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With a dwindling population and an out of control HIV infection rate in Russia, the future looks bleak. Estimates place Russia on the forefront of the battle against HIV and in a worse position than Africa. Largely ignored by the media and the government, HIV has become the rapidly spreading epidemic in Russia, especially among the youth who are supposed to be future of the country.

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Lentivirus vector is a gene therapy vector developed on the base of HIV-1 (human immunodeficiency virus type 1). Lentivirus vector is a powerful tool for introduction of exogenous genes, with the advantages of wide infection spectrum, effective infection and long-term stable expression of exogenous genes. Now the lentivirus system has been widely used in various cell lines for gene overexpression, RNA interference, microRNA research, as well as in vivo experiments.