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Patients with epilepsy undergoing deep brain stimulation (DBS) have electroencephalograms (EEGs) recorded before and during their stimulation treatment. Subsequently we will be using computer-assisted analysis of the digitally-recorded EEG signals to assess the effects of DBS on the brain-wave frequency content and any abnormal seizure-like patterns that may be present.

Preterm infants are born with immature lungs and often require help with breathing shortly after birth. This currently involves administering 100% oxygen. Unfortunately, delivery of high oxygen concentrations leads to the production of free radicals that can injure many organ systems. Term and near-term newborns deprived of oxygen during or prior to birth respond as well or better to resuscitation with room air (21% oxygen) compared to 100% oxygen. However, a static concentration of 21% oxygen may be inappropriate for preterm infants with lung disease. Our study will investigate how adjusting the amount of oxygen given to sick preterm newborns will affect the ability to maintain a safe oxygen level in their blood

Study to demonstrate beneficial effects of parenteral carnitine supplementation in premature neonates for liver, heart and muscle metabolism and functions.

Hypothesis of study is that among women with twin or triplet pregnancies, weekly injections of 17-alpha-hydroxyprogesterone caproate (17OHP), started before 24 weeks of gestation, will reduce neonatal morbidity by reducing the rate of preterm delivery.This study involves two concurrent double-blinded randomized clinical trials of 17OHP versus placebo. Each trial will test the efficacy and safety of 17OHP in women with a specific risk factor for preterm birth. The two risk factors to be studied are: Twin pregnancy - Triplet pregnancy

Ongoing study sponsored by NICHD will compare the use of continuous positive airway pressure initiated at birth with the early administration of surfactant administered through a tube in the windpipe within 1 hour of birth for premature infants born at 24 to 27 weeks gestation. In addition, these infants within 2 hours of birth, will have a special pulse oximeter placed to continuously monitor their oxygen saturation in two different target ranges (85-89% or 91-95%). This study will determine whether or not these two management strategies affect chronic lung disease and survival of premature infants.

National Institute of Neurological Disorders and Stroke NINDS study will use high-resolution magnetic resonance imaging (MRI) to look for subtle differences in brain anatomy between patients with focal hand dystonia (also called writer's cramp) and healthy normal volunteers. Patients with hand dystonia have prolonged muscle contractions that cause sustained twisting movements and abnormal postures. These abnormal movements often occur with activities such as writing, typing, playing certain musical instruments such as guitar or piano, or playing golf or darts.

Ivestigation is to learn whether intense swallowing exercise or intense swallowing exercise coupled with electrical stimulation (E-Stim) helps patients who had head/neck cancer and currently have dysphagia swallow better.

Completed study classified types of Hypertonia in patients with Cerebral Palsy and determine if the classifications are reasonable in relation to the functional task of walking. Hypertonia is an abnormal increase in muscle tension. It is a common symptom of Cerebral Palsy that can lead to loss of function and deformity. This study may help scientists improve evaluation criteria for hypertonia and, ultimately, treatment results.

Clinical trial being conducted by Eunice Kennedy Shriver NationalInstitute of Child Health and Human Development NICHD to examine botulinum toxin (BOTOX, or BTX) for the treatment of muscle twitches and spasticity associated with cerebral palsy in children. Botulinum toxin is a naturally occurring bacterial toxin (botulinum toxin) that inactivates certain parts of muscles.

National Institute of Neurological Disorders and Stroke NINDS - Neurological Diagnostic Tests and Procedures

Clinical Trial - Omega-3 Fatty Acid supplementation to Prevent Preterm Birth in High Risk Pregnancies - A recently completed trial of weekly injections of 17 alpha hydroxyprogesterone caproate (17P) found significant effectiveness for 17P in preventing recurrent preterm birth. However, the group who received 17P in this trial still had a high rate of preterm birth. Several reports have shown that dietary supplementation of fish oil, which is rich in Omega-3 fatty acids, reduces the risk of preterm birth. This trial tests whether adding the Omega-3 supplement to 17P therapy has the potential for further reducing the risk of preterm birth in women who have previously had a spontaneous preterm delivery. The trial will compare Omega-3 fatty acid with placebo in women receiving 17P therapy.

2010 Ongoing study being conducted by NICHD - STAN Fetal Heart Monitor trial at clinicaltrials.gov - Research to test a new instrument, called a fetal STAN monitor, that may be used during labor to monitor the electrical activity of the baby's heart. This new instrument is designed to help the doctor determine how well the baby is doing during labor. It will be used along with the existing electronic fetal monitor used to measure the baby's heart rate and the mother's contractions during birth. The specific purpose of this research study is to see if this new instrument (fetal STAN monitor) will have an impact on newborn health.

Apraxia-KIDS - The Childhood Apraxia of Speech Association of North America (CASANA) - The mission of CASANA is to strengthen the support systems in the lives of children with apraxia, so that each child has their best opportunity to develop speech

2007 Clinical trial to determine the effectiveness of acupuncture when used as an adjunct to intense conventional physical, occupational and hydro therapies to improve function and quality of life in children with Spastic Cerebral Palsy.

Completed study sponsored by Children's Hospital, Denver to determine which pain management stategy continuous analgesic pump or orally, should be used in the management of children with cerebral palsy

Information regarding ongoing Clinical trial to determine the effectiveness of acupuncture when used as an adjunct to intense "conventional" physical, occupational and hydro therapies to improve function and quality of life in children with spastic CP.

A randomized control trial being sponsored by Columbia University to test the efficacy of contraint-induced movement therapy and a new treatment involving bimanual (Hand-Arm Bimanual Intensive Therapy (HABIT).

Information regarding ongoing study being sponsored by University of Southern California assessing the effect of an exercise program using stationary bicycling for children with spastic diplegic cerebral palsy

Information on completed study sponsored by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) to determine the effects of high frequency, low magnitude vibration on bone and muscle in children with cerebral palsy

Information on research and on going clinic trial being sponsored by Eunice Kennedy Shriver National Institute of Child Halth and Human Development (NICHD) to determine safety, doseage and efficacy in the use of Oral Baclofen with children with cerebral palsy