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In 2014-15, the Ebola virus was a source of devastation for millions in West Africa. The disease-which quickly causes severe hemorrhaging, organ failure, and death-was primarily found in isolated parts of central Africa until the outbreak. The three nations at the center of the epidemic were Guinea, Liberia and Sierra Leone, all of which share borders. According to the Centers for Disease Control, the World Health Organization confirmed more than 11,000 deaths from 28,000 cases of Ebola through the end of August 2015. The Ebola epidemic was a major test for crisis responders in the public health field. First responders and crisis response agencies can learn from the way organizations across the globe worked together to ultimately contain the virus. Examining both global and local efforts reveals some key lessons about readiness in any situation. Some of these lessons may be important immediately, as the Zika virus spreads and becomes a global threat.