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katherine-medina

Frontiers | Cerebrospinal Fluid Pressure-Related Features in Chronic Headache: A Prospe... - 0 views

www.frontiersin.org/...full

CSF-pressure HSR-2023 methods headaches

shared by katherine-medina on 01 Jun 23 - No Cached
  • magnetic resonance
  • magnetic resonance
    • katherine-medina
      katherine-medina on 01 Jun 23
       
      A non-invasive imaging software
  • A respondent to medical treatment (good outcome) was considered a subject who achieved a 50% or greater reduction in number of headache days per month.
  • ...14 more annotations...
  • The pressure transducer (Transducer kit, Edwards Lifesciences, Irvine, CA, USA) was attached to the hub of needle via a 10-cm long flexible tube without loss of CSF.
  • 93 had abnormal CSF pressure pulsations, with opening pressures ranging from 206 to 385 mm
  • . Group 1 comprised 55 patients, each with an opening pressure below 200 mm H2O
  • Group 2 comprised 56 patients, each with a slight elevation of CSF opening pressure (mean = 231.8
  • Group 3 included 37 patients, all with both elevated CSF opening pressure (mean = 282.2 mm H2O,
  • n Group 3, patients with severe abnormal pressure pulsations and mean pressure >250 mm H2O had the most severe headaches (highest scores on VAS and MIDAS) and associated symptoms (high frequency of: nocturnal headache, postural headache, photopsias, transient visual obscurations).
  • In Group 2, patients with less severe abnormal pressure pulsations and mean pressure >200 mm H2O, had less severe symptoms; in Group 1, patients who had no abnormal pressure pulsations and mean pressures below 200 mm H2O had primary chronic headache disorder (Figure 1).
  • . All of the subjects in the control group, all with opening pressures below 200 mm H2o and normal CSF pressure pulsations, had no headache.
    • katherine-medina
      katherine-medina on 01 Jun 23
       
      So essentially if the CSF pressure was too low the patient had chronic headache disorder, but if the patients had a higher level of pressure they would suffer from the most painful headaches. (This occurring as nocturnal headaches, postural headaches, and transient visual obstructions.
  • An improvement in the intensity of pain and frequency of headaches was observed following CSF removal in all patients with ICH
  • 69 (74%) out 93 patients achieved ≥50% reduction in headache days.
  • Our results provide evidence that nocturnal and postural headache, and abnormal pressure pulsations are the most common pressure-related features of isolated high CSF pressure in patients with chronic headache
  • o explain this mimicry, we hypothesize that abnormal pulsations in CSF pressure may trigger the same mechanism that cause the pain in a primary headache attack. The mimicry thereby emerges as a variation of pre-existing primary headache; as such, it could be considered a triggered headache rather than a secondary or primary one.
  • The pathogenesis of these abnormal pulsations in CSF pressure (B waves and plateau waves) may be clarified by reference to the theory that CSF pressure is derived from the circulation of cerebral blood and cerebrospinal fluid
    • katherine-medina
      katherine-medina on 01 Jun 23
       
      Hmmm... I had no idea that there is a theory that states that CSF pressure is derived from the circulation of blood. (I might wanna look into the further)
  • This suggests that CSF pressure assessment by measuring the height of the fluid column in the manometer line connected to a spinal puncture needle may be misleading in the case of headache sufferers.
  • katherine-medina on 01 Jun 23
     
    A good study to look at when looking at possible causes of headaches, and more information about CSF.
prishabpatel

Melatonin and its relationship to plant hormones | Annals of Botany | Oxford Academic - 2 views

academic.oup.com/...4560814

HSR-2023 botany biology

shared by prishabpatel on 24 Aug 23 - No Cached
Sean Nash liked it
  • Sean Nash on 24 Aug 23
     
    This is super interesting to me... both the content itself AND the fact that this is not far from feasible for an advanced HS study. Phytohormones: FASCINATING, accessible, relatively easy to apply, and the immediate question is... is it measurable? We can certainly measure the effects of applied plant hormones simply by recording the growth and development data of the plants we apply them to. What this article gets at (from a VERY brief SKIM) is the need to measure increases of hormones levels INSIDE plant tissue. Now, this is something that requires sophistication beyond what we have a BLHS. However, it might be able to be detected by NMR (nuclear magnetic resonance), HPLC (high-pressure liquid chromatography), or IR spectroscopy. If we know exactly what we're looking for in plant specimens/samples, and we ask super professionally, perhaps we could get the chem department at UMKC to help us use the right tool for the job to detect and measure these things.
ryleighnyp

Real-time dialogue between experimenters and dreamers during REM sleep: Current Biology - 3 views

www.cell.com/...S0960-9822(21)00059-2

shared by ryleighnyp on 21 May 23 - No Cached
  • study by Strauss and Dehaene13Strauss M. Dehaene S. Detection of arithmetic violations during sleep.Sleep (Basel). 2019; 42: zsy232PubMed Google Scholar focused on electro- and magnetoencephalographic responses to spoken arithmetic equations (addition, multiplication, or subtraction operations).
  • study by Strauss and Dehaene13Strauss M. Dehaene S. Detection of arithmetic violations during sleep.Sleep (Basel). 2019; 42: zsy232PubMed Google Scholar focused on electro- and magnetoencephalographic responses to spoken arithmetic equations (addition, multiplication, or subtraction operations).
    • ryleighnyp
      ryleighnyp on 23 May 23
       
      Magnetoencephalography is a technique used to measure the magnetic fields produced by electrical activity in the brain. It is a non-invasive method that can provide high temporal and spatial resolution of brain activity. In the context of the research paper, the authors mention a study by Strauss and Dehaene that focused on electro- and magnetoencephalographic responses to spoken arithmetic equations during wakefulness and sleep. (Copilot)
  • katherine-medina on 21 May 23
     
    An interesting Sleep study about how scientist can communicate with people who are sleeping
katherine-medina

Sci-Hub | Amyloid-β as a Blood Biomarker for Alzheimer's Disease: A Review of... - 0 views

sci-hub.ru/...31868667

blood-plasma biomarkers Alzheimer's-disease potential research idea HSR-2023

shared by katherine-medina on 31 May 23 - No Cached
    • katherine-medina
      katherine-medina on 31 May 23
       
      So seeing as if scientists have mostly studied AB40-42, and 38 why don't they look at the other peptides under the name of AB.
    • katherine-medina
      katherine-medina on 31 May 23
       
      I shall take note of this excerpt of the passage for future reference, "The discrep- 104 ancy between these two ultrasensitive assays may 105 be due to the different principle and design that 106 IMR assay could inhibit the oligomerization of A42 107 by the iron-chelating effect of magnetic Fe3O4 108 nanoparticles."
    • katherine-medina
      katherine-medina on 31 May 23
       
      Important to see that they are figuring out that, "that there is a blood-brain transportation mechanism 261 for A and indicated that plasma A may be able to 262 reflect the brain A condition."
  • ...1 more annotation...
    • katherine-medina
      katherine-medina on 31 May 23
       
      Maybe I could look into the blood plasma levels AB1-40 and make it into a sort of predictor that could show if somehow may in future years live with some sort of Alzeheimer's Dementia.
  • katherine-medina on 31 May 23
     
    A good look at what scientist have found about the presence of Amyloid B in the blood as a biomarker for Alzheimer's disease
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