The UK Health Security Agency (UKHSA) has suggested that the Live Attenuated Influenza Vaccine (LAIV) vaccine that offers protection to children against flu
may also help reduce the rate of group A strep infections.
LAIV is a nasal spray offered each season to most children aged 2 and 3 years old, and to school-aged children, to help protect against flu.
The new study looked back at data from 2013 to 2017, comparing rates of group A strep (GAS) infections in pilot areas and comparing them to other areas where the
vaccine was not being offered as widely.
It was found that incidence of GAS was lower in pilot areas where the LAIV vaccine was being offered to all primary school children, compared to areas where it was
being incrementally rolled out.
The study revealed, in 2 to 4 year olds, rates of GAS were 73.5 per 100,000 children in pilot areas, compared to 93 per 100,000 children in non-pilot areas. In 5 to
10 year olds, rates of GAS were 50.3 per 100,000 children in pilot areas, compared to 57.8 per 100,000 in non-pilot areas.
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Breast is a gland made up of different tissues and supported by connectives to tissues and surrounded by fats. It is easier to understand the breast structure when it is compared to an upward turned bush such as the leaves can be compared to the lobes that are used to produce the milk and ducts are like branches of a tree used to drain the milk from lobes into the larger ducts which transfer the milk to the nipples from where the infants get their feed.
The government has launched a consultation into radically changing the Statutory Scheme for branded medicines (known as the Statutory Scheme).
The consultation comes as delicate negotiations for replacing the alternative Voluntary Scheme are underway, potentially undermining these talks, while also further
damaging industry confidence in the UK as a viable place to research, launch and supply medicine.
The government proposals seek to hold average revenue clawback rates under the Statutory Scheme at historic highs of between 21-27%, compared to the pre-pandemic
averages of 9.4% for the Statutory Scheme (2019-2021), and 6.88% for the Voluntary Scheme (2014-2021). The accompanying cost-benefit analysis ignores any negative
impact this may have on medicine supply and wrongly claims it will boost investment.
The consultation comes on the heels of government data last week showing UK life sciences foreign direct investment (FDI) fell by 47% between 2021 and 2022, down
by £900m year on year. This large fall in investment coincided with a rise in the main UK clawback rate under the Voluntary Scheme from 5% to 15%, and led to the
UK falling from 2nd to 9th out of 18 comparator countries for life sciences FDI in 2022. The Voluntary Scheme clawback rate now sits at a record 26.5% in 2023.
National Institute of Health and Care Excellence (NICE) has not recommended 'Tirzepatide', also known as Mounjaro, developed by Eli Lilly, in its draft
guidance issued on Tuesday (27 June) for treating type 2 diabetes in adults alongside diet and exercise.
The independent NICE committee recognised the importance of new treatment options given that fewer than two-thirds of the adults with type 2 diabetes have adequate
glucose control when using current treatment options.
Evidence submitted to the committee from clinical trials showed the use of tirzepatide at any dose resulted in better glucose control and lower weight compared with
semaglutide or insulin therapy.
The weight reduction was more pronounced with higher doses of tirzepatide, while the effect on glucose levels seemed less dose-dependent. Similar effects were
observed against all GLP-1 receptor agonists in company's network meta-analysis, but this was uncertain.
The committee have asked the company to provide more data to address the uncertainties in the clinical evidence, when compared to all relevant alternative
treatments.
The drug, alpelisib, which is the 100th cancer drug that has being fast-tracked to patients under the NHS Cancer Drugs Fund (CDF) will be used in combination
with the hormone therapy, fulvestrant, to target the gene that causes fast-growing tumours.
Up to 3,000 people a year with a certain type of secondary breast cancer will benefit from the treatment.
The approach has contributed to people in England having access to nearly one third more cancer drugs compared to the European average.
The drug which is manufactured by pharmaceutical company Novartis, is part of a growing number of precision treatments that target a tumour based on mutations in
its DNA and that the NHS is rolling out.
John Stewart, NHS National Director for Specialised Commissioning said, "In just over five years, more than 80,000 people have benefitted from earlier access to a
range of cancer drugs, with people in England having access to nearly one third more cancer drugs compared to the European average, and this latest innovative new
treatment will help up to 3,000 more to live a better quality of life.
Covid-vaccine maker AstraZeneca said Friday that profits fell sharply in the first half on ballooning costs linked to its takeover of US biotech firm Alexion.
The pharmaceutical group added that sales of its Covid-19 vaccine Vaxzevria slumped 49 percent in the second quarter.
Net profit slumped 64 per cent to $746 million compared with the first six months of last year, AstraZeneca said in a statement.
Operating expenses jumped 33 percent, "reflecting the addition of Alexion, and continued investment in new launches and the pipeline" of drugs, the group said.
That offset a 48-percent jump in revenue to more than $22 billion.
Revenue rose strongly thanks to sales of Alexion medicines.
The group said annual revenue from Covid-19 medicines is anticipated to be broadly flat compared with 2021.
An oral drug combination by Novartis showed promise in treating a subgroup of patients suffering from a common childhood brain cancer in a trial.
In the mid-stage trial, 47 per cent of the patients that were given the two drugs Tafinlar and Mekinist saw their tumours shrink, far above a rate of 11 per cent
in a comparative group of participants on standard chemotherapy, the drugmaker said on Monday, June 6.
The participants, aged one to 17 years, were suffering from low-grade gliomas (LGG), the most common childhood brain cancer.
The trial only included those who were found to have a mutation known as BRAF V600, a genetic contributor in about 15 per cent to 20 per cent of paediatric LGG cases.
Among further results of the trial with 110 participants, the median time without disease progression was 20.1 months for those given the Novartis drug combo,
compared to 7.4 months on chemotherapy.
The new oral treatment candidate also caused less severe side effects than burdensome chemotherapy.
The UK has witnessed a nearly 50 percent increase in pharmacy closures this year compared to the same period in 2023, which was already considered the
worst year in recent memory.
A new analysis by the National Pharmacy Association (NPA) revealed that 177 pharmacies closed their doors between January and April 2024, compared to 116 in the
same period last year. This is the equivalent of 10 local pharmacies shutting down every week.
Analysis of NHS figures by the NPA showed that 403 pharmacies closed their doors last year, nearly five times higher than the number that closed in 2022.
Since 2017, over 1,400 pharmacies have shut down across the UK.
Rising costs and declining real terms funding have led to the fastest rate of closures in decades, said the NPA, highlighting that "real terms funding has
decreased by 40 per cent over the last decade."
Insect bites and stings typically increase in the summer in England. This year, however, there's been an earlier-than-usual spike in the number of people
seeking NHS advice on the condition.
According to the NHS England, visits to its insect bites and stings web page have nearly tripled in the last three weeks compared to the same period last year,
peaking at an average of one visit every 22 seconds in the past week.
Over the span of 21 days, a total of 68,986 visited the page, marking a significant 162 per cent increase compared to the 26,368 visits recorded in the first three
weeks of May 2023.
Although insect bites or stings are usually not serious and people tend to get better after a few days, the health service has cautioned that they can lead to
infection or severe allergic reactions.
People are encouraged to refer to the NHS website for advice or visit their local pharmacy to get advice and treatment for common health conditions, including
infected insect bites.
Despite being more connected than ever, the majority of Europeans are experiencing feelings of loneliness. The STADA Health Report 2024, released on Monday,
revealed that over half (52 per cent) of Europeans "always, often or occasionally" feel lonely.
Although the younger generation reports the highest levels of overall happiness, they are the ones most affected by this current loneliness epidemic.
Nearly two-thirds (63 per cent) of Europeans aged 18 to 35 reported feeling lonely, compared to 41 percent of those aged 55 and older - according to the report,
based on a survey of over 46,000 respondents aged 18 to 99 across 32 countries.
Extensive screen time is contributing to increased loneliness among younger people. Europeans under the age of 34 are much more likely to spend long hours on
their devices (41 per cent) than those aged 35-54 (22 per cent) and those over 55 (13 per cent).
The survey found that people who spend a "long" or "fair" amount of time on social media were significantly more prone to feelings of loneliness compared to
those who restrict their screen time. Moreover, extensive screen time was also associated with more intense feelings of loneliness.
Online pharmacy delivery partner Gophr has released new data showing a further drop in pharmacy numbers in England, resulting in a phenomenon they
call 'Pharmacy Deserts'.
Gophr highlighted that a significant portion of the population now lives in 'pharmacy deserts,' referring to the situation where an increasing number of urban
residents struggle to access a shrinking number of pharmacies.
For the second consecutive year, Gophr has analysed the data for its 'Prescription For Pressure' initiative.
The analysis showed that in 2023, pharmacists dispensed 1.18 billion prescriptions across England, marking an increase of 137 million compared to 2022.
The average number of prescriptions per pharmacy stands at 103,380, which equates to 283 a day.
As calculated by Gophr's data experts, pharmacy numbers decreased from 11,522 in 2022 to 11,414 in 2023, reflecting a decline of 108 compared to the previous
year's 'Prescription For Pressure'.
Gophr's data also showed that pharmacy deserts are most prominent in the South East (6,024 people per pharmacy), the East of England (5,327), the South West
(5,284), and the Midlands (4,975).
London, which ranked high last year, fell out of the top four, with 4,759 people per pharmacy.
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wheelchair category (standard, transport, power, etc.) could be classified as a reclining wheelchairs, since the product class is built around one key feature: the capability to adjust the backrest and/or footrest into a reclined position. This feature is especially important to users who find it difficult or impossible to sit in a fully upright position, and users who sleep in their chairs frequently. For those that are looking for a more portable chair, however, products from this category may not be a great fit. When compared with a similar, non-reclining chair, a reclining wheelchair tends to weigh more and - unlike other manual models - manual wheelchairs that recline typically aren't foldable
Women being the delicate creature are at increased risk of developing cancer as compare to men and the difference between the breast of men and women is that both have different breast structure as women breast are made up of many breast tissues which include connective, fatty and glandular tissues and the difference of structure start developing at the time of puberty as after puberty women breasts become larger and developed to perform different functions such as to maintain attractive physique, produce milk for infants and give pleasure to the partner during sex.
People whose heart rates increased from under 70 beats per minute to more than 85 beats per minute over 10 years had a 90 percent increased risk of dying from heart disease compared to people whose heart rates stayed around 70 beats per minute, according to the large study.