing treatments for schizophrenia and depression; AXS Biomedical Animations Studio - a company that creates 3D medical animation for biomedical research and other applications; and Kanata Chemical Technologies (KCT), which has had great success developing catalysts for the chemical industry (catalysts speed up chemical reactions without being changed or consumed in those reactions

All of the above definitions could apply to the wider innovation community connected with the MaRS Centre. Located in the heart of Toronto's Discovery District - a 2.5 sq. kilometre downtown research district, MaRS is a non-profit environment for the birt

KCT founder and president Kamal Abdur-Rashid came to Canada in 1997 with a degree from the University of the West Indies

For Dr. John Evans, growing a strong biotechnology industry is much the same: cities must provide a nurturing environment where science and business can thrive together.

That's why Evans, former president of the University of Toronto and current chairman of Torstar Corp., is spearheading the $345-million Medical and Related Science initiative, or MaRS--a petri dish of sorts for commercializing science research. "A lot of intellectual property is being commercialized outside Canada," says Evans. "I think we've been slow in realizing just how important technology developments are to the economic future of the country. MaRS is an attempt to give this a kick into a higher gear." The centrepiece of the MaRS plan, which will officially launch May 12, is a 1.3-million-square-foot, five-building complex in downtown Toronto that will provide office and lab space for small and medium-size companies and incubators, including the not-for-profit Toronto Biotechnology Commercialization Centre. While Evans is reluctant to limit its scope, MaRS will generally focus on health-related technologies, from new drugs and genetic treatments to medical devices and imaging software. Branded a "convergence centre," it will also house a careful mix of support services: intellectual property lawyers, accountants, marketing experts, government funding organizations and venture capital financiers. Plus, start-ups will have access to all the latest equipment on site. For instance, MaRS is in talks with MDS Sciex to supply mass spectrometers, used in proteomics research.

But MaRS will be more than just a New Economy real estate development. Evans's intention is to funnel tenants' rent money into services--such as entrepreneurship seminars and angel-matching programs--that MaRS will offer to the broader biotech community. That's why MaRS's location is key: the centre will be built in the heart of what Toronto has dubbed the "Discovery District," a two-square-kilometre chunk of the downtown core, encompassing U of T and four major hospitals. From there, MaRS hopes to act as a network hub across Ontario, with links to research-intensive universities. "None of them," says Evans, "have the critical mass to put it all together on their own."

the Chief of Research at the Hospital for Sick Children in Toronto, collaboration is the key to the future.

That's why Dr. Janet Rossant is so enthusiastic about the work being done in the MaRS Discovery District - a unique zone in the city where innovations in science and technology are commercialized through partnerships between researchers and private enterprise.

"The MaRS Centre and biomedical community have seen tremendous growth over the past few years," says Dr. Janet Rossant. "And it continues to grow." "This growth is attracting the world's best scientists to come work here, which is very exciting."

MaRS Innovation is honoured to announce its permanent Board of Directors, who brings together a remarkable and broad set of experiences and networks to support the development of this dynamic partnership of Toronto research institutions.  Designed to enhance the commercial output of Toronto’s world-leading research cluster, MaRS Innovation is positioned to make a significant contribution to Canada’s innovation economy and the quality of life for Canadians and others around the world.

upported by the Government of Canada through the Centres of Excellence in Research and Commercialization (CECR) program, and its member institutions, MaRS Innovation is focused on converting important discoveries into a new generation of products, services and high value jobs. The newly appointed Board of Directors, which includes academic and business leaders from across Canada and the United States, has the targeted expertise to guide MaRS Innovation to deliver on this critical mission.   MaRS Innovation represents a unique collaborative model, which aggregates the exceptional discovery pipeline of 14 leading Toronto academic institutions to build a diversified portfolio of assets, and harness the economic and job creation potential of the best opportunities for Toronto, Ontario and Canada.

“MaRS Innovation is privileged to announce a Board of Directors of this caliber and breadth of skill,” said Mary Jo Haddad, Chair of the MaRS Innovation Board and President and CEO of The Hospital for Sick Children. “The collective experience and guidance of these individuals will be critical to developing a collaborative, integrated and agile approach to this transformational organization that will move Canada into its next phase of economic development.”

Tony Pawson has been studying how cells communicate for more than 30 years.

Scientists had long known that cells communicated, but no one knew the exact mechanisms until Pawson and his team pinpointed the specific protein interactions controlling cell signals.

Since his initial discovery, Pawson has been inundated with every possible award for biomedical sciences, including the Gairdner Foundation International Award (considered the baby Nobel), and, in 2007, was named to the Order of the Companions of Honour, one of only nine Canadians to receive the award from the Queen

On June 9-11, 2009, the Martin Prosperity Institute, in partnership with the Ontario Ministry of Culture, and the City of Toronto - Economic Development, Culture & Tourism Division, will be hosting the inaugural Placing Creativity Conference at the MaRS Centre, 101 College Street, Toronto, Ontario, Canada.

The Conference brings together diverse stakeholders from government, the private sector and the academic world to explore the importance of mapping culture in relation to creative spaces and places.

"The mission of Placing Creativity is to advance the understanding and practice of cultural resource mapping by developing reusable maps that showcase the cultural sector in Toronto and that can be shared with other jurisdictions and groups," said Kevin Stolarick, Research Director, The Martin Prosperity Institute.

In November, Skymeter moved into the incubator at the MaRS Centre, where marketing expert Peter Evans has become their mentor and godfather. "Being surrounded by other entrepreneurs is inspiring and enlightening," Hassan says. "MaRS is an amazing place, with excellent speakers and events that are open to the public."

The father of Skymeter Corp. – which developed a BlackBerry-sized device that uses GPS signals; placed in vehicles, it meters the use of roads, parking and pay-as-you-drive insurance

Skymeter's black box will be attached to the windshield of cars so the box has a clear view of the sky. (Grush has figured out how to cope with tall buildings blocking signals.) The box contains a GPS receiver, some memory, a processor and a telecommunications chip. The satellite beams down to the earth, the GPS receiver computes where it is and uploads its history to a data centre to generate the bill. The vehicle measures its own use; the bill is itemized like a cellphone bill. If you prepay, the bill can be calculated on board.

Five cleantech companies receive support at the Cleantech Forum in Boston from Canadian incubation and innovation center MaRS.

Alternative Fuels was just one of a lineup of early-stage startups being supported by MaRS, a nonprofit innovation center in Toronto’s downtown Discovery District that connects entrepreneurs with business skills, networks and capital to stimulate innovation and grow Canadian companies.

This week’s forum marked the organization’s first foray into the cleantech sector, said MaRS Venture Group Associate Kevin Downing. Downing said he wanted to connect cleantech-related companies in the MaRS portfolio that were “investment ready” with the forum’s audience. “I don’t have a motive to push any one client over any other because they’re not paying me,” Downing said. Of the 1,300 MaRS portfolio companies, he said the cleantech sector has been its fastest growing segment and an expanding sector in country as well (see Canadian cleantech looks to the future and IPO drought? Cleantech companies flood Canadian markets). Since 2006, cleantech and environmental technology companies have made up 9 percent of MaRS' portfolio. MaRS currently has 350 active clients. The center isn’t government funded, but does receive some government support, he said. It has been funded through donations from the public and private sector. MaRS has the ability to provide some funding, around $40,000, to startups on a competitive basis. Other companies showcased at the forum through MaRS included NIMtech, Real Tech, Vicicog and Skymeter.

2009 Cleantech Issue

exclusive look at the continent’s greenest hotel: The Planet Traveler Hotel in Kensignton Market, Toronto.

The big talk by the cleantech lead at the MaRS Discovery District, and the man behind VCi Greenfunds and Green Bonds, is backed by bigger action. Rand’s latest project is what he claims to be “the continent’s greenest hotel”, which Corporate Knights first told you about in October 2008.

The Ivey Centre for Health Innovation and Leadership was launched this year with a $5-million push from the Canadian government. The latest Ivey initiative has the goal of bringing students together with experts from the science and business sectors, with the ultimate goal of better identifying and commercializing health technologies.Dr. Kellie Leitch, a Hospital for Sick Children orthopedic surgeon, is the first executive director of the centre, which is based at Western.

She is sitting in the basement of MaRS, a scientific hub of activity in downtown Toronto where labs, business and major Toronto teaching hospitals are brought together under one roof.

The Ivey centre will focus on giving the educational capability to our students so they become really well educated in innovation and commercialization, so we can keep things here at home in Canada and grow those products."

This is Toronto's research district, a maze of concrete and glass where the finest minds collaborate, turning the city into a global centre of biomedical discovery.

Nine research institutes employing 5,000 university faculty members, 2,000 graduate students and 1,100 postdoctoral and clinical fellows lie within a 20-minute walk of each other. This biomedical cluster at the heart of Toronto is one of the largest on the continent, and is one of the 10 largest in the world.

Tom Hudson from Montreal; cell biologist Ben Neel from Boston; and stem-cell biologist Gordon Keller, who came to Toronto in 2006, just months after New York magazine named him one of the scientists that city could not afford to lose. Toronto is also home to Tak Mak, who discovered the "key to the immune system" T-cell receptor, and John Dick, who discovered the first cancer stem cell in 1994 and last year grew a human cancer in a lab mouse for the first time.

Charles Plant, Managing Director of the Market Readiness Program for entrepreneurs at MaRS

Plant says that acceptance of failure is a cultural problem in Canada in that we tend not to reward the people who have failed. "We tend to punish people who fail whereas in Silicon Valley, they tend to reward people who have failed because they've learned lessons and can gain from that failure.

"I think you have to quickly acknowledge when something is a failure and have a back up plan of what you're going to do," says Plant. "Don't keep flogging a dead horse."