As defined by Park & Lakes (2007), a biomaterial is a material that replaces either a tissue within the body or a function of the body.

In the first generation of biomaterial development, individuals used materials in their local environments for replacing tissues that were lost to damage or disease.

The goal during the first generation of biomaterial development was the creation of materials that exhibited inert behaviour when placed in the body. Surgeons sought materials that provided (i) appropriate mechanical properties for the intended use, (ii) corrosion resistance, and (iii) an absence of injurious effects such as carcinogenicity, toxicity, allergy and inflammation.

Although synthetic polymers are widely used in medicine, in direct contact with blood, these polymers are still prone to initiate the formation of clots due to activation of platelets and other components of the blood coagulation system ([Aiping and Tian 2006]). It is well known that interactions between the surface of an artificial biomaterial and biological environment are the key factor to determine the biocompatibility

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Bioglass® is a clear bioactive material made of calcium, phosphorous, silicon, and sodium salts. It is a type of artificially made glass classified as a bioceramic. It chemically reacts with body fluids to form a bond at the surfaces of tissues and bones. The elements that make up Bioglass® are needed to repair and grow tissues and bones.

There is no risk of disease or rejection since Bioglass® is made completely of elements found in the human body.

In 1987, a group of experts defined the word biomaterial as “a non-viable material used in a medical device, intended to interact with biological systems” (Europeon Society of Biomaterials Conference, 1987). This definition reflected the state of the field at the time, which was focused on developing materials and coatings to prevent the rejection of implantable medical device