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This sort of late-breaking Democratic vote is the new, though still underappreciated, normal in national elections. Americans have become accustomed to knowing who won our elections promptly, but there are many legitimate votes that are not counted immediately every election year. For reasons that are not totally understood by election observers, these votes tend to be heavily Democratic, leading results to tilt toward Democrats as more of them are counted, in what has become known as the "blue shift." In most cases, the blue shift is relatively inconsequential, changing final vote counts but not results. But in others, as in 2018, it can materially change the outcome.

In December 2019, the Coronavirus disease 2019 (COVID-19), caused by a novel coronavirus SARS-CoV-2, emerged in Wuhan, Hubei province, China1 and soon spread across the world. In this ongoing pandemic, public health concerns and the urgent need for effective therapeutic measures require a deep understanding of its epidemiology, transmissibility and pathogenesis. Here we analyzed the clinical, molecular and immunological data from 326 confirmed cases of COVID-19 in Shanghai. Genomic sequences of SARS-CoV-2 assembled from 112 quality samples together with sequences in the Global Initiative on Sharing All Influenza Data (GISAID) showed a stable evolution and suggested two major lineages with differential exposure history during the early phase of the outbreak in Wuhan. Nevertheless, they exhibited similar virulence and clinical outcomes. Lymphocytopenia, especially the reduced CD4+ and CD8+ T cell counts upon admission, was predictive of disease progression. High levels of IL-6 and IL-8 during treatment were observed in patients with severe or critical disease and correlated with decreased lymphocyte count. The determinants of disease severity seemed to stem mostly from host factors such as age, lymphocytopenia, and its associated cytokine storm, whereas viral genetic variation did not significantly affect the outcomes.

A strange thing has happened to men over the past few decades: We've become increasingly infertile, so much so that within a generation we may lose the ability to reproduce entirely. What's causing this mysterious drop in sperm counts-and is there any way to reverse it before it's too late?

"That said, there's another factor driving the reaction of Clinton's supporters, and the best way I can find to approach it is to consider one of the more thoughtful responses from that side of the political landscape, an incisive essay posted to Livejournal last week by someone who goes by the nom de Web "Ferrett Steinmetz." The essay's titled The Cold, Cold Math We'll Need to Survive the Next Twenty Years, and it comes so close to understanding what happened last Tuesday that the remaining gap offers an unsparing glimpse straight to the heart of the failure of the Left to make its case to the rest of the American people. At the heart of the essay are two indisputable points. The first is that the core constituencies of the Democratic Party are not large enough by themselves to decide who gets to be president. That's just as true of the Republican party, by the way, and with few exceptions it's true in every democratic society.  Each party large enough to matter has a set of core constituencies who can be counted on to vote for it under most circumstances, and then has to figure out how to appeal to enough people outside its own base to win elections. That's something that both parties in the US tend to forget from time to time, and when they do so, they lose. The second indisputable point is that if Democrats want to win an election in today's America, they have to find ways to reach out to people who don't share the values and interests of the Left. It's the way that Ferrett Steinmetz frames that second point, though, that shows why the Democratic Party failed to accomplish that necessary task this time. "We have to reach out to people who hate us," Steinmetz says, and admits that he has no idea at all how to do that. "

I offer three specific recommendations: * Paperless DRE voting machines should be immediately phased out from US elections in favor of systems, such as precinct-counted optical scan ballots, that leave a direct artifact of the voter's choice. * Statistical "risk limiting audits" should be used after every election to detect software failures and attacks. * Additional resources, infrastructure, and training should be made available to state and local voting officials to help them more effectively defend their systems against increasingly sophisticated adversaries.