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Influenza is a highly contagious viral infection of the nose, throat, and lungs that occurs most often in the late fall, winter, and early spring

How flu spreads

How serious is the flu?

Complications of flu can include bacterial pneumonia, ear infections, sinus infections, dehydration, and worsening of chronic medical conditions, such as congestive heart failure, asthma, or diabetes.

While seasonal influenza outbreaks can happen as early as October, most of the time influenza activity peaks in January or later. Since it takes about two weeks after vaccination for antibodies to develop in the body that protect against influenza virus infection, it is best that people get vaccinated so they are protected before influenza begins spreading in their community.

contagious respiratory illness caused by influenza viruses that infect the nose, throat, and lungs.

contagious respiratory illness

influenza is responsible for an average of more than 20,000 deaths annually.[1]

The percentage of seniors with postvaccination hemagglutination-inhibition titers of 1:40

-dose vaccine, according to results from a phase IIIb-IV double-blind, active-controlled trial.[

A total of 31,989 participants were randomly assigned to receive either a high dose (IIV3-HD) (60 μg of hemagglutinin per strain) or a standard dose (IIV3-SD) (15 μg of hemagglutinin per strain) of a trivalent, inactivated influenza vaccine.

Although reports of at least one serious adverse event were greater in the IIV3-HD group (8.3%) than in the IIV3-SD group (9.0%) (relative risk, 0.92; 95% CI, 0.85 to 0.99), all resolved by the end of the study and none required discontinuation from the study

High-dose influenza vaccine appears to have the potential to prevent nearly one-quarter of all breakthrough influenza illnesses in seniors (≥65 y) compared with

The presentation of influenza virus infection varies, but it usually includes many of the following signs and symptoms:

Fever Sore throat Myalgias Frontal or retro-orbital headache Nasal discharge Weakness and severe fatigue Cough and other respiratory symptoms Tachycardia Red, watery eyes

Avian influenza (H5N1) is rare in humans in developed countries

nfluenza and its complications can be deadly.

Young children Older adults Pregnant women People with weakened immune systems People who have chronic illnesses

People at higher risk of developing flu complications include: Young children under 5, and especially those under 2 years Adults older than 65 Residents of nursing homes and other long-term care facilities Pregnant women People with weakened immune systems People who have chronic illnesses, such as asthma, heart disease, kidney disease and diabetes People who are very obese, with a body mass index (BMI) of 40 or higher

Influenza is a viral infection that attacks your respiratory system — your nose, throat and lungs. Influenza, commonly called the flu, is not the same as stomach "flu" viruses that cause diarrhea and vomiting.

For most people, influenza resolves on its own, but sometimes,

People at higher risk of developing flu complications include: Young children under 5, and especially those under 2 years Adults older than 65 Residents of nursing homes and other long-term care facilities Pregnant women People with weakened immune systems People who have chronic illnesses, such as asthma, heart disease, kidney disease and diabetes People who are very obese, with a body mass index (BMI) of 40 or higher

he best way to protect against influenza is to receive an influenza vaccination e

very year.

Influenza is a highly contagious viral infection of the nose, throat, and lungs that occurs most often in the late fall, winter, and early spring.

Common symptoms include a high fever (101ºF-102ºF) that begins suddenly, muscle/body aches, chills, tiredness, and sudden onset. Influenza frequently causes people to miss school and work but in some cases there are severe complications such as pneumonia

ommon symptoms include a high fever (101ºF-102ºF) that begins suddenly, muscle/body aches, chills, tiredness, and sudden onset. Influenza frequently causes people to miss school and work but in some cases there are severe complications such as pneumonia.

affect

impacts people of all ages. 

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5-20%

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US populatio

3,000-49,000 deaths occur from influenza-related complications. 

200,000 individuals

ospitalized

fever (101ºF-102ºF)

influenza vaccination

chills

udden onset

tiredness,

muscle/body aches

nfluenza is a highly contagious viral infection of the nose, throat, and lungs that occurs most often in the late fall, winter, and early spring. It is a serious infection that affects between 5-20% of the US population annually. Each year, more than 200,000 individuals are hospitalized and 3,000-49,000 deaths occur from influenza-related complications. 

everyone six months of age and older receive an annual vaccination.

early fall, as soon as the vaccine is available.

January or later, is still beneficia

happen as early as October, but most of the time flu activity peaks between December and February

The most effective way to prevent influenza is by getting the influenza vaccine (the flu shot or flu nasal spray) and using simple infection control measures such as hand washing. Antiviral medicines can also help prevent infection if you are exposed to the flu.

 Because the influenza virus changes (or "mutates") slightly from year to year, you need a new influenza vaccine before each flu season. People should get the flu vaccine soon after it has become available to get the most benefit.

People who are vaccinated form antibodies (proteins), which destroy the influenza virus after the person is exposed. It generally takes about two weeks to make these antibodies.

Vaccine formulations — The flu vaccine is available in three forms in the United States, as an injection into the muscle, as an injection into the skin, and as a nasal spray

The injection of the flu vaccine into the muscle (regular flu shot) is approved for adults and children 6 months and older. In older adults, a high-dose version of this vaccine works a little better than the standard-dose version;

The injection of flu vaccine into the skin in what is called an intradermal injection is approved for adults aged 18 to 64 years.

The nasal spray is approved only for healthy children age 2 years and older and healthy adults up to 49 years. In 2014, the Advisory Committee on Immunization Practices recommended the nasal spray instead of the regular flu shot for healthy children 2 to 8 years of age when it is immediately available.

Vaccine side effects — People who get the vaccine as an injection (either into muscle or skin) can have reactions at the injection site. Intramuscular injections can cause redness, swelling, and/or soreness at the site. Intradermal injections can cause redness, swelling, and/or itching. The high-dose intramuscular vaccine and the intradermal vaccine are more likely to cause local reactions than the standard-dose intramuscular vaccine

Antiviral medicines can help to reduce the chances of developing the flu after being exposed to someone who is infected. These medicines can also be used in certain people who are at risk for developing complications from the flu and who cannot receive the flu vaccine.

INFLUENZA VACCINE

Third, many seasonal flu-related deaths occur one or two weeks after a person’s initial infection, either because the person may develop a secondary bacterial co-infection (such as bacterial pneumonia) or because seasonal influenza can aggravate an existing chronic illness (such as congestive heart failure or chronic obstructive pulmonary disease).

Antigenic diversity of the virus and constant influx of new subtypes allow the virus to become resistant to these antiviral drugs and evade vaccines. There is therefore a continuing need for new anti-influenza therapeutics using novel targets and creative strategies.

An aggressive immune response known as the cytokine storm plays an important role in causing significant tissue injury and mortality following human pathogenic influenza virus

bacterial infections in the lungGSK starts shipping FLUARIX

infection

most vaccine formulations for influenza are still produced by rather old-fashioned techniques that have been in use for over 60 years. Such methods involve the growth and passaging of the vaccine strains in embryonated chicken eggs, therefore production and subsequent formulation can take several months and rely

Children 0-4 years of age have the second-highest hospitalization rate this season.

Symptoms of influenza infection include fever, chills, cough, sore throat, runny or stuffy nose, muscle or body aches, headache, fatigue (tiredness), and sometimes vomiting and diarrhea (more common in children than adults).

The United States experiences epidemics of seasonal flu each year. This time of year is called "flu season." While influenza activity has declined in recent weeks and the flu season is coming to a close, most of CDC’s influenza surveillance systems still show elevated activity.

There are several factors that make it difficult to determine accurate numbers of deaths caused by flu regardless of reporting.

he timi

Flu viruses are constantly changing and it's not unusual for new seasonal flu viruses to appear each year.

When viruses change in that way, they are said to be “drifted” viruses.

the sheer volume of deaths to be counted; not everyone that dies with an influenza-like illness is tested for influenza; and influenza-associated deaths are often a result of complications secondary to underlying medical problems, and this may be difficult to sort out.

g of flu

s very unpredictable and can vary in different parts of the country and from season to season

However, seasonal flu activity can begin as early as October and continue to occur as late as May.

CDC recommends a yearly flu vaccine(http://www.cdc.gov/flu/protect/vaccine/index.htm) for everyone 6 months of age and older as the first and most important step in protecting against this serious disease.

In addition to getting a seasonal flu vaccine if you have not already gotten vaccinated, you can take everyday preventive actions(http://www.cdc.gov/flu/protect/habits/index.htm) like staying away from sick people and washing your hands to reduce the spread of germs. If you are sick with flu, stay home from work or school to prevent spreading flu to others.

A number of different manufacturers produce trivalent (three component) influenza vaccines for the U.S. market, including intramuscular (IM), intradermal, and nasal spray vaccines.

Multiple studies conducted over different seasons and across vaccine types and influenza virus subtypes have shown that the body’s immunity to influenza viruses (acquired either through natural infection or vaccination) declines over time.

Yes. It’s possible to get sick with the flu even if you have been vaccinated (although you won’t know for sure unless you get a flu test). This is possible for the following reasons:

You may be exposed to a flu virus shortly before getting vaccinated or during the period that it takes the body to gain protection after getting vaccinated. This exposure may result in you becoming ill with flu before the vaccine begins to protect you. (About 2 weeks after vaccination, antibodies that provide protection develop in the body.) You may be exposed to a flu virus that is not included in the seasonal flu vaccine. There are many different flu viruses that circulate every year. The flu vaccine is made to protect against the three or four flu viruses that research suggests will be most common. Unfortunately, some people can become infected with a flu virus the flu vaccine is designed to protect against, despite getting vaccinated. Protection provided by flu vaccination can vary widely, based in part on health and age factors of the person getting vaccinated. In general, the flu vaccine works best among healthy younger adults and older children. Some older people and people with certain chronic illnesses may develop less immunity after vaccination. Flu vaccination is not a perfect tool, but it is the best way to protect against flu infection.

Some of the complications caused by flu include bacterial pneumonia, dehydration, and worsening of chronic medical conditions, such as congestive heart failure, asthma, or diabetes. Children may get sinus problems and ear infections.

more severe and last longer than those of the cold.

Recovery takes about one to two weeks. Influenza can be deadly, especially for the weak, old or chronically ill.

Most people who get influenza will recover in one to two weeks, but others will develop life-threatening complications (such as pneumonia). Millions of people in the United States (about 10% to 20% of U.S. residents) are infected with influenza each year.

influenza A

Influenza is an extremely variable disease; similar viruses are found in pigs and domestic fowl.

It is possible to get vaccinated against influenza

People at high risk for complications from the flu; People 65 years and older; People who live in nursing homes and other long-term care facilities that house those with long-term illnesses; Adults and children 6 months and older with chronic heart or lung conditions, including asthma; Adults and children 6 months and older who needed regular medical care or were in a hospital during the previous year because of a metabolic disease (like diabetes), chronic kidney disease, or weakened immune system (including immune system problems caused by medicines or by infection with human immunodeficiency virus [HIV/AIDS]); Children 6 months to 18 years of age who are on long-term aspirin therapy. (Children given aspirin while they have influenza are at risk of Reye syndrome.); Women who will be pregnant during the influenza season; and All children 6 to 23 months of age.

There are some people who should not be vaccinated. This includes: People who have a severe allergy to chicken eggs. People who have had a severe reaction to an influenza vaccination in the past. People who developed Guillain-Barré syndrome (GBS) within 6 weeks of getting an influenza vaccine previously.

Children less

People who are sick with a fever. (These people can get vaccinated once their symptoms lessen.)

Yearly immunization with the inactivated influenza vaccine(What is a PDF document?) (flu shot) or the nasal spray flu vaccine(What is a PDF document?) prevents flu infection and its complications in most people.

Yearly immunization with the inactivated influenza vaccine(What is a PDF document?) (flu shot) or the nasal spray flu vaccine(What is a PDF document?) prevents flu infection and its complications in most people.

Have heart disease.

Have diabetes or kidney disease.Have a disease or take a medicine that causes problems with your immune system.

can result in hospitalization or death

upcoming season's flu vaccine(http://www.cdc.gov/flu/about/season/index.htm) will protect against the influenza viruses that research indicates will be most common during the season

Vaccinations against influenza are usually made available to people in developed countries.[12] Farmed poultry is often vaccinated to

avoid devastation of the flocks.[13]

The most common human vaccine is the trivalent influenza vaccine (TIV) that contains purified and inactivated antigens from three viral strains. Typically, this vaccine includes material from two influenza A virus subtypes and one

C infection usually causes either a very mild respiratory illness or no symptoms at all

Efforts to control the impact of influenza are aimed at types A an

Influenza viruses continually change over time, usually by mutation

A host infected with influenza virus develops antibodies against that virus; as the virus changes, the "first" antibody no longer recognizes the "newer" virus and infection can occur because the host does not recognize the new flu virus as a problem until the infection is well under way.

Type A viruses are divided into subtypes or strains based on differences in two viral surface proteins called the hemagglutinin (H) and the neuraminidase (N)