Study to evaluate the effects of pre-operative gait analysis testing on surgical outcomes in children with cerebral palsy who have problems walking.

United Kingdom study investigating new ways to stretch knee contractures in children with cerebral palsy using a specially designed splint.

Data involving orthopaedic conditions and rehabilitation aspects of musculoskeletal and neuromuscular disorders will be collected and stored as part of the normal clinical care of patients seen in the University of Florida (UF) and Shands Orthopaedics and Sports Medicine Institute.

This study is an observational study to prove that a new device, which measures the force of delivering a baby, (US patent 6,684,165) functions as described in the patent. This is the first time this has been used with patients. The device measures the force (pounds/kilograms) that is exerted as a doctor/midwife pulls on a baby during the delivery

Multicenter, randomized, controlled trial to compare the anti-seizure effect of parenteral MgSO4 versus oral labetalol in hypertensive pregnant women who are eligible for MgSO4 therapy. The primary outcome measure is eclampsia, and the secondary outcome measures include blood pressure control, and relevant antenatal, intrapartum, and postnatal maternal and fetal/neonatal parameters including adverse effects and complications.

The purpose of this study is to provide additional information on safety and tolerability after multiple does of pantoprazole in infants

Ongoing study sponsored by the University of Texas Health Science Center, Houston to evaluate the efficacy of fundoplication in premature infants with GERD and BPD.

Completed study sponsored by NINDS to determine the feasibility of using extrinsic laryngeal muscle stimulation to elevate the larynx in a manner similar to that which occurs during normal swallowing. This research will also determine whether laryngeal elevation will open the upper esophageal sphincter to assist with entry of the bolus into the esophagus. Includes studies in normal volunteers and patients with swallowing disorders.

Ongoing study sponsored by the University of Utah to determine the percentage of patients presenting with dysphagia who are found to have eosinophilic esophagitis (EoE) and to establish which presenting factors warrant esophageal biopsies.

Completed study examined tongue strength and endurance, how the tongue applies pressure during swallowing, and how the chin muscles react during swallowing in healthy volunteers and in patients with dysphagia (difficulty swallowing). The information from this study may be helpful in developing better treatments for people with swallowing problems

Completed study sponsored by Fortaleza Univerity with the purpose of describing functional endoscopic evaluation of swallowing findings in children with cerebral palsy.

Completed study sponsored by National Institutes of Health Clinical Center CC to identify clinical signs and symptoms critical for diagnosing swallowing disorders and will characterize swallowing problems in various patient populations, such as patients with Parkinson's disease, stroke, post-polio syndrome, multiple sclerosis and other conditions that cause swallowing abnormalities.

Ongoing clinical trial sponsored by the University of Texas Southwestern Medical Center to Evaluate the Effects of a Single Dose of Intravenous Premarin for the Treatment of Severe Traumatic Brain Injury

NICHD program focuses on developing research that links PCCR medicine and science to the epidemiology, prevention, and treatment of childhood disabilities. The effort sponsors competitive research on all aspects of PCCR-including critical analyses of outcomes for children who are survivors of trauma, congenital anomalies, neonatal asphyxia, infectious processes, septic shock, and many other less common, but still devastating hildhood processes. The PCCR program also provides support for the Pediatric Critical Care Scientist Development Program (PCCSDP) , a national faculty training and career development program that develops successful pediatric critical care physician scientists conducting research to enhance the scientific understanding, clinical management, and rehabilitation of pediatric critical illness.

NICHD Center for Developmental Biology & Perinatal Medicine (CDBPM). The CDBPM supports scientists who are advancing fundamental and clinical knowledge about maternal health and problems of child development, including preterm labor and birth, intellectual and developmental disabilities, congenital and genetic disorders, fetal growth restriction, and other conditions. The Center and its programs aim to maximize human development, prevent diseases and disorders, and improve diagnoses, therapy, and clinical care.

The IDD Branch sponsors research and research training aimed at preventing and ameliorating intellectual and related developmental disabilities. The program supports biomedical, biobehavioral, behavioral, and translational research in etiology, pathophysiology, screening, prevention, treatment, and epidemiology.

Completed study sponsored by Eunice Kennedy Shriver National Institute of Child Health and Human Development NICHD and conducted in two cities in Zambia to determine if the combined Neonatal Resuscitation Program/Essential Newborn Care Program compared to the new World Health Organization (W.H.O.) basic perinatal care education of health care providers (Essential Newborn Care Program) results in reduced mortality due to perinatal asphyxia

Future planned study sponsored by Ullevaal University Hospital to find out whether 4 different protein sources affect the rate of gastric emptying and electrofysiology in study group of children

Completed study sponsored by University Hospital, Ghent assessing Pharmacokinetics of Enteral Omeprazole Suspension in Patients With Cerebral Palsy and Mental Retardation. Trial aims to compare the pharmacokinetics of omeprazole administered through the gastrostomy tube as a suspension in pediatric patients with cerebral palsy and mental retardation versus the pharmacokinetics of omeprazole administered as a multi-unit-pellet system (MUPS®).

Study to investigate the clinical results after different rehabilitation regimens(Limited or unlimited weightbearing after surgery) in Open-wedge High Tibial Osteotomies. The hypothesis is that unlimited weightbearing is beneficial for the healing and rehabilitation